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The map label for this gene is tpiA [H]

Identifier: 238923896

GI number: 238923896

Start: 1408346

End: 1409095

Strand: Direct

Name: tpiA [H]

Synonym: EUBREC_1524

Alternate gene names: 238923896

Gene position: 1408346-1409095 (Clockwise)

Preceding gene: 238923895

Following gene: 238923897

Centisome position: 40.83

GC content: 45.07

Gene sequence:

>750_bases
ATGGCAAGAAAGAAAATTGTAGCCGGCAACTGGAAGATGAACATGACTCCAAGCCAGGCTGTTAAATTAGTAGAAGAGTT
AAAACCACTCGTAGTTTCAGATGATGTTGAAGTTGTTTACTGTGTACCTGCAATCGACATCGTACCTGTTGTAGAAGCAT
TAAAGGGTACAAATGTTGCTGTTGGAGCAGAGAATATGTACTTCGAGGAGAAGGGTGCTTACACAGGAGAAATCTCAGCA
GAGATGCTTCTTGATGCAGGTGTTAAGTATGTTATCATCGGACATTCAGAGAGAAGAGATTACTTCAAAGAGGATGACGC
ACTTCTCAACAAGAAGGTAAAGAAGGCTATCGAGGCTGGACTTACACCAATCCTTTGCTGTGGTGAGACACTTGAGCAGA
GAGAGAGCGGTGTTACACTTGACTGGATCAGACTTCAGATTAAGTCAGATCTCGCAGGTGTTGCTGCATCAGATGTTGCA
AACATGGTTATCGCTTACGAGCCAATCTGGGCAATCGGAACAGGAAAGACAGCTACTTCTGACCAGGCTCAGGAGGTCTG
CGGTGCAATCCGTGAGTGTGTAGCAGAGATCTATGATCAGGCTACAGCAGATTCAGTTCGTATCCAGTACGGCGGATCTG
TAAATGCAGGAAATGCAGCAGAGCTTTTTGCAAAGCCTGACATCGACGGTGGATTAGTTGGTGGCGCTTCACTCAAGGCT
GATTTTGGAAAGATCGTAAACTACAAGTAA

Upstream 100 bases:

>100_bases
CCTGGCGTAGCTTGTGCTGATGATAAATAAGCCGAAAGCAGCTTAATGAAATCAAGCCGCAGGCAAAAAATATTTGTATA
TAAATACAAGGAGATATAAA

Downstream 100 bases:

>100_bases
TTATTAAATCATAATTTAATATTTGATTTGACAATCACAATAACTAAATGTCACTAAATTCACCAGCTTAGCTGCATTTA
GTGGCATTTATTATGTAATG

Product: triosephosphate isomerase

Products: NA

Alternate protein names: TIM; Triose-phosphate isomerase [H]

Number of amino acids: Translated: 249; Mature: 248

Protein sequence:

>249_residues
MARKKIVAGNWKMNMTPSQAVKLVEELKPLVVSDDVEVVYCVPAIDIVPVVEALKGTNVAVGAENMYFEEKGAYTGEISA
EMLLDAGVKYVIIGHSERRDYFKEDDALLNKKVKKAIEAGLTPILCCGETLEQRESGVTLDWIRLQIKSDLAGVAASDVA
NMVIAYEPIWAIGTGKTATSDQAQEVCGAIRECVAEIYDQATADSVRIQYGGSVNAGNAAELFAKPDIDGGLVGGASLKA
DFGKIVNYK

Sequences:

>Translated_249_residues
MARKKIVAGNWKMNMTPSQAVKLVEELKPLVVSDDVEVVYCVPAIDIVPVVEALKGTNVAVGAENMYFEEKGAYTGEISA
EMLLDAGVKYVIIGHSERRDYFKEDDALLNKKVKKAIEAGLTPILCCGETLEQRESGVTLDWIRLQIKSDLAGVAASDVA
NMVIAYEPIWAIGTGKTATSDQAQEVCGAIRECVAEIYDQATADSVRIQYGGSVNAGNAAELFAKPDIDGGLVGGASLKA
DFGKIVNYK
>Mature_248_residues
ARKKIVAGNWKMNMTPSQAVKLVEELKPLVVSDDVEVVYCVPAIDIVPVVEALKGTNVAVGAENMYFEEKGAYTGEISAE
MLLDAGVKYVIIGHSERRDYFKEDDALLNKKVKKAIEAGLTPILCCGETLEQRESGVTLDWIRLQIKSDLAGVAASDVAN
MVIAYEPIWAIGTGKTATSDQAQEVCGAIRECVAEIYDQATADSVRIQYGGSVNAGNAAELFAKPDIDGGLVGGASLKAD
FGKIVNYK

Specific function: Plays an important role in several metabolic pathways. [C]

COG id: COG0149

COG function: function code G; Triosephosphate isomerase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the triosephosphate isomerase family [H]

Homologues:

Organism=Homo sapiens, GI226529917, Length=248, Percent_Identity=44.758064516129, Blast_Score=192, Evalue=3e-49,
Organism=Homo sapiens, GI4507645, Length=248, Percent_Identity=44.758064516129, Blast_Score=191, Evalue=4e-49,
Organism=Escherichia coli, GI1790353, Length=246, Percent_Identity=49.5934959349593, Blast_Score=208, Evalue=2e-55,
Organism=Caenorhabditis elegans, GI17536593, Length=250, Percent_Identity=50, Blast_Score=210, Evalue=6e-55,
Organism=Saccharomyces cerevisiae, GI6320255, Length=249, Percent_Identity=44.9799196787149, Blast_Score=209, Evalue=3e-55,
Organism=Drosophila melanogaster, GI28572004, Length=249, Percent_Identity=46.1847389558233, Blast_Score=206, Evalue=1e-53,
Organism=Drosophila melanogaster, GI28572008, Length=249, Percent_Identity=46.1847389558233, Blast_Score=206, Evalue=1e-53,
Organism=Drosophila melanogaster, GI28572006, Length=249, Percent_Identity=46.1847389558233, Blast_Score=206, Evalue=1e-53,

Paralogues:

None

Copy number: 1120 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 60 Molecules/Cell In: Stationary Phase, Rich Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013785
- InterPro:   IPR022896
- InterPro:   IPR000652
- InterPro:   IPR020861 [H]

Pfam domain/function: PF00121 TIM [H]

EC number: =5.3.1.1 [H]

Molecular weight: Translated: 26695; Mature: 26564

Theoretical pI: Translated: 4.50; Mature: 4.50

Prosite motif: PS00171 TIM

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.0 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
4.4 %Cys+Met (Translated Protein)
2.0 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
4.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MARKKIVAGNWKMNMTPSQAVKLVEELKPLVVSDDVEVVYCVPAIDIVPVVEALKGTNVA
CCCCEEEECCEEECCCHHHHHHHHHHHCCEEEECCCCEEEEECCCHHHHHHHHHCCCCEE
VGAENMYFEEKGAYTGEISAEMLLDAGVKYVIIGHSERRDYFKEDDALLNKKVKKAIEAG
ECCCCEEEECCCCCCCCCHHHHHHHCCCEEEEEECCHHHHHHHHHHHHHHHHHHHHHHHC
LTPILCCGETLEQRESGVTLDWIRLQIKSDLAGVAASDVANMVIAYEPIWAIGTGKTATS
CCEEEECCHHHHHHHCCCEEEHEEEEEHHHHHHHHHHHHHHEEEEECCEEEEECCCCCCC
DQAQEVCGAIRECVAEIYDQATADSVRIQYGGSVNAGNAAELFAKPDIDGGLVGGASLKA
HHHHHHHHHHHHHHHHHHCCCCCCCEEEEECCCCCCCCHHHEEECCCCCCCEECCCCCHH
DFGKIVNYK
HHHHHCCCC
>Mature Secondary Structure 
ARKKIVAGNWKMNMTPSQAVKLVEELKPLVVSDDVEVVYCVPAIDIVPVVEALKGTNVA
CCCEEEECCEEECCCHHHHHHHHHHHCCEEEECCCCEEEEECCCHHHHHHHHHCCCCEE
VGAENMYFEEKGAYTGEISAEMLLDAGVKYVIIGHSERRDYFKEDDALLNKKVKKAIEAG
ECCCCEEEECCCCCCCCCHHHHHHHCCCEEEEEECCHHHHHHHHHHHHHHHHHHHHHHHC
LTPILCCGETLEQRESGVTLDWIRLQIKSDLAGVAASDVANMVIAYEPIWAIGTGKTATS
CCEEEECCHHHHHHHCCCEEEHEEEEEHHHHHHHHHHHHHHEEEEECCEEEEECCCCCCC
DQAQEVCGAIRECVAEIYDQATADSVRIQYGGSVNAGNAAELFAKPDIDGGLVGGASLKA
HHHHHHHHHHHHHHHHHHCCCCCCCEEEEECCCCCCCCHHHEEECCCCCCCEECCCCCHH
DFGKIVNYK
HHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA