| Definition | Eubacterium eligens ATCC 27750 plasmid unnamed, complete sequence. |
|---|---|
| Accession | NC_012780 |
| Length | 626,744 |
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The map label for this gene is relA [H]
Identifier: 238922253
GI number: 238922253
Start: 450409
End: 452721
Strand: Reverse
Name: relA [H]
Synonym: EUBELI_20488
Alternate gene names: 238922253
Gene position: 452721-450409 (Counterclockwise)
Preceding gene: 238922254
Following gene: 238922252
Centisome position: 72.23
GC content: 39.04
Gene sequence:
>2313_bases ATGGAGGCACGTATGCCAGAGAATATAGAGTTACCAGGCGCAAGCCATAACAAAACTAATCAGGTTGAAAGAGCGGTGGA TACACCAGCAGATTTTACAAGTCCTGAGGAATTATATAAGGATCTTATTGCAGCTATAAAGAAATACCACCCATCTACAG ATCTGTCTGATATCGAGAAGGCATACGAGACTGCAAGAAAGGCACATGAGGGACAGTTCAGAAAATCGGGTGAGCCATAT ATAATCCACCCTTTATGTGTTGCTATTATTCTGGCTGAATTAGAGCTTGATAAGGAGTCAATTATTGCAGGTCTTCTTCA TGATGTTGTTGAAGATACAGTTATGACAAGTGAAGATGTTGCAAAAGAATTTGGTGATGAGGTAGCACTGTTAGTAGATG GTGTAACAAAGCTGACACAGCTCAATTACCAGCATGATAAGATTGAGGTCCAGGCAGAAAACCTTAGAAAAATGTTTCTT GCAATGGCAAAGGATATAAGAGTTATCCTTATAAAGCTTGCCGACAGACTGCATAATATGCGTACAATGCAGTATCAGTC ACCGGCAAAGCAGATTGAGAAATCAAGAGAGACAATGGAAATATATGCTCCAATAGCCCACAGGTTAGGTATTTCCAAGA TTAAGGTAGAGCTTGATGATTTATCAATGAAATATCTTATGCCTGATGTATATAATGATCTTGTTGAACAGGTCAACTTA AACAGACCAGGCAGGGAAGCATTTATAAAGAGCATAATTAAAGAAGTCGGCATGCATATAAGCAATGCCGGTATTGAGGC TGAGATTGACGGAAGAGTTAAACATTTCTTCTCAATCTATAGAAAAATGGTCAACCAGAATAAGACGCTTGACCAGATAT ATGACATATTTGCAGTAAGAATAAAGGTTGATACAGTTAAAGACTGTTATGCGGCACTTGGTGTAATACACGAAATGTAT AAGCCTATTCCGGGACGTTTCAAAGATTATATTGCCATGCCTAAGCCTAATAATTACCAGTCGCTCCATACAACACTTAT TGCATCTAACGGACAGCCGTTTGAGATACAGATAAGAACTTACGAAATGCATAAGATTGCTGAGTATGGTATTGCAGCCC ACTGGAAATATAAAGAGGGAAAAACCGGCGAGAAGGACAACCAGAGTGAGGAAGCAAAACTTAGCTGGTTAAGACAGATT CTTGAATGGCAGAAGGAAATGTCTGATAACAAGGAATTCTTATCATCTATTAAGAATGACCTTAACCTTTTCTCAGACAG CGTATACTGCTTTACACCTTCGGGTGATGTCAAGAACCTTCCTGCAGGTTCATGCCCTATAGATTTTGCGTACAGTATCC ACAGTGCTGTAGGTAATAAAATGGTAGGTGCAAGAGTTAATGGAAAGCTTGTTACTATTGATTATGTTATTAAGAATGGT GACAGAATCGAGATTATAACATCGCAGAATTCCAAGGGACCAAGCCGTGACTGGCTTTCAATTGTAAAGAGCACACAGGC AAAGAATAAGATTAACCAGTGGTTTAAGCAGGAGTTAAAGGAAGATAATATCATTAAGGGCAAGGAAATGATTGTTAACT ACTGTAAGACTAAAGGAATCGTTCTTTCTGACATTACCAAGCCTGAATATGTTGAAAAATGTCTTAACAAATATGGCTTT AAAGACTGGGATTCTATTCTTGCAGCTGTCGGACATGGTGCACTTAAAGAGAGCCAGATAGTAAACAGGCTTAATGAGGA GCATTTAAAGACCAAGAAGGCAGAAGTTACAGATAAAGATGTACTTGAGGAAATCGTTGCCGCTGAGTCTAAGGAAAAGT CAAAGAAGAAGGAAGGCAAAGGTGGAATTGTCGTTAAGGGAATCCATGATGTTGCTGTCAGATTTTCAAAATGCTGTAAT CCGGTTCCTGGTGATGAGATTGTTGGTTTTGTTACAAGAGGAAGAGGCATATCAATTCACAGAACAGACTGTGTTAATAT AATCAACTTCCCGGCTAATGAACGTGCGCGTCTTATTGAGGCTGAATGGGAGCAGGGACAGACAGCAGGCGATACTTATG AGGTTGAAATCAATATATTTGCCAATAACAGAACTGGACTTATTGTTGATATATCAAGGATGTTCACAGAGGCAGAGATT GATGTGAAGTCTATGAACTGTCGTCTTAATAAGAAGGAAGTTGCGACAATAAGTGTCGGCTTTGATATTCACGGCAAGGA AGAACTTAACAGAATTATAGATAAATTAAGAAAGATAGACGGAGTTACTGATATAACAAGAACTGCCGGCTAA
Upstream 100 bases:
>100_bases CTGAGAATGCAGTGGCTACAAGAGAATTTATGGAAAGAACATATGCCAGTGTATAAATAATGGGCTTAAGAAAACTATAA CGCTGGACAATTACCAGAGA
Downstream 100 bases:
>100_bases GAAAGGTTTGCAGATTATGATTAAGATAGAATCAAGAGTATTGGGACCGGTAGCTACTAACTGCTATCTTATAATTAATA AAGATAACAATGAGAGCATT
Product: GTP pyrophosphokinase
Products: NA
Alternate protein names: (p)ppGpp synthase; ATP:GTP 3'-pyrophosphotransferase; ppGpp synthase I [H]
Number of amino acids: Translated: 770; Mature: 770
Protein sequence:
>770_residues MEARMPENIELPGASHNKTNQVERAVDTPADFTSPEELYKDLIAAIKKYHPSTDLSDIEKAYETARKAHEGQFRKSGEPY IIHPLCVAIILAELELDKESIIAGLLHDVVEDTVMTSEDVAKEFGDEVALLVDGVTKLTQLNYQHDKIEVQAENLRKMFL AMAKDIRVILIKLADRLHNMRTMQYQSPAKQIEKSRETMEIYAPIAHRLGISKIKVELDDLSMKYLMPDVYNDLVEQVNL NRPGREAFIKSIIKEVGMHISNAGIEAEIDGRVKHFFSIYRKMVNQNKTLDQIYDIFAVRIKVDTVKDCYAALGVIHEMY KPIPGRFKDYIAMPKPNNYQSLHTTLIASNGQPFEIQIRTYEMHKIAEYGIAAHWKYKEGKTGEKDNQSEEAKLSWLRQI LEWQKEMSDNKEFLSSIKNDLNLFSDSVYCFTPSGDVKNLPAGSCPIDFAYSIHSAVGNKMVGARVNGKLVTIDYVIKNG DRIEIITSQNSKGPSRDWLSIVKSTQAKNKINQWFKQELKEDNIIKGKEMIVNYCKTKGIVLSDITKPEYVEKCLNKYGF KDWDSILAAVGHGALKESQIVNRLNEEHLKTKKAEVTDKDVLEEIVAAESKEKSKKKEGKGGIVVKGIHDVAVRFSKCCN PVPGDEIVGFVTRGRGISIHRTDCVNIINFPANERARLIEAEWEQGQTAGDTYEVEINIFANNRTGLIVDISRMFTEAEI DVKSMNCRLNKKEVATISVGFDIHGKEELNRIIDKLRKIDGVTDITRTAG
Sequences:
>Translated_770_residues MEARMPENIELPGASHNKTNQVERAVDTPADFTSPEELYKDLIAAIKKYHPSTDLSDIEKAYETARKAHEGQFRKSGEPY IIHPLCVAIILAELELDKESIIAGLLHDVVEDTVMTSEDVAKEFGDEVALLVDGVTKLTQLNYQHDKIEVQAENLRKMFL AMAKDIRVILIKLADRLHNMRTMQYQSPAKQIEKSRETMEIYAPIAHRLGISKIKVELDDLSMKYLMPDVYNDLVEQVNL NRPGREAFIKSIIKEVGMHISNAGIEAEIDGRVKHFFSIYRKMVNQNKTLDQIYDIFAVRIKVDTVKDCYAALGVIHEMY KPIPGRFKDYIAMPKPNNYQSLHTTLIASNGQPFEIQIRTYEMHKIAEYGIAAHWKYKEGKTGEKDNQSEEAKLSWLRQI LEWQKEMSDNKEFLSSIKNDLNLFSDSVYCFTPSGDVKNLPAGSCPIDFAYSIHSAVGNKMVGARVNGKLVTIDYVIKNG DRIEIITSQNSKGPSRDWLSIVKSTQAKNKINQWFKQELKEDNIIKGKEMIVNYCKTKGIVLSDITKPEYVEKCLNKYGF KDWDSILAAVGHGALKESQIVNRLNEEHLKTKKAEVTDKDVLEEIVAAESKEKSKKKEGKGGIVVKGIHDVAVRFSKCCN PVPGDEIVGFVTRGRGISIHRTDCVNIINFPANERARLIEAEWEQGQTAGDTYEVEINIFANNRTGLIVDISRMFTEAEI DVKSMNCRLNKKEVATISVGFDIHGKEELNRIIDKLRKIDGVTDITRTAG >Mature_770_residues MEARMPENIELPGASHNKTNQVERAVDTPADFTSPEELYKDLIAAIKKYHPSTDLSDIEKAYETARKAHEGQFRKSGEPY IIHPLCVAIILAELELDKESIIAGLLHDVVEDTVMTSEDVAKEFGDEVALLVDGVTKLTQLNYQHDKIEVQAENLRKMFL AMAKDIRVILIKLADRLHNMRTMQYQSPAKQIEKSRETMEIYAPIAHRLGISKIKVELDDLSMKYLMPDVYNDLVEQVNL NRPGREAFIKSIIKEVGMHISNAGIEAEIDGRVKHFFSIYRKMVNQNKTLDQIYDIFAVRIKVDTVKDCYAALGVIHEMY KPIPGRFKDYIAMPKPNNYQSLHTTLIASNGQPFEIQIRTYEMHKIAEYGIAAHWKYKEGKTGEKDNQSEEAKLSWLRQI LEWQKEMSDNKEFLSSIKNDLNLFSDSVYCFTPSGDVKNLPAGSCPIDFAYSIHSAVGNKMVGARVNGKLVTIDYVIKNG DRIEIITSQNSKGPSRDWLSIVKSTQAKNKINQWFKQELKEDNIIKGKEMIVNYCKTKGIVLSDITKPEYVEKCLNKYGF KDWDSILAAVGHGALKESQIVNRLNEEHLKTKKAEVTDKDVLEEIVAAESKEKSKKKEGKGGIVVKGIHDVAVRFSKCCN PVPGDEIVGFVTRGRGISIHRTDCVNIINFPANERARLIEAEWEQGQTAGDTYEVEINIFANNRTGLIVDISRMFTEAEI DVKSMNCRLNKKEVATISVGFDIHGKEELNRIIDKLRKIDGVTDITRTAG
Specific function: In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance. This enzyme catalyzes the formation of pppGpp which i
COG id: COG0317
COG function: function code TK; Guanosine polyphosphate pyrophosphohydrolases/synthetases
Gene ontology:
Cell location: Cytoplasm [C]
Metaboloic importance: Essential [C]
Operon status: Not Known
Operon components: None
Similarity: Contains 1 HD domain [H]
Homologues:
Organism=Escherichia coli, GI1790082, Length=730, Percent_Identity=38.3561643835616, Blast_Score=523, Evalue=1e-149, Organism=Escherichia coli, GI1789147, Length=692, Percent_Identity=37.7167630057803, Blast_Score=509, Evalue=1e-145, Organism=Caenorhabditis elegans, GI25143118, Length=157, Percent_Identity=34.3949044585987, Blast_Score=70, Evalue=4e-12, Organism=Drosophila melanogaster, GI24650996, Length=139, Percent_Identity=38.1294964028777, Blast_Score=72, Evalue=1e-12,
Paralogues:
None
Copy number: NA
Swissprot (AC and ID): NA
Other databases:
- InterPro: IPR002912 - InterPro: IPR012675 - InterPro: IPR003607 - InterPro: IPR007685 - InterPro: IPR004811 - InterPro: IPR004095 - InterPro: IPR012676 [H]
Pfam domain/function: PF01842 ACT; PF04607 RelA_SpoT; PF02824 TGS [H]
EC number: =2.7.6.5 [H]
Molecular weight: Translated: 87192; Mature: 87192
Theoretical pI: Translated: 6.86; Mature: 6.86
Prosite motif: NA
Important sites: NA
Signals:
None
Transmembrane regions:
None
Cys/Met content:
1.3 %Cys (Translated Protein) 2.6 %Met (Translated Protein) 3.9 %Cys+Met (Translated Protein) 1.3 %Cys (Mature Protein) 2.6 %Met (Mature Protein) 3.9 %Cys+Met (Mature Protein)
Secondary structure:
>Translated Secondary Structure MEARMPENIELPGASHNKTNQVERAVDTPADFTSPEELYKDLIAAIKKYHPSTDLSDIEK CCCCCCCCCCCCCCCCCCHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHCCCCCCHHHHHH AYETARKAHEGQFRKSGEPYIIHPLCVAIILAELELDKESIIAGLLHDVVEDTVMTSEDV HHHHHHHHHCCCHHCCCCCEEEHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHCCHHHH AKEFGDEVALLVDGVTKLTQLNYQHDKIEVQAENLRKMFLAMAKDIRVILIKLADRLHNM HHHHCCCEEHHHHHHHHHHHCCCCCCEEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHH RTMQYQSPAKQIEKSRETMEIYAPIAHRLGISKIKVELDDLSMKYLMPDVYNDLVEQVNL HHHHHCCHHHHHHHHHHHHHHHHHHHHHCCCHHEEEEHHHHHHHHHCHHHHHHHHHHHCC NRPGREAFIKSIIKEVGMHISNAGIEAEIDGRVKHFFSIYRKMVNQNKTLDQIYDIFAVR CCCCHHHHHHHHHHHHCCEEECCCCEEEECHHHHHHHHHHHHHHCCCCCHHHHHHHHEEE IKVDTVKDCYAALGVIHEMYKPIPGRFKDYIAMPKPNNYQSLHTTLIASNGQPFEIQIRT EEEHHHHHHHHHHHHHHHHHCCCCCCHHHCCCCCCCCCCHHHEEEEEECCCCEEEEEEEE YEMHKIAEYGIAAHWKYKEGKTGEKDNQSEEAKLSWLRQILEWQKEMSDNKEFLSSIKND EHHHHHHHCCCEEEEEECCCCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHH LNLFSDSVYCFTPSGDVKNLPAGSCPIDFAYSIHSAVGNKMVGARVNGKLVTIDYVIKNG HHHHCCCEEEECCCCCCCCCCCCCCCCHHHHHHHHHHCCCEECEEECCEEEEEEEEEECC DRIEIITSQNSKGPSRDWLSIVKSTQAKNKINQWFKQELKEDNIIKGKEMIVNYCKTKGI CEEEEEECCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHCCCE VLSDITKPEYVEKCLNKYGFKDWDSILAAVGHGALKESQIVNRLNEEHLKTKKAEVTDKD EEECCCCHHHHHHHHHHCCCCCHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHCCCHHH VLEEIVAAESKEKSKKKEGKGGIVVKGIHDVAVRFSKCCNPVPGDEIVGFVTRGRGISIH HHHHHHHHHHHHHHHHHCCCCCEEEECHHHHHHHHHHHCCCCCCHHHEEEEECCCCEEEE RTDCVNIINFPANERARLIEAEWEQGQTAGDTYEVEINIFANNRTGLIVDISRMFTEAEI CCCCHHEEECCCCCCHHEEECHHHCCCCCCCEEEEEEEEEECCCCEEEEEHHHHHHHHHC DVKSMNCRLNKKEVATISVGFDIHGKEELNRIIDKLRKIDGVTDITRTAG EEECCCCCCCCCEEEEEEEECCCCCHHHHHHHHHHHHHHCCCHHHHHCCC >Mature Secondary Structure MEARMPENIELPGASHNKTNQVERAVDTPADFTSPEELYKDLIAAIKKYHPSTDLSDIEK CCCCCCCCCCCCCCCCCCHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHCCCCCCHHHHHH AYETARKAHEGQFRKSGEPYIIHPLCVAIILAELELDKESIIAGLLHDVVEDTVMTSEDV HHHHHHHHHCCCHHCCCCCEEEHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHCCHHHH AKEFGDEVALLVDGVTKLTQLNYQHDKIEVQAENLRKMFLAMAKDIRVILIKLADRLHNM HHHHCCCEEHHHHHHHHHHHCCCCCCEEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHH RTMQYQSPAKQIEKSRETMEIYAPIAHRLGISKIKVELDDLSMKYLMPDVYNDLVEQVNL HHHHHCCHHHHHHHHHHHHHHHHHHHHHCCCHHEEEEHHHHHHHHHCHHHHHHHHHHHCC NRPGREAFIKSIIKEVGMHISNAGIEAEIDGRVKHFFSIYRKMVNQNKTLDQIYDIFAVR CCCCHHHHHHHHHHHHCCEEECCCCEEEECHHHHHHHHHHHHHHCCCCCHHHHHHHHEEE IKVDTVKDCYAALGVIHEMYKPIPGRFKDYIAMPKPNNYQSLHTTLIASNGQPFEIQIRT EEEHHHHHHHHHHHHHHHHHCCCCCCHHHCCCCCCCCCCHHHEEEEEECCCCEEEEEEEE YEMHKIAEYGIAAHWKYKEGKTGEKDNQSEEAKLSWLRQILEWQKEMSDNKEFLSSIKND EHHHHHHHCCCEEEEEECCCCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHH LNLFSDSVYCFTPSGDVKNLPAGSCPIDFAYSIHSAVGNKMVGARVNGKLVTIDYVIKNG HHHHCCCEEEECCCCCCCCCCCCCCCCHHHHHHHHHHCCCEECEEECCEEEEEEEEEECC DRIEIITSQNSKGPSRDWLSIVKSTQAKNKINQWFKQELKEDNIIKGKEMIVNYCKTKGI CEEEEEECCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHCCCE VLSDITKPEYVEKCLNKYGFKDWDSILAAVGHGALKESQIVNRLNEEHLKTKKAEVTDKD EEECCCCHHHHHHHHHHCCCCCHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHCCCHHH VLEEIVAAESKEKSKKKEGKGGIVVKGIHDVAVRFSKCCNPVPGDEIVGFVTRGRGISIH HHHHHHHHHHHHHHHHHCCCCCEEEECHHHHHHHHHHHCCCCCCHHHEEEEECCCCEEEE RTDCVNIINFPANERARLIEAEWEQGQTAGDTYEVEINIFANNRTGLIVDISRMFTEAEI CCCCHHEEECCCCCCHHEEECHHHCCCCCCCEEEEEEEEEECCCCEEEEEHHHHHHHHHC DVKSMNCRLNKKEVATISVGFDIHGKEELNRIIDKLRKIDGVTDITRTAG EEECCCCCCCCCEEEEEEEECCCCCHHHHHHHHHHHHHHCCCHHHHHCCC
PDB accession: NA
Resolution: NA
Structure class: Alpha Beta
Cofactors: NA
Metal ions: NA
Kcat value (1/min): NA
Specific activity: NA
Km value (mM): NA
Substrates: NA
Specific reaction: NA
General reaction: NA
Inhibitor: NA
Structure determination priority: 9.0
TargetDB status: NA
Availability: NA
References: 9383190; 9384377 [H]