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The map label for this gene is yclK [H]

Identifier: 238923308

GI number: 238923308

Start: 825447

End: 826994

Strand: Direct

Name: yclK [H]

Synonym: EUBREC_0925

Alternate gene names: 238923308

Gene position: 825447-826994 (Clockwise)

Preceding gene: 238923307

Following gene: 238923309

Centisome position: 23.93

GC content: 42.18

Gene sequence:

>1548_bases
ATGAAATTCAGGTACAAGGTATTGTTCACAAACTTAATACTGCTTTCACTTGGACTGGGGCTGGTGGGATACCTCATGAT
ACACAAGAATTTTGAGCTGGCGAAGCAGACACAGCTTAAAAACGCTATTGTGCAGAATAATCTGGTACAGTCCTCTGTGG
AGTATGAGCTTTTGCAGCTTTTAAATTCAGTTTCCGATAATTCTGAAACTTCGAACAATAATACAGATAACAATAATGCA
GAAAAGAGCAGCATTTCCGCATCATCAATAGCCGCGCAACTTCCGCAGATCGGAAGCCGTGTAAGCAGCAGTGTGCGCTC
AAGGGATTCATTTTTCTACATATATTTTGATGGTGAAAAAGTATATACAGATGACAAAAGTGATGCAAGGATAAGTGATA
CACTTTTTAAAAATCTCACAACAGGAAACAAAAACTATGTGATAAAAGAAGAATCCCAAAAGCACTATATCTATGTTACA
TCGCAGAGTGTGATAAATGAAAAAAATCTCTGGATAGTAAGTAAATGCGATGCATCAGAGGCGTATACACTGCTTGATGA
GCAGATAAACTATTTCAGGCTGATAATAATAGTCATATTGATTGCAGAGTCGGCAGCAATGTATTTTATCAGCAGGTACA
TGACAAAGCCGCTCGAGAAGCTTAACCATGTCAGCGAGGAAATAGCGCAGGGGGATTATGCCACAAGGGTAAACGTAAAA
AGTCATGATGAGATAGGGCTTCTTGCGCAGAAATTTAATATCATGGCGCAGGCAGTATCGGATCATGTAGACGAGCTTAA
CGATATGGTGCACAGGCGTGAGCAGTTTGTAGCGGATTTTACACACGAGATAAAAACCCCTATGACGTCGATCATTGGAT
ATGCAGACACGATGCGTTCACTGGAGCTTCCGAGAGAGGAGCAGATGATGGCGCTTGGATATATCTTTTCGGAGGGAAAA
CGTCTGGAGAGCATGTCGCAGAAGCTTTTTGAGCTGATATATCTGCGCCGGCATGATATTGAAAAAGCGCGGGTTCATAT
GGCAGATCTTTGTGCAGAGGTGGTAAAGGTTGTTGAGCCTGCATACGAAAACAGGCATCTTACTATAGAAACAGAGATAG
AGGATACTGTGCTGACCGTGAATAGAGAGCTTTTGGTTACAGCACTTGTCAATCTGATGGATAATGCAAGGAAAGCGTCA
GAAGAAGGTCAGCAGGTTGAGGTTACAGGAAAATTTGTGGACAATATGGCTTGTAATATACCTAAAGATAAAACGGATAT
AGGCGAAGCCGAATCAGCAGATGACAGGAAATGCACGAGGGCATATGAAATATGCATAATCGATCACGGAATCGGAATGA
CTAAGGAACAGGCAGAAAGAATTTGTGATGAGTTTTATATGGCAGACAAATCCAGAGCCAGAAAAGAGGGCGGTGCCGGA
ATCGGAATGTCGCTTGTGGCAATCATTTTAGAGCACCATAATGCAGTACTTTCAGTGGAAAGTGAACCCGGATGCGGAAC
AACGATGAGGATTTTGCTTCCGTGGTAA

Upstream 100 bases:

>100_bases
ACAGCCTTAAAACCGTATTTAAGGCAGGATACAGGCTGGAAGAATAGAAAACTAAAGACCATTAAATATGGGTAAGCGTA
ATATACAAAAAGAGGGATAA

Downstream 100 bases:

>100_bases
TCTGAACGCAGTATAGATATAAAAAATGGTAAATTCGTAAGATTTAAAGGAAGATATGAAAAAAGACAGCTTCAAATTAA
TAATAATGTCTGTTGCAGTA

Product: sensor histidine kinase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 515; Mature: 515

Protein sequence:

>515_residues
MKFRYKVLFTNLILLSLGLGLVGYLMIHKNFELAKQTQLKNAIVQNNLVQSSVEYELLQLLNSVSDNSETSNNNTDNNNA
EKSSISASSIAAQLPQIGSRVSSSVRSRDSFFYIYFDGEKVYTDDKSDARISDTLFKNLTTGNKNYVIKEESQKHYIYVT
SQSVINEKNLWIVSKCDASEAYTLLDEQINYFRLIIIVILIAESAAMYFISRYMTKPLEKLNHVSEEIAQGDYATRVNVK
SHDEIGLLAQKFNIMAQAVSDHVDELNDMVHRREQFVADFTHEIKTPMTSIIGYADTMRSLELPREEQMMALGYIFSEGK
RLESMSQKLFELIYLRRHDIEKARVHMADLCAEVVKVVEPAYENRHLTIETEIEDTVLTVNRELLVTALVNLMDNARKAS
EEGQQVEVTGKFVDNMACNIPKDKTDIGEAESADDRKCTRAYEICIIDHGIGMTKEQAERICDEFYMADKSRARKEGGAG
IGMSLVAIILEHHNAVLSVESEPGCGTTMRILLPW

Sequences:

>Translated_515_residues
MKFRYKVLFTNLILLSLGLGLVGYLMIHKNFELAKQTQLKNAIVQNNLVQSSVEYELLQLLNSVSDNSETSNNNTDNNNA
EKSSISASSIAAQLPQIGSRVSSSVRSRDSFFYIYFDGEKVYTDDKSDARISDTLFKNLTTGNKNYVIKEESQKHYIYVT
SQSVINEKNLWIVSKCDASEAYTLLDEQINYFRLIIIVILIAESAAMYFISRYMTKPLEKLNHVSEEIAQGDYATRVNVK
SHDEIGLLAQKFNIMAQAVSDHVDELNDMVHRREQFVADFTHEIKTPMTSIIGYADTMRSLELPREEQMMALGYIFSEGK
RLESMSQKLFELIYLRRHDIEKARVHMADLCAEVVKVVEPAYENRHLTIETEIEDTVLTVNRELLVTALVNLMDNARKAS
EEGQQVEVTGKFVDNMACNIPKDKTDIGEAESADDRKCTRAYEICIIDHGIGMTKEQAERICDEFYMADKSRARKEGGAG
IGMSLVAIILEHHNAVLSVESEPGCGTTMRILLPW
>Mature_515_residues
MKFRYKVLFTNLILLSLGLGLVGYLMIHKNFELAKQTQLKNAIVQNNLVQSSVEYELLQLLNSVSDNSETSNNNTDNNNA
EKSSISASSIAAQLPQIGSRVSSSVRSRDSFFYIYFDGEKVYTDDKSDARISDTLFKNLTTGNKNYVIKEESQKHYIYVT
SQSVINEKNLWIVSKCDASEAYTLLDEQINYFRLIIIVILIAESAAMYFISRYMTKPLEKLNHVSEEIAQGDYATRVNVK
SHDEIGLLAQKFNIMAQAVSDHVDELNDMVHRREQFVADFTHEIKTPMTSIIGYADTMRSLELPREEQMMALGYIFSEGK
RLESMSQKLFELIYLRRHDIEKARVHMADLCAEVVKVVEPAYENRHLTIETEIEDTVLTVNRELLVTALVNLMDNARKAS
EEGQQVEVTGKFVDNMACNIPKDKTDIGEAESADDRKCTRAYEICIIDHGIGMTKEQAERICDEFYMADKSRARKEGGAG
IGMSLVAIILEHHNAVLSVESEPGCGTTMRILLPW

Specific function: Could be member of the two-component regulatory system yclK/yclJ. Potentially phosphorylates yclJ [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 histidine kinase domain [H]

Homologues:

Organism=Escherichia coli, GI1786600, Length=285, Percent_Identity=25.6140350877193, Blast_Score=96, Evalue=8e-21,
Organism=Escherichia coli, GI1790346, Length=325, Percent_Identity=25.2307692307692, Blast_Score=93, Evalue=4e-20,
Organism=Escherichia coli, GI1788393, Length=306, Percent_Identity=23.202614379085, Blast_Score=92, Evalue=9e-20,
Organism=Escherichia coli, GI1786783, Length=327, Percent_Identity=23.5474006116208, Blast_Score=82, Evalue=1e-16,
Organism=Escherichia coli, GI1788713, Length=247, Percent_Identity=22.6720647773279, Blast_Score=77, Evalue=3e-15,
Organism=Escherichia coli, GI1788549, Length=243, Percent_Identity=23.4567901234568, Blast_Score=63, Evalue=4e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003594
- InterPro:   IPR003660
- InterPro:   IPR004358
- InterPro:   IPR003661
- InterPro:   IPR005467
- InterPro:   IPR009082 [H]

Pfam domain/function: PF00672 HAMP; PF02518 HATPase_c; PF00512 HisKA [H]

EC number: =2.7.13.3 [H]

Molecular weight: Translated: 58377; Mature: 58377

Theoretical pI: Translated: 5.06; Mature: 5.06

Prosite motif: PS50885 HAMP ; PS50109 HIS_KIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
3.5 %Met     (Translated Protein)
4.9 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
3.5 %Met     (Mature Protein)
4.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKFRYKVLFTNLILLSLGLGLVGYLMIHKNFELAKQTQLKNAIVQNNLVQSSVEYELLQL
CCEEHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LNSVSDNSETSNNNTDNNNAEKSSISASSIAAQLPQIGSRVSSSVRSRDSFFYIYFDGEK
HHHHCCCCCCCCCCCCCCCCHHHHCHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEECCCE
VYTDDKSDARISDTLFKNLTTGNKNYVIKEESQKHYIYVTSQSVINEKNLWIVSKCDASE
EECCCCCCCHHHHHHHHHHCCCCCCEEEEECCCCEEEEEECHHHCCCCCEEEEEECCCHH
AYTLLDEQINYFRLIIIVILIAESAAMYFISRYMTKPLEKLNHVSEEIAQGDYATRVNVK
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEECCC
SHDEIGLLAQKFNIMAQAVSDHVDELNDMVHRREQFVADFTHEIKTPMTSIIGYADTMRS
CCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LELPREEQMMALGYIFSEGKRLESMSQKLFELIYLRRHDIEKARVHMADLCAEVVKVVEP
HCCCCHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHH
AYENRHLTIETEIEDTVLTVNRELLVTALVNLMDNARKASEEGQQVEVTGKFVDNMACNI
HHCCCEEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEHHHHCCCCCCC
PKDKTDIGEAESADDRKCTRAYEICIIDHGIGMTKEQAERICDEFYMADKSRARKEGGAG
CCCCCCCCCCCCCCCHHHHHHEEEEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCC
IGMSLVAIILEHHNAVLSVESEPGCGTTMRILLPW
HHHHHHHHHHHCCCEEEEEECCCCCCCEEEEEECC
>Mature Secondary Structure
MKFRYKVLFTNLILLSLGLGLVGYLMIHKNFELAKQTQLKNAIVQNNLVQSSVEYELLQL
CCEEHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LNSVSDNSETSNNNTDNNNAEKSSISASSIAAQLPQIGSRVSSSVRSRDSFFYIYFDGEK
HHHHCCCCCCCCCCCCCCCCHHHHCHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEECCCE
VYTDDKSDARISDTLFKNLTTGNKNYVIKEESQKHYIYVTSQSVINEKNLWIVSKCDASE
EECCCCCCCHHHHHHHHHHCCCCCCEEEEECCCCEEEEEECHHHCCCCCEEEEEECCCHH
AYTLLDEQINYFRLIIIVILIAESAAMYFISRYMTKPLEKLNHVSEEIAQGDYATRVNVK
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEECCC
SHDEIGLLAQKFNIMAQAVSDHVDELNDMVHRREQFVADFTHEIKTPMTSIIGYADTMRS
CCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LELPREEQMMALGYIFSEGKRLESMSQKLFELIYLRRHDIEKARVHMADLCAEVVKVVEP
HCCCCHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHH
AYENRHLTIETEIEDTVLTVNRELLVTALVNLMDNARKASEEGQQVEVTGKFVDNMACNI
HHCCCEEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEHHHHCCCCCCC
PKDKTDIGEAESADDRKCTRAYEICIIDHGIGMTKEQAERICDEFYMADKSRARKEGGAG
CCCCCCCCCCCCCCCHHHHHHEEEEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCC
IGMSLVAIILEHHNAVLSVESEPGCGTTMRILLPW
HHHHHHHHHHHCCCEEEEEECCCCCCCEEEEEECC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 8969502; 9384377 [H]