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The map label for this gene is pyrG [H]

Identifier: 238923098

GI number: 238923098

Start: 630862

End: 632466

Strand: Direct

Name: pyrG [H]

Synonym: EUBREC_0690

Alternate gene names: 238923098

Gene position: 630862-632466 (Clockwise)

Preceding gene: 238923097

Following gene: 238923099

Centisome position: 18.29

GC content: 47.66

Gene sequence:

>1605_bases
ATGCCTGTAAAATACGTGTTCGTCACCGGTGGAGTTGTTTCCGGTCTTGGAAAAGGAATTACCGCAGCGTCTCTTGGACG
TCTTTTAAAAGCTCGTGGATACAAGGTGACAATGCAGAAGTTCGATCCATACATTAATATTGATCCGGGTACCATGAACC
CTATTCAGCACGGAGAGGTGTTTGTAACAGACGATGGAGCTGAGACAGATCTTGACCTGGGACACTATGAGCGTTTTATT
GATGAGAGCCTGACAAAGAACTCAAACGTCACCACAGGAAAGGTATACTGGTCAGTATTACAGAAGGAACGTCGTGGTGA
CTACGGCGGAGGAACAGTACAGGTTATCCCTCATATCACCAATGAGATAAAGAGCAGATTCTACAGGGATTTCACATCTG
AGGATACCACAATCGCAATCATCGAGGTGGGCGGTACAGTCGGCGATATCGAGAGTCAGCCGTTCCTCGAGGCAATCAGA
CAGTTCCAGCATGAGGTGGGACATGACAATGCCATCCTGTGCCATGTGACACTGATTCCATACATCAAGGCGTCAGGAGA
GCTCAAGACAAAGCCTACACAGGCAAGTGTAAAGGAGCTTCAGGGCATGGGAATCCAGCCGGATATCATTGTATGCCGTT
CAGAGCATGAGCTTGATCAGAAGCTTAAGGACAAGATTGCGCTGTTTTGTAATGTACCGAATTCACACGTATTACAGAAC
CTTGATGTGGAGTATCTCTATGAGGCACCACTTGCCATGGAGCAGGAGAATCTTGCAAAGGTTGCATGCGAGTGCTTGAA
TCTCGACTGTCCTGAGCCGGATCTTGCAGACTGGAAGCAGATGGTTGAGGATCTCCGTCATCCTGATAAAGAGGTCAAGA
TCGCACTTGTCGGAAAATATACAGCACTTCACGATGCATACATTTCAGTTGTTGAGGCACTGAAGCATGGCGGTATTCCT
GAGCATACCACAGTTGATATAAAGTGGGTTGACTCAGAGGAGCTTAATGATGACAATGCAGCAGAGGTATTCAAGGGCAT
TCAGGGAATTATCGTTCCGGGAGGCTTTGGAGATCGTGGTGTTGAGGGCATGATTGCAGCAGCTAAGTATGCCAGGGAAA
ACGATATCCCATATCTGGGACTCTGCCTTGGAATGCAGGTGGCAATCATCGAGTATGCGCGCCACGTATGTATGTTCCAT
GATGCACACAGTATAGAGCTTGATCCAAACACTACTCATCCGGTTATCGCACTTATGCCTGACCAGAACGGAATAGAGGA
TATCGGAGGTACACTTAGACTTGGCTCTTATCCATGTGTACTCGACAAGACATCAAAGGCATATCAGGTATATGGCACAG
AGAATATAAGCGAGCGTCATCGTCACCGTTATGAGGTCAACAATGACTACAGAACAGCTCTCACAGAGCATGGCATGAAG
CTTTGCGGTACATCACCGGATGGCAGAATCGTGGAGATGATTGAGATTCCGGAGCATCCGTGGTTTATTGCCACACAGGC
ACATCCTGAGCTTAAGTCACGTCCGAACCGTCCACATCCGCTTTTCCATGGCTTCATAGAGGCGGCAAACAAGGTGAACA
GATAA

Upstream 100 bases:

>100_bases
AATAAATTGCATTAATCAATTTAAGGCTGTATAATAAGTTGGTTATTTTAAAAATTAAGAATTTACAAATATACAAAGCA
TATTGATAAGGAGGAAAATT

Downstream 100 bases:

>100_bases
TTTTTCGTTATATTTAATACAATATTTAGAAAGTGCGGTTGATTTTGACCGCACTTTTTCTTATAATAAAGTGAAGCTTC
ACACTTTATATATTGTGAGG

Product: CTP synthetase

Products: NA

Alternate protein names: CTP synthetase; UTP--ammonia ligase [H]

Number of amino acids: Translated: 534; Mature: 533

Protein sequence:

>534_residues
MPVKYVFVTGGVVSGLGKGITAASLGRLLKARGYKVTMQKFDPYINIDPGTMNPIQHGEVFVTDDGAETDLDLGHYERFI
DESLTKNSNVTTGKVYWSVLQKERRGDYGGGTVQVIPHITNEIKSRFYRDFTSEDTTIAIIEVGGTVGDIESQPFLEAIR
QFQHEVGHDNAILCHVTLIPYIKASGELKTKPTQASVKELQGMGIQPDIIVCRSEHELDQKLKDKIALFCNVPNSHVLQN
LDVEYLYEAPLAMEQENLAKVACECLNLDCPEPDLADWKQMVEDLRHPDKEVKIALVGKYTALHDAYISVVEALKHGGIP
EHTTVDIKWVDSEELNDDNAAEVFKGIQGIIVPGGFGDRGVEGMIAAAKYARENDIPYLGLCLGMQVAIIEYARHVCMFH
DAHSIELDPNTTHPVIALMPDQNGIEDIGGTLRLGSYPCVLDKTSKAYQVYGTENISERHRHRYEVNNDYRTALTEHGMK
LCGTSPDGRIVEMIEIPEHPWFIATQAHPELKSRPNRPHPLFHGFIEAANKVNR

Sequences:

>Translated_534_residues
MPVKYVFVTGGVVSGLGKGITAASLGRLLKARGYKVTMQKFDPYINIDPGTMNPIQHGEVFVTDDGAETDLDLGHYERFI
DESLTKNSNVTTGKVYWSVLQKERRGDYGGGTVQVIPHITNEIKSRFYRDFTSEDTTIAIIEVGGTVGDIESQPFLEAIR
QFQHEVGHDNAILCHVTLIPYIKASGELKTKPTQASVKELQGMGIQPDIIVCRSEHELDQKLKDKIALFCNVPNSHVLQN
LDVEYLYEAPLAMEQENLAKVACECLNLDCPEPDLADWKQMVEDLRHPDKEVKIALVGKYTALHDAYISVVEALKHGGIP
EHTTVDIKWVDSEELNDDNAAEVFKGIQGIIVPGGFGDRGVEGMIAAAKYARENDIPYLGLCLGMQVAIIEYARHVCMFH
DAHSIELDPNTTHPVIALMPDQNGIEDIGGTLRLGSYPCVLDKTSKAYQVYGTENISERHRHRYEVNNDYRTALTEHGMK
LCGTSPDGRIVEMIEIPEHPWFIATQAHPELKSRPNRPHPLFHGFIEAANKVNR
>Mature_533_residues
PVKYVFVTGGVVSGLGKGITAASLGRLLKARGYKVTMQKFDPYINIDPGTMNPIQHGEVFVTDDGAETDLDLGHYERFID
ESLTKNSNVTTGKVYWSVLQKERRGDYGGGTVQVIPHITNEIKSRFYRDFTSEDTTIAIIEVGGTVGDIESQPFLEAIRQ
FQHEVGHDNAILCHVTLIPYIKASGELKTKPTQASVKELQGMGIQPDIIVCRSEHELDQKLKDKIALFCNVPNSHVLQNL
DVEYLYEAPLAMEQENLAKVACECLNLDCPEPDLADWKQMVEDLRHPDKEVKIALVGKYTALHDAYISVVEALKHGGIPE
HTTVDIKWVDSEELNDDNAAEVFKGIQGIIVPGGFGDRGVEGMIAAAKYARENDIPYLGLCLGMQVAIIEYARHVCMFHD
AHSIELDPNTTHPVIALMPDQNGIEDIGGTLRLGSYPCVLDKTSKAYQVYGTENISERHRHRYEVNNDYRTALTEHGMKL
CGTSPDGRIVEMIEIPEHPWFIATQAHPELKSRPNRPHPLFHGFIEAANKVNR

Specific function: Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen [H]

COG id: COG0504

COG function: function code F; CTP synthase (UTP-ammonia lyase)

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 glutamine amidotransferase type-1 domain [H]

Homologues:

Organism=Homo sapiens, GI148491070, Length=548, Percent_Identity=45.2554744525547, Blast_Score=488, Evalue=1e-138,
Organism=Homo sapiens, GI28559085, Length=548, Percent_Identity=44.1605839416058, Blast_Score=464, Evalue=1e-131,
Organism=Homo sapiens, GI28559083, Length=548, Percent_Identity=44.1605839416058, Blast_Score=464, Evalue=1e-131,
Organism=Homo sapiens, GI221316689, Length=548, Percent_Identity=44.1605839416058, Blast_Score=464, Evalue=1e-131,
Organism=Escherichia coli, GI1789142, Length=544, Percent_Identity=53.6764705882353, Blast_Score=590, Evalue=1e-170,
Organism=Caenorhabditis elegans, GI25148299, Length=603, Percent_Identity=40.7960199004975, Blast_Score=423, Evalue=1e-118,
Organism=Saccharomyces cerevisiae, GI6319432, Length=559, Percent_Identity=44.3649373881932, Blast_Score=466, Evalue=1e-132,
Organism=Saccharomyces cerevisiae, GI6322563, Length=561, Percent_Identity=44.5632798573975, Blast_Score=459, Evalue=1e-130,
Organism=Drosophila melanogaster, GI24664469, Length=548, Percent_Identity=46.7153284671533, Blast_Score=481, Evalue=1e-136,
Organism=Drosophila melanogaster, GI21357815, Length=492, Percent_Identity=45.1219512195122, Blast_Score=409, Evalue=1e-114,

Paralogues:

None

Copy number: 480 Molecules/Cell In: Growth-Phase, Minimal-Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004468
- InterPro:   IPR017456
- InterPro:   IPR017926
- InterPro:   IPR000991 [H]

Pfam domain/function: PF06418 CTP_synth_N; PF00117 GATase [H]

EC number: =6.3.4.2 [H]

Molecular weight: Translated: 59507; Mature: 59376

Theoretical pI: Translated: 5.34; Mature: 5.34

Prosite motif: PS00442 GATASE_TYPE_I

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.9 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
4.1 %Cys+Met (Translated Protein)
1.9 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
3.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPVKYVFVTGGVVSGLGKGITAASLGRLLKARGYKVTMQKFDPYINIDPGTMNPIQHGEV
CCEEEEEEECCHHHHHCCCCHHHHHHHHHHHCCCEEEEECCCCEEEECCCCCCCCCCCEE
FVTDDGAETDLDLGHYERFIDESLTKNSNVTTGKVYWSVLQKERRGDYGGGTVQVIPHIT
EEECCCCCCCCCHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHCCCCCCCEEEECCHHH
NEIKSRFYRDFTSEDTTIAIIEVGGTVGDIESQPFLEAIRQFQHEVGHDNAILCHVTLIP
HHHHHHHHHHCCCCCCEEEEEEECCCCCCCCCCHHHHHHHHHHHHHCCCCEEEEEEEEEE
YIKASGELKTKPTQASVKELQGMGIQPDIIVCRSEHELDQKLKDKIALFCNVPNSHVLQN
HEECCCCCCCCCCHHHHHHHHCCCCCCCEEEECCCHHHHHHHHCCEEEEEECCCHHHHHC
LDVEYLYEAPLAMEQENLAKVACECLNLDCPEPDLADWKQMVEDLRHPDKEVKIALVGKY
CCHHEEECCCCCCCHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHCCCCCEEEEEEECH
TALHDAYISVVEALKHGGIPEHTTVDIKWVDSEELNDDNAAEVFKGIQGIIVPGGFGDRG
HHHHHHHHHHHHHHHHCCCCCCEEEEEEECCCCCCCCCCHHHHHHCCCEEEEECCCCCCC
VEGMIAAAKYARENDIPYLGLCLGMQVAIIEYARHVCMFHDAHSIELDPNTTHPVIALMP
CHHHHHHHHHHHCCCCCEEEHHHHHHHHHHHHHHHHHHEECCCEEEECCCCCCCEEEEEC
DQNGIEDIGGTLRLGSYPCVLDKTSKAYQVYGTENISERHRHRYEVNNDYRTALTEHGMK
CCCCHHHCCCEEEECCCCEEECCCCCEEEEECCCCHHHHHHHCCCCCCCHHHHHHHCCCE
LCGTSPDGRIVEMIEIPEHPWFIATQAHPELKSRPNRPHPLFHGFIEAANKVNR
EECCCCCCCEEEEEECCCCCEEEEECCCCHHHCCCCCCCHHHHHHHHHHHHCCC
>Mature Secondary Structure 
PVKYVFVTGGVVSGLGKGITAASLGRLLKARGYKVTMQKFDPYINIDPGTMNPIQHGEV
CEEEEEEECCHHHHHCCCCHHHHHHHHHHHCCCEEEEECCCCEEEECCCCCCCCCCCEE
FVTDDGAETDLDLGHYERFIDESLTKNSNVTTGKVYWSVLQKERRGDYGGGTVQVIPHIT
EEECCCCCCCCCHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHCCCCCCCEEEECCHHH
NEIKSRFYRDFTSEDTTIAIIEVGGTVGDIESQPFLEAIRQFQHEVGHDNAILCHVTLIP
HHHHHHHHHHCCCCCCEEEEEEECCCCCCCCCCHHHHHHHHHHHHHCCCCEEEEEEEEEE
YIKASGELKTKPTQASVKELQGMGIQPDIIVCRSEHELDQKLKDKIALFCNVPNSHVLQN
HEECCCCCCCCCCHHHHHHHHCCCCCCCEEEECCCHHHHHHHHCCEEEEEECCCHHHHHC
LDVEYLYEAPLAMEQENLAKVACECLNLDCPEPDLADWKQMVEDLRHPDKEVKIALVGKY
CCHHEEECCCCCCCHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHCCCCCEEEEEEECH
TALHDAYISVVEALKHGGIPEHTTVDIKWVDSEELNDDNAAEVFKGIQGIIVPGGFGDRG
HHHHHHHHHHHHHHHHCCCCCCEEEEEEECCCCCCCCCCHHHHHHCCCEEEEECCCCCCC
VEGMIAAAKYARENDIPYLGLCLGMQVAIIEYARHVCMFHDAHSIELDPNTTHPVIALMP
CHHHHHHHHHHHCCCCCEEEHHHHHHHHHHHHHHHHHHEECCCEEEECCCCCCCEEEEEC
DQNGIEDIGGTLRLGSYPCVLDKTSKAYQVYGTENISERHRHRYEVNNDYRTALTEHGMK
CCCCHHHCCCEEEECCCCEEECCCCCEEEEECCCCHHHHHHHCCCCCCCHHHHHHHCCCE
LCGTSPDGRIVEMIEIPEHPWFIATQAHPELKSRPNRPHPLFHGFIEAANKVNR
EECCCCCCCEEEEEECCCCCEEEEECCCCHHHCCCCCCCHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA