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The map label for this gene is ribD [H]

Identifier: 238921881

GI number: 238921881

Start: 87156

End: 88277

Strand: Reverse

Name: ribD [H]

Synonym: EUBELI_20114

Alternate gene names: 238921881

Gene position: 88277-87156 (Counterclockwise)

Preceding gene: 238921882

Following gene: 238921880

Centisome position: 14.09

GC content: 43.05

Gene sequence:

>1122_bases
ATGCAGCAGGAAATAAATAACAATTTTTCAAAACAAGATGAATTCTACATGAGGCGGGCAATTGAACTGGCAAAGAATGG
AACAGGCTGGGTTAATCCTAATCCGCTGGTTGGAGCTGTTATTGTAAAGGATGACAGAATCATAGGTGAAGGCTGGCATA
GGAAATATGGTGAGCTTCATGCGGAAAGAGACGCACTTTCAAGATGTATGGAGGATACCAGTGGAGCAACCATATATGTG
ACACTTGAGCCGTGCTGCCATCATGGGAAACAGCCGCCTTGCACTGAAGCACTTGTGCAGGCAGGAATAAGCAGGGTTGT
GATAGGTTCGATGGATCCTAATCCCCTGGTAAGTGGAAAAGGTGTTAAATATCTGGAAGAACACGGGATTAAAGTCGAAG
GTTGTGTATGCAATGAAGAATGTCTTGCGATGAATTATGTATTCTTTCATTACATAAGGAATAAAGAGCCATATGTTGTG
ATGAAAACAGCACAGACACTTGATGGAAAAATTGCCACATATAAGGGACTTTCCAAGTGGATTACAGGTGAGCAGGCAAG
AGAAAATGTGCATGCAGACCGTCACAGATATGCGGCAATTATGGTTGGGGTTGGCACTGTGATTGCTGATAATCCAATGC
TTGACTGCAGAAGTACAGCCATAAGCAACCCACACAATCCTGTGCGAATCATATGCGACAGCAGATTGAGAACTCCGCTT
GACAGCAGAATTGTAAAAAGTGCAGGGCAGATACCAACAATAATTGCTACATGTAGTACCGACAGCGACAGGAAATCTTT
ATATGAAAATGCAGGCTGTGAAGTGATAATTACAAAAGAATCAGAGCAGCACGTTGATCTTAAAGAGCTTATGAACATAC
TTGGAGAAAAAGGTATCGACAGCGTGATTCTAGAGGGAGGCGGAACACTTAACTTTTCGGCATTGCAGGCTGGAATTGTG
AACCGGGTTCAGACTTACATTGCACCTAAGATATTTGGCGGGGTAGACAGTAAGACAGCAGTTGAAGGGCAGGGTATTGC
AAATGTAGATGAAGCATATCGGTTGAGAAACAAAACCGTTCGTCTTCTTGGTGACGATATTCTGATTGAAGGAGAGTTGT
AA

Upstream 100 bases:

>100_bases
AGATGCAGCAGACAAGGCAAATAGGGATAGAGGAAATCAGGACAGAAAAAAGCAGAATAGAGAAAAGCAGGACAGGAAGG
AACAGAAAGAAGGTGTAGAT

Downstream 100 bases:

>100_bases
TGTTTACAGGAATTATTGAAGAAATCGGACATGTAAATAATGTAAAAAAAGGAACGGCATCAGCAATTCTTACAATACAG
GCAGAAAAAGTCCTTAAGGG

Product: 5-amino-6-(5-phosphoribosylamino)uracil reductase

Products: NA

Alternate protein names: Diaminohydroxyphosphoribosylaminopyrimidine deaminase; DRAP deaminase; Riboflavin-specific deaminase; 5-amino-6-(5-phosphoribosylamino)uracil reductase; HTP reductase [H]

Number of amino acids: Translated: 373; Mature: 373

Protein sequence:

>373_residues
MQQEINNNFSKQDEFYMRRAIELAKNGTGWVNPNPLVGAVIVKDDRIIGEGWHRKYGELHAERDALSRCMEDTSGATIYV
TLEPCCHHGKQPPCTEALVQAGISRVVIGSMDPNPLVSGKGVKYLEEHGIKVEGCVCNEECLAMNYVFFHYIRNKEPYVV
MKTAQTLDGKIATYKGLSKWITGEQARENVHADRHRYAAIMVGVGTVIADNPMLDCRSTAISNPHNPVRIICDSRLRTPL
DSRIVKSAGQIPTIIATCSTDSDRKSLYENAGCEVIITKESEQHVDLKELMNILGEKGIDSVILEGGGTLNFSALQAGIV
NRVQTYIAPKIFGGVDSKTAVEGQGIANVDEAYRLRNKTVRLLGDDILIEGEL

Sequences:

>Translated_373_residues
MQQEINNNFSKQDEFYMRRAIELAKNGTGWVNPNPLVGAVIVKDDRIIGEGWHRKYGELHAERDALSRCMEDTSGATIYV
TLEPCCHHGKQPPCTEALVQAGISRVVIGSMDPNPLVSGKGVKYLEEHGIKVEGCVCNEECLAMNYVFFHYIRNKEPYVV
MKTAQTLDGKIATYKGLSKWITGEQARENVHADRHRYAAIMVGVGTVIADNPMLDCRSTAISNPHNPVRIICDSRLRTPL
DSRIVKSAGQIPTIIATCSTDSDRKSLYENAGCEVIITKESEQHVDLKELMNILGEKGIDSVILEGGGTLNFSALQAGIV
NRVQTYIAPKIFGGVDSKTAVEGQGIANVDEAYRLRNKTVRLLGDDILIEGEL
>Mature_373_residues
MQQEINNNFSKQDEFYMRRAIELAKNGTGWVNPNPLVGAVIVKDDRIIGEGWHRKYGELHAERDALSRCMEDTSGATIYV
TLEPCCHHGKQPPCTEALVQAGISRVVIGSMDPNPLVSGKGVKYLEEHGIKVEGCVCNEECLAMNYVFFHYIRNKEPYVV
MKTAQTLDGKIATYKGLSKWITGEQARENVHADRHRYAAIMVGVGTVIADNPMLDCRSTAISNPHNPVRIICDSRLRTPL
DSRIVKSAGQIPTIIATCSTDSDRKSLYENAGCEVIITKESEQHVDLKELMNILGEKGIDSVILEGGGTLNFSALQAGIV
NRVQTYIAPKIFGGVDSKTAVEGQGIANVDEAYRLRNKTVRLLGDDILIEGEL

Specific function: Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate [H]

COG id: COG1985

COG function: function code H; Pyrimidine reductase, riboflavin biosynthesis

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: In the C-terminal section; belongs to the HTP reductase family [H]

Homologues:

Organism=Escherichia coli, GI1786616, Length=368, Percent_Identity=39.4021739130435, Blast_Score=258, Evalue=6e-70,
Organism=Escherichia coli, GI145693172, Length=155, Percent_Identity=34.1935483870968, Blast_Score=75, Evalue=8e-15,
Organism=Saccharomyces cerevisiae, GI6319629, Length=185, Percent_Identity=29.7297297297297, Blast_Score=78, Evalue=2e-15,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR016192
- InterPro:   IPR002125
- InterPro:   IPR016193
- InterPro:   IPR004794
- InterPro:   IPR011549
- InterPro:   IPR002734 [H]

Pfam domain/function: PF00383 dCMP_cyt_deam_1; PF01872 RibD_C [H]

EC number: =3.5.4.26; =1.1.1.193 [H]

Molecular weight: Translated: 41117; Mature: 41117

Theoretical pI: Translated: 6.35; Mature: 6.35

Prosite motif: PS00903 CYT_DCMP_DEAMINASES

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.9 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
5.4 %Cys+Met (Translated Protein)
2.9 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
5.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MQQEINNNFSKQDEFYMRRAIELAKNGTGWVNPNPLVGAVIVKDDRIIGEGWHRKYGELH
CCCCCCCCCCHHHHHHHHHHHHHHCCCCCCCCCCCCEEEEEEECCEEECCCHHHHHHHHH
AERDALSRCMEDTSGATIYVTLEPCCHHGKQPPCTEALVQAGISRVVIGSMDPNPLVSGK
HHHHHHHHHHHCCCCCEEEEEECHHHCCCCCCCHHHHHHHCCCCEEEEECCCCCCCCCCC
GVKYLEEHGIKVEGCVCNEECLAMNYVFFHYIRNKEPYVVMKTAQTLDGKIATYKGLSKW
CCHHHHHCCCEEEEEEECHHHHHHHHHHHHHHCCCCCEEEEEECCCCCCCHHHHHHHHHH
ITGEQARENVHADRHRYAAIMVGVGTVIADNPMLDCRSTAISNPHNPVRIICDSRLRTPL
HCCHHHHHHHHHHHHHEEEEEEECCCEEECCCCCHHHHHHCCCCCCCEEEEECCCCCCCH
DSRIVKSAGQIPTIIATCSTDSDRKSLYENAGCEVIITKESEQHVDLKELMNILGEKGID
HHHHHHHCCCCCEEEEECCCCHHHHHHHHCCCCEEEEECCCCCCCCHHHHHHHHCCCCCC
SVILEGGGTLNFSALQAGIVNRVQTYIAPKIFGGVDSKTAVEGQGIANVDEAYRLRNKTV
EEEECCCCEEEHHHHHHHHHHHHHHHHHHHHHCCCCCCCEECCCCCCCHHHHHHHHHCEE
RLLGDDILIEGEL
EEECCEEEEECCC
>Mature Secondary Structure
MQQEINNNFSKQDEFYMRRAIELAKNGTGWVNPNPLVGAVIVKDDRIIGEGWHRKYGELH
CCCCCCCCCCHHHHHHHHHHHHHHCCCCCCCCCCCCEEEEEEECCEEECCCHHHHHHHHH
AERDALSRCMEDTSGATIYVTLEPCCHHGKQPPCTEALVQAGISRVVIGSMDPNPLVSGK
HHHHHHHHHHHCCCCCEEEEEECHHHCCCCCCCHHHHHHHCCCCEEEEECCCCCCCCCCC
GVKYLEEHGIKVEGCVCNEECLAMNYVFFHYIRNKEPYVVMKTAQTLDGKIATYKGLSKW
CCHHHHHCCCEEEEEEECHHHHHHHHHHHHHHCCCCCEEEEEECCCCCCCHHHHHHHHHH
ITGEQARENVHADRHRYAAIMVGVGTVIADNPMLDCRSTAISNPHNPVRIICDSRLRTPL
HCCHHHHHHHHHHHHHEEEEEEECCCEEECCCCCHHHHHHCCCCCCCEEEEECCCCCCCH
DSRIVKSAGQIPTIIATCSTDSDRKSLYENAGCEVIITKESEQHVDLKELMNILGEKGID
HHHHHHHCCCCCEEEEECCCCHHHHHHHHCCCCEEEEECCCCCCCCHHHHHHHHCCCCCC
SVILEGGGTLNFSALQAGIVNRVQTYIAPKIFGGVDSKTAVEGQGIANVDEAYRLRNKTV
EEEECCCCEEEHHHHHHHHHHHHHHHHHHHHHCCCCCCCEECCCCCCCHHHHHHHHHCEE
RLLGDDILIEGEL
EEECCEEEEECCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8522537 [H]