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The map label for this gene is cobS [H]

Identifier: 238921944

GI number: 238921944

Start: 141834

End: 142604

Strand: Reverse

Name: cobS [H]

Synonym: EUBELI_20178

Alternate gene names: 238921944

Gene position: 142604-141834 (Counterclockwise)

Preceding gene: 238921945

Following gene: 238921943

Centisome position: 22.75

GC content: 36.96

Gene sequence:

>771_bases
ATGTCGATAATTAAATCACTGGTGATTGCATTTTCAATGTATTCCAAAATACCAATGCCACATCTTGAATTAGATGAAAA
AGACATGAAATATGTAATGGGATTCTTTCCGCTGATTGGACTTATAACTGGAGCTTATGTTTATGGATGGATATATGCCG
GGGAAATTTTATATGTGCCGGATATAAGCAGGACTTTGGTACTTATCATACTGCCGGTTATTATAACAGGGGGAATCCAT
GTTGACGGTTATATGGATACATGTGATGCACTTAATTCATATGGTGACAGGGAAAAGAAACTGGCAATATTAAAGGATTC
GCATATTGGTGCATTTGCAGTTATTAAACTTCTGGTTTATTATGTGCTGTATTTTGCTGCTGCATTTATTGTTGTACAGA
AGGCGGGAAATATGCAGATTATTATTATGGCATTTACTTTTTATCTGTCGAGAATTATCAGCGGACTGGCAGCAGTTAAT
TTCCGCGGTGCAAGAAATAACGGAATGCTTCATACATTTACAAGTGTTACAGCCAGAAAGAGGGTAAATATAATGCTTGT
AATGCAGCTTATATTATGTATTTCATGTATGTGTATGTGCAGTATTATAACAGCAATAGTTGTTGTCATTGTAGCATTCC
TTGTTTTACTCTATTACAGGCATATGGCATATAAGCAGTTTGGCGGGGTGACAGGTGACCTTGCGGGCTATCTGCTTTGT
GTGAGTGAGTTGTGCATGACGGCTGCAATTGCAGTAATTACATTAATTTAG

Upstream 100 bases:

>100_bases
AGGCGGCTTGGGGAGATTAATGTGAGGCTTTCCAGAGCAGCAGATGCAGTTGTAGAAGTTGTATATTCAATTCCTGTATT
TTTAAAGGGGGATATTGGCG

Downstream 100 bases:

>100_bases
CCAGCAGAATGGAGATAATATGGAAGTATATTTTGGTGGGGCTTATCAGGGAAAACTTGATTATGTATGTAGTAAGAAAA
ATATGTCGGTTGTGGCAGAT

Product: adenosylcobinamide-GDP ribazoletransferase

Products: GMP; adenosylcobalamin

Alternate protein names: NA

Number of amino acids: Translated: 256; Mature: 255

Protein sequence:

>256_residues
MSIIKSLVIAFSMYSKIPMPHLELDEKDMKYVMGFFPLIGLITGAYVYGWIYAGEILYVPDISRTLVLIILPVIITGGIH
VDGYMDTCDALNSYGDREKKLAILKDSHIGAFAVIKLLVYYVLYFAAAFIVVQKAGNMQIIIMAFTFYLSRIISGLAAVN
FRGARNNGMLHTFTSVTARKRVNIMLVMQLILCISCMCMCSIITAIVVVIVAFLVLLYYRHMAYKQFGGVTGDLAGYLLC
VSELCMTAAIAVITLI

Sequences:

>Translated_256_residues
MSIIKSLVIAFSMYSKIPMPHLELDEKDMKYVMGFFPLIGLITGAYVYGWIYAGEILYVPDISRTLVLIILPVIITGGIH
VDGYMDTCDALNSYGDREKKLAILKDSHIGAFAVIKLLVYYVLYFAAAFIVVQKAGNMQIIIMAFTFYLSRIISGLAAVN
FRGARNNGMLHTFTSVTARKRVNIMLVMQLILCISCMCMCSIITAIVVVIVAFLVLLYYRHMAYKQFGGVTGDLAGYLLC
VSELCMTAAIAVITLI
>Mature_255_residues
SIIKSLVIAFSMYSKIPMPHLELDEKDMKYVMGFFPLIGLITGAYVYGWIYAGEILYVPDISRTLVLIILPVIITGGIHV
DGYMDTCDALNSYGDREKKLAILKDSHIGAFAVIKLLVYYVLYFAAAFIVVQKAGNMQIIIMAFTFYLSRIISGLAAVNF
RGARNNGMLHTFTSVTARKRVNIMLVMQLILCISCMCMCSIITAIVVVIVAFLVLLYYRHMAYKQFGGVTGDLAGYLLCV
SELCMTAAIAVITLI

Specific function: Joins Ado-cobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin) [H]

COG id: COG0368

COG function: function code H; Cobalamin-5-phosphate synthase

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the CobS family [H]

Homologues:

Organism=Escherichia coli, GI1788301, Length=240, Percent_Identity=27.0833333333333, Blast_Score=69, Evalue=2e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003805 [H]

Pfam domain/function: PF02654 CobS [H]

EC number: 2.7.8.26

Molecular weight: Translated: 28383; Mature: 28252

Theoretical pI: Translated: 8.61; Mature: 8.61

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.7 %Cys     (Translated Protein)
5.9 %Met     (Translated Protein)
8.6 %Cys+Met (Translated Protein)
2.7 %Cys     (Mature Protein)
5.5 %Met     (Mature Protein)
8.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSIIKSLVIAFSMYSKIPMPHLELDEKDMKYVMGFFPLIGLITGAYVYGWIYAGEILYVP
CHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCEEECC
DISRTLVLIILPVIITGGIHVDGYMDTCDALNSYGDREKKLAILKDSHIGAFAVIKLLVY
CCHHHHHHHHHHHHHHCCCEECCHHHHHHHHHHCCCHHHHEEEEECCCCHHHHHHHHHHH
YVLYFAAAFIVVQKAGNMQIIIMAFTFYLSRIISGLAAVNFRGARNNGMLHTFTSVTARK
HHHHHHHHHHHHHCCCCEEEHHHHHHHHHHHHHHHHHHHCCCCCCCCCCEEHHHHHHHHH
RVNIMLVMQLILCISCMCMCSIITAIVVVIVAFLVLLYYRHMAYKQFGGVTGDLAGYLLC
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHH
VSELCMTAAIAVITLI
HHHHHHHHHHHHHHCC
>Mature Secondary Structure 
SIIKSLVIAFSMYSKIPMPHLELDEKDMKYVMGFFPLIGLITGAYVYGWIYAGEILYVP
HHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCEEECC
DISRTLVLIILPVIITGGIHVDGYMDTCDALNSYGDREKKLAILKDSHIGAFAVIKLLVY
CCHHHHHHHHHHHHHHCCCEECCHHHHHHHHHHCCCHHHHEEEEECCCCHHHHHHHHHHH
YVLYFAAAFIVVQKAGNMQIIIMAFTFYLSRIISGLAAVNFRGARNNGMLHTFTSVTARK
HHHHHHHHHHHHHCCCCEEEHHHHHHHHHHHHHHHHHHHCCCCCCCCCCEEHHHHHHHHH
RVNIMLVMQLILCISCMCMCSIITAIVVVIVAFLVLLYYRHMAYKQFGGVTGDLAGYLLC
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHH
VSELCMTAAIAVITLI
HHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: adenosylcobinamide-GDP; alpha-ribazole

Specific reaction: adenosylcobinamide-GDP + alpha-ribazole = GMP + adenosylcobalamin

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: NA