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The map label for this gene is hom [H]

Identifier: 238923131

GI number: 238923131

Start: 666329

End: 667519

Strand: Direct

Name: hom [H]

Synonym: EUBREC_0724

Alternate gene names: 238923131

Gene position: 666329-667519 (Clockwise)

Preceding gene: 238923130

Following gene: 238923132

Centisome position: 19.32

GC content: 44.42

Gene sequence:

>1191_bases
ATGAAGATTGCAGTTATGGGTTACGGCACAATTGGATCAGGTGTCGTAGAAGTATTAGAAATCAACAAAGAAAAAATCGC
AAAGAGAGCAGGAGAGCCAATCGAGGTCAAGTATGTGCTTGATTTAAGAGAGTTCCCGGGTACACCTATTGAGAACAAAA
TAGTTCATGATTATAAGGTTATTGCAGAGGACCCTGAAATCGGTATAGTTGTAGAGACAATGGGAGGCGTTGAGCCTGCA
TTTACATTCGTAAAGGCAATGCTTGAGGCAGGAAAACAGGTAGCAACATCAAACAAGAACCTTGTTGCTGCAAAGGGTGC
TGAGCTCATCAAGGTTGCCAGGGATCATGGAGTGAACTTCCAGTTTGAGGCCAGTGTCGGTGGTGGAATCCCTATTATCA
GACCTCTCAACAAGTGTCTCACAGCAGACGAGATTGAGGAAATCACAGGTATCTTAAACGGAACAACCAACTACATGCTT
ACAAAGATGACAGAGGAAGGTGCAGACTTTGATGAGGTATTAAAGGATGCTCAGGATAAGGGCTATGCAGAGAAGGATCC
TACAGCCGACATAGAGGGATATGATCCATGCAGAAAGATAGCCATTCTCACATCGCTTGTTGCAGGACAGCAGGTGGATT
TCGAGGATATCCACTGTGAGGGTATCACAAAGATTACACCTGAGGATATTAAGTATGCAAAGGCAATGCACCGTGCAATC
AAGCTTCTTGCTTCAAGCCGCAAGGTGGGTGACAGCTATACCTGTCTCGTTGCACCATATATGATAGATGACACACATCC
GCTCTCAGGAGTAAATGGAGTGTTCAACGGCGTATTTTTACGCGGAAATGTGCTCGGAGATGCTATGTTCTACGGCAGTG
GAGCAGGAAAGCTTCCAACAGCAAGTGCTGTAGTGGCAGATGTTGTTGATATGACAAAGCATCAGAACACAAATATTTAT
ATCGACTGGAAGCCTGAGAAGCTCACACTTGTAAGCTATGATGACAGTGTAAACAGCTTCTTTGTGAGAACTGACTCACC
AAAGAGCGAGGTTGAGGCTGTATTCGGACATGTAGACTACATTGAGGATGTGGTTGACGGCGAGTATGCATTCACAACAG
GCGACATGACAGAGAAGGATTTTGCCGACAAGGCATCAAAGATAAACGTTATCAACAGAATCAGATTATAA

Upstream 100 bases:

>100_bases
GTATTTCCCGAGTCGGATGATGTGGATGATATGGCAAAGCAGATTGAGTCCTTAAAGGGCATACATTACGTAAAAATTTT
AGCCAGGGAGTAACAAAAAG

Downstream 100 bases:

>100_bases
AGGACAAAAATATGGTAAAAGGCTTATACACCGCTCACACCGGTATGGTTAATGAGATGAAGCGCATGGATGTTCTTGCG
AACAACCTGGCCAATTCCGA

Product: homoserine dehydrogenase

Products: NA

Alternate protein names: HDH [H]

Number of amino acids: Translated: 396; Mature: 396

Protein sequence:

>396_residues
MKIAVMGYGTIGSGVVEVLEINKEKIAKRAGEPIEVKYVLDLREFPGTPIENKIVHDYKVIAEDPEIGIVVETMGGVEPA
FTFVKAMLEAGKQVATSNKNLVAAKGAELIKVARDHGVNFQFEASVGGGIPIIRPLNKCLTADEIEEITGILNGTTNYML
TKMTEEGADFDEVLKDAQDKGYAEKDPTADIEGYDPCRKIAILTSLVAGQQVDFEDIHCEGITKITPEDIKYAKAMHRAI
KLLASSRKVGDSYTCLVAPYMIDDTHPLSGVNGVFNGVFLRGNVLGDAMFYGSGAGKLPTASAVVADVVDMTKHQNTNIY
IDWKPEKLTLVSYDDSVNSFFVRTDSPKSEVEAVFGHVDYIEDVVDGEYAFTTGDMTEKDFADKASKINVINRIRL

Sequences:

>Translated_396_residues
MKIAVMGYGTIGSGVVEVLEINKEKIAKRAGEPIEVKYVLDLREFPGTPIENKIVHDYKVIAEDPEIGIVVETMGGVEPA
FTFVKAMLEAGKQVATSNKNLVAAKGAELIKVARDHGVNFQFEASVGGGIPIIRPLNKCLTADEIEEITGILNGTTNYML
TKMTEEGADFDEVLKDAQDKGYAEKDPTADIEGYDPCRKIAILTSLVAGQQVDFEDIHCEGITKITPEDIKYAKAMHRAI
KLLASSRKVGDSYTCLVAPYMIDDTHPLSGVNGVFNGVFLRGNVLGDAMFYGSGAGKLPTASAVVADVVDMTKHQNTNIY
IDWKPEKLTLVSYDDSVNSFFVRTDSPKSEVEAVFGHVDYIEDVVDGEYAFTTGDMTEKDFADKASKINVINRIRL
>Mature_396_residues
MKIAVMGYGTIGSGVVEVLEINKEKIAKRAGEPIEVKYVLDLREFPGTPIENKIVHDYKVIAEDPEIGIVVETMGGVEPA
FTFVKAMLEAGKQVATSNKNLVAAKGAELIKVARDHGVNFQFEASVGGGIPIIRPLNKCLTADEIEEITGILNGTTNYML
TKMTEEGADFDEVLKDAQDKGYAEKDPTADIEGYDPCRKIAILTSLVAGQQVDFEDIHCEGITKITPEDIKYAKAMHRAI
KLLASSRKVGDSYTCLVAPYMIDDTHPLSGVNGVFNGVFLRGNVLGDAMFYGSGAGKLPTASAVVADVVDMTKHQNTNIY
IDWKPEKLTLVSYDDSVNSFFVRTDSPKSEVEAVFGHVDYIEDVVDGEYAFTTGDMTEKDFADKASKINVINRIRL

Specific function: Catalyzes 2 nonconsecutive reactions in the common biosynthetic pathway leading from Asp to diaminopimelate and Lys, to Met, and to Thr and Ile. [C]

COG id: COG0460

COG function: function code E; Homoserine dehydrogenase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 ACT domain [H]

Homologues:

Organism=Escherichia coli, GI1786183, Length=104, Percent_Identity=36.5384615384615, Blast_Score=71, Evalue=1e-13,
Organism=Saccharomyces cerevisiae, GI6322599, Length=227, Percent_Identity=29.5154185022026, Blast_Score=75, Evalue=2e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002912
- InterPro:   IPR005106
- InterPro:   IPR016204
- InterPro:   IPR001342
- InterPro:   IPR019811
- InterPro:   IPR016040 [H]

Pfam domain/function: PF01842 ACT; PF00742 Homoserine_dh; PF03447 NAD_binding_3 [H]

EC number: =1.1.1.3 [H]

Molecular weight: Translated: 43193; Mature: 43193

Theoretical pI: Translated: 4.58; Mature: 4.58

Prosite motif: PS01042 HOMOSER_DHGENASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
3.8 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
2.8 %Met     (Mature Protein)
3.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKIAVMGYGTIGSGVVEVLEINKEKIAKRAGEPIEVKYVLDLREFPGTPIENKIVHDYKV
CEEEEEECCCCCHHHHHHHHCCHHHHHHHCCCCEEEEEEEEHHHCCCCCCCCCEEECEEE
IAEDPEIGIVVETMGGVEPAFTFVKAMLEAGKQVATSNKNLVAAKGAELIKVARDHGVNF
EECCCCCEEEEECCCCCCHHHHHHHHHHHCCHHHHCCCCCEEEECCHHHHHHHHHCCCCE
QFEASVGGGIPIIRPLNKCLTADEIEEITGILNGTTNYMLTKMTEEGADFDEVLKDAQDK
EEECCCCCCCHHHHHHHHHCCHHHHHHHHHHHCCCCCEEEEEECCCCCCHHHHHHHHHHC
GYAEKDPTADIEGYDPCRKIAILTSLVAGQQVDFEDIHCEGITKITPEDIKYAKAMHRAI
CCCCCCCCCCCCCCCHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHH
KLLASSRKVGDSYTCLVAPYMIDDTHPLSGVNGVFNGVFLRGNVLGDAMFYGSGAGKLPT
HHHHHCCCCCCCEEEEEEEEEECCCCCCCCCCHHHCCEEEECCEEECEEEECCCCCCCCC
ASAVVADVVDMTKHQNTNIYIDWKPEKLTLVSYDDSVNSFFVRTDSPKSEVEAVFGHVDY
HHHHHHHHHHHHHCCCCEEEEEECCCEEEEEEECCCCCEEEEECCCCHHHHHHHHHHHHH
IEDVVDGEYAFTTGDMTEKDFADKASKINVINRIRL
HHHHHCCCEEEECCCCCHHHHHHHHHHCCHHHHCCC
>Mature Secondary Structure
MKIAVMGYGTIGSGVVEVLEINKEKIAKRAGEPIEVKYVLDLREFPGTPIENKIVHDYKV
CEEEEEECCCCCHHHHHHHHCCHHHHHHHCCCCEEEEEEEEHHHCCCCCCCCCEEECEEE
IAEDPEIGIVVETMGGVEPAFTFVKAMLEAGKQVATSNKNLVAAKGAELIKVARDHGVNF
EECCCCCEEEEECCCCCCHHHHHHHHHHHCCHHHHCCCCCEEEECCHHHHHHHHHCCCCE
QFEASVGGGIPIIRPLNKCLTADEIEEITGILNGTTNYMLTKMTEEGADFDEVLKDAQDK
EEECCCCCCCHHHHHHHHHCCHHHHHHHHHHHCCCCCEEEEEECCCCCCHHHHHHHHHHC
GYAEKDPTADIEGYDPCRKIAILTSLVAGQQVDFEDIHCEGITKITPEDIKYAKAMHRAI
CCCCCCCCCCCCCCCHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHH
KLLASSRKVGDSYTCLVAPYMIDDTHPLSGVNGVFNGVFLRGNVLGDAMFYGSGAGKLPT
HHHHHCCCCCCCEEEEEEEEEECCCCCCCCCCHHHCCEEEECCEEECEEEECCCCCCCCC
ASAVVADVVDMTKHQNTNIYIDWKPEKLTLVSYDDSVNSFFVRTDSPKSEVEAVFGHVDY
HHHHHHHHHHHHHCCCCEEEEEECCCEEEEEEECCCCCEEEEECCCCHHHHHHHHHHHHH
IEDVVDGEYAFTTGDMTEKDFADKASKINVINRIRL
HHHHHCCCEEEECCCCCHHHHHHHHHHCCHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8590279; 8905231 [H]