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The map label for this gene is gltA [H]

Identifier: 238923555

GI number: 238923555

Start: 1086596

End: 1087936

Strand: Direct

Name: gltA [H]

Synonym: EUBREC_1175

Alternate gene names: 238923555

Gene position: 1086596-1087936 (Clockwise)

Preceding gene: 238923554

Following gene: 238923556

Centisome position: 31.5

GC content: 44.44

Gene sequence:

>1341_bases
ATGACAAAAAGCAATAATTTATTAGCGGATTACGCTGCAAAAAAACAGGATATCTGTATTAAAAATGACACAATTTCAGA
TAGTCTTTTCAGGGAATATGGTGTCAACAGAGGACTTAGGGATGTAAACGGAAAGGGAGTTCTGACAGGTCTTACGAATA
TTTCGGAGATTGTTTCATTTAAGACGGGCGAGGATGGCAGCAGCGTGCCATGTGACGGACAATTGTGGTACAGGGGCTAC
AATGTAAAGACACTTACGAACAACTTAAGGCCCGGTGAGTTTGGTTTTGAAAAAATTGCTTATCTGCTGCTTTTCGGGCA
GCTGCCATCTGAGAGTGAATTGGCTGAGTTTACAGAGGTTTTAGGAAGAAGCAGAACCCTTCCTACCAATTTTACGAGGG
ATGTCATCATGAAGGCTCCGTCAAAGGATATCATGAATTCCATGACGAGAAGTATACTGACACTGGCTTCATATGATCCT
CTTGTAGCAAAGGCGGGCATCGACAACAATATCAGACAGTGCTTATCACTTGTTGCAATATTCCCGATGCTTGCAGTTTA
CGGTTATCATGCGTATAATCATTATGAAAATGATCAGAGCATGTATATTCACAGGCCGGATCCAAAGCTTTCGACAGCTG
AAAACTTCCTTAGGATGCTCAGAGCTGACAATCAATATACAGAGCTTGAAGCAAGGGTGCTTGATATGGCACTTATTCTT
CATATGGAGCACGGCGGTGGAAACAACTCTACATTTACCACCCGTGTGGTTACATCGGCAGGTACAGATACATACTCTGC
TATCGCGGCAGCCATGTCATCCCTTAAGGGACCAAAGCACGGCGGTGCCAATATCAAGGTGATGGAGATGATGCGGGACA
TCCGTTCGCATGTGAAGCACTGGGATGATGAGGATGAGGTGAGAGCATACCTCAGAAAAATGATGGATGGTGAGGTGTTT
GACCACAAGGGACTCATCTATGGAATGGGACATGCGGTGTATTCACTTTCTGACCCGAGGGAGCGTATATTCAGAGGCTA
TGTGGAGAAGCTTTCAGTTGCAAAGAAGAGAGATAATGAGATGAACCTCTATAATACAATAGAGAAGGTGGCTCCTGAGA
TTATCGCTGAAAAGCGCCATATCTTTAAGGGTGTTTCTCCGAATGTCGATTTCTACAGCGGCTTTGTTTATGAGATGCTT
GGTATTCCTATGGAGCTTTACACACCTCTTTTTGCCATTGCGCGAATCGTTGGCTGGAGTGCCCACAGGCTTGAGGAGAT
TGTCGGCATGAACAAGATTATCCGTCCGGCTTACAAGAGCGTCATGAAAGAGATAGAGTAA

Upstream 100 bases:

>100_bases
CCCAAATAAAATTTTTGGCTACGGATTCATGAATGGGTTTGCCAATTTCTAAGAAAACGGATATAATATATTCTAAAAGA
TAAAAAGGAAGGGTGAATGG

Downstream 100 bases:

>100_bases
CGAGAGGATGTTACAGTCTATCGTTCATATATCAATAATACGATATGTTGGGGATTGGACATATTAAAAGAATCGAGGTA
TTATACAAATGAGTTTTACA

Product: citrate synthase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 446; Mature: 445

Protein sequence:

>446_residues
MTKSNNLLADYAAKKQDICIKNDTISDSLFREYGVNRGLRDVNGKGVLTGLTNISEIVSFKTGEDGSSVPCDGQLWYRGY
NVKTLTNNLRPGEFGFEKIAYLLLFGQLPSESELAEFTEVLGRSRTLPTNFTRDVIMKAPSKDIMNSMTRSILTLASYDP
LVAKAGIDNNIRQCLSLVAIFPMLAVYGYHAYNHYENDQSMYIHRPDPKLSTAENFLRMLRADNQYTELEARVLDMALIL
HMEHGGGNNSTFTTRVVTSAGTDTYSAIAAAMSSLKGPKHGGANIKVMEMMRDIRSHVKHWDDEDEVRAYLRKMMDGEVF
DHKGLIYGMGHAVYSLSDPRERIFRGYVEKLSVAKKRDNEMNLYNTIEKVAPEIIAEKRHIFKGVSPNVDFYSGFVYEML
GIPMELYTPLFAIARIVGWSAHRLEEIVGMNKIIRPAYKSVMKEIE

Sequences:

>Translated_446_residues
MTKSNNLLADYAAKKQDICIKNDTISDSLFREYGVNRGLRDVNGKGVLTGLTNISEIVSFKTGEDGSSVPCDGQLWYRGY
NVKTLTNNLRPGEFGFEKIAYLLLFGQLPSESELAEFTEVLGRSRTLPTNFTRDVIMKAPSKDIMNSMTRSILTLASYDP
LVAKAGIDNNIRQCLSLVAIFPMLAVYGYHAYNHYENDQSMYIHRPDPKLSTAENFLRMLRADNQYTELEARVLDMALIL
HMEHGGGNNSTFTTRVVTSAGTDTYSAIAAAMSSLKGPKHGGANIKVMEMMRDIRSHVKHWDDEDEVRAYLRKMMDGEVF
DHKGLIYGMGHAVYSLSDPRERIFRGYVEKLSVAKKRDNEMNLYNTIEKVAPEIIAEKRHIFKGVSPNVDFYSGFVYEML
GIPMELYTPLFAIARIVGWSAHRLEEIVGMNKIIRPAYKSVMKEIE
>Mature_445_residues
TKSNNLLADYAAKKQDICIKNDTISDSLFREYGVNRGLRDVNGKGVLTGLTNISEIVSFKTGEDGSSVPCDGQLWYRGYN
VKTLTNNLRPGEFGFEKIAYLLLFGQLPSESELAEFTEVLGRSRTLPTNFTRDVIMKAPSKDIMNSMTRSILTLASYDPL
VAKAGIDNNIRQCLSLVAIFPMLAVYGYHAYNHYENDQSMYIHRPDPKLSTAENFLRMLRADNQYTELEARVLDMALILH
MEHGGGNNSTFTTRVVTSAGTDTYSAIAAAMSSLKGPKHGGANIKVMEMMRDIRSHVKHWDDEDEVRAYLRKMMDGEVFD
HKGLIYGMGHAVYSLSDPRERIFRGYVEKLSVAKKRDNEMNLYNTIEKVAPEIIAEKRHIFKGVSPNVDFYSGFVYEMLG
IPMELYTPLFAIARIVGWSAHRLEEIVGMNKIIRPAYKSVMKEIE

Specific function: Catalyzes The Synthesis Of 2-Methylcitrate From Propionyl-CoA And Oxaloacetate. Also Catalyzes The Condensation Of Oxaloacetate With Acetyl-CoA But With A Lower Specificity. [C]

COG id: COG0372

COG function: function code C; Citrate synthase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the citrate synthase family [H]

Homologues:

Organism=Homo sapiens, GI38327625, Length=417, Percent_Identity=26.378896882494, Blast_Score=107, Evalue=3e-23,
Organism=Escherichia coli, GI1786527, Length=371, Percent_Identity=32.3450134770889, Blast_Score=173, Evalue=2e-44,
Organism=Escherichia coli, GI1786939, Length=415, Percent_Identity=30.3614457831325, Blast_Score=142, Evalue=5e-35,
Organism=Caenorhabditis elegans, GI17555174, Length=359, Percent_Identity=30.08356545961, Blast_Score=122, Evalue=4e-28,
Organism=Saccharomyces cerevisiae, GI6324328, Length=409, Percent_Identity=26.8948655256724, Blast_Score=103, Evalue=6e-23,
Organism=Saccharomyces cerevisiae, GI6319850, Length=403, Percent_Identity=27.0471464019851, Blast_Score=100, Evalue=7e-22,
Organism=Saccharomyces cerevisiae, GI6325257, Length=386, Percent_Identity=25.6476683937824, Blast_Score=97, Evalue=4e-21,
Organism=Drosophila melanogaster, GI24640124, Length=386, Percent_Identity=27.4611398963731, Blast_Score=119, Evalue=5e-27,
Organism=Drosophila melanogaster, GI24640126, Length=386, Percent_Identity=27.4611398963731, Blast_Score=118, Evalue=6e-27,
Organism=Drosophila melanogaster, GI21356863, Length=415, Percent_Identity=22.6506024096386, Blast_Score=85, Evalue=8e-17,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011278
- InterPro:   IPR016142
- InterPro:   IPR016143
- InterPro:   IPR002020
- InterPro:   IPR016141
- InterPro:   IPR019810 [H]

Pfam domain/function: PF00285 Citrate_synt [H]

EC number: =2.3.3.1 [H]

Molecular weight: Translated: 50386; Mature: 50255

Theoretical pI: Translated: 7.41; Mature: 7.41

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
4.7 %Met     (Translated Protein)
5.4 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
4.5 %Met     (Mature Protein)
5.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTKSNNLLADYAAKKQDICIKNDTISDSLFREYGVNRGLRDVNGKGVLTGLTNISEIVSF
CCCCCCCHHHHHCCCCCCEECCCCCHHHHHHHHCCCCCCCCCCCCEEEEHHHHHHHHHHC
KTGEDGSSVPCDGQLWYRGYNVKTLTNNLRPGEFGFEKIAYLLLFGQLPSESELAEFTEV
CCCCCCCCCCCCCEEEEECCCEEECCCCCCCCCCCHHHHHHHHHHCCCCCHHHHHHHHHH
LGRSRTLPTNFTRDVIMKAPSKDIMNSMTRSILTLASYDPLVAKAGIDNNIRQCLSLVAI
HCCCCCCCCCCHHHHHHCCCCHHHHHHHHHHHHHHHCCCCHHHHCCCCHHHHHHHHHHHH
FPMLAVYGYHAYNHYENDQSMYIHRPDPKLSTAENFLRMLRADNQYTELEARVLDMALIL
HHHHHHHHHHHHHCCCCCCEEEEECCCCCCHHHHHHHHHHHCCCHHHHHHHHHHHHHHHH
HMEHGGGNNSTFTTRVVTSAGTDTYSAIAAAMSSLKGPKHGGANIKVMEMMRDIRSHVKH
EEECCCCCCCEEEEEEEECCCCHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHC
WDDEDEVRAYLRKMMDGEVFDHKGLIYGMGHAVYSLSDPRERIFRGYVEKLSVAKKRDNE
CCCHHHHHHHHHHHHCCCCCCCCCCEEECCHHHEECCCHHHHHHHHHHHHHHHHHHCCCC
MNLYNTIEKVAPEIIAEKRHIFKGVSPNVDFYSGFVYEMLGIPMELYTPLFAIARIVGWS
CHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHCCCHHHHHHHHHHHHHHCCH
AHRLEEIVGMNKIIRPAYKSVMKEIE
HHHHHHHHHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure 
TKSNNLLADYAAKKQDICIKNDTISDSLFREYGVNRGLRDVNGKGVLTGLTNISEIVSF
CCCCCCHHHHHCCCCCCEECCCCCHHHHHHHHCCCCCCCCCCCCEEEEHHHHHHHHHHC
KTGEDGSSVPCDGQLWYRGYNVKTLTNNLRPGEFGFEKIAYLLLFGQLPSESELAEFTEV
CCCCCCCCCCCCCEEEEECCCEEECCCCCCCCCCCHHHHHHHHHHCCCCCHHHHHHHHHH
LGRSRTLPTNFTRDVIMKAPSKDIMNSMTRSILTLASYDPLVAKAGIDNNIRQCLSLVAI
HCCCCCCCCCCHHHHHHCCCCHHHHHHHHHHHHHHHCCCCHHHHCCCCHHHHHHHHHHHH
FPMLAVYGYHAYNHYENDQSMYIHRPDPKLSTAENFLRMLRADNQYTELEARVLDMALIL
HHHHHHHHHHHHHCCCCCCEEEEECCCCCCHHHHHHHHHHHCCCHHHHHHHHHHHHHHHH
HMEHGGGNNSTFTTRVVTSAGTDTYSAIAAAMSSLKGPKHGGANIKVMEMMRDIRSHVKH
EEECCCCCCCEEEEEEEECCCCHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHC
WDDEDEVRAYLRKMMDGEVFDHKGLIYGMGHAVYSLSDPRERIFRGYVEKLSVAKKRDNE
CCCHHHHHHHHHHHHCCCCCCCCCCEEECCHHHEECCCHHHHHHHHHHHHHHHHHHCCCC
MNLYNTIEKVAPEIIAEKRHIFKGVSPNVDFYSGFVYEMLGIPMELYTPLFAIARIVGWS
CHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHCCCHHHHHHHHHHHHHHCCH
AHRLEEIVGMNKIIRPAYKSVMKEIE
HHHHHHHHHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8590279; 8905231 [H]