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The map label for this gene is guaA

Identifier: 238923030

GI number: 238923030

Start: 565819

End: 567393

Strand: Direct

Name: guaA

Synonym: EUBREC_0620

Alternate gene names: 238923030

Gene position: 565819-567393 (Clockwise)

Preceding gene: 238923027

Following gene: 238923033

Centisome position: 16.4

GC content: 48.63

Gene sequence:

>1575_bases
ATGGATCAGGAAAAGGTCATAGTCATAGACTTTGGTGGTCAGTACAATCAGCTTGTTGCGCGCCGTGTCCGCGAGTGCAA
CGTGTACTGTGAGATTTACTCATACAAAATAGACATTGAGAAAATCAAAGAAATGAATCCAAAGGGCATCATCCTTACAG
GAGGTCCAAACAGCTGTTATGAAGAGAATTCTCCATCATACCGGAAAGAGCTGTTTGAGCTGGGAATACCGGTGCTTGGC
ATCTGCTACGGTGCACAGCTTATGATGCATAAATTAGGCGGAAAGGTAATCACACCGGAGGTTGGAGAGTATGGAAAGAC
AGAAATCACATATTCTGCAAACGGCGTGATGTTCAAGGATTTGCCATCAGAATCAGTATGCTGGATGAGTCATTTCGACA
GAATTGCAGAAGCAGCACCGGGCTTTGAGGTAGTTGCGCACACTGCAGACTGTCCAATAGCCGCAACACAGAATGTTGAG
AAGAAATTATATGCAGTACAGTTCCATCCGGAGGTACTTCACACCAAGAACGGAACACAGATGATTTACAATTTCGTCCG
TGGTGTATGTGGATGTGCAGGCACATGGAAGATGGATTCATTCGTCAAAAACACAATCGACGAAATCAGAGAGCAGGTCG
GTGACGGCAAAGTGCTCCTTGCACTTTCGGGTGGAGTAGACTCATCAGTACTCGCAGCACTCCTTGCCAAGGCAATCGGC
AAGCAGCTCACCTGCGTATTCGTAGACCACGGACTTCTCCGTAAGAACGAGGGCGATGAGGTAGAGGGCGTATTCGGCAA
AGACGGTTCGTTCGACATCAACTTTGTCCGCGTCAACGCACAGGAGCGCTACTACAGCAAGCTTGCAGGCGTCACAGAGC
CTGAGCGCAAGCGTAAAATCATCGGTGAGGAATTCATCCGTGTATTCGAGGAAGAAGCTAAGAAAATCGGAAAGGTTGAC
TTTCTTGCGCAGGGAACCATCTATCCGGACGTAGTGGAGAGTGGACTCGGCGGAGAATCTGCAGTCATCAAATCACACCA
CAACGTAGGAGGTCTCCCGGAGCATGTCGATTTCAAGGACATCGTGGAGCCACTTAGAAACCTCTTCAAGGACGAGGTAC
GCAAGGTCGGACTGGAGCTTGGATTACCTGATTATCTCGTATTCCGTCAGCCATTCCCAGGCCCGGGCCTTGGAATCCGT
ATCATCGGCGAAGTCACAGCCGAAAAGGTACGCATTGTCCAGGATGCAGACTGGATTTACAGAAGCGAAGTGGAAAAGGC
AGCAAAAGAGTACAAAGAGGCCCACGGCGAGGAACCATCATGGATGCCAAACCAGTACTTTGCAGCCCTTACCAACATGC
GTTCAGTAGGTGTCATGGGTGATGAGAGAACATATGATTATGCCGTTGCAGTCCGTGCAGTCCGCACTGTGGACTTCATG
ACAGCCGAAGCCGCCGAGATACCGTTTGAGGTACTTCAGACAGTGATGAGCAGAATTATAAATGAGGTAAAGGGAGTCAA
TAGAGTATTCTATGATTTGACCAGTAAGCCACCGGGAACTATTGAGTTTGAATAA

Upstream 100 bases:

>100_bases
TTTTGTTATTGTTTACACCACAGTGTGGCAAACAGCAATTACGTGATGTTTCAAAGATTATAAAACAGCAGCATAGCGAA
TAAACAATTAGGAGGAAAAC

Downstream 100 bases:

>100_bases
AATATAAGAGCCAAGAAATGCCTATTTTACGGGCTTTCTTGGCTCTTTCTATGTCTGGTGACAATCAAATGACAATACTT
TTTTATTTTTGGATAGTATT

Product: bifunctional GMP synthase/glutamine amidotransferase protein

Products: NA

Alternate protein names: GMP synthetase; Glutamine amidotransferase

Number of amino acids: Translated: 524; Mature: 524

Protein sequence:

>524_residues
MDQEKVIVIDFGGQYNQLVARRVRECNVYCEIYSYKIDIEKIKEMNPKGIILTGGPNSCYEENSPSYRKELFELGIPVLG
ICYGAQLMMHKLGGKVITPEVGEYGKTEITYSANGVMFKDLPSESVCWMSHFDRIAEAAPGFEVVAHTADCPIAATQNVE
KKLYAVQFHPEVLHTKNGTQMIYNFVRGVCGCAGTWKMDSFVKNTIDEIREQVGDGKVLLALSGGVDSSVLAALLAKAIG
KQLTCVFVDHGLLRKNEGDEVEGVFGKDGSFDINFVRVNAQERYYSKLAGVTEPERKRKIIGEEFIRVFEEEAKKIGKVD
FLAQGTIYPDVVESGLGGESAVIKSHHNVGGLPEHVDFKDIVEPLRNLFKDEVRKVGLELGLPDYLVFRQPFPGPGLGIR
IIGEVTAEKVRIVQDADWIYRSEVEKAAKEYKEAHGEEPSWMPNQYFAALTNMRSVGVMGDERTYDYAVAVRAVRTVDFM
TAEAAEIPFEVLQTVMSRIINEVKGVNRVFYDLTSKPPGTIEFE

Sequences:

>Translated_524_residues
MDQEKVIVIDFGGQYNQLVARRVRECNVYCEIYSYKIDIEKIKEMNPKGIILTGGPNSCYEENSPSYRKELFELGIPVLG
ICYGAQLMMHKLGGKVITPEVGEYGKTEITYSANGVMFKDLPSESVCWMSHFDRIAEAAPGFEVVAHTADCPIAATQNVE
KKLYAVQFHPEVLHTKNGTQMIYNFVRGVCGCAGTWKMDSFVKNTIDEIREQVGDGKVLLALSGGVDSSVLAALLAKAIG
KQLTCVFVDHGLLRKNEGDEVEGVFGKDGSFDINFVRVNAQERYYSKLAGVTEPERKRKIIGEEFIRVFEEEAKKIGKVD
FLAQGTIYPDVVESGLGGESAVIKSHHNVGGLPEHVDFKDIVEPLRNLFKDEVRKVGLELGLPDYLVFRQPFPGPGLGIR
IIGEVTAEKVRIVQDADWIYRSEVEKAAKEYKEAHGEEPSWMPNQYFAALTNMRSVGVMGDERTYDYAVAVRAVRTVDFM
TAEAAEIPFEVLQTVMSRIINEVKGVNRVFYDLTSKPPGTIEFE
>Mature_524_residues
MDQEKVIVIDFGGQYNQLVARRVRECNVYCEIYSYKIDIEKIKEMNPKGIILTGGPNSCYEENSPSYRKELFELGIPVLG
ICYGAQLMMHKLGGKVITPEVGEYGKTEITYSANGVMFKDLPSESVCWMSHFDRIAEAAPGFEVVAHTADCPIAATQNVE
KKLYAVQFHPEVLHTKNGTQMIYNFVRGVCGCAGTWKMDSFVKNTIDEIREQVGDGKVLLALSGGVDSSVLAALLAKAIG
KQLTCVFVDHGLLRKNEGDEVEGVFGKDGSFDINFVRVNAQERYYSKLAGVTEPERKRKIIGEEFIRVFEEEAKKIGKVD
FLAQGTIYPDVVESGLGGESAVIKSHHNVGGLPEHVDFKDIVEPLRNLFKDEVRKVGLELGLPDYLVFRQPFPGPGLGIR
IIGEVTAEKVRIVQDADWIYRSEVEKAAKEYKEAHGEEPSWMPNQYFAALTNMRSVGVMGDERTYDYAVAVRAVRTVDFM
TAEAAEIPFEVLQTVMSRIINEVKGVNRVFYDLTSKPPGTIEFE

Specific function: Catalyzes the synthesis of GMP from XMP

COG id: COG0519

COG function: function code F; GMP synthase, PP-ATPase domain/subunit

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 GMP-binding domain

Homologues:

Organism=Homo sapiens, GI4504035, Length=564, Percent_Identity=35.8156028368794, Blast_Score=299, Evalue=5e-81,
Organism=Escherichia coli, GI1788854, Length=534, Percent_Identity=49.063670411985, Blast_Score=520, Evalue=1e-148,
Organism=Caenorhabditis elegans, GI71992717, Length=573, Percent_Identity=36.4746945898778, Blast_Score=312, Evalue=2e-85,
Organism=Caenorhabditis elegans, GI71992710, Length=573, Percent_Identity=36.4746945898778, Blast_Score=312, Evalue=2e-85,
Organism=Caenorhabditis elegans, GI133901714, Length=573, Percent_Identity=36.4746945898778, Blast_Score=312, Evalue=4e-85,
Organism=Saccharomyces cerevisiae, GI6323873, Length=531, Percent_Identity=44.8210922787194, Blast_Score=441, Evalue=1e-124,
Organism=Drosophila melanogaster, GI281365319, Length=553, Percent_Identity=35.4430379746835, Blast_Score=288, Evalue=7e-78,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): GUAA_EUBR3 (C4ZCQ4)

Other databases:

- EMBL:   CP001107
- RefSeq:   YP_002936543.1
- ProteinModelPortal:   C4ZCQ4
- GeneID:   7964624
- GenomeReviews:   CP001107_GR
- KEGG:   ere:EUBREC_0620
- ProtClustDB:   CLSK2548418
- HAMAP:   MF_00344
- InterPro:   IPR006220
- InterPro:   IPR001962
- InterPro:   IPR001317
- InterPro:   IPR011702
- InterPro:   IPR017926
- InterPro:   IPR000991
- InterPro:   IPR001674
- InterPro:   IPR004739
- InterPro:   IPR022955
- InterPro:   IPR014729
- Gene3D:   G3DSA:3.40.50.620
- PRINTS:   PR00097
- PRINTS:   PR00099
- PRINTS:   PR00096
- TIGRFAMs:   TIGR00884
- TIGRFAMs:   TIGR00888

Pfam domain/function: PF00733 Asn_synthase; PF00117 GATase; PF00958 GMP_synt_C

EC number: =6.3.5.2

Molecular weight: Translated: 58463; Mature: 58463

Theoretical pI: Translated: 5.09; Mature: 5.09

Prosite motif: PS51273 GATASE_TYPE_1; PS00442 GATASE_TYPE_I

Important sites: ACT_SITE 82-82 ACT_SITE 169-169 ACT_SITE 171-171

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.7 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
4.2 %Cys+Met (Translated Protein)
1.7 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
4.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDQEKVIVIDFGGQYNQLVARRVRECNVYCEIYSYKIDIEKIKEMNPKGIILTGGPNSCY
CCCCCEEEEECCCCHHHHHHHHHHHCEEEEEEEEEEEEHHHHHCCCCCEEEEECCCCCCC
EENSPSYRKELFELGIPVLGICYGAQLMMHKLGGKVITPEVGEYGKTEITYSANGVMFKD
CCCCCHHHHHHHHHCCCHHHHHHHHHHHHHHHCCEEECCCCCCCCCEEEEEECCCEEEEC
LPSESVCWMSHFDRIAEAAPGFEVVAHTADCPIAATQNVEKKLYAVQFHPEVLHTKNGTQ
CCCCCHHHHHHHHHHHHHCCCCEEEEECCCCCCCCCCCHHHEEEEEEECCHHHCCCCCHH
MIYNFVRGVCGCAGTWKMDSFVKNTIDEIREQVGDGKVLLALSGGVDSSVLAALLAKAIG
HHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHCCCEEEEEEECCCCHHHHHHHHHHHHC
KQLTCVFVDHGLLRKNEGDEVEGVFGKDGSFDINFVRVNAQERYYSKLAGVTEPERKRKI
CCEEEEEECCCHHCCCCCCCCCEEECCCCCEEEEEEEECCHHHHHHHHCCCCCCHHHHHH
IGEEFIRVFEEEAKKIGKVDFLAQGTIYPDVVESGLGGESAVIKSHHNVGGLPEHVDFKD
HHHHHHHHHHHHHHHCCCEEEEECCCCCHHHHHCCCCCCHHHEECCCCCCCCCCCCCHHH
IVEPLRNLFKDEVRKVGLELGLPDYLVFRQPFPGPGLGIRIIGEVTAEKVRIVQDADWIY
HHHHHHHHHHHHHHHHHHHCCCCCCEEEECCCCCCCCCEEEEEHHHHHHEEEECCCCHHH
RSEVEKAAKEYKEAHGEEPSWMPNQYFAALTNMRSVGVMGDERTYDYAVAVRAVRTVDFM
HHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHH
TAEAAEIPFEVLQTVMSRIINEVKGVNRVFYDLTSKPPGTIEFE
HHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEECC
>Mature Secondary Structure
MDQEKVIVIDFGGQYNQLVARRVRECNVYCEIYSYKIDIEKIKEMNPKGIILTGGPNSCY
CCCCCEEEEECCCCHHHHHHHHHHHCEEEEEEEEEEEEHHHHHCCCCCEEEEECCCCCCC
EENSPSYRKELFELGIPVLGICYGAQLMMHKLGGKVITPEVGEYGKTEITYSANGVMFKD
CCCCCHHHHHHHHHCCCHHHHHHHHHHHHHHHCCEEECCCCCCCCCEEEEEECCCEEEEC
LPSESVCWMSHFDRIAEAAPGFEVVAHTADCPIAATQNVEKKLYAVQFHPEVLHTKNGTQ
CCCCCHHHHHHHHHHHHHCCCCEEEEECCCCCCCCCCCHHHEEEEEEECCHHHCCCCCHH
MIYNFVRGVCGCAGTWKMDSFVKNTIDEIREQVGDGKVLLALSGGVDSSVLAALLAKAIG
HHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHCCCEEEEEEECCCCHHHHHHHHHHHHC
KQLTCVFVDHGLLRKNEGDEVEGVFGKDGSFDINFVRVNAQERYYSKLAGVTEPERKRKI
CCEEEEEECCCHHCCCCCCCCCEEECCCCCEEEEEEEECCHHHHHHHHCCCCCCHHHHHH
IGEEFIRVFEEEAKKIGKVDFLAQGTIYPDVVESGLGGESAVIKSHHNVGGLPEHVDFKD
HHHHHHHHHHHHHHHCCCEEEEECCCCCHHHHHCCCCCCHHHEECCCCCCCCCCCCCHHH
IVEPLRNLFKDEVRKVGLELGLPDYLVFRQPFPGPGLGIRIIGEVTAEKVRIVQDADWIY
HHHHHHHHHHHHHHHHHHHCCCCCCEEEECCCCCCCCCEEEEEHHHHHHEEEECCCCHHH
RSEVEKAAKEYKEAHGEEPSWMPNQYFAALTNMRSVGVMGDERTYDYAVAVRAVRTVDFM
HHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHH
TAEAAEIPFEVLQTVMSRIINEVKGVNRVFYDLTSKPPGTIEFE
HHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA