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The map label for this gene is patB [H]

Identifier: 238921892

GI number: 238921892

Start: 101466

End: 102671

Strand: Reverse

Name: patB [H]

Synonym: EUBELI_20126

Alternate gene names: 238921892

Gene position: 102671-101466 (Counterclockwise)

Preceding gene: 238921893

Following gene: 238921891

Centisome position: 16.38

GC content: 41.54

Gene sequence:

>1206_bases
ATGCAGGAATTAATAAGTAGAATTAAGAAGGGAAATCCGAGAATGAAATATGATTTTGATACAGTAGTGAACCGCCGTAA
TACGGATTCTTTAAAATGGAACGTGGCAGAGAATGAGCTTCCTATGTGGGTTGCTGACATGGATTTTAAGACAGCACCTG
AGATAACTGAGGCTATTAAGGCAAAGGCAGACCTCGGTGTATACGGTTATACTGAGATATCAAAGGACTGGTATGACGCA
TACACAGGCTGGTGGGAAAGACGCCACAATTTCAGGATGGAAGACGACTGGCTTATGTTCGTAACAGGCGTTATACCTGC
AATATCAAGCTCTGTAAGAAAGCTTACGACACCAGCAGAGAATGTTGTAATCATGACACCTGTATACAACATTTTCTTTA
ACAGTATTCTTAATAATGGCAGAAATGTGTTACAGAGCCAGCTTGCATATGAGAATGGCAGGTATGTAATAGATTTTGAA
GACCTTGAAGTTAAGCTCAAGAACCCACAGACAACACTTCTTATTCTGTGCAACCCACAGAATCCGGGTGGAAATGTATG
GAGAAAGGAAGAACTTGCACGTATCGGAGAGCTTGCTTACAAGTATGGAGTCGTTGTTATATCTGATGAGATTCACTGCG
AGCTTACAGACCCGGGCATTGATTATGTGCCATTTGCAAGTGTTTCGGAGGTGTGTAAGAATATATCTGTAACATGCATA
GCACCTACGAAAACATTTAACATGGCAGGCTTACAGACAGCAGCAATATGTGTGCCGGATGAGCGACTCCGTCACAAGGT
TTGGCGTGCAATCAATACCGATGAGGTAGCTGAGCCAAATGTTTTCGCAGTTGATGCGGCTATAGCTGCATTTACAAAGG
GTGAGGAATGGCTTGAGCAGTTAAGAGAATATATCTACGAGAATAAACAGATTACCGAAAAGTTCATAAAAGACAATATT
CCGAGAGTGTCAATGGTGGAATCACATGCAACTTATCTTTGTTGGCTTGATGTGTCTGATATCACAGACAATTCAACAAG
GCTTGCGGCATATATAAGAAAGAATACAGGACTTTTCCTGTCAGCGGGAGAAGGCTTTGGCGGAGATGGAAAACATTTCT
TAAGACTGAATGTTGCATGTCCTAAGACAACTTTAATGGATGGGCTTGAAAGACTTAGAAATGGCATATTGAGTTTTGAC
AGGTAG

Upstream 100 bases:

>100_bases
ACAGCGTGTTAAATCCAACTTCCGGAACGATAACAGCAGACAGTATAGATAAGCTTATAATTGAGAAGGATAAGGTTGAT
CCTTCGCTTACTAAGATAGT

Downstream 100 bases:

>100_bases
TGGGTTACAATAATATAAGTGAAATAACACATGAGATACGAGTGTATCTAAGAATAATAAGCGAGGAGATAATGATATGA
ATATTGTATGTTTAGACCTT

Product: aminotransferase

Products: NA

Alternate protein names: CBL; Beta-cystathionase; Cysteine lyase [H]

Number of amino acids: Translated: 401; Mature: 401

Protein sequence:

>401_residues
MQELISRIKKGNPRMKYDFDTVVNRRNTDSLKWNVAENELPMWVADMDFKTAPEITEAIKAKADLGVYGYTEISKDWYDA
YTGWWERRHNFRMEDDWLMFVTGVIPAISSSVRKLTTPAENVVIMTPVYNIFFNSILNNGRNVLQSQLAYENGRYVIDFE
DLEVKLKNPQTTLLILCNPQNPGGNVWRKEELARIGELAYKYGVVVISDEIHCELTDPGIDYVPFASVSEVCKNISVTCI
APTKTFNMAGLQTAAICVPDERLRHKVWRAINTDEVAEPNVFAVDAAIAAFTKGEEWLEQLREYIYENKQITEKFIKDNI
PRVSMVESHATYLCWLDVSDITDNSTRLAAYIRKNTGLFLSAGEGFGGDGKHFLRLNVACPKTTLMDGLERLRNGILSFD
R

Sequences:

>Translated_401_residues
MQELISRIKKGNPRMKYDFDTVVNRRNTDSLKWNVAENELPMWVADMDFKTAPEITEAIKAKADLGVYGYTEISKDWYDA
YTGWWERRHNFRMEDDWLMFVTGVIPAISSSVRKLTTPAENVVIMTPVYNIFFNSILNNGRNVLQSQLAYENGRYVIDFE
DLEVKLKNPQTTLLILCNPQNPGGNVWRKEELARIGELAYKYGVVVISDEIHCELTDPGIDYVPFASVSEVCKNISVTCI
APTKTFNMAGLQTAAICVPDERLRHKVWRAINTDEVAEPNVFAVDAAIAAFTKGEEWLEQLREYIYENKQITEKFIKDNI
PRVSMVESHATYLCWLDVSDITDNSTRLAAYIRKNTGLFLSAGEGFGGDGKHFLRLNVACPKTTLMDGLERLRNGILSFD
R
>Mature_401_residues
MQELISRIKKGNPRMKYDFDTVVNRRNTDSLKWNVAENELPMWVADMDFKTAPEITEAIKAKADLGVYGYTEISKDWYDA
YTGWWERRHNFRMEDDWLMFVTGVIPAISSSVRKLTTPAENVVIMTPVYNIFFNSILNNGRNVLQSQLAYENGRYVIDFE
DLEVKLKNPQTTLLILCNPQNPGGNVWRKEELARIGELAYKYGVVVISDEIHCELTDPGIDYVPFASVSEVCKNISVTCI
APTKTFNMAGLQTAAICVPDERLRHKVWRAINTDEVAEPNVFAVDAAIAAFTKGEEWLEQLREYIYENKQITEKFIKDNI
PRVSMVESHATYLCWLDVSDITDNSTRLAAYIRKNTGLFLSAGEGFGGDGKHFLRLNVACPKTTLMDGLERLRNGILSFD
R

Specific function: Catalyzes the transformation of cystathionine to homocysteine. Also exhibits cysteine desulfhydrase activity in vitro, producing sulfide from cysteine [H]

COG id: COG1168

COG function: function code E; Bifunctional PLP-dependent enzyme with beta-cystathionase and maltose regulon repressor activities

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. MalY/PatB cystathionine beta-lyase subfamily [H]

Homologues:

Organism=Escherichia coli, GI1787909, Length=388, Percent_Identity=30.1546391752577, Blast_Score=200, Evalue=1e-52,
Organism=Caenorhabditis elegans, GI17567369, Length=218, Percent_Identity=25.2293577981651, Blast_Score=72, Evalue=5e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004839
- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422 [H]

Pfam domain/function: PF00155 Aminotran_1_2 [H]

EC number: =4.4.1.8 [H]

Molecular weight: Translated: 45729; Mature: 45729

Theoretical pI: Translated: 5.10; Mature: 5.10

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.7 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
4.2 %Cys+Met (Translated Protein)
1.7 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
4.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MQELISRIKKGNPRMKYDFDTVVNRRNTDSLKWNVAENELPMWVADMDFKTAPEITEAIK
CHHHHHHHHCCCCCEEEEHHHHHCCCCCCCEEEEEECCCCCEEEECCCCCCCHHHHHHHH
AKADLGVYGYTEISKDWYDAYTGWWERRHNFRMEDDWLMFVTGVIPAISSSVRKLTTPAE
HHCCCCEEECHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCC
NVVIMTPVYNIFFNSILNNGRNVLQSQLAYENGRYVIDFEDLEVKLKNPQTTLLILCNPQ
CEEEECHHHHHHHHHHHHCCHHHHHHHHHHCCCCEEEEEECCEEEECCCCEEEEEEECCC
NPGGNVWRKEELARIGELAYKYGVVVISDEIHCELTDPGIDYVPFASVSEVCKNISVTCI
CCCCCCCHHHHHHHHHHHHHHCCEEEEECCEEEEECCCCCCCCCCHHHHHHHHCCEEEEE
APTKTFNMAGLQTAAICVPDERLRHKVWRAINTDEVAEPNVFAVDAAIAAFTKGEEWLEQ
ECCCCCCCCCCCEEEEECCHHHHHHHHHHHCCCCCCCCCCEEEEHHHHHHHCCCHHHHHH
LREYIYENKQITEKFIKDNIPRVSMVESHATYLCWLDVSDITDNSTRLAAYIRKNTGLFL
HHHHHHCCHHHHHHHHHCCCCCEEEECCCCEEEEEEEECCCCCCCCEEEEEEECCCCEEE
SAGEGFGGDGKHFLRLNVACPKTTLMDGLERLRNGILSFDR
ECCCCCCCCCCEEEEEEECCCHHHHHHHHHHHHHHCCCCCC
>Mature Secondary Structure
MQELISRIKKGNPRMKYDFDTVVNRRNTDSLKWNVAENELPMWVADMDFKTAPEITEAIK
CHHHHHHHHCCCCCEEEEHHHHHCCCCCCCEEEEEECCCCCEEEECCCCCCCHHHHHHHH
AKADLGVYGYTEISKDWYDAYTGWWERRHNFRMEDDWLMFVTGVIPAISSSVRKLTTPAE
HHCCCCEEECHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCC
NVVIMTPVYNIFFNSILNNGRNVLQSQLAYENGRYVIDFEDLEVKLKNPQTTLLILCNPQ
CEEEECHHHHHHHHHHHHCCHHHHHHHHHHCCCCEEEEEECCEEEECCCCEEEEEEECCC
NPGGNVWRKEELARIGELAYKYGVVVISDEIHCELTDPGIDYVPFASVSEVCKNISVTCI
CCCCCCCHHHHHHHHHHHHHHCCEEEEECCEEEEECCCCCCCCCCHHHHHHHHCCEEEEE
APTKTFNMAGLQTAAICVPDERLRHKVWRAINTDEVAEPNVFAVDAAIAAFTKGEEWLEQ
ECCCCCCCCCCCEEEEECCHHHHHHHHHHHCCCCCCCCCCEEEEHHHHHHHCCCHHHHHH
LREYIYENKQITEKFIKDNIPRVSMVESHATYLCWLDVSDITDNSTRLAAYIRKNTGLFL
HHHHHHCCHHHHHHHHHCCCCCEEEECCCCEEEEEEEECCCCCCCCEEEEEEECCCCEEE
SAGEGFGGDGKHFLRLNVACPKTTLMDGLERLRNGILSFDR
ECCCCCCCCCCEEEEEEECCCHHHHHHHHHHHHHHCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8497199; 9274030; 9384377 [H]