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The map label for this gene is ung

Identifier: 238923841

GI number: 238923841

Start: 1347232

End: 1347909

Strand: Direct

Name: ung

Synonym: EUBREC_1469

Alternate gene names: 238923841

Gene position: 1347232-1347909 (Clockwise)

Preceding gene: 238923840

Following gene: 238923842

Centisome position: 39.05

GC content: 45.87

Gene sequence:

>678_bases
ATGAGTATGCTTGATGGCGAGTGGGCAAAGGCTGTGGGAGCCGAGTTTAAAAAACCGTATTATAGGGATTTGTACAATTT
TGTAAGAGATGAATATGCCACACATGTGGTATATCCTCCGGCAGATGACATATTTAATGCCATGCATTTTACGCCACTTG
ACAAGGTGAAGGTACTCATCCTCGGACAGGATCCGTACCACAATGTCAATCAGGCGCATGGATTGTCGTTTTCTGTGCTT
CCGTCTCAGAAGGATATTCCACCATCACTGCAGAATATCTACAAGGAACTGCACGACGATTTAGGGTGTGATATCCCCAA
TAACGGATACCTGAAGAAATGGGCTGACCAGGGTGTTTTACTATTGAATACGGTGCTCACTGTCAGAGCTCATCAGGCAA
ACTCGCATCAGGGGCACGGCTGGGAGAAGTTCACGGATGCAATCATAGAGGCTGTAAATGAGCAGGATAGACCTATAGTG
TATATGCTCTGGGGACGTCCGGCGCAGTCAAAGATTCCTATGCTTACAAATCCAAAGCATCTGATATTGAAAGCACCGCA
TCCAAGCCCGCTGTCGGCTTACAGAGGCTTTTTTGGTTGCAAGCATTTTAGTAAAGCCAATGAGTTTCTTAAGGAGCATG
GAGTGGAGCCTGTTGACTGGCAGATAGAGGATATATAA

Upstream 100 bases:

>100_bases
GCTTCACTTTTCCACTACAAGGAGCTTGAAATTATGGATTTAAAGAATTATCTGGCAGATAAAGGTGTGTCGGTCAGAAG
ATAGGCGGGAGATAAAGATT

Downstream 100 bases:

>100_bases
AGGACGACAATACCGGCTCATATGTTAGTAATACCTGGCTGGGTAATATCGGCAGATATTATCTTGACATAAATTGGAAA
AGCGTCTATATTAAAAATAT

Product: uracil-DNA glycosylase

Products: NA

Alternate protein names: UDG

Number of amino acids: Translated: 225; Mature: 224

Protein sequence:

>225_residues
MSMLDGEWAKAVGAEFKKPYYRDLYNFVRDEYATHVVYPPADDIFNAMHFTPLDKVKVLILGQDPYHNVNQAHGLSFSVL
PSQKDIPPSLQNIYKELHDDLGCDIPNNGYLKKWADQGVLLLNTVLTVRAHQANSHQGHGWEKFTDAIIEAVNEQDRPIV
YMLWGRPAQSKIPMLTNPKHLILKAPHPSPLSAYRGFFGCKHFSKANEFLKEHGVEPVDWQIEDI

Sequences:

>Translated_225_residues
MSMLDGEWAKAVGAEFKKPYYRDLYNFVRDEYATHVVYPPADDIFNAMHFTPLDKVKVLILGQDPYHNVNQAHGLSFSVL
PSQKDIPPSLQNIYKELHDDLGCDIPNNGYLKKWADQGVLLLNTVLTVRAHQANSHQGHGWEKFTDAIIEAVNEQDRPIV
YMLWGRPAQSKIPMLTNPKHLILKAPHPSPLSAYRGFFGCKHFSKANEFLKEHGVEPVDWQIEDI
>Mature_224_residues
SMLDGEWAKAVGAEFKKPYYRDLYNFVRDEYATHVVYPPADDIFNAMHFTPLDKVKVLILGQDPYHNVNQAHGLSFSVLP
SQKDIPPSLQNIYKELHDDLGCDIPNNGYLKKWADQGVLLLNTVLTVRAHQANSHQGHGWEKFTDAIIEAVNEQDRPIVY
MLWGRPAQSKIPMLTNPKHLILKAPHPSPLSAYRGFFGCKHFSKANEFLKEHGVEPVDWQIEDI

Specific function: Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine

COG id: COG0692

COG function: function code L; Uracil DNA glycosylase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the uracil-DNA glycosylase family

Homologues:

Organism=Homo sapiens, GI19718751, Length=217, Percent_Identity=52.073732718894, Blast_Score=229, Evalue=2e-60,
Organism=Homo sapiens, GI6224979, Length=218, Percent_Identity=51.8348623853211, Blast_Score=229, Evalue=2e-60,
Organism=Escherichia coli, GI1788934, Length=215, Percent_Identity=53.4883720930233, Blast_Score=232, Evalue=2e-62,
Organism=Caenorhabditis elegans, GI17556304, Length=225, Percent_Identity=48, Blast_Score=206, Evalue=1e-53,
Organism=Saccharomyces cerevisiae, GI6323620, Length=240, Percent_Identity=47.0833333333333, Blast_Score=207, Evalue=1e-54,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): UNG_EUBR3 (C4Z8Z2)

Other databases:

- EMBL:   CP001107
- RefSeq:   YP_002937357.1
- GeneID:   7963834
- GenomeReviews:   CP001107_GR
- KEGG:   ere:EUBREC_1469
- ProtClustDB:   CLSK2506353
- GO:   GO:0005737
- HAMAP:   MF_00148
- InterPro:   IPR002043
- InterPro:   IPR018085
- InterPro:   IPR005122
- Gene3D:   G3DSA:3.40.470.10
- PANTHER:   PTHR11264
- TIGRFAMs:   TIGR00628

Pfam domain/function: PF03167 UDG; SSF52141 UDNA_glycsylseSF

EC number: =3.2.2.27

Molecular weight: Translated: 25689; Mature: 25558

Theoretical pI: Translated: 6.65; Mature: 6.65

Prosite motif: PS00130 U_DNA_GLYCOSYLASE

Important sites: ACT_SITE 64-64

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
3.1 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
2.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSMLDGEWAKAVGAEFKKPYYRDLYNFVRDEYATHVVYPPADDIFNAMHFTPLDKVKVLI
CCCCCCHHHHHHHHHHCCCHHHHHHHHHHHHHCCEEEECCHHHHHHHHCCCCCCCEEEEE
LGQDPYHNVNQAHGLSFSVLPSQKDIPPSLQNIYKELHDDLGCDIPNNGYLKKWADQGVL
ECCCCCCCCCHHCCCEEEECCCCCCCCHHHHHHHHHHHHHHCCCCCCCCCHHHHHCCCEE
LLNTVLTVRAHQANSHQGHGWEKFTDAIIEAVNEQDRPIVYMLWGRPAQSKIPMLTNPKH
EEHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHCCCCCCEEEEEECCCCCCCCCCCCCCCE
LILKAPHPSPLSAYRGFFGCKHFSKANEFLKEHGVEPVDWQIEDI
EEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEECCC
>Mature Secondary Structure 
SMLDGEWAKAVGAEFKKPYYRDLYNFVRDEYATHVVYPPADDIFNAMHFTPLDKVKVLI
CCCCCHHHHHHHHHHCCCHHHHHHHHHHHHHCCEEEECCHHHHHHHHCCCCCCCEEEEE
LGQDPYHNVNQAHGLSFSVLPSQKDIPPSLQNIYKELHDDLGCDIPNNGYLKKWADQGVL
ECCCCCCCCCHHCCCEEEECCCCCCCCHHHHHHHHHHHHHHCCCCCCCCCHHHHHCCCEE
LLNTVLTVRAHQANSHQGHGWEKFTDAIIEAVNEQDRPIVYMLWGRPAQSKIPMLTNPKH
EEHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHCCCCCCEEEEEECCCCCCCCCCCCCCCE
LILKAPHPSPLSAYRGFFGCKHFSKANEFLKEHGVEPVDWQIEDI
EEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEECCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA