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The map label for this gene is coaBC [H]

Identifier: 238923232

GI number: 238923232

Start: 750558

End: 751751

Strand: Direct

Name: coaBC [H]

Synonym: EUBREC_0828

Alternate gene names: 238923232

Gene position: 750558-751751 (Clockwise)

Preceding gene: 238923231

Following gene: 238923234

Centisome position: 21.76

GC content: 45.64

Gene sequence:

>1194_bases
ATGTTAAAAGGAAAAACAGTAGTTTTGGGAGTGACAGGAAGTATAGCGGCATACAAGATAGCAAACCTTGCGAGTATGCT
TGTAAAACAGCACGCCGATGTCAACGTCATAATGACACACAATGCAACAAATTTTATAAATCCAATCACATTTGAAACTC
TCACAGGCAACAAGTGCCTCGTGGACACATTTGACAGAAACTTTGAATTCAATGTAGAGCATGTGGCGCTCGCAAAGAGA
GCAGACATCTTTATGGTGGCACCTGCATCAGCCAATGTGATAGGCAAGATGGCAAACGGAATCGCAGACGATATGCTTAC
CACCACAATACTTGCAGCCAAATGTCCTAAGCTTGTTTCTCCTGCCATGAACACCAATATGTACGAGAACAGGATTGTGC
AGGACAATATCAAAAAGCTCGAACACTACGGCTTTGAGATGATAAAGCCGGCTGAAGGATATCTTGCATGCGGAGACACA
GGTGCAGGAAAAATGCCGGAGCCACAGACACTTTTCAACTACATAATGAGGACAATAGCCTGTGAAAAGGACCTGGCAGG
CAAGAATGTACTCATCACAGCCGGAGCGACGCAGGAAAAAATAGACCCAGTACGTTTTATCACCAATCACTCAACAGGCA
AGATGGGGCGTGCCATAGCAGAAAACTGTATGCTCCGCGGTGCGCATGTTACACTGGTCAACGCTTCGGTATCTGTTGAG
CCACCTATGTTTGTAGATGTGGTAAATGTGACATCGGCCGCAGACATGGCAGACGTGGTGAAATCAAAGGCTGCTGAACA
GGATATTATCATCATGACCGCAGCAGTAGCGGATTTTTGCCCATCACATCCGGCTGATGAGAAAATAAAGAAAAATGACA
GCTCATATGAGTCTGTAATTGAGCTTGAGCGCACAGAGGACATACTTTCATACCTCGGAGCACACAAGGCTAAGGGACAG
CTCATATGCGGTTTTTCTATGGAAACCCAGAATATGCTTGAAAACTCGAAAGCAAAGCTTGCAAAGAAAAATGCAGATAT
GATAGTGGCAAACAACCTCAAGGTAGCAGGTGCAGGCTTTGGAACAGATACCAATGTGGTCACACTCATCACGGCTGACG
ACTGCACAGAGCTTGAAATCATGGACAAGAGCTGCGTTGCAGCTAGGATTATGGACCGGTTGCTGCAGATGTAG

Upstream 100 bases:

>100_bases
CAGCTAGAAGTGCAAAGTCTGTGGATGGCTACAAAGCATTTTGCGATGTAAACAAAAAATGACTGCAGAATAATAATAGT
TTTATACAGAGGTGAAAATC

Downstream 100 bases:

>100_bases
AATTACTACACCATGCAGTCCACAGCCGGCAGCTCCCCGGTCACATCGAGGAAGAGATTTGTAAAGGTCTGCTCATAGTA
AGGCTCCACCCAGAGCAGGC

Product: phosphopantothenoylcysteine decarboxylase/phosphopantothenate--cysteine ligase, putative

Products: NA

Alternate protein names: DNA/pantothenate metabolism flavoprotein; Phosphopantothenoylcysteine decarboxylase; PPCDC; CoaC; Phosphopantothenate--cysteine ligase; CoaB; PPC synthetase; PPCS; Phosphopantothenoylcysteine synthase [H]

Number of amino acids: Translated: 397; Mature: 397

Protein sequence:

>397_residues
MLKGKTVVLGVTGSIAAYKIANLASMLVKQHADVNVIMTHNATNFINPITFETLTGNKCLVDTFDRNFEFNVEHVALAKR
ADIFMVAPASANVIGKMANGIADDMLTTTILAAKCPKLVSPAMNTNMYENRIVQDNIKKLEHYGFEMIKPAEGYLACGDT
GAGKMPEPQTLFNYIMRTIACEKDLAGKNVLITAGATQEKIDPVRFITNHSTGKMGRAIAENCMLRGAHVTLVNASVSVE
PPMFVDVVNVTSAADMADVVKSKAAEQDIIIMTAAVADFCPSHPADEKIKKNDSSYESVIELERTEDILSYLGAHKAKGQ
LICGFSMETQNMLENSKAKLAKKNADMIVANNLKVAGAGFGTDTNVVTLITADDCTELEIMDKSCVAARIMDRLLQM

Sequences:

>Translated_397_residues
MLKGKTVVLGVTGSIAAYKIANLASMLVKQHADVNVIMTHNATNFINPITFETLTGNKCLVDTFDRNFEFNVEHVALAKR
ADIFMVAPASANVIGKMANGIADDMLTTTILAAKCPKLVSPAMNTNMYENRIVQDNIKKLEHYGFEMIKPAEGYLACGDT
GAGKMPEPQTLFNYIMRTIACEKDLAGKNVLITAGATQEKIDPVRFITNHSTGKMGRAIAENCMLRGAHVTLVNASVSVE
PPMFVDVVNVTSAADMADVVKSKAAEQDIIIMTAAVADFCPSHPADEKIKKNDSSYESVIELERTEDILSYLGAHKAKGQ
LICGFSMETQNMLENSKAKLAKKNADMIVANNLKVAGAGFGTDTNVVTLITADDCTELEIMDKSCVAARIMDRLLQM
>Mature_397_residues
MLKGKTVVLGVTGSIAAYKIANLASMLVKQHADVNVIMTHNATNFINPITFETLTGNKCLVDTFDRNFEFNVEHVALAKR
ADIFMVAPASANVIGKMANGIADDMLTTTILAAKCPKLVSPAMNTNMYENRIVQDNIKKLEHYGFEMIKPAEGYLACGDT
GAGKMPEPQTLFNYIMRTIACEKDLAGKNVLITAGATQEKIDPVRFITNHSTGKMGRAIAENCMLRGAHVTLVNASVSVE
PPMFVDVVNVTSAADMADVVKSKAAEQDIIIMTAAVADFCPSHPADEKIKKNDSSYESVIELERTEDILSYLGAHKAKGQ
LICGFSMETQNMLENSKAKLAKKNADMIVANNLKVAGAGFGTDTNVVTLITADDCTELEIMDKSCVAARIMDRLLQM

Specific function: Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine [H]

COG id: COG0452

COG function: function code H; Phosphopantothenoylcysteine synthetase/decarboxylase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: In the C-terminal section; belongs to the PPC synthetase family [H]

Homologues:

Organism=Homo sapiens, GI71725351, Length=173, Percent_Identity=35.2601156069364, Blast_Score=95, Evalue=1e-19,
Organism=Escherichia coli, GI87082301, Length=395, Percent_Identity=38.2278481012658, Blast_Score=252, Evalue=3e-68,
Organism=Caenorhabditis elegans, GI17560194, Length=178, Percent_Identity=31.4606741573034, Blast_Score=79, Evalue=5e-15,
Organism=Saccharomyces cerevisiae, GI6322762, Length=190, Percent_Identity=32.1052631578947, Blast_Score=91, Evalue=4e-19,
Organism=Drosophila melanogaster, GI24657262, Length=187, Percent_Identity=32.620320855615, Blast_Score=96, Evalue=6e-20,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005252
- InterPro:   IPR007085
- InterPro:   IPR003382 [H]

Pfam domain/function: PF04127 DFP; PF02441 Flavoprotein [H]

EC number: =4.1.1.36; =6.3.2.5 [H]

Molecular weight: Translated: 42968; Mature: 42968

Theoretical pI: Translated: 6.11; Mature: 6.11

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.3 %Cys     (Translated Protein)
5.5 %Met     (Translated Protein)
7.8 %Cys+Met (Translated Protein)
2.3 %Cys     (Mature Protein)
5.5 %Met     (Mature Protein)
7.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLKGKTVVLGVTGSIAAYKIANLASMLVKQHADVNVIMTHNATNFINPITFETLTGNKCL
CCCCCEEEEEECCCHHHHHHHHHHHHHHHHCCCEEEEEECCCCCCCCCEEEEEECCCEEE
VDTFDRNFEFNVEHVALAKRADIFMVAPASANVIGKMANGIADDMLTTTILAAKCPKLVS
EEECCCCEEECHHHEEEEECCCEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHCHHHHC
PAMNTNMYENRIVQDNIKKLEHYGFEMIKPAEGYLACGDTGAGKMPEPQTLFNYIMRTIA
CHHCCCHHHHHHHHHHHHHHHHCCCEEECCCCCEEEECCCCCCCCCCHHHHHHHHHHHHH
CEKDLAGKNVLITAGATQEKIDPVRFITNHSTGKMGRAIAENCMLRGAHVTLVNASVSVE
HCCCCCCCEEEEECCCCHHHCCCEEEEECCCCCHHHHHHHHHHHCCCCEEEEEEEEEEEC
PPMFVDVVNVTSAADMADVVKSKAAEQDIIIMTAAVADFCPSHPADEKIKKNDSSYESVI
CCEEEEEECCCCHHHHHHHHHHHCCCCCEEEEEEHHHHHCCCCCCCHHHHCCCCHHHHHH
ELERTEDILSYLGAHKAKGQLICGFSMETQNMLENSKAKLAKKNADMIVANNLKVAGAGF
HHHHHHHHHHHHCCCCCCCCEEEEECCCHHHHHHHHHHHHHHCCCCEEEECCEEEEECCC
GTDTNVVTLITADDCTELEIMDKSCVAARIMDRLLQM
CCCCCEEEEEECCCCCEEEEHHHHHHHHHHHHHHHCC
>Mature Secondary Structure
MLKGKTVVLGVTGSIAAYKIANLASMLVKQHADVNVIMTHNATNFINPITFETLTGNKCL
CCCCCEEEEEECCCHHHHHHHHHHHHHHHHCCCEEEEEECCCCCCCCCEEEEEECCCEEE
VDTFDRNFEFNVEHVALAKRADIFMVAPASANVIGKMANGIADDMLTTTILAAKCPKLVS
EEECCCCEEECHHHEEEEECCCEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHCHHHHC
PAMNTNMYENRIVQDNIKKLEHYGFEMIKPAEGYLACGDTGAGKMPEPQTLFNYIMRTIA
CHHCCCHHHHHHHHHHHHHHHHCCCEEECCCCCEEEECCCCCCCCCCHHHHHHHHHHHHH
CEKDLAGKNVLITAGATQEKIDPVRFITNHSTGKMGRAIAENCMLRGAHVTLVNASVSVE
HCCCCCCCEEEEECCCCHHHCCCEEEEECCCCCHHHHHHHHHHHCCCCEEEEEEEEEEEC
PPMFVDVVNVTSAADMADVVKSKAAEQDIIIMTAAVADFCPSHPADEKIKKNDSSYESVI
CCEEEEEECCCCHHHHHHHHHHHCCCCCEEEEEEHHHHHCCCCCCCHHHHCCCCHHHHHH
ELERTEDILSYLGAHKAKGQLICGFSMETQNMLENSKAKLAKKNADMIVANNLKVAGAGF
HHHHHHHHHHHHCCCCCCCCEEEEECCCHHHHHHHHHHHHHHCCCCEEEECCEEEEECCC
GTDTNVVTLITADDCTELEIMDKSCVAARIMDRLLQM
CCCCCEEEEEECCCCCEEEEHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9534248; 9384377 [H]