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The map label for this gene is gntU [H]

Identifier: 238921970

GI number: 238921970

Start: 167517

End: 168872

Strand: Reverse

Name: gntU [H]

Synonym: EUBELI_20205

Alternate gene names: 238921970

Gene position: 168872-167517 (Counterclockwise)

Preceding gene: 238921974

Following gene: 238921969

Centisome position: 26.94

GC content: 39.68

Gene sequence:

>1356_bases
ATGGAGCAGACAGTATTTGTTGCAAATCCAACCAGATTACTGATAGCGGCAGCAGTCGGAATTATTGTGTTACTGTTGTT
AATAATCAAATTTAAGCTTCATCCTGTTATATCGATGATGATAGCAGCTATTATCATAGGTGTTGGAGCAGGGATGCCGC
TTACAATGATATCAGATACGGTTGAAAAGGGTGTTGGCAAAACGCTTCAGGGAATAGCATTACTTGTAGGTCTCGGTTCA
ATGTTTGGCGGAATTCTTGAGGTAAGTGGCGGGGCACAAAGAATAGCACAGACACTTATTGATAAGCTTGGTCAGAAGAA
GGCTGGAATTGCACTGGGAATTACAGGATTGGTTATAGGAACAACAGTATTTTTTGAAGCAGGTGTGGTTGTACTTATAC
CACTTGCATTCAGTGTTGCAAAGCAGACTAAGAAGTCAACATTATATTATGCAATACCGCTTCTTGCAGGTCTTGCAAGT
GGATACGCATTTGTTCCACCATCAGCAGGTTCTGTTCTCGTGGCAGATTCACTTGGAGTTAATCTTGGAGTGATGATTAT
GGTTGGTATCCCAACTGCATTGATATGTATGATAGTAGCAGGTGTAATATGGGGACGATTCATTGGAAACAAAGTGTTTA
CTAAATTACCGGTTAATGTGGAAGAGATTAAGGAAGATTCTAAGGAACTGCCTCCATTTGGACTGGTGCTTGGAGTGATT
CTTATACCACTTGTATTAATACTGGTAAGTACTGTTTCTAAATACATGCCGATTCCGGTTGATGTGAAAAATGTGCTGGG
ATTCATTGGAAAACCATTCCTTGCATTGACAATAGCAACACTTGCTGCAATGTATTTCCTTGGAATAAAAAGAGGATATA
CAGGAGCCCAGTTAAAGAAGATACTTGATCATTCATTACGCCCAGTCGGAATGATACTTCTGGTAATAGCAAGTGGTGGA
GTAATCAGATGGATGCTTCAGGATTCAGGACTTGGAGATATAATAGGTCCGGCATTGGAGAAGAGCGGAATGCCACTTAT
ACTTGTAGCATTTCTTATTGCATTACTTGTAAGAGCATCTGTAGGAAGTTCTATGGTTGCAATGACTATGGCATCAGGAA
TAATGGCAACTATGCCTGCAGTTATGGCAACAAGCATGTTATACAGAGCAGCAATGTGTTGTGCAATATGTGGTGGTGCA
ACAGCATTAAGTCATGTAAATGATGCTGGTTTCTGGCTTGTAGGAACATTTCTTGAGATAGATGAGAAAACTACATTAAA
GTCGTGGACTATTATGGAAACACTTATAGGTATAACAGCATTAATTGTAAGTCTGATTATTTCAATATTTGCTTAG

Upstream 100 bases:

>100_bases
TCGAAATAAATCTCAGAAAAAGGCAAAAAAGTTACAAGAAACAAAGAAAAGGTATGATGTATTAACTAAGATACATCAGA
TGATTAGGAGGTAAAACGAT

Downstream 100 bases:

>100_bases
ATATTATTAAAGGTCACTATTTAATTAAGAAGATATAAAACAGGAGGATGCAAATGGTAAAAATACCGGTATGTTTGAAC
AATATGACTGATGCAAAGCA

Product: gluconate:H+ symporter, GntP family

Products: Proton [Cytoplasm]; gluconate [Cytoplasm] [C]

Alternate protein names: Gluconate permease; Gnt-I system [H]

Number of amino acids: Translated: 451; Mature: 451

Protein sequence:

>451_residues
MEQTVFVANPTRLLIAAAVGIIVLLLLIIKFKLHPVISMMIAAIIIGVGAGMPLTMISDTVEKGVGKTLQGIALLVGLGS
MFGGILEVSGGAQRIAQTLIDKLGQKKAGIALGITGLVIGTTVFFEAGVVVLIPLAFSVAKQTKKSTLYYAIPLLAGLAS
GYAFVPPSAGSVLVADSLGVNLGVMIMVGIPTALICMIVAGVIWGRFIGNKVFTKLPVNVEEIKEDSKELPPFGLVLGVI
LIPLVLILVSTVSKYMPIPVDVKNVLGFIGKPFLALTIATLAAMYFLGIKRGYTGAQLKKILDHSLRPVGMILLVIASGG
VIRWMLQDSGLGDIIGPALEKSGMPLILVAFLIALLVRASVGSSMVAMTMASGIMATMPAVMATSMLYRAAMCCAICGGA
TALSHVNDAGFWLVGTFLEIDEKTTLKSWTIMETLIGITALIVSLIISIFA

Sequences:

>Translated_451_residues
MEQTVFVANPTRLLIAAAVGIIVLLLLIIKFKLHPVISMMIAAIIIGVGAGMPLTMISDTVEKGVGKTLQGIALLVGLGS
MFGGILEVSGGAQRIAQTLIDKLGQKKAGIALGITGLVIGTTVFFEAGVVVLIPLAFSVAKQTKKSTLYYAIPLLAGLAS
GYAFVPPSAGSVLVADSLGVNLGVMIMVGIPTALICMIVAGVIWGRFIGNKVFTKLPVNVEEIKEDSKELPPFGLVLGVI
LIPLVLILVSTVSKYMPIPVDVKNVLGFIGKPFLALTIATLAAMYFLGIKRGYTGAQLKKILDHSLRPVGMILLVIASGG
VIRWMLQDSGLGDIIGPALEKSGMPLILVAFLIALLVRASVGSSMVAMTMASGIMATMPAVMATSMLYRAAMCCAICGGA
TALSHVNDAGFWLVGTFLEIDEKTTLKSWTIMETLIGITALIVSLIISIFA
>Mature_451_residues
MEQTVFVANPTRLLIAAAVGIIVLLLLIIKFKLHPVISMMIAAIIIGVGAGMPLTMISDTVEKGVGKTLQGIALLVGLGS
MFGGILEVSGGAQRIAQTLIDKLGQKKAGIALGITGLVIGTTVFFEAGVVVLIPLAFSVAKQTKKSTLYYAIPLLAGLAS
GYAFVPPSAGSVLVADSLGVNLGVMIMVGIPTALICMIVAGVIWGRFIGNKVFTKLPVNVEEIKEDSKELPPFGLVLGVI
LIPLVLILVSTVSKYMPIPVDVKNVLGFIGKPFLALTIATLAAMYFLGIKRGYTGAQLKKILDHSLRPVGMILLVIASGG
VIRWMLQDSGLGDIIGPALEKSGMPLILVAFLIALLVRASVGSSMVAMTMASGIMATMPAVMATSMLYRAAMCCAICGGA
TALSHVNDAGFWLVGTFLEIDEKTTLKSWTIMETLIGITALIVSLIISIFA

Specific function: Part of the gluconate utilization system Gnt-I; low- affinity intake of gluconate [H]

COG id: COG2610

COG function: function code GE; H+/gluconate symporter and related permeases

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the gntP permease family [H]

Homologues:

Organism=Escherichia coli, GI48994939, Length=438, Percent_Identity=38.5844748858447, Blast_Score=264, Evalue=1e-71,
Organism=Escherichia coli, GI48994935, Length=438, Percent_Identity=33.5616438356164, Blast_Score=234, Evalue=1e-62,
Organism=Escherichia coli, GI1790716, Length=440, Percent_Identity=33.8636363636364, Blast_Score=232, Evalue=4e-62,
Organism=Escherichia coli, GI1788707, Length=434, Percent_Identity=34.1013824884793, Blast_Score=222, Evalue=4e-59,
Organism=Escherichia coli, GI1790776, Length=436, Percent_Identity=30.2752293577982, Blast_Score=213, Evalue=3e-56,
Organism=Escherichia coli, GI1789097, Length=444, Percent_Identity=31.5315315315315, Blast_Score=199, Evalue=4e-52,
Organism=Escherichia coli, GI2367370, Length=426, Percent_Identity=32.1596244131455, Blast_Score=195, Evalue=6e-51,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003474 [H]

Pfam domain/function: PF02447 GntP_permease [H]

EC number: NA

Molecular weight: Translated: 47108; Mature: 47108

Theoretical pI: Translated: 9.78; Mature: 9.78

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
5.1 %Met     (Translated Protein)
6.0 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
5.1 %Met     (Mature Protein)
6.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MEQTVFVANPTRLLIAAAVGIIVLLLLIIKFKLHPVISMMIAAIIIGVGAGMPLTMISDT
CCCCEEEECCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHH
VEKGVGKTLQGIALLVGLGSMFGGILEVSGGAQRIAQTLIDKLGQKKAGIALGITGLVIG
HHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHCCCCCCEEEEHHHHHHH
TTVFFEAGVVVLIPLAFSVAKQTKKSTLYYAIPLLAGLASGYAFVPPSAGSVLVADSLGV
HHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEECCCCCCCEEEECCCCC
NLGVMIMVGIPTALICMIVAGVIWGRFIGNKVFTKLPVNVEEIKEDSKELPPFGLVLGVI
CCHHHEEEHHHHHHHHHHHHHHHHHHHHCCHHHHCCCCCHHHHHHHHHCCCHHHHHHHHH
LIPLVLILVSTVSKYMPIPVDVKNVLGFIGKPFLALTIATLAAMYFLGIKRGYTGAQLKK
HHHHHHHHHHHHHHHCCCCCCHHHHHHHHCCHHHHHHHHHHHHHHHHHHHCCCCHHHHHH
ILDHSLRPVGMILLVIASGGVIRWMLQDSGLGDIIGPALEKSGMPLILVAFLIALLVRAS
HHHHCCCHHHHHHHHHHCCCEEEEEECCCCCCHHHHHHHHCCCCCHHHHHHHHHHHHHHH
VGSSMVAMTMASGIMATMPAVMATSMLYRAAMCCAICGGATALSHVNDAGFWLVGTFLEI
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHCCCCCCEEEHHHHHC
DEKTTLKSWTIMETLIGITALIVSLIISIFA
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHC
>Mature Secondary Structure
MEQTVFVANPTRLLIAAAVGIIVLLLLIIKFKLHPVISMMIAAIIIGVGAGMPLTMISDT
CCCCEEEECCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHH
VEKGVGKTLQGIALLVGLGSMFGGILEVSGGAQRIAQTLIDKLGQKKAGIALGITGLVIG
HHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHCCCCCCEEEEHHHHHHH
TTVFFEAGVVVLIPLAFSVAKQTKKSTLYYAIPLLAGLASGYAFVPPSAGSVLVADSLGV
HHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEECCCCCCCEEEECCCCC
NLGVMIMVGIPTALICMIVAGVIWGRFIGNKVFTKLPVNVEEIKEDSKELPPFGLVLGVI
CCHHHEEEHHHHHHHHHHHHHHHHHHHHCCHHHHCCCCCHHHHHHHHHCCCHHHHHHHHH
LIPLVLILVSTVSKYMPIPVDVKNVLGFIGKPFLALTIATLAAMYFLGIKRGYTGAQLKK
HHHHHHHHHHHHHHHCCCCCCHHHHHHHHCCHHHHHHHHHHHHHHHHHHHCCCCHHHHHH
ILDHSLRPVGMILLVIASGGVIRWMLQDSGLGDIIGPALEKSGMPLILVAFLIALLVRAS
HHHHCCCHHHHHHHHHHCCCEEEEEECCCCCCHHHHHHHHCCCCCHHHHHHHHHHHHHHH
VGSSMVAMTMASGIMATMPAVMATSMLYRAAMCCAICGGATALSHVNDAGFWLVGTFLEI
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHCCCCCCEEEHHHHHC
DEKTTLKSWTIMETLIGITALIVSLIISIFA
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Proton [Periplasm]; gluconate [Periplasm] [C]

Specific reaction: Proton [Periplasm] + gluconate [Periplasm] = Proton [Cytoplasm] + gluconate [Cytoplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]