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The map label for this gene is glmS [H]

Identifier: 238923229

GI number: 238923229

Start: 746464

End: 748278

Strand: Direct

Name: glmS [H]

Synonym: EUBREC_0825

Alternate gene names: 238923229

Gene position: 746464-748278 (Clockwise)

Preceding gene: 238923228

Following gene: 238923230

Centisome position: 21.64

GC content: 43.31

Gene sequence:

>1815_bases
ATGTGTGGAATTATAGGATTTACAGGCCGTTTAGAGGCACAGAAGATTTTGACTGAAGGACTCGCAGCGTTAGAGTATCG
TGGATACGACAGTGCAGGTATTGCCTATTTCAAGGATACTGGCAAGATTTCTATTCGCAAAACCGTCGGAAAGGTTAAGG
ATCTTCTCGCTATCTGCGATGATGAGAACAATTCAACCTGTGGAATCGGACATACAAGATGGGCAACACACGGCGGAGTT
ACCAATGCCAATGCTCATCCTCACAAGGTTGGAAATGTCGCACTCATCCACAATGGTATCATTGAGAACTACCACGAGAT
TGTAAACAAGTATGATCTTGCAGACTCTCTTATATCTGAGACAGATACAGAGGTAGCAGCGGCTCTTATCAACAAGCTCT
ATGACGGAGATCCAAAGGCTACTATTAAGAAGGTAGTAGCAGAGCTTCAGGGTTCATTTGCGTTCTGTATCATGTTCAAG
GATCAGCCGGGAAAGATTTTTGCTGTCAGAAATGTAAGCCCGATGGTTGCAACATATTGCGATGACGGGGCATTTATTGC
ATCAGATCTTACAGCGTTTATTAAATATTCGAAGCGCTATTTTATACTTCCGGAGTACACTATCATGACAATGACTGCTG
ATGGAATCGAAATGGAGGATTTAGAGGGTAAGAAAGTTGAGCCGGATTATCTTGAGGTAAACTGGGATGTAACGGCAGCT
CAGAAGGATGGATATCCGCATTTCATGATCAAGGAAATTCATGAGCAGCCGACAGCTATCACAAGGACTATCACTCCAAG
AATCAAGGATTCACTTCCTTGCTTTGAGGATGATAATATTCCTGATTCGTTCTTCGAGGATATAAGCGACATAACAGTTG
TAGCCTGTGGTACAGCTATGTATGCAGGAATGGTCGGAAAAGCTCTTTTAAAGAACAAGTTTGGTATTCCTGTTTCTGTT
GAGATTGCATCAGAGTTCAGATATGAGCAGCCTGTTCTCACAGACAGGTCAATGGTTATTTTTGTGTCACAGTCAGGTGA
GACAATTGATACCTTAGAGGCACTTCGTCTGGCTAATAAATATACTAAAAAGACGCTTTCTATCGTAAATGTAAAGGGTT
CAACAATAGCCCGTGAGAGCAACTATGTACTTTATACACACGCAGGTCCTGAGATTGCCGTGGCAAGTACCAAGGCATAC
ACAGTTCAGGTGGCAAGCTTTTACCTGATTGGATGCAAGATTGGTCTTGTATCCGGCCGTATGACCAAGGAAGAGGCAAA
GACATTTATTGAGAATCTGCAGGAGGTTCCAAATCTCATTGAGTCAGTTATCACACAGGCACCTGAGATTGAACAGCTTA
CGAAGAGAATGACAAATGCTACAAATGCGTTTTACATAGGCCGAGGACTTGATTATGCATTAAGCATGGAGGGCGCACTC
AAGCTCAAAGAGATTTCATATATTCATGCTGAGGCTTATGCAGCAGGAGAGTTAAAGCACGGTACAATCGCGCTCATCAG
CGAGGGTGTTCCGGTTATCGCAGTTGCTACACAGAGCCATGTATACAGCAAGGTCATCTCAAATATCCGCGAGGTAAAGG
CGAGAGGCGCATACGTTATCCTTCTTAGCAAGGACAAGGATATTACAGATAAGTCAATCTGTGATGTGCATATCTCACTC
CCACAGGCACCGGATGAGTTTGTGATTTTCGAGTCAGTTATAATCTGTCAGCTTATCGCTTACTACACATCAACAGGAAA
GGGCTTAAACCCTGACCAGCCACGTAACCTTGCAAAATCAGTTACAGTAGAATAA

Upstream 100 bases:

>100_bases
AACAAAGCGAGAGAACCATAAAAATCAAGTAGCTGTTCAGTACAGAACAGTTACATATTTGTACATTTAAAATTATATAT
CGAAAAGGAGATCTAACACT

Downstream 100 bases:

>100_bases
ATAATTTCCCCGGACATTTATACGATGTCCGGGGATTTTTTCATGCTTGTGCGATACAATGCAGCATATGTAAGACATCG
ATGTATATGTCGGTGATTTG

Product: D-fructose-6-phosphate amidotransferase

Products: NA

Alternate protein names: D-fructose-6-phosphate amidotransferase; GFAT; Glucosamine-6-phosphate synthase; Hexosephosphate aminotransferase; L-glutamine-D-fructose-6-phosphate amidotransferase [H]

Number of amino acids: Translated: 604; Mature: 604

Protein sequence:

>604_residues
MCGIIGFTGRLEAQKILTEGLAALEYRGYDSAGIAYFKDTGKISIRKTVGKVKDLLAICDDENNSTCGIGHTRWATHGGV
TNANAHPHKVGNVALIHNGIIENYHEIVNKYDLADSLISETDTEVAAALINKLYDGDPKATIKKVVAELQGSFAFCIMFK
DQPGKIFAVRNVSPMVATYCDDGAFIASDLTAFIKYSKRYFILPEYTIMTMTADGIEMEDLEGKKVEPDYLEVNWDVTAA
QKDGYPHFMIKEIHEQPTAITRTITPRIKDSLPCFEDDNIPDSFFEDISDITVVACGTAMYAGMVGKALLKNKFGIPVSV
EIASEFRYEQPVLTDRSMVIFVSQSGETIDTLEALRLANKYTKKTLSIVNVKGSTIARESNYVLYTHAGPEIAVASTKAY
TVQVASFYLIGCKIGLVSGRMTKEEAKTFIENLQEVPNLIESVITQAPEIEQLTKRMTNATNAFYIGRGLDYALSMEGAL
KLKEISYIHAEAYAAGELKHGTIALISEGVPVIAVATQSHVYSKVISNIREVKARGAYVILLSKDKDITDKSICDVHISL
PQAPDEFVIFESVIICQLIAYYTSTGKGLNPDQPRNLAKSVTVE

Sequences:

>Translated_604_residues
MCGIIGFTGRLEAQKILTEGLAALEYRGYDSAGIAYFKDTGKISIRKTVGKVKDLLAICDDENNSTCGIGHTRWATHGGV
TNANAHPHKVGNVALIHNGIIENYHEIVNKYDLADSLISETDTEVAAALINKLYDGDPKATIKKVVAELQGSFAFCIMFK
DQPGKIFAVRNVSPMVATYCDDGAFIASDLTAFIKYSKRYFILPEYTIMTMTADGIEMEDLEGKKVEPDYLEVNWDVTAA
QKDGYPHFMIKEIHEQPTAITRTITPRIKDSLPCFEDDNIPDSFFEDISDITVVACGTAMYAGMVGKALLKNKFGIPVSV
EIASEFRYEQPVLTDRSMVIFVSQSGETIDTLEALRLANKYTKKTLSIVNVKGSTIARESNYVLYTHAGPEIAVASTKAY
TVQVASFYLIGCKIGLVSGRMTKEEAKTFIENLQEVPNLIESVITQAPEIEQLTKRMTNATNAFYIGRGLDYALSMEGAL
KLKEISYIHAEAYAAGELKHGTIALISEGVPVIAVATQSHVYSKVISNIREVKARGAYVILLSKDKDITDKSICDVHISL
PQAPDEFVIFESVIICQLIAYYTSTGKGLNPDQPRNLAKSVTVE
>Mature_604_residues
MCGIIGFTGRLEAQKILTEGLAALEYRGYDSAGIAYFKDTGKISIRKTVGKVKDLLAICDDENNSTCGIGHTRWATHGGV
TNANAHPHKVGNVALIHNGIIENYHEIVNKYDLADSLISETDTEVAAALINKLYDGDPKATIKKVVAELQGSFAFCIMFK
DQPGKIFAVRNVSPMVATYCDDGAFIASDLTAFIKYSKRYFILPEYTIMTMTADGIEMEDLEGKKVEPDYLEVNWDVTAA
QKDGYPHFMIKEIHEQPTAITRTITPRIKDSLPCFEDDNIPDSFFEDISDITVVACGTAMYAGMVGKALLKNKFGIPVSV
EIASEFRYEQPVLTDRSMVIFVSQSGETIDTLEALRLANKYTKKTLSIVNVKGSTIARESNYVLYTHAGPEIAVASTKAY
TVQVASFYLIGCKIGLVSGRMTKEEAKTFIENLQEVPNLIESVITQAPEIEQLTKRMTNATNAFYIGRGLDYALSMEGAL
KLKEISYIHAEAYAAGELKHGTIALISEGVPVIAVATQSHVYSKVISNIREVKARGAYVILLSKDKDITDKSICDVHISL
PQAPDEFVIFESVIICQLIAYYTSTGKGLNPDQPRNLAKSVTVE

Specific function: Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source [H]

COG id: COG0449

COG function: function code M; Glucosamine 6-phosphate synthetase, contains amidotransferase and phosphosugar isomerase domains

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 2 SIS domains [H]

Homologues:

Organism=Homo sapiens, GI205277386, Length=701, Percent_Identity=32.2396576319544, Blast_Score=307, Evalue=2e-83,
Organism=Homo sapiens, GI4826742, Length=693, Percent_Identity=33.3333333333333, Blast_Score=298, Evalue=1e-80,
Organism=Escherichia coli, GI1790167, Length=612, Percent_Identity=40.5228758169935, Blast_Score=424, Evalue=1e-120,
Organism=Escherichia coli, GI1788651, Length=114, Percent_Identity=32.4561403508772, Blast_Score=65, Evalue=9e-12,
Organism=Caenorhabditis elegans, GI17539970, Length=724, Percent_Identity=31.353591160221, Blast_Score=305, Evalue=5e-83,
Organism=Caenorhabditis elegans, GI17532897, Length=435, Percent_Identity=33.5632183908046, Blast_Score=218, Evalue=8e-57,
Organism=Caenorhabditis elegans, GI17532899, Length=435, Percent_Identity=33.5632183908046, Blast_Score=217, Evalue=1e-56,
Organism=Saccharomyces cerevisiae, GI6322745, Length=440, Percent_Identity=34.7727272727273, Blast_Score=231, Evalue=2e-61,
Organism=Saccharomyces cerevisiae, GI6323731, Length=435, Percent_Identity=28.735632183908, Blast_Score=161, Evalue=2e-40,
Organism=Saccharomyces cerevisiae, GI6323730, Length=203, Percent_Identity=34.9753694581281, Blast_Score=97, Evalue=1e-20,
Organism=Drosophila melanogaster, GI21357745, Length=686, Percent_Identity=30.9037900874636, Blast_Score=308, Evalue=8e-84,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000583
- InterPro:   IPR017932
- InterPro:   IPR005855
- InterPro:   IPR001347 [H]

Pfam domain/function: PF00310 GATase_2; PF01380 SIS [H]

EC number: =2.6.1.16 [H]

Molecular weight: Translated: 66360; Mature: 66360

Theoretical pI: Translated: 5.41; Mature: 5.41

Prosite motif: PS00443 GATASE_TYPE_II

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.7 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
3.8 %Cys+Met (Translated Protein)
1.7 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
3.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MCGIIGFTGRLEAQKILTEGLAALEYRGYDSAGIAYFKDTGKISIRKTVGKVKDLLAICD
CCCEEECCCCHHHHHHHHHHHHHHEECCCCCCCEEEEECCCCEEEHHHHHHHHHHHHHCC
DENNSTCGIGHTRWATHGGVTNANAHPHKVGNVALIHNGIIENYHEIVNKYDLADSLISE
CCCCCEECCCCCCEECCCCCCCCCCCCCCCCCEEEEECHHHHHHHHHHHHHHHHHHHHHH
TDTEVAAALINKLYDGDPKATIKKVVAELQGSFAFCIMFKDQPGKIFAVRNVSPMVATYC
CHHHHHHHHHHHHHCCCCHHHHHHHHHHHCCCEEEEEEEECCCCCEEEEECCCCEEEEEC
DDGAFIASDLTAFIKYSKRYFILPEYTIMTMTADGIEMEDLEGKKVEPDYLEVNWDVTAA
CCCCCHHHHHHHHHHHCCEEEEECCEEEEEEEECCCEEECCCCCCCCCCEEEEEEEEEEC
QKDGYPHFMIKEIHEQPTAITRTITPRIKDSLPCFEDDNIPDSFFEDISDITVVACGTAM
CCCCCCHHHHHHHHCCCCCEEEEECCHHHCCCCCCCCCCCCHHHHHHHHCEEEEEEHHHH
YAGMVGKALLKNKFGIPVSVEIASEFRYEQPVLTDRSMVIFVSQSGETIDTLEALRLANK
HHHHHHHHHHHCCCCCCEEEEEHHHCCCCCCCCCCCEEEEEEECCCCHHHHHHHHHHHHH
YTKKTLSIVNVKGSTIARESNYVLYTHAGPEIAVASTKAYTVQVASFYLIGCKIGLVSGR
HHHHEEEEEEECCCEEEECCCEEEEEECCCEEEEECCCEEEEEEEEEEEEEEEEEEECCC
MTKEEAKTFIENLQEVPNLIESVITQAPEIEQLTKRMTNATNAFYIGRGLDYALSMEGAL
CCHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHCCCCEEEEECCCCEEEECCCCE
KLKEISYIHAEAYAAGELKHGTIALISEGVPVIAVATQSHVYSKVISNIREVKARGAYVI
EEEHHHEEEHHHEECCCCCCCEEEEEECCCCEEEEECHHHHHHHHHHHHHHHHCCCCEEE
LLSKDKDITDKSICDVHISLPQAPDEFVIFESVIICQLIAYYTSTGKGLNPDQPRNLAKS
EEECCCCCCCCCEEEEEEECCCCCCCHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHH
VTVE
CCCC
>Mature Secondary Structure
MCGIIGFTGRLEAQKILTEGLAALEYRGYDSAGIAYFKDTGKISIRKTVGKVKDLLAICD
CCCEEECCCCHHHHHHHHHHHHHHEECCCCCCCEEEEECCCCEEEHHHHHHHHHHHHHCC
DENNSTCGIGHTRWATHGGVTNANAHPHKVGNVALIHNGIIENYHEIVNKYDLADSLISE
CCCCCEECCCCCCEECCCCCCCCCCCCCCCCCEEEEECHHHHHHHHHHHHHHHHHHHHHH
TDTEVAAALINKLYDGDPKATIKKVVAELQGSFAFCIMFKDQPGKIFAVRNVSPMVATYC
CHHHHHHHHHHHHHCCCCHHHHHHHHHHHCCCEEEEEEEECCCCCEEEEECCCCEEEEEC
DDGAFIASDLTAFIKYSKRYFILPEYTIMTMTADGIEMEDLEGKKVEPDYLEVNWDVTAA
CCCCCHHHHHHHHHHHCCEEEEECCEEEEEEEECCCEEECCCCCCCCCCEEEEEEEEEEC
QKDGYPHFMIKEIHEQPTAITRTITPRIKDSLPCFEDDNIPDSFFEDISDITVVACGTAM
CCCCCCHHHHHHHHCCCCCEEEEECCHHHCCCCCCCCCCCCHHHHHHHHCEEEEEEHHHH
YAGMVGKALLKNKFGIPVSVEIASEFRYEQPVLTDRSMVIFVSQSGETIDTLEALRLANK
HHHHHHHHHHHCCCCCCEEEEEHHHCCCCCCCCCCCEEEEEEECCCCHHHHHHHHHHHHH
YTKKTLSIVNVKGSTIARESNYVLYTHAGPEIAVASTKAYTVQVASFYLIGCKIGLVSGR
HHHHEEEEEEECCCEEEECCCEEEEEECCCEEEEECCCEEEEEEEEEEEEEEEEEEECCC
MTKEEAKTFIENLQEVPNLIESVITQAPEIEQLTKRMTNATNAFYIGRGLDYALSMEGAL
CCHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHCCCCEEEEECCCCEEEECCCCE
KLKEISYIHAEAYAAGELKHGTIALISEGVPVIAVATQSHVYSKVISNIREVKARGAYVI
EEEHHHEEEHHHEECCCCCCCEEEEEECCCCEEEEECHHHHHHHHHHHHHHHHCCCCEEE
LLSKDKDITDKSICDVHISLPQAPDEFVIFESVIICQLIAYYTSTGKGLNPDQPRNLAKS
EEECCCCCCCCCEEEEEEECCCCCCCHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHH
VTVE
CCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11997336 [H]