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The map label for this gene is cdr [H]

Identifier: 238923599

GI number: 238923599

Start: 1122169

End: 1123860

Strand: Direct

Name: cdr [H]

Synonym: EUBREC_1221

Alternate gene names: 238923599

Gene position: 1122169-1123860 (Clockwise)

Preceding gene: 238923598

Following gene: 238923601

Centisome position: 32.53

GC content: 41.19

Gene sequence:

>1692_bases
ATGAAGGTAATAATTGTAGGAGGTGTAGCCGGAGGAGCTACAGCCGCAGCAAGAATACGCAGACTGAATGAGCATGCTGA
AATTACTGTGTTTGAAAGATCCGGATACATATCCTATGCAAATTGTGGACTTCCATATTATATTGGAGACGTGATCACAG
ACCTGGAAGAACTTACACTACAGACACCAGAGAGTTTTTTTAAACGCTTCCGTATTAACATGAAAATTCATCATGAAGTT
ATCTCAATACATCCCGAATATAAAACTGTTTCAGTTAAGAATTTAGAAAACGGTGAAATATTTGAAGAAAACTATGATAA
GCTAATCCTCTCTCCAGGTGCAAAGCCTACACAGCCGAGACTTCCCGGAGTAGGTATTGATAAACTTTTTACACTTCGTA
CTGTAGAAGACACTTTTCGGATAAAGGAATATATAAATAAGAATCATCCAAAATCGGCTGTATTGGCAGGTGGCGGTTTT
ATTGGTCTGGAACTGGCAGAAAATTTGAGGGAGCTTGGCATGGATGTTACGATTGTCCAGCGGCCTAAGCAGCTGATGAA
CCCTTTTGACCCGGATATGGCATCCATGATCCATAATGAAATGAGAAAGCATGGGATAAAACTGGTACTGGGCTATACAG
TAGAAGGATTTAAAGAAAAAGACAACGGAGTAGAGGTTCTGTTGAAAGATAATCCATCCCTTCAGGCTGATATGGTAGTT
CTGGCAATCGGAGTCACACCAGACACAGTATTAGCAAAAGAAGCAGGTCTGGAACTTGGCATCAAGGAAAGTATTGTAGT
GAATGACAGAATGGAAACCTCTGTACCGGATATTTATGCTGCAGGTGATGCAGTTCAGGTAAAACATTATGTTACGGGTA
ATGATGCGCTGATTTCTTTGGCAGGACCAGCCAATAAACAGGGCAGAATCATCGCTGATAATATTTGTGGCGGTGATAGT
CGTTACTTGGGTAGTCAGGGAAGCTCCGTTATAAAAGTGTTTGATATGACAGCAGCCACTACAGGTATCAATGAAACCAA
TGCCCAAAAGTCAGGATTAGAGGTAGATACAGTAATTCTTTCTCCTATGAGTCATGCCGGTTACTATCCTGGTGGAAAAG
TGATGACCATGAAGGTGATTTTTGAAAAAGAGAGCTATCGTTTGCTTGGCGCTCAGATTATTGGATATGAAGGAGTTGAT
AAACGTATTGATGTGCTGGCAACAGCAATTCATGCGGGGCTGAATGCAACCCAGTTGAAAGATCTGGATCTGGCATATGC
ACCACCTTATTCTTCTGCCAAGGATCCGGTAAACATGGCTGGATTTATGATAGACAATATTGCAAAAGGGACATTAAAGC
AATGGCATTTGGAAGATATGGACAAGATTTCTAAAGATAAAGATGTGGTGTTGCTAGATGTGAGAACTGTAGGTGAATTC
AGCAGGGGGCATATTGATGGATTCAAAAACATACCTGTAGATGAACTGAGAGAACGAATTAGTGAAATTGAGAAAGGAAA
GCCTGTGTATCTGATATGCCAGAGTGGTTTGCGCAGTTATATTGCGAGCCGTATTCTGGAAGGAAACGGCTATGAAACGT
ATAATTTCTCTGGCGGATTTCGCTTCTATGATGCAGTGGTCAATGACCGTGCGCTGATTGAAAGGACATATGCATGTGGT
ATGGATTATTAA

Upstream 100 bases:

>100_bases
CGGAGCCGTCAGGCAACTGGGATGTTGCAACGAATGGGATATTCTAAAGTAAATAATATCGGTGGCATTGCAGCTTACTC
AGGAAAGGTGGAAAAATAAG

Downstream 100 bases:

>100_bases
AAAATAATCACGATATTTTTATAATTTTCTTATAGCATAAAAAGATCCCCTATTTATTAGAATGACTTTCATAATTCTGA
TAAATGGAGGATTCTTCTTT

Product: NADH dehydrogenase

Products: NA

Alternate protein names: CoA-disulfide reductase; CoADR [H]

Number of amino acids: Translated: 563; Mature: 563

Protein sequence:

>563_residues
MKVIIVGGVAGGATAAARIRRLNEHAEITVFERSGYISYANCGLPYYIGDVITDLEELTLQTPESFFKRFRINMKIHHEV
ISIHPEYKTVSVKNLENGEIFEENYDKLILSPGAKPTQPRLPGVGIDKLFTLRTVEDTFRIKEYINKNHPKSAVLAGGGF
IGLELAENLRELGMDVTIVQRPKQLMNPFDPDMASMIHNEMRKHGIKLVLGYTVEGFKEKDNGVEVLLKDNPSLQADMVV
LAIGVTPDTVLAKEAGLELGIKESIVVNDRMETSVPDIYAAGDAVQVKHYVTGNDALISLAGPANKQGRIIADNICGGDS
RYLGSQGSSVIKVFDMTAATTGINETNAQKSGLEVDTVILSPMSHAGYYPGGKVMTMKVIFEKESYRLLGAQIIGYEGVD
KRIDVLATAIHAGLNATQLKDLDLAYAPPYSSAKDPVNMAGFMIDNIAKGTLKQWHLEDMDKISKDKDVVLLDVRTVGEF
SRGHIDGFKNIPVDELRERISEIEKGKPVYLICQSGLRSYIASRILEGNGYETYNFSGGFRFYDAVVNDRALIERTYACG
MDY

Sequences:

>Translated_563_residues
MKVIIVGGVAGGATAAARIRRLNEHAEITVFERSGYISYANCGLPYYIGDVITDLEELTLQTPESFFKRFRINMKIHHEV
ISIHPEYKTVSVKNLENGEIFEENYDKLILSPGAKPTQPRLPGVGIDKLFTLRTVEDTFRIKEYINKNHPKSAVLAGGGF
IGLELAENLRELGMDVTIVQRPKQLMNPFDPDMASMIHNEMRKHGIKLVLGYTVEGFKEKDNGVEVLLKDNPSLQADMVV
LAIGVTPDTVLAKEAGLELGIKESIVVNDRMETSVPDIYAAGDAVQVKHYVTGNDALISLAGPANKQGRIIADNICGGDS
RYLGSQGSSVIKVFDMTAATTGINETNAQKSGLEVDTVILSPMSHAGYYPGGKVMTMKVIFEKESYRLLGAQIIGYEGVD
KRIDVLATAIHAGLNATQLKDLDLAYAPPYSSAKDPVNMAGFMIDNIAKGTLKQWHLEDMDKISKDKDVVLLDVRTVGEF
SRGHIDGFKNIPVDELRERISEIEKGKPVYLICQSGLRSYIASRILEGNGYETYNFSGGFRFYDAVVNDRALIERTYACG
MDY
>Mature_563_residues
MKVIIVGGVAGGATAAARIRRLNEHAEITVFERSGYISYANCGLPYYIGDVITDLEELTLQTPESFFKRFRINMKIHHEV
ISIHPEYKTVSVKNLENGEIFEENYDKLILSPGAKPTQPRLPGVGIDKLFTLRTVEDTFRIKEYINKNHPKSAVLAGGGF
IGLELAENLRELGMDVTIVQRPKQLMNPFDPDMASMIHNEMRKHGIKLVLGYTVEGFKEKDNGVEVLLKDNPSLQADMVV
LAIGVTPDTVLAKEAGLELGIKESIVVNDRMETSVPDIYAAGDAVQVKHYVTGNDALISLAGPANKQGRIIADNICGGDS
RYLGSQGSSVIKVFDMTAATTGINETNAQKSGLEVDTVILSPMSHAGYYPGGKVMTMKVIFEKESYRLLGAQIIGYEGVD
KRIDVLATAIHAGLNATQLKDLDLAYAPPYSSAKDPVNMAGFMIDNIAKGTLKQWHLEDMDKISKDKDVVLLDVRTVGEF
SRGHIDGFKNIPVDELRERISEIEKGKPVYLICQSGLRSYIASRILEGNGYETYNFSGGFRFYDAVVNDRALIERTYACG
MDY

Specific function: Catalyzes specifically the NADPH-dependent reduction of coenzyme A disulfide [H]

COG id: COG0446

COG function: function code R; Uncharacterized NAD(FAD)-dependent dehydrogenases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-III pyridine nucleotide-disulfide oxidoreductase family [H]

Homologues:

Organism=Homo sapiens, GI21389617, Length=319, Percent_Identity=27.8996865203762, Blast_Score=114, Evalue=3e-25,
Organism=Homo sapiens, GI65787454, Length=319, Percent_Identity=27.8996865203762, Blast_Score=114, Evalue=3e-25,
Organism=Homo sapiens, GI226437568, Length=319, Percent_Identity=27.8996865203762, Blast_Score=114, Evalue=4e-25,
Organism=Homo sapiens, GI22035672, Length=228, Percent_Identity=30.2631578947368, Blast_Score=74, Evalue=4e-13,
Organism=Homo sapiens, GI91199540, Length=344, Percent_Identity=26.7441860465116, Blast_Score=70, Evalue=4e-12,
Organism=Homo sapiens, GI33519430, Length=339, Percent_Identity=24.4837758112094, Blast_Score=68, Evalue=2e-11,
Organism=Homo sapiens, GI33519428, Length=339, Percent_Identity=24.4837758112094, Blast_Score=68, Evalue=2e-11,
Organism=Homo sapiens, GI33519426, Length=339, Percent_Identity=24.4837758112094, Blast_Score=68, Evalue=2e-11,
Organism=Homo sapiens, GI148277065, Length=339, Percent_Identity=24.4837758112094, Blast_Score=67, Evalue=4e-11,
Organism=Homo sapiens, GI148277071, Length=339, Percent_Identity=24.7787610619469, Blast_Score=67, Evalue=6e-11,
Organism=Homo sapiens, GI291045266, Length=324, Percent_Identity=24.6913580246914, Blast_Score=66, Evalue=9e-11,
Organism=Escherichia coli, GI1789065, Length=319, Percent_Identity=24.7648902821317, Blast_Score=107, Evalue=2e-24,
Organism=Escherichia coli, GI1789765, Length=375, Percent_Identity=26.1333333333333, Blast_Score=92, Evalue=7e-20,
Organism=Escherichia coli, GI1788892, Length=284, Percent_Identity=27.4647887323944, Blast_Score=90, Evalue=3e-19,
Organism=Escherichia coli, GI1786307, Length=333, Percent_Identity=26.4264264264264, Blast_Score=84, Evalue=3e-17,
Organism=Escherichia coli, GI87082354, Length=295, Percent_Identity=24.0677966101695, Blast_Score=80, Evalue=4e-16,
Organism=Escherichia coli, GI87081717, Length=333, Percent_Identity=26.4264264264264, Blast_Score=74, Evalue=3e-14,
Organism=Escherichia coli, GI1789915, Length=365, Percent_Identity=24.9315068493151, Blast_Score=70, Evalue=3e-13,
Organism=Escherichia coli, GI1787352, Length=240, Percent_Identity=25.4166666666667, Blast_Score=63, Evalue=5e-11,
Organism=Caenorhabditis elegans, GI17559934, Length=233, Percent_Identity=28.755364806867, Blast_Score=96, Evalue=6e-20,
Organism=Caenorhabditis elegans, GI17557007, Length=329, Percent_Identity=23.7082066869301, Blast_Score=65, Evalue=8e-11,
Organism=Saccharomyces cerevisiae, GI6325166, Length=194, Percent_Identity=29.3814432989691, Blast_Score=64, Evalue=5e-11,
Organism=Drosophila melanogaster, GI24639257, Length=320, Percent_Identity=25.9375, Blast_Score=92, Evalue=1e-18,
Organism=Drosophila melanogaster, GI281359715, Length=320, Percent_Identity=25.9375, Blast_Score=92, Evalue=1e-18,
Organism=Drosophila melanogaster, GI281359713, Length=320, Percent_Identity=25.9375, Blast_Score=92, Evalue=1e-18,
Organism=Drosophila melanogaster, GI24639250, Length=320, Percent_Identity=25.9375, Blast_Score=92, Evalue=1e-18,
Organism=Drosophila melanogaster, GI18543267, Length=320, Percent_Identity=25.9375, Blast_Score=92, Evalue=1e-18,
Organism=Drosophila melanogaster, GI24639252, Length=320, Percent_Identity=25.9375, Blast_Score=92, Evalue=1e-18,
Organism=Drosophila melanogaster, GI24585130, Length=335, Percent_Identity=24.7761194029851, Blast_Score=81, Evalue=2e-15,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR017758
- InterPro:   IPR016156
- InterPro:   IPR013027
- InterPro:   IPR004099
- InterPro:   IPR001327 [H]

Pfam domain/function: PF00070 Pyr_redox; PF07992 Pyr_redox_2; PF02852 Pyr_redox_dim [H]

EC number: =1.8.1.14 [H]

Molecular weight: Translated: 62046; Mature: 62046

Theoretical pI: Translated: 5.68; Mature: 5.68

Prosite motif: PS50206 RHODANESE_3

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
3.0 %Met     (Translated Protein)
3.7 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
3.0 %Met     (Mature Protein)
3.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKVIIVGGVAGGATAAARIRRLNEHAEITVFERSGYISYANCGLPYYIGDVITDLEELTL
CEEEEEECCCCCHHHHHHHHHHCCCCEEEEEECCCEEEEECCCCCHHHHHHHHHHHHHHC
QTPESFFKRFRINMKIHHEVISIHPEYKTVSVKNLENGEIFEENYDKLILSPGAKPTQPR
CCHHHHHHHEECCEEEEEEEEEECCCCEEEEEECCCCCCEECCCCCEEEECCCCCCCCCC
LPGVGIDKLFTLRTVEDTFRIKEYINKNHPKSAVLAGGGFIGLELAENLRELGMDVTIVQ
CCCCCHHHEEEEEHHHHHHHHHHHHCCCCCCCEEEECCCEEHHHHHHHHHHCCCCEEEEE
RPKQLMNPFDPDMASMIHNEMRKHGIKLVLGYTVEGFKEKDNGVEVLLKDNPSLQADMVV
CCHHHCCCCCHHHHHHHHHHHHHCCEEEEEEEEECCCCCCCCCEEEEEECCCCCCEEEEE
LAIGVTPDTVLAKEAGLELGIKESIVVNDRMETSVPDIYAAGDAVQVKHYVTGNDALISL
EEEECCCCHHHHHHCCCCCCCCCEEEECCCCCCCCCCEEECCCEEEEEEEEECCCEEEEE
AGPANKQGRIIADNICGGDSRYLGSQGSSVIKVFDMTAATTGINETNAQKSGLEVDTVIL
CCCCCCCCCEEEECCCCCCCCCCCCCCCCEEEEEEEHHHHCCCCCCCCCCCCCEEEEEEE
SPMSHAGYYPGGKVMTMKVIFEKESYRLLGAQIIGYEGVDKRIDVLATAIHAGLNATQLK
CCHHHCCCCCCCEEEEEEEEEECCCCEEEEEEEECCCCCCHHHHHHHHHHHCCCCCCEEE
DLDLAYAPPYSSAKDPVNMAGFMIDNIAKGTLKQWHLEDMDKISKDKDVVLLDVRTVGEF
CCCEEECCCCCCCCCCCHHHHHHHHHHHHHHHHHCCHHHHHHHCCCCCEEEEEEHCCCCC
SRGHIDGFKNIPVDELRERISEIEKGKPVYLICQSGLRSYIASRILEGNGYETYNFSGGF
CCCCCCCCCCCCHHHHHHHHHHHHCCCCEEEEEHHHHHHHHHHHHHCCCCEEEEECCCCC
RFYDAVVNDRALIERTYACGMDY
EEEHHHHCCHHHHHHHHHCCCCC
>Mature Secondary Structure
MKVIIVGGVAGGATAAARIRRLNEHAEITVFERSGYISYANCGLPYYIGDVITDLEELTL
CEEEEEECCCCCHHHHHHHHHHCCCCEEEEEECCCEEEEECCCCCHHHHHHHHHHHHHHC
QTPESFFKRFRINMKIHHEVISIHPEYKTVSVKNLENGEIFEENYDKLILSPGAKPTQPR
CCHHHHHHHEECCEEEEEEEEEECCCCEEEEEECCCCCCEECCCCCEEEECCCCCCCCCC
LPGVGIDKLFTLRTVEDTFRIKEYINKNHPKSAVLAGGGFIGLELAENLRELGMDVTIVQ
CCCCCHHHEEEEEHHHHHHHHHHHHCCCCCCCEEEECCCEEHHHHHHHHHHCCCCEEEEE
RPKQLMNPFDPDMASMIHNEMRKHGIKLVLGYTVEGFKEKDNGVEVLLKDNPSLQADMVV
CCHHHCCCCCHHHHHHHHHHHHHCCEEEEEEEEECCCCCCCCCEEEEEECCCCCCEEEEE
LAIGVTPDTVLAKEAGLELGIKESIVVNDRMETSVPDIYAAGDAVQVKHYVTGNDALISL
EEEECCCCHHHHHHCCCCCCCCCEEEECCCCCCCCCCEEECCCEEEEEEEEECCCEEEEE
AGPANKQGRIIADNICGGDSRYLGSQGSSVIKVFDMTAATTGINETNAQKSGLEVDTVIL
CCCCCCCCCEEEECCCCCCCCCCCCCCCCEEEEEEEHHHHCCCCCCCCCCCCCEEEEEEE
SPMSHAGYYPGGKVMTMKVIFEKESYRLLGAQIIGYEGVDKRIDVLATAIHAGLNATQLK
CCHHHCCCCCCCEEEEEEEEEECCCCEEEEEEEECCCCCCHHHHHHHHHHHCCCCCCEEE
DLDLAYAPPYSSAKDPVNMAGFMIDNIAKGTLKQWHLEDMDKISKDKDVVLLDVRTVGEF
CCCEEECCCCCCCCCCCHHHHHHHHHHHHHHHHHCCHHHHHHHCCCCCEEEEEEHCCCCC
SRGHIDGFKNIPVDELRERISEIEKGKPVYLICQSGLRSYIASRILEGNGYETYNFSGGF
CCCCCCCCCCCCHHHHHHHHHHHHCCCCEEEEEHHHHHHHHHHHHHCCCCEEEEECCCCC
RFYDAVVNDRALIERTYACGMDY
EEEHHHHCCHHHHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA