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The map label for this gene is moeZ [H]

Identifier: 238923288

GI number: 238923288

Start: 803645

End: 804490

Strand: Direct

Name: moeZ [H]

Synonym: EUBREC_0899

Alternate gene names: 238923288

Gene position: 803645-804490 (Clockwise)

Preceding gene: 238923287

Following gene: 238923289

Centisome position: 23.3

GC content: 47.75

Gene sequence:

>846_bases
ATGCTAATGGCAATGACTGATGAGCAGATCGAGCGCTATTCACGCCACATTATCCTTAATGAGGTGGGCGTTAAAGGTCA
GAAGAAATTATTAAAGGGCAAGGTGCTTATTATCGGTGCCGGCGGACTTGGAGCTCCGGCAGCCATGTATCTTGCAGCAG
CAGGAGTTGGCACAATCGGTATTGTGGATGCGGATGAGGTAGATTTATCCAACCTGCAGAGACAGATTATCCACGGAACA
GCCGATGTGGGAAAAGCCAAGGTAAAGTCAGCAAAAGAGACAATGAACGCCATGAACCCGGACGTTCAGGTCAATACATA
CCGTATGTTTGTAGATGCGTCAAACATCAGAGAGCTTATCAGGGATTATGATTTCATCATCGATGGAACTGACAATTTCC
CGGCAAAGTTCTTAATCAATGATGCATGTGTGCTTGAGAAAAAGCCGTTTTCACATGCAGGAATCATCCGTTTTAAGGGT
CAGCTCATGACATATGTGCCGGGAGAGGGACCTTGCTACAGATGTGTATTCAAGAATCCGCCACCAAAGGATGCAGTGCC
TACATGTAAGCAGGCAGGCGTTATCGGAGCTATGGGCGGAGTAATCGGTTCGCTTCAGGCTATGGAGGCTATCAAGTATT
TAATCGGTGTTGGAGAGCTGCTCACAGGATATCTGCTTACATATGATGCACTCACCATGGAGTTCCACAAGATTAAGCTT
CCAAAGGATACACACAACTGTGCAGTCTGTGGCGACCATCCGACCATTCTCGAGCCAATCGACTACGAGCAGGAGGTCTG
CGAGGAGACAGCGGGCAGATTTGATGCACCTCGTACACAGGAATAA

Upstream 100 bases:

>100_bases
CAGTTTCAATAAATGAGGAATTTGTTGCCACAGAGGATAAGCCAAAGACAGTGCTTAAGGATGGCGACAATGTAGAGTTC
CTTTACTTCATGGGAGGTGG

Downstream 100 bases:

>100_bases
AAAGACAGTAAGGAAAGGAACGATATGAGTATCATAAGAATGAAATATCCGTTTCTGGATGAAATAGCAAAATATGCTAA
AGAGCATCTTCCGGAGGAGG

Product: hypothetical protein

Products: NA

Alternate protein names: Sulfur carrier protein CysO adenylyltransferase; Sulfur carrier protein CysO sulfurtransferase [H]

Number of amino acids: Translated: 281; Mature: 281

Protein sequence:

>281_residues
MLMAMTDEQIERYSRHIILNEVGVKGQKKLLKGKVLIIGAGGLGAPAAMYLAAAGVGTIGIVDADEVDLSNLQRQIIHGT
ADVGKAKVKSAKETMNAMNPDVQVNTYRMFVDASNIRELIRDYDFIIDGTDNFPAKFLINDACVLEKKPFSHAGIIRFKG
QLMTYVPGEGPCYRCVFKNPPPKDAVPTCKQAGVIGAMGGVIGSLQAMEAIKYLIGVGELLTGYLLTYDALTMEFHKIKL
PKDTHNCAVCGDHPTILEPIDYEQEVCEETAGRFDAPRTQE

Sequences:

>Translated_281_residues
MLMAMTDEQIERYSRHIILNEVGVKGQKKLLKGKVLIIGAGGLGAPAAMYLAAAGVGTIGIVDADEVDLSNLQRQIIHGT
ADVGKAKVKSAKETMNAMNPDVQVNTYRMFVDASNIRELIRDYDFIIDGTDNFPAKFLINDACVLEKKPFSHAGIIRFKG
QLMTYVPGEGPCYRCVFKNPPPKDAVPTCKQAGVIGAMGGVIGSLQAMEAIKYLIGVGELLTGYLLTYDALTMEFHKIKL
PKDTHNCAVCGDHPTILEPIDYEQEVCEETAGRFDAPRTQE
>Mature_281_residues
MLMAMTDEQIERYSRHIILNEVGVKGQKKLLKGKVLIIGAGGLGAPAAMYLAAAGVGTIGIVDADEVDLSNLQRQIIHGT
ADVGKAKVKSAKETMNAMNPDVQVNTYRMFVDASNIRELIRDYDFIIDGTDNFPAKFLINDACVLEKKPFSHAGIIRFKG
QLMTYVPGEGPCYRCVFKNPPPKDAVPTCKQAGVIGAMGGVIGSLQAMEAIKYLIGVGELLTGYLLTYDALTMEFHKIKL
PKDTHNCAVCGDHPTILEPIDYEQEVCEETAGRFDAPRTQE

Specific function: Catalyzes the conversion of the sulfur carrier protein CysO to CysO-thiocarboxylate. The reaction is thought to proceed in two steps:first, ATP-dependent activation of CysO as acyl- adenylate (CysO-COOAMP), followed by sulfur transfer to give CysO- thioca

COG id: COG0476

COG function: function code H; Dinucleotide-utilizing enzymes involved in molybdopterin and thiamine biosynthesis family 2

Gene ontology:

Cell location: Membrane; Single-pass membrane protein (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 rhodanese domain [H]

Homologues:

Organism=Homo sapiens, GI7657339, Length=260, Percent_Identity=45, Blast_Score=227, Evalue=9e-60,
Organism=Homo sapiens, GI4885649, Length=171, Percent_Identity=29.2397660818713, Blast_Score=83, Evalue=3e-16,
Organism=Homo sapiens, GI38045942, Length=177, Percent_Identity=31.638418079096, Blast_Score=79, Evalue=3e-15,
Organism=Homo sapiens, GI38045944, Length=177, Percent_Identity=31.638418079096, Blast_Score=79, Evalue=3e-15,
Organism=Homo sapiens, GI23510338, Length=195, Percent_Identity=27.6923076923077, Blast_Score=79, Evalue=5e-15,
Organism=Homo sapiens, GI23510340, Length=195, Percent_Identity=27.6923076923077, Blast_Score=79, Evalue=5e-15,
Organism=Homo sapiens, GI13376212, Length=262, Percent_Identity=27.8625954198473, Blast_Score=75, Evalue=6e-14,
Organism=Homo sapiens, GI38327032, Length=227, Percent_Identity=26.431718061674, Blast_Score=70, Evalue=1e-12,
Organism=Escherichia coli, GI1787048, Length=249, Percent_Identity=41.7670682730924, Blast_Score=197, Evalue=1e-51,
Organism=Escherichia coli, GI87082356, Length=248, Percent_Identity=40.7258064516129, Blast_Score=179, Evalue=1e-46,
Organism=Escherichia coli, GI1789177, Length=155, Percent_Identity=28.3870967741935, Blast_Score=65, Evalue=4e-12,
Organism=Caenorhabditis elegans, GI17540406, Length=252, Percent_Identity=44.4444444444444, Blast_Score=230, Evalue=7e-61,
Organism=Caenorhabditis elegans, GI193203301, Length=165, Percent_Identity=28.4848484848485, Blast_Score=85, Evalue=5e-17,
Organism=Caenorhabditis elegans, GI71984476, Length=183, Percent_Identity=31.6939890710383, Blast_Score=81, Evalue=6e-16,
Organism=Caenorhabditis elegans, GI17508819, Length=279, Percent_Identity=23.6559139784946, Blast_Score=74, Evalue=6e-14,
Organism=Caenorhabditis elegans, GI86565433, Length=176, Percent_Identity=26.7045454545455, Blast_Score=70, Evalue=1e-12,
Organism=Caenorhabditis elegans, GI86565431, Length=176, Percent_Identity=26.7045454545455, Blast_Score=70, Evalue=2e-12,
Organism=Saccharomyces cerevisiae, GI6321903, Length=257, Percent_Identity=38.1322957198444, Blast_Score=184, Evalue=1e-47,
Organism=Saccharomyces cerevisiae, GI6322639, Length=194, Percent_Identity=29.3814432989691, Blast_Score=87, Evalue=4e-18,
Organism=Saccharomyces cerevisiae, GI6325323, Length=174, Percent_Identity=31.6091954022989, Blast_Score=81, Evalue=2e-16,
Organism=Saccharomyces cerevisiae, GI6320598, Length=169, Percent_Identity=28.4023668639053, Blast_Score=78, Evalue=1e-15,
Organism=Drosophila melanogaster, GI24582879, Length=259, Percent_Identity=44.4015444015444, Blast_Score=245, Evalue=3e-65,
Organism=Drosophila melanogaster, GI24660640, Length=167, Percent_Identity=31.7365269461078, Blast_Score=92, Evalue=3e-19,
Organism=Drosophila melanogaster, GI28573937, Length=186, Percent_Identity=29.0322580645161, Blast_Score=84, Evalue=9e-17,
Organism=Drosophila melanogaster, GI20129973, Length=177, Percent_Identity=29.3785310734463, Blast_Score=76, Evalue=2e-14,
Organism=Drosophila melanogaster, GI24641311, Length=264, Percent_Identity=28.7878787878788, Blast_Score=74, Evalue=1e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR007901
- InterPro:   IPR009036
- InterPro:   IPR016040
- InterPro:   IPR001763
- InterPro:   IPR000594 [H]

Pfam domain/function: PF05237 MoeZ_MoeB; PF00581 Rhodanese; PF00899 ThiF [H]

EC number: NA

Molecular weight: Translated: 30639; Mature: 30639

Theoretical pI: Translated: 5.97; Mature: 5.97

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.5 %Cys     (Translated Protein)
3.9 %Met     (Translated Protein)
6.4 %Cys+Met (Translated Protein)
2.5 %Cys     (Mature Protein)
3.9 %Met     (Mature Protein)
6.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLMAMTDEQIERYSRHIILNEVGVKGQKKLLKGKVLIIGAGGLGAPAAMYLAAAGVGTIG
CCEECCHHHHHHHHHEEEEECCCCCHHHHHHCCCEEEEECCCCCCHHHHHHHHCCCCEEE
IVDADEVDLSNLQRQIIHGTADVGKAKVKSAKETMNAMNPDVQVNTYRMFVDASNIRELI
EECCCCCCHHHHHHHHHHCCCHHHHHHHHHHHHHHHHCCCCEEEEEEEEEEEHHHHHHHH
RDYDFIIDGTDNFPAKFLINDACVLEKKPFSHAGIIRFKGQLMTYVPGEGPCYRCVFKNP
HHCCEEEECCCCCCCEEEECCEEEECCCCCCCCCEEEECCEEEEEECCCCCEEEEEECCC
PPKDAVPTCKQAGVIGAMGGVIGSLQAMEAIKYLIGVGELLTGYLLTYDALTMEFHKIKL
CCCCCCCCHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEEEEEEC
PKDTHNCAVCGDHPTILEPIDYEQEVCEETAGRFDAPRTQE
CCCCCCEEEECCCCCCCCCCCCHHHHHHHHHCCCCCCCCCC
>Mature Secondary Structure
MLMAMTDEQIERYSRHIILNEVGVKGQKKLLKGKVLIIGAGGLGAPAAMYLAAAGVGTIG
CCEECCHHHHHHHHHEEEEECCCCCHHHHHHCCCEEEEECCCCCCHHHHHHHHCCCCEEE
IVDADEVDLSNLQRQIIHGTADVGKAKVKSAKETMNAMNPDVQVNTYRMFVDASNIRELI
EECCCCCCHHHHHHHHHHCCCHHHHHHHHHHHHHHHHCCCCEEEEEEEEEEEHHHHHHHH
RDYDFIIDGTDNFPAKFLINDACVLEKKPFSHAGIIRFKGQLMTYVPGEGPCYRCVFKNP
HHCCEEEECCCCCCCEEEECCEEEECCCCCCCCCEEEECCEEEEEECCCCCEEEEEECCC
PPKDAVPTCKQAGVIGAMGGVIGSLQAMEAIKYLIGVGELLTGYLLTYDALTMEFHKIKL
CCCCCCCCHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEEEEEEC
PKDTHNCAVCGDHPTILEPIDYEQEVCEETAGRFDAPRTQE
CCCCCCEEEECCCCCCCCCCCCHHHHHHHHHCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 9634230; 12218036 [H]