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The map label for this gene is hemZ [H]

Identifier: 238922251

GI number: 238922251

Start: 448204

End: 449619

Strand: Reverse

Name: hemZ [H]

Synonym: EUBELI_20486

Alternate gene names: 238922251

Gene position: 449619-448204 (Counterclockwise)

Preceding gene: 238922252

Following gene: 238922250

Centisome position: 71.74

GC content: 40.04

Gene sequence:

>1416_bases
ATGATATATATTAAGATTGACAATGATGTATTTTATGATGATGCGGTTGTACTTGTCCGCTCGTTTTATCCAAGAATTGA
GGTTATGGCACTTAAGGCAGATTCCAAGCCGGAAGAGAATGATGAGATTCTTTCAATAGAAGTGCCTGATATCACAGGGC
TTGATAAGAAGAATGCCCACGAAGTATTTAAGGACAGTTTATATAAGAAGCTTTCAGAAAAAACTGGCAAGAAGCTTCCA
TGGGGATATCTTACAGGAGTAAGACCAAGTAAGATTGCGTACACAATGCTTGAAGAGGGTGCAACCAAGGAACAGATTAA
GAAACATTTTATGGACAAGCATTATGCAAGTGAAGAAAAGGCTGACCTTGCGCTCACAGTAGCGAGGAAAGAACTGGATA
TACTTACAGATATGGATTATAAGACAGGCTACAGCCTGTATATTGGAATTCCGTTCTGTCCAAGTATATGTCTGTACTGC
TCATTTTCATCATATGCACTTGGTGCGTACAAAGATTATGTAGATAATTATGTAGATGCGCTTATTAAGGAGATAAGATT
CGTCGCTGAAACTATGAAGGGCAGAAGACTGGATACAGTGTATATGGGTGGTGGAACACCTACAACTTTGAGTGCAGCAC
AGTTAGATAAAGTACTGACAGTGGTTGAAGAAGCATTTGACTTGAGCAGATGCCGAGAGCTTACTGTAGAAGCTGGAAGA
CCGGACAGCGTGACACCAGATAAATTCAAGGTTCTTAAAGCTCATAATGTGGGAAGAATATCTATTAATCCACAGACAAT
GAACCAGAAAACACTTGACCTGATTGGAAGAAAGCATACGGTTGAAGATATTAAGAATGCTTATGCAATGGCAAGAGAAG
CAGGACTTGATAATATCAACATGGATATGATTCTTGGACTTCCGGGAGAGGGTGTAGACGAGGTTTACCATACACTTAAT
GAAATTAAGGCGATGCGGCCGGAGAGTCTTACCGTTCATTCACTTGCAATCAAGAGAGCTTCAAGACTTAACATATTGCG
TCAGCAGTACACAGAGCTTTCAATCGAAAACACAGACAGCATTATCGCAATGACTGAGCAGACAGCAAGAGATCTTAACA
TGCAGCCTTATTATATGTATCGCCAGAAGAATATGGCAGGCAATTTTGAAAATGTAGGCTATGCAGTTGCTGGACTTGAA
TGCATTTATAATATTCTTATTATGGAAGAAAAGCAGACAATAATTGCGTGCGGCGCAGGTGCTTCAACCAAGGTTGTGTT
CCATAATGAAGGCGATGAAAACCATTCTGTGCGTATTGAGAGAATTGAGAATGTCAAAGATGTTAGAAGCTATGTCGAGA
GAATTGATGAGATGATTGAGAGAAAGCGGAAGTTCTTTGGGGAGAATGAGTTTTGA

Upstream 100 bases:

>100_bases
GGACATCAACGAGCAAACGCCTGCGAAGCAGGCTGGAAAGCACGATAGTGCGAGTTTGCGAGTATAAAAGCACAAATATC
AGTGCGAAAAGGAAGCAACG

Downstream 100 bases:

>100_bases
CAGAATAATTGTTTGGAAATGAGGGCAGTATCATTTTTGGCTAACTGTACAGTAGATGATTTTAGAATAATATTAGAACG
TCGAAACTGGTCTGTTAATA

Product: coproporphyrinogen III oxidase

Products: NA

Alternate protein names: Coprogen oxidase; Coproporphyrinogenase [H]

Number of amino acids: Translated: 471; Mature: 471

Protein sequence:

>471_residues
MIYIKIDNDVFYDDAVVLVRSFYPRIEVMALKADSKPEENDEILSIEVPDITGLDKKNAHEVFKDSLYKKLSEKTGKKLP
WGYLTGVRPSKIAYTMLEEGATKEQIKKHFMDKHYASEEKADLALTVARKELDILTDMDYKTGYSLYIGIPFCPSICLYC
SFSSYALGAYKDYVDNYVDALIKEIRFVAETMKGRRLDTVYMGGGTPTTLSAAQLDKVLTVVEEAFDLSRCRELTVEAGR
PDSVTPDKFKVLKAHNVGRISINPQTMNQKTLDLIGRKHTVEDIKNAYAMAREAGLDNINMDMILGLPGEGVDEVYHTLN
EIKAMRPESLTVHSLAIKRASRLNILRQQYTELSIENTDSIIAMTEQTARDLNMQPYYMYRQKNMAGNFENVGYAVAGLE
CIYNILIMEEKQTIIACGAGASTKVVFHNEGDENHSVRIERIENVKDVRSYVERIDEMIERKRKFFGENEF

Sequences:

>Translated_471_residues
MIYIKIDNDVFYDDAVVLVRSFYPRIEVMALKADSKPEENDEILSIEVPDITGLDKKNAHEVFKDSLYKKLSEKTGKKLP
WGYLTGVRPSKIAYTMLEEGATKEQIKKHFMDKHYASEEKADLALTVARKELDILTDMDYKTGYSLYIGIPFCPSICLYC
SFSSYALGAYKDYVDNYVDALIKEIRFVAETMKGRRLDTVYMGGGTPTTLSAAQLDKVLTVVEEAFDLSRCRELTVEAGR
PDSVTPDKFKVLKAHNVGRISINPQTMNQKTLDLIGRKHTVEDIKNAYAMAREAGLDNINMDMILGLPGEGVDEVYHTLN
EIKAMRPESLTVHSLAIKRASRLNILRQQYTELSIENTDSIIAMTEQTARDLNMQPYYMYRQKNMAGNFENVGYAVAGLE
CIYNILIMEEKQTIIACGAGASTKVVFHNEGDENHSVRIERIENVKDVRSYVERIDEMIERKRKFFGENEF
>Mature_471_residues
MIYIKIDNDVFYDDAVVLVRSFYPRIEVMALKADSKPEENDEILSIEVPDITGLDKKNAHEVFKDSLYKKLSEKTGKKLP
WGYLTGVRPSKIAYTMLEEGATKEQIKKHFMDKHYASEEKADLALTVARKELDILTDMDYKTGYSLYIGIPFCPSICLYC
SFSSYALGAYKDYVDNYVDALIKEIRFVAETMKGRRLDTVYMGGGTPTTLSAAQLDKVLTVVEEAFDLSRCRELTVEAGR
PDSVTPDKFKVLKAHNVGRISINPQTMNQKTLDLIGRKHTVEDIKNAYAMAREAGLDNINMDMILGLPGEGVDEVYHTLN
EIKAMRPESLTVHSLAIKRASRLNILRQQYTELSIENTDSIIAMTEQTARDLNMQPYYMYRQKNMAGNFENVGYAVAGLE
CIYNILIMEEKQTIIACGAGASTKVVFHNEGDENHSVRIERIENVKDVRSYVERIDEMIERKRKFFGENEF

Specific function: Anaerobic transformation of coproporphyrinogen-III into protoporphyrinogen-IX [H]

COG id: COG0635

COG function: function code H; Coproporphyrinogen III oxidase and related Fe-S oxidoreductases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the anaerobic coproporphyrinogen-III oxidase family [H]

Homologues:

Organism=Homo sapiens, GI8922911, Length=299, Percent_Identity=25.0836120401338, Blast_Score=97, Evalue=4e-20,
Organism=Escherichia coli, GI1789325, Length=313, Percent_Identity=29.3929712460064, Blast_Score=127, Evalue=2e-30,
Organism=Escherichia coli, GI87082341, Length=192, Percent_Identity=31.25, Blast_Score=109, Evalue=3e-25,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006638
- InterPro:   IPR007197 [H]

Pfam domain/function: PF04055 Radical_SAM [H]

EC number: =1.3.99.22 [H]

Molecular weight: Translated: 53600; Mature: 53600

Theoretical pI: Translated: 5.44; Mature: 5.44

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
3.8 %Met     (Translated Protein)
5.1 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
3.8 %Met     (Mature Protein)
5.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIYIKIDNDVFYDDAVVLVRSFYPRIEVMALKADSKPEENDEILSIEVPDITGLDKKNAH
CEEEEECCCEEEHHHHHHHHHHCCCEEEEEEECCCCCCCCCCEEEEECCCCCCCCCCHHH
EVFKDSLYKKLSEKTGKKLPWGYLTGVRPSKIAYTMLEEGATKEQIKKHFMDKHYASEEK
HHHHHHHHHHHHHHCCCCCCCHHHCCCCHHHHHHHHHHCCCCHHHHHHHHHHHHHCCCCC
ADLALTVARKELDILTDMDYKTGYSLYIGIPFCPSICLYCSFSSYALGAYKDYVDNYVDA
CCEEEEEHHHHHHHHCCCCCCCCCEEEEECCCHHHHHHHHCCCHHHHHHHHHHHHHHHHH
LIKEIRFVAETMKGRRLDTVYMGGGTPTTLSAAQLDKVLTVVEEAFDLSRCRELTVEAGR
HHHHHHHHHHHHCCCEEEEEEECCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCC
PDSVTPDKFKVLKAHNVGRISINPQTMNQKTLDLIGRKHTVEDIKNAYAMAREAGLDNIN
CCCCCCCHHEEEEECCCCEEEECCCCCCHHHHHHHCCCHHHHHHHHHHHHHHHCCCCCCC
MDMILGLPGEGVDEVYHTLNEIKAMRPESLTVHSLAIKRASRLNILRQQYTELSIENTDS
CEEEEECCCCCHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCC
IIAMTEQTARDLNMQPYYMYRQKNMAGNFENVGYAVAGLECIYNILIMEEKQTIIACGAG
EEEEEHHHHHHCCCCCEEEEECCCCCCCCCCCCHHHHHHHHHHHHHEEECCCEEEEECCC
ASTKVVFHNEGDENHSVRIERIENVKDVRSYVERIDEMIERKRKFFGENEF
CCEEEEEECCCCCCCCEEHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCC
>Mature Secondary Structure
MIYIKIDNDVFYDDAVVLVRSFYPRIEVMALKADSKPEENDEILSIEVPDITGLDKKNAH
CEEEEECCCEEEHHHHHHHHHHCCCEEEEEEECCCCCCCCCCEEEEECCCCCCCCCCHHH
EVFKDSLYKKLSEKTGKKLPWGYLTGVRPSKIAYTMLEEGATKEQIKKHFMDKHYASEEK
HHHHHHHHHHHHHHCCCCCCCHHHCCCCHHHHHHHHHHCCCCHHHHHHHHHHHHHCCCCC
ADLALTVARKELDILTDMDYKTGYSLYIGIPFCPSICLYCSFSSYALGAYKDYVDNYVDA
CCEEEEEHHHHHHHHCCCCCCCCCEEEEECCCHHHHHHHHCCCHHHHHHHHHHHHHHHHH
LIKEIRFVAETMKGRRLDTVYMGGGTPTTLSAAQLDKVLTVVEEAFDLSRCRELTVEAGR
HHHHHHHHHHHHCCCEEEEEEECCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCC
PDSVTPDKFKVLKAHNVGRISINPQTMNQKTLDLIGRKHTVEDIKNAYAMAREAGLDNIN
CCCCCCCHHEEEEECCCCEEEECCCCCCHHHHHHHCCCHHHHHHHHHHHHHHHCCCCCCC
MDMILGLPGEGVDEVYHTLNEIKAMRPESLTVHSLAIKRASRLNILRQQYTELSIENTDS
CEEEEECCCCCHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCC
IIAMTEQTARDLNMQPYYMYRQKNMAGNFENVGYAVAGLECIYNILIMEEKQTIIACGAG
EEEEEHHHHHHCCCCCEEEEECCCCCCCCCCCCHHHHHHHHHHHHHEEECCCEEEEECCC
ASTKVVFHNEGDENHSVRIERIENVKDVRSYVERIDEMIERKRKFFGENEF
CCEEEEEECCCCCCCCEEHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9579061; 9384377; 10568751 [H]