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The map label for this gene is hisC [H]

Identifier: 238923768

GI number: 238923768

Start: 1268949

End: 1270007

Strand: Direct

Name: hisC [H]

Synonym: EUBREC_1390

Alternate gene names: 238923768

Gene position: 1268949-1270007 (Clockwise)

Preceding gene: 238923766

Following gene: 238923769

Centisome position: 36.78

GC content: 39.66

Gene sequence:

>1059_bases
ATGAGAGACTGGGAAAATAACATTCGAAAGGTTGTACCTTATACACCGGGAGAACAGCCAAAGAATACCTGTGTTATTAA
GTTAAATACAAATGAGAATCCCTATCCGCCAGCACCGGGAGTGAAGGAAGTTTTAAGTAATTTCAATACAGATGATTTAA
GACTGTATCCTGATCCAAGGGTTGATAAGCTGGTAAATGCAATTGCGGATTTCTATAAGATAGACAGCTCAAAGGTGTTT
GTCGGAGTTGGCTCTGATGATGTACTTGCCATGATTTTTATGACATTTTTCAATTCGAAAAAGCCGATACTGTTTCCTGA
TATTACATATTCATTTTATGATGTGTGGGCAGATATGCTTCGAATCCCTTATGAGCAACTTCCATTGTCTGATGATTTTT
CAATAGTACCGTCAGATTACTATAAGGCAAACGGCGGAGTCGTATTTCCAAACCCTAATGCCCCGACAGGAAAGCTCATG
CCTCTTGATGAGATAGAGGATATAATAAAGCATAATCAGGATGTAATTGTCGTAGTAGATGAGGCATATGTGGATTTTGG
CGGGGAGAGTGCGCTTCCACTCATTGACAAATATGATAATGTCATCGTGGTACAGACATTCTCGAAATCACGCGCGCTGG
CAGGCTCAAGAGTTGGTTTTGCCATGGCAAGTCCTGTGCTTATCAAGTATCTGAATGATGTGAAATATTCGTTCAATTCA
TATACAATGGACAGAATCACAATCGAAGCAGCTACAGCAGCGGTAAAAGACAGAGCATACTTTGAAGAGACCACAGCAAA
GGTTATAAAGACACGTGAATGGACAAAGAAAGAGCTTAAGAGACTTGGCTTTACATTCTGTGACTCAAAGAGCAACTTTA
TATTTGCAAAGCCCGCAAATGTTTCTGCAACAAAGCTTTTTGAGGACCTTAAGGCAGACAATATATTTGTCAGACATTTC
AGCTCACCTGAGCGAATCAACGACTATCTGCGAATATCCATAGGAACGGATGAGCAGATGCATACACTAATTAAATTTTT
GGAGAATTATTCATGTTAA

Upstream 100 bases:

>100_bases
AACGCTGATTTTATGTTTGATATCATGTTTTTTTGAGAAGAAAATTGAATGATTAGTAAATATGTATGGGCTGACATATA
ATTAAATTTGGAGGAAAAGA

Downstream 100 bases:

>100_bases
AAAAATATATTTACATCTTTTTAATTTCAATGGTACCACTTATTGAACTCAGAGGAGCGGTTCCGGTTTCACAGGTGATG
GGGCTGCCGATAGTGCCATC

Product: histidinol-phosphate aminotransferase

Products: NA

Alternate protein names: Imidazole acetol-phosphate transaminase [H]

Number of amino acids: Translated: 352; Mature: 352

Protein sequence:

>352_residues
MRDWENNIRKVVPYTPGEQPKNTCVIKLNTNENPYPPAPGVKEVLSNFNTDDLRLYPDPRVDKLVNAIADFYKIDSSKVF
VGVGSDDVLAMIFMTFFNSKKPILFPDITYSFYDVWADMLRIPYEQLPLSDDFSIVPSDYYKANGGVVFPNPNAPTGKLM
PLDEIEDIIKHNQDVIVVVDEAYVDFGGESALPLIDKYDNVIVVQTFSKSRALAGSRVGFAMASPVLIKYLNDVKYSFNS
YTMDRITIEAATAAVKDRAYFEETTAKVIKTREWTKKELKRLGFTFCDSKSNFIFAKPANVSATKLFEDLKADNIFVRHF
SSPERINDYLRISIGTDEQMHTLIKFLENYSC

Sequences:

>Translated_352_residues
MRDWENNIRKVVPYTPGEQPKNTCVIKLNTNENPYPPAPGVKEVLSNFNTDDLRLYPDPRVDKLVNAIADFYKIDSSKVF
VGVGSDDVLAMIFMTFFNSKKPILFPDITYSFYDVWADMLRIPYEQLPLSDDFSIVPSDYYKANGGVVFPNPNAPTGKLM
PLDEIEDIIKHNQDVIVVVDEAYVDFGGESALPLIDKYDNVIVVQTFSKSRALAGSRVGFAMASPVLIKYLNDVKYSFNS
YTMDRITIEAATAAVKDRAYFEETTAKVIKTREWTKKELKRLGFTFCDSKSNFIFAKPANVSATKLFEDLKADNIFVRHF
SSPERINDYLRISIGTDEQMHTLIKFLENYSC
>Mature_352_residues
MRDWENNIRKVVPYTPGEQPKNTCVIKLNTNENPYPPAPGVKEVLSNFNTDDLRLYPDPRVDKLVNAIADFYKIDSSKVF
VGVGSDDVLAMIFMTFFNSKKPILFPDITYSFYDVWADMLRIPYEQLPLSDDFSIVPSDYYKANGGVVFPNPNAPTGKLM
PLDEIEDIIKHNQDVIVVVDEAYVDFGGESALPLIDKYDNVIVVQTFSKSRALAGSRVGFAMASPVLIKYLNDVKYSFNS
YTMDRITIEAATAAVKDRAYFEETTAKVIKTREWTKKELKRLGFTFCDSKSNFIFAKPANVSATKLFEDLKADNIFVRHF
SSPERINDYLRISIGTDEQMHTLIKFLENYSC

Specific function: Histidine biosynthesis; seventh step. [C]

COG id: COG0079

COG function: function code E; Histidinol-phosphate/aromatic aminotransferase and cobyric acid decarboxylase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily [H]

Homologues:

Organism=Escherichia coli, GI1788332, Length=351, Percent_Identity=26.7806267806268, Blast_Score=111, Evalue=7e-26,
Organism=Saccharomyces cerevisiae, GI6322075, Length=361, Percent_Identity=31.3019390581717, Blast_Score=120, Evalue=3e-28,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004839
- InterPro:   IPR005861
- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422 [H]

Pfam domain/function: PF00155 Aminotran_1_2 [H]

EC number: =2.6.1.9 [H]

Molecular weight: Translated: 40037; Mature: 40037

Theoretical pI: Translated: 5.02; Mature: 5.02

Prosite motif: PS00599 AA_TRANSFER_CLASS_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
3.1 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
3.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRDWENNIRKVVPYTPGEQPKNTCVIKLNTNENPYPPAPGVKEVLSNFNTDDLRLYPDPR
CCCCCCCCEEECCCCCCCCCCCEEEEEECCCCCCCCCCCCHHHHHHCCCCCCEEECCCCC
VDKLVNAIADFYKIDSSKVFVGVGSDDVLAMIFMTFFNSKKPILFPDITYSFYDVWADML
HHHHHHHHHHHHCCCCCEEEEEECCCHHHHHHHHHHHCCCCCEEECCCCHHHHHHHHHHH
RIPYEQLPLSDDFSIVPSDYYKANGGVVFPNPNAPTGKLMPLDEIEDIIKHNQDVIVVVD
HCCHHHCCCCCCCCCCCCCCEECCCCEEECCCCCCCCCCCCHHHHHHHHHCCCCEEEEEE
EAYVDFGGESALPLIDKYDNVIVVQTFSKSRALAGSRVGFAMASPVLIKYLNDVKYSFNS
CCEECCCCCCCCCHHHCCCCEEEEEECCCCHHCCCCCCCHHHHHHHHHHHHHHHHHCCCC
YTMDRITIEAATAAVKDRAYFEETTAKVIKTREWTKKELKRLGFTFCDSKSNFIFAKPAN
EEEEEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEECCCCCEEEECCCC
VSATKLFEDLKADNIFVRHFSSPERINDYLRISIGTDEQMHTLIKFLENYSC
CHHHHHHHHHCCCCEEEEECCCHHHCCCEEEEEECCCHHHHHHHHHHHHCCC
>Mature Secondary Structure
MRDWENNIRKVVPYTPGEQPKNTCVIKLNTNENPYPPAPGVKEVLSNFNTDDLRLYPDPR
CCCCCCCCEEECCCCCCCCCCCEEEEEECCCCCCCCCCCCHHHHHHCCCCCCEEECCCCC
VDKLVNAIADFYKIDSSKVFVGVGSDDVLAMIFMTFFNSKKPILFPDITYSFYDVWADML
HHHHHHHHHHHHCCCCCEEEEEECCCHHHHHHHHHHHCCCCCEEECCCCHHHHHHHHHHH
RIPYEQLPLSDDFSIVPSDYYKANGGVVFPNPNAPTGKLMPLDEIEDIIKHNQDVIVVVD
HCCHHHCCCCCCCCCCCCCCEECCCCEEECCCCCCCCCCCCHHHHHHHHHCCCCEEEEEE
EAYVDFGGESALPLIDKYDNVIVVQTFSKSRALAGSRVGFAMASPVLIKYLNDVKYSFNS
CCEECCCCCCCCCHHHCCCCEEEEEECCCCHHCCCCCCCHHHHHHHHHHHHHHHHHCCCC
YTMDRITIEAATAAVKDRAYFEETTAKVIKTREWTKKELKRLGFTFCDSKSNFIFAKPAN
EEEEEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEECCCCCEEEECCCC
VSATKLFEDLKADNIFVRHFSSPERINDYLRISIGTDEQMHTLIKFLENYSC
CHHHHHHHHHCCCCEEEEECCCHHHCCCEEEEEECCCHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA