Click here to switch to the map view.

The map label for this gene is hemC [H]

Identifier: 238923292

GI number: 238923292

Start: 806531

End: 807547

Strand: Direct

Name: hemC [H]

Synonym: EUBREC_0903

Alternate gene names: 238923292

Gene position: 806531-807547 (Clockwise)

Preceding gene: 238923291

Following gene: 238923293

Centisome position: 23.38

GC content: 43.46

Gene sequence:

>1017_bases
ATGAAGTATTTAATAGGAACGAGAGGCTCAAAGCTTGCTCTTGTTCAGACTGATTACGTGATAGATAAGTTAAAAAGAGC
ATATCCGGATGATGATTTTAAGGCTGTTATCATAAAGACAACAGGCGATTTAGAGCAGAAAAAGGCACTCGATAAGATTG
GCTCAAAGGGTATCTTCGTAAAGGAGATAGAGGACGAGCTTTTATCGGGAAAGATTCATATGGCAGTCCATTCCATGAAA
GACATGCCTGATGAACCGGCAGCAGGGCTTACATTTGCAAAGGCATGGAAGCGTGAAGATCCAAGGGATGTTTTGGTGCT
AAAAAATGCCGCTTCACTGGATGAGCTTCCTCATGGTGCCGTGATAGGAACCGGAAGCAAGCGCAGAAAGTATCAGCTTT
TAAAGCTGCGCCCTGACCTTAAGGTGGTTGGCATACGCGGAAATATCGATACGAGGCTTCGTAAGCTATATGATGGTGAA
ATTATATATGAAGAGGTTGCCGATAATACTGTAAATAACAATGAGATAGCTAACGAAAAAAAGAATAAGTATAGCGAATA
CAGGCTGGATGGAATCGTACTTGCAGCGGCGGGAATAAAGCGTATCGGAAGAGATTCTGAGATCACACAGTACTTTTCAG
AGGATGATATGATTCCGGCTCCGGCACAGGGCACACTGGCGCTTGAGCTACGTGCTGACAATGCTAAGCTGATGGCAAAG
CTAGATGCTTTGTCAGATGAGAAAACCAATCTGTGCGCAGGCATTGAGAGAGAATTTTTAAAGCAAATCGGTGGTAACTG
TCATCTGCCTGTGGCTGCATACTGTGATATTGTAAGTGAAAAAGACCGCGGTAATGACAGCAACAAAAATAACAGGCTAA
AGCTTCTTGCGATGTTTGGCTCAGAGGATGGAAAACAGCTTGCAAGGACAGAGCAGGTATGGGATATGACATCAGACAGA
AACAATATTGTGGAGCGTGCCGTGCACGATATTCGGTATAAATTAGAAATCGACTAA

Upstream 100 bases:

>100_bases
GATTCCGGAAATATAGTTTAAAGTATGGTATTACAGATTTTAAGTTGTTGTTCATTTATAAATGATAAATGGAAAATGGC
ATGATCCGTAGGAGAGTAAA

Downstream 100 bases:

>100_bases
AAAAATATCAAGTCATAATTTTTAATCATAATAATTCAGTAGAAAAATAATTAGGAAAATCATGAGAGAAAACACAGGAA
AAGTAGTATTAGTTGGAGCA

Product: porphobilinogen deaminase

Products: NA

Alternate protein names: PBG; Hydroxymethylbilane synthase; HMBS; Pre-uroporphyrinogen synthase [H]

Number of amino acids: Translated: 338; Mature: 338

Protein sequence:

>338_residues
MKYLIGTRGSKLALVQTDYVIDKLKRAYPDDDFKAVIIKTTGDLEQKKALDKIGSKGIFVKEIEDELLSGKIHMAVHSMK
DMPDEPAAGLTFAKAWKREDPRDVLVLKNAASLDELPHGAVIGTGSKRRKYQLLKLRPDLKVVGIRGNIDTRLRKLYDGE
IIYEEVADNTVNNNEIANEKKNKYSEYRLDGIVLAAAGIKRIGRDSEITQYFSEDDMIPAPAQGTLALELRADNAKLMAK
LDALSDEKTNLCAGIEREFLKQIGGNCHLPVAAYCDIVSEKDRGNDSNKNNRLKLLAMFGSEDGKQLARTEQVWDMTSDR
NNIVERAVHDIRYKLEID

Sequences:

>Translated_338_residues
MKYLIGTRGSKLALVQTDYVIDKLKRAYPDDDFKAVIIKTTGDLEQKKALDKIGSKGIFVKEIEDELLSGKIHMAVHSMK
DMPDEPAAGLTFAKAWKREDPRDVLVLKNAASLDELPHGAVIGTGSKRRKYQLLKLRPDLKVVGIRGNIDTRLRKLYDGE
IIYEEVADNTVNNNEIANEKKNKYSEYRLDGIVLAAAGIKRIGRDSEITQYFSEDDMIPAPAQGTLALELRADNAKLMAK
LDALSDEKTNLCAGIEREFLKQIGGNCHLPVAAYCDIVSEKDRGNDSNKNNRLKLLAMFGSEDGKQLARTEQVWDMTSDR
NNIVERAVHDIRYKLEID
>Mature_338_residues
MKYLIGTRGSKLALVQTDYVIDKLKRAYPDDDFKAVIIKTTGDLEQKKALDKIGSKGIFVKEIEDELLSGKIHMAVHSMK
DMPDEPAAGLTFAKAWKREDPRDVLVLKNAASLDELPHGAVIGTGSKRRKYQLLKLRPDLKVVGIRGNIDTRLRKLYDGE
IIYEEVADNTVNNNEIANEKKNKYSEYRLDGIVLAAAGIKRIGRDSEITQYFSEDDMIPAPAQGTLALELRADNAKLMAK
LDALSDEKTNLCAGIEREFLKQIGGNCHLPVAAYCDIVSEKDRGNDSNKNNRLKLLAMFGSEDGKQLARTEQVWDMTSDR
NNIVERAVHDIRYKLEID

Specific function: Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps [H]

COG id: COG0181

COG function: function code H; Porphobilinogen deaminase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the HMBS family [H]

Homologues:

Organism=Homo sapiens, GI66933009, Length=273, Percent_Identity=35.1648351648352, Blast_Score=164, Evalue=1e-40,
Organism=Homo sapiens, GI20149500, Length=273, Percent_Identity=35.1648351648352, Blast_Score=164, Evalue=1e-40,
Organism=Escherichia coli, GI48994974, Length=308, Percent_Identity=36.6883116883117, Blast_Score=186, Evalue=2e-48,
Organism=Saccharomyces cerevisiae, GI6319996, Length=276, Percent_Identity=36.5942028985507, Blast_Score=171, Evalue=1e-43,
Organism=Drosophila melanogaster, GI20130425, Length=285, Percent_Identity=36.8421052631579, Blast_Score=179, Evalue=2e-45,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000860
- InterPro:   IPR022417
- InterPro:   IPR022418 [H]

Pfam domain/function: PF01379 Porphobil_deam; PF03900 Porphobil_deamC [H]

EC number: =2.5.1.61 [H]

Molecular weight: Translated: 37924; Mature: 37924

Theoretical pI: Translated: 7.05; Mature: 7.05

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
3.3 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
3.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKYLIGTRGSKLALVQTDYVIDKLKRAYPDDDFKAVIIKTTGDLEQKKALDKIGSKGIFV
CCEEECCCCCEEEEEEHHHHHHHHHHHCCCCCCEEEEEEECCCHHHHHHHHHHCCCCEEE
KEIEDELLSGKIHMAVHSMKDMPDEPAAGLTFAKAWKREDPRDVLVLKNAASLDELPHGA
HHHHHHHHCCCHHEEHHHHHCCCCCCCCCCHHHHHHCCCCCCCEEEEECCCCHHHCCCCC
VIGTGSKRRKYQLLKLRPDLKVVGIRGNIDTRLRKLYDGEIIYEEVADNTVNNNEIANEK
EEECCCCCCEEEEEEECCCEEEEEEECCHHHHHHHHHCCCEEEHHHHCCCCCCCHHHHHH
KNKYSEYRLDGIVLAAAGIKRIGRDSEITQYFSEDDMIPAPAQGTLALELRADNAKLMAK
HHHHHHHHHCEEEEEEHHHHHHCCCHHHHHHHCCCCCCCCCCCCEEEEEEECCCHHHHHH
LDALSDEKTNLCAGIEREFLKQIGGNCHLPVAAYCDIVSEKDRGNDSNKNNRLKLLAMFG
HHHCCCCCHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHCCCCCCCCCCCCCEEEEEEEEC
SEDGKQLARTEQVWDMTSDRNNIVERAVHDIRYKLEID
CCCCHHHHHHHHHHHCCCCHHHHHHHHHHHEEEEEEEC
>Mature Secondary Structure
MKYLIGTRGSKLALVQTDYVIDKLKRAYPDDDFKAVIIKTTGDLEQKKALDKIGSKGIFV
CCEEECCCCCEEEEEEHHHHHHHHHHHCCCCCCEEEEEEECCCHHHHHHHHHHCCCCEEE
KEIEDELLSGKIHMAVHSMKDMPDEPAAGLTFAKAWKREDPRDVLVLKNAASLDELPHGA
HHHHHHHHCCCHHEEHHHHHCCCCCCCCCCHHHHHHCCCCCCCEEEEECCCCHHHCCCCC
VIGTGSKRRKYQLLKLRPDLKVVGIRGNIDTRLRKLYDGEIIYEEVADNTVNNNEIANEK
EEECCCCCCEEEEEEECCCEEEEEEECCHHHHHHHHHCCCEEEHHHHCCCCCCCHHHHHH
KNKYSEYRLDGIVLAAAGIKRIGRDSEITQYFSEDDMIPAPAQGTLALELRADNAKLMAK
HHHHHHHHHCEEEEEEHHHHHHCCCHHHHHHHCCCCCCCCCCCCEEEEEEECCCHHHHHH
LDALSDEKTNLCAGIEREFLKQIGGNCHLPVAAYCDIVSEKDRGNDSNKNNRLKLLAMFG
HHHCCCCCHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHCCCCCCCCCCCCCEEEEEEEEC
SEDGKQLARTEQVWDMTSDRNNIVERAVHDIRYKLEID
CCCCHHHHHHHHHHHCCCCHHHHHHHHHHHEEEEEEEC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA