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The map label for this gene is rnz

Identifier: 238923242

GI number: 238923242

Start: 759098

End: 760009

Strand: Direct

Name: rnz

Synonym: EUBREC_0839

Alternate gene names: 238923242

Gene position: 759098-760009 (Clockwise)

Preceding gene: 238923241

Following gene: 238923243

Centisome position: 22.0

GC content: 46.38

Gene sequence:

>912_bases
ATGTTAGACGTGTGTTTACTTGGAACAGCAGGCATGATGCCTTTGCCAAACAGATGGCTTACGGCACTTTCACTAAAATA
TAACGGCAGCAATATACTTATTGACTGCGGTGAGGGAACGCAGATTGCGATGAAGGAAGCCGGAATCAATTTCAAGCCGA
TAGATATTTTATGCATCACCCACTTTCATGCAGACCATATCAGCGGATTGCCGGGGCTTCTTCTTACAATGGGAAATGCC
GAGCGCACCGAGCCGCTTACCATTATTGGACCTAAGGGGCTTACAAGGGTTGTCACTGCACTTCGGACGATTGCGCCGGA
GCTGCCTTTTGAGATAAAATGCATAGAGCTCAATGAGCAGGATGAATATTTTGAGATGAACGGATATCATATCCATGCAT
TCCGCGTAAAGCATGCGGTGCTGTGCTATGGCTATTCGGTTGAGATAAAACGTAGTGGCAGATTTTCCGTGGAAAGAGCA
AATGAAAAAGAAATTCCGATGCGCCTGTGGAATCCTCTTCAGAAAGGCAATACCGTTGAATTTGAGGGCAGGGTGTATAC
TCCGGATATGGTGCTAGGACCGGCAAGAAAGGGCATAAAGGTCACATATTGTACGGACTCAAGGCCACTTGAGCACATAG
TGGAGGCTGCAGAGGGATCAGACCTTTTTATCTGCGAGGGCATGTATGCTGAAAAGGAAAAGATAGTAAAAGCAAAGCAG
TATAAGCATATGACCTTTTATGAGGCAGCAGACATGGCAAAGAGAGCCGGCGTGAAGGAGCTGTGGCTTACACATTTTTC
GCCGTCACTTGTCAGGGCAGATGACTATATGCCACAGGTGAGGGATATTTTTGCAAACGCATATCTTGGAAAAGACGCAA
AGAGCGTGGAGCTTATGTTTGACGAGGACTAA

Upstream 100 bases:

>100_bases
ATCAGAAGATGGGGTTTGTAAACCTTGGAATCAGAAAAAATCTATATGAGCATCCGGTAGAGGACGGTGTCATCATGTCC
TATACTGCGGAGGAAAATTT

Downstream 100 bases:

>100_bases
GGAGGGGCGATATGAAGAAAACAGGTATAGTTATTTTAACAATAGCGCTGATTGCCGCGATATGTGGTTCGTTTTATGTC
GTAAACGACAAGTCTAAAAG

Product: ribonuclease Z

Products: NA

Alternate protein names: RNase Z; tRNA 3 endonuclease; tRNase Z

Number of amino acids: Translated: 303; Mature: 303

Protein sequence:

>303_residues
MLDVCLLGTAGMMPLPNRWLTALSLKYNGSNILIDCGEGTQIAMKEAGINFKPIDILCITHFHADHISGLPGLLLTMGNA
ERTEPLTIIGPKGLTRVVTALRTIAPELPFEIKCIELNEQDEYFEMNGYHIHAFRVKHAVLCYGYSVEIKRSGRFSVERA
NEKEIPMRLWNPLQKGNTVEFEGRVYTPDMVLGPARKGIKVTYCTDSRPLEHIVEAAEGSDLFICEGMYAEKEKIVKAKQ
YKHMTFYEAADMAKRAGVKELWLTHFSPSLVRADDYMPQVRDIFANAYLGKDAKSVELMFDED

Sequences:

>Translated_303_residues
MLDVCLLGTAGMMPLPNRWLTALSLKYNGSNILIDCGEGTQIAMKEAGINFKPIDILCITHFHADHISGLPGLLLTMGNA
ERTEPLTIIGPKGLTRVVTALRTIAPELPFEIKCIELNEQDEYFEMNGYHIHAFRVKHAVLCYGYSVEIKRSGRFSVERA
NEKEIPMRLWNPLQKGNTVEFEGRVYTPDMVLGPARKGIKVTYCTDSRPLEHIVEAAEGSDLFICEGMYAEKEKIVKAKQ
YKHMTFYEAADMAKRAGVKELWLTHFSPSLVRADDYMPQVRDIFANAYLGKDAKSVELMFDED
>Mature_303_residues
MLDVCLLGTAGMMPLPNRWLTALSLKYNGSNILIDCGEGTQIAMKEAGINFKPIDILCITHFHADHISGLPGLLLTMGNA
ERTEPLTIIGPKGLTRVVTALRTIAPELPFEIKCIELNEQDEYFEMNGYHIHAFRVKHAVLCYGYSVEIKRSGRFSVERA
NEKEIPMRLWNPLQKGNTVEFEGRVYTPDMVLGPARKGIKVTYCTDSRPLEHIVEAAEGSDLFICEGMYAEKEKIVKAKQ
YKHMTFYEAADMAKRAGVKELWLTHFSPSLVRADDYMPQVRDIFANAYLGKDAKSVELMFDED

Specific function: Zinc phosphodiesterase, which displays some tRNA 3'- processing endonuclease activity. Probably involved in tRNA maturation, by removing a 3'-trailer from precursor tRNA

COG id: COG1234

COG function: function code R; Metal-dependent hydrolases of the beta-lactamase superfamily III

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the RNase Z family

Homologues:

Organism=Homo sapiens, GI8922122, Length=314, Percent_Identity=30.2547770700637, Blast_Score=103, Evalue=2e-22,
Organism=Escherichia coli, GI87082078, Length=304, Percent_Identity=28.9473684210526, Blast_Score=112, Evalue=2e-26,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): RNZ_EUBR3 (C4ZFN9)

Other databases:

- EMBL:   CP001107
- RefSeq:   YP_002936757.1
- ProteinModelPortal:   C4ZFN9
- GeneID:   7966758
- GenomeReviews:   CP001107_GR
- KEGG:   ere:EUBREC_0839
- ProtClustDB:   PRK00055
- HAMAP:   MF_01818
- InterPro:   IPR001279
- InterPro:   IPR013471
- TIGRFAMs:   TIGR02651

Pfam domain/function: PF00753 Lactamase_B

EC number: =3.1.26.11

Molecular weight: Translated: 34185; Mature: 34185

Theoretical pI: Translated: 6.24; Mature: 6.24

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.3 %Cys     (Translated Protein)
4.3 %Met     (Translated Protein)
6.6 %Cys+Met (Translated Protein)
2.3 %Cys     (Mature Protein)
4.3 %Met     (Mature Protein)
6.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLDVCLLGTAGMMPLPNRWLTALSLKYNGSNILIDCGEGTQIAMKEAGINFKPIDILCIT
CEEEEEECCCCCCCCCCCEEEEEEEEECCCEEEEECCCCCEEEEECCCCCCCCEEEEEEE
HFHADHISGLPGLLLTMGNAERTEPLTIIGPKGLTRVVTALRTIAPELPFEIKCIELNEQ
EECHHHHCCCCEEEEEECCCCCCCCEEEECCCCHHHHHHHHHHHCCCCCEEEEEEEECCC
DEYFEMNGYHIHAFRVKHAVLCYGYSVEIKRSGRFSVERANEKEIPMRLWNPLQKGNTVE
CCEEEECCEEEEEEEEEEEEEEEEEEEEEEECCCEEEECCCCCCCCHHHHCHHHCCCEEE
FEGRVYTPDMVLGPARKGIKVTYCTDSRPLEHIVEAAEGSDLFICEGMYAEKEKIVKAKQ
ECCEEECCCEEECCCCCCEEEEEECCCCCHHHHHHHCCCCCEEEECCCCCCHHHHHHHHH
YKHMTFYEAADMAKRAGVKELWLTHFSPSLVRADDYMPQVRDIFANAYLGKDAKSVELMF
HCCEEHHHHHHHHHHCCHHHHHHHHCCCCEEECCCCCHHHHHHHHHHHCCCCCCEEEEEE
DED
ECC
>Mature Secondary Structure
MLDVCLLGTAGMMPLPNRWLTALSLKYNGSNILIDCGEGTQIAMKEAGINFKPIDILCIT
CEEEEEECCCCCCCCCCCEEEEEEEEECCCEEEEECCCCCEEEEECCCCCCCCEEEEEEE
HFHADHISGLPGLLLTMGNAERTEPLTIIGPKGLTRVVTALRTIAPELPFEIKCIELNEQ
EECHHHHCCCCEEEEEECCCCCCCCEEEECCCCHHHHHHHHHHHCCCCCEEEEEEEECCC
DEYFEMNGYHIHAFRVKHAVLCYGYSVEIKRSGRFSVERANEKEIPMRLWNPLQKGNTVE
CCEEEECCEEEEEEEEEEEEEEEEEEEEEEECCCEEEECCCCCCCCHHHHCHHHCCCEEE
FEGRVYTPDMVLGPARKGIKVTYCTDSRPLEHIVEAAEGSDLFICEGMYAEKEKIVKAKQ
ECCEEECCCEEECCCCCCEEEEEECCCCCHHHHHHHCCCCCEEEECCCCCCHHHHHHHHH
YKHMTFYEAADMAKRAGVKELWLTHFSPSLVRADDYMPQVRDIFANAYLGKDAKSVELMF
HCCEEHHHHHHHHHHCCHHHHHHHHCCCCEEECCCCCHHHHHHHHHHHCCCCCCEEEEEE
DED
ECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA