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The map label for this gene is hpt [H]

Identifier: 238922946

GI number: 238922946

Start: 493142

End: 493687

Strand: Direct

Name: hpt [H]

Synonym: EUBREC_0534

Alternate gene names: 238922946

Gene position: 493142-493687 (Clockwise)

Preceding gene: 238922945

Following gene: 238922947

Centisome position: 14.3

GC content: 41.94

Gene sequence:

>546_bases
ATGGATTTTTCAAAAAAATATGATATTTCGGTTTACCTGACAGAGGAGCAGCTCAATAAGCGTATTGCAGAGATTGGAGC
GCAAATCACAGAAAAATACAGGGGACAGTCAGTATATCTCATTTGCATACTCAAGGGCTCAATATTCTTTACCACTGAGC
TTGCAAAGAGAATTGATTTGCCTATGACTATGGATTTCATGTCGGTATCCAGCTATGGCTCAGGCACAGAGTCATCAGGC
GATGTCAAGATTAAAAAGGACCTTGAGCATTCTATCGAGGGAGAGAATGTCATCATCATAGAAGATATCATTGATTCGGG
AAATACTCTTAGCAGGCTTTCAAAGCTCCTTGCCAAAAGAAACCCGAAGAGTCTCACAATCTGTACACTTTTGGACAAGC
CTGAGCGCCGTGTGGTTGATGATGTAAATGTAGACTACGTGGGCTTTGTGATTCCTGATAAGTTTGTGGTAGGCTATGGC
CTTGACTATGATCAGAGGTTCAGAAATCTGCCTTACATCGGCTTCGTCGAGGGCGAAATAAAATAA

Upstream 100 bases:

>100_bases
CTGGTGCATGCCATTATCGGATACAGATCCGGCTGCAGCGCACTTGTCACACCACAGACAGGAAAAGTACTTAAGATCAC
ATTTTACGGAGGAAAACAAA

Downstream 100 bases:

>100_bases
AAAGGAGAAGTAAATTGAATAAACAAAAAAGCGGTATGCGCGGAATAGGCGTATACATTATCATTGTATTTGCAGTAATC
TGCATCTGGTACTGGCTGAG

Product: hypoxanthine phosphoribosyltransferase

Products: NA

Alternate protein names: HPRT [H]

Number of amino acids: Translated: 181; Mature: 181

Protein sequence:

>181_residues
MDFSKKYDISVYLTEEQLNKRIAEIGAQITEKYRGQSVYLICILKGSIFFTTELAKRIDLPMTMDFMSVSSYGSGTESSG
DVKIKKDLEHSIEGENVIIIEDIIDSGNTLSRLSKLLAKRNPKSLTICTLLDKPERRVVDDVNVDYVGFVIPDKFVVGYG
LDYDQRFRNLPYIGFVEGEIK

Sequences:

>Translated_181_residues
MDFSKKYDISVYLTEEQLNKRIAEIGAQITEKYRGQSVYLICILKGSIFFTTELAKRIDLPMTMDFMSVSSYGSGTESSG
DVKIKKDLEHSIEGENVIIIEDIIDSGNTLSRLSKLLAKRNPKSLTICTLLDKPERRVVDDVNVDYVGFVIPDKFVVGYG
LDYDQRFRNLPYIGFVEGEIK
>Mature_181_residues
MDFSKKYDISVYLTEEQLNKRIAEIGAQITEKYRGQSVYLICILKGSIFFTTELAKRIDLPMTMDFMSVSSYGSGTESSG
DVKIKKDLEHSIEGENVIIIEDIIDSGNTLSRLSKLLAKRNPKSLTICTLLDKPERRVVDDVNVDYVGFVIPDKFVVGYG
LDYDQRFRNLPYIGFVEGEIK

Specific function: This enzyme acts exclusively on hypoxanthine; it does not act on guanine [H]

COG id: COG0634

COG function: function code F; Hypoxanthine-guanine phosphoribosyltransferase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the purine/pyrimidine phosphoribosyltransferase family [H]

Homologues:

Organism=Homo sapiens, GI4504483, Length=173, Percent_Identity=36.4161849710983, Blast_Score=106, Evalue=1e-23,
Organism=Homo sapiens, GI9910262, Length=163, Percent_Identity=31.9018404907975, Blast_Score=83, Evalue=1e-16,
Organism=Escherichia coli, GI87081689, Length=173, Percent_Identity=53.1791907514451, Blast_Score=191, Evalue=3e-50,
Organism=Caenorhabditis elegans, GI17510817, Length=172, Percent_Identity=36.6279069767442, Blast_Score=100, Evalue=6e-22,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005904
- InterPro:   IPR000836 [H]

Pfam domain/function: PF00156 Pribosyltran [H]

EC number: =2.4.2.8 [H]

Molecular weight: Translated: 20539; Mature: 20539

Theoretical pI: Translated: 4.93; Mature: 4.93

Prosite motif: PS00103 PUR_PYR_PR_TRANSFER

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
3.3 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
3.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDFSKKYDISVYLTEEQLNKRIAEIGAQITEKYRGQSVYLICILKGSIFFTTELAKRIDL
CCCCCCEEEEEEEEHHHHHHHHHHHHHHHHHHHCCCEEEEEEEEECCEEEEEHHHHHCCC
PMTMDFMSVSSYGSGTESSGDVKIKKDLEHSIEGENVIIIEDIIDSGNTLSRLSKLLAKR
CEEEHHHHHCCCCCCCCCCCCEEEEECHHHCCCCCCEEEEEECCCCCCHHHHHHHHHHHC
NPKSLTICTLLDKPERRVVDDVNVDYVGFVIPDKFVVGYGLDYDQRFRNLPYIGFVEGEI
CCCCEEEEEECCCCCHHHHCCCCCCEEEEEECCCEEEEECCCHHHHHHCCCEEEEEECCC
K
C
>Mature Secondary Structure
MDFSKKYDISVYLTEEQLNKRIAEIGAQITEKYRGQSVYLICILKGSIFFTTELAKRIDL
CCCCCCEEEEEEEEHHHHHHHHHHHHHHHHHHHCCCEEEEEEEEECCEEEEEHHHHHCCC
PMTMDFMSVSSYGSGTESSGDVKIKKDLEHSIEGENVIIIEDIIDSGNTLSRLSKLLAKR
CEEEHHHHHCCCCCCCCCCCCEEEEECHHHCCCCCCEEEEEECCCCCCHHHHHHHHHHHC
NPKSLTICTLLDKPERRVVDDVNVDYVGFVIPDKFVVGYGLDYDQRFRNLPYIGFVEGEI
CCCCEEEEEECCCCCHHHHCCCCCCEEEEEECCCEEEEECCCHHHHHHCCCEEEEEECCC
K
C

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 12471157 [H]