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The map label for this gene is pyrC [H]

Identifier: 238921827

GI number: 238921827

Start: 38998

End: 41184

Strand: Reverse

Name: pyrC [H]

Synonym: EUBELI_20060

Alternate gene names: 238921827

Gene position: 41184-38998 (Counterclockwise)

Preceding gene: 238921828

Following gene: 238921826

Centisome position: 6.57

GC content: 37.77

Gene sequence:

>2187_bases
ATGGGGAAAGTAAAGGTTACATCAAAGAATAATCAGGTTAAAGTTCAAATCAGAAGTTCTAATGGTGAGCAACTCAATCA
GAATATGGCTGCCTACCTTTCTAGTGTTAATGTTGAGGGATTTCTGCCTTTTTATATAGTTACTAATTCAGAAGGATTTA
CAGCAGAGTATGGTGCTGCTGGATTTGAGACTGCGAAGGATTTTTTTAAAAACAGAGTGATAGATCAGAATACATTTTAT
AATTTTATCGATAGCAGTGTTAAAGCATTATCAGGAATGTCGGCATATAATATGGAGTATGGCAATGTTTTAGTTTCACT
TGATACTGTACTTGTTGAATCAAGAACAGGAAGGGCAATGTACTTGTATTATCCGGTATATGGATATAATAATGGCAACT
TTTTTAATACTTTTTTGGGCGATGTTGTCAGCAACATGACGACACCATCTGCTACAGACGTGTCATATATTGAACGACTT
AATGATATGTTAAGGCATCCGGACAGCATGTCGTGGGATACTCTTAAGGAATATGCCGATTCAGTAAAGGTTATTATTCC
AAATGTGCCACAGATGCATCCTGCTTCATATTCTGAGCCGGTAATAACACCAGTACAGCCAATAAATAGTGGTAATGCAG
GGAAAACATGTCCGGTGTGTGGAACATATAATGCTTTGGCAGATGCAGTGTTCTGTAGTAATTGCGGAAACAGACTCAAC
TTAGATGATATTAATGTATCAATTGTTGAAACTGAATATAAAACATGTCCAGCATGTGGTTTTGTTAATAGTCCTGATTC
TGTATTTTGTGCAGGATGTGGAATTAAGATGGATGAATATAAAATGCCAGAAGATAAACAGGAAACAGATGAGAAGAAAG
AGATACAGAATACAAGTATTCTCATTAAGAATGGCCGTGTTGTTGATCCTGTGTCTGGAACAGATGAGGTTATTGATGTT
TTTATTAAGAATAATGTTATTGAAGAAATCGGTCATGACATTAATGCAGCTGATTTCAATTCTGAAGAATCTGATAATAT
TAAGATTATTAATGCAGATGGCATGATTGTAGCTCCAGGTCTTGTGGATACTCATGTGCATTTCAGGGATCCGGGTTTTA
CCTATAAGGAAGATATTATCACAGGTGCATCTGCAGCAGCCAGAGGAGGTTTTACAACTGTTGTATGTATGGCTAATACA
AAGCCAGTTGTAGATAATGTAGAGACTCTTAGGTATATTCAGGAAAAAGGTGAAACAACAGGAATTCATGTTATGCAGAC
AGCTACTGTTACGAAGGAACTTAATGGAACAGAGCTTGTAGATATGGAAGCACTTGCAGATGCAGGAGCAGCAGGATTTA
CAGATGATGGTATTCCTATTATGGATGAACATGTTCTTGTTACAGCCATGAAGAAAGCTGTAGAACTGGATCTGCCAATA
AGTCTGCATGAAGAAGACCCTGAATTTATAATAAGGCCGGGAGTTAATCAGGGAAAGGTATCTGATCAGCTTGGCTATGG
TGGAGCTTCTGCAACGGCAGAGGATGTTATGGTTGCCAGAGATTGTATGCTGGCATTAAATACAGGAGCATCAGTATGCA
TTCAGCATATCAGTTCAGGTAATTCTGTAGAACTGGTAAGACTTGCAAAGAAACTGGGCGCTGATATACATGCAGAAGCC
ACTCCTCATCACTTTACACTTACTGAGGATGCTGTACTTAAGTATGGAACTAATGCAAGGATGAATCCTCCACTAAGAAC
AGAGAATGACAGAGAAAAGATTATAGAAGGCATAAAAGATGGAACGATTGATATGATAGTAACAGATCATGCTCCGCATA
GTGAAGAAGAAAAAGCAAAGCCATTAGAAAATGCACCAAGTGGAATAACAGGATTAGAGACATCACTTGCACTTGGTATA
AAATCGCTTGTTGAACCGGGACATATATCATTAATGAAACTTATTGAGCTTATGAGTAAGAATCCTGCTGAGTTTTATAG
AATGGTTCCTGGAAGTATAACAAAAGGTGCATCAGCGGATATTGTTATTTTTGGAGAGAAAGATTTGTGGACAGTCAATA
GAGAGGATTTTGCATCTAAGGCATGTAACAGTCCGTTTATAGGATGGGAGCTTCCTGGGAAAGTACACTATACTATATGC
TCAGGAAAGATTATTTATCAGGCGTAA

Upstream 100 bases:

>100_bases
AGAAATGGTCTTGTAAACAGGCATACAATGATATTGACTTTCGAATGATTTATATATATCTTTTATTATATCTGAATTAA
AGAAAAGAGAGGAGTTTATT

Downstream 100 bases:

>100_bases
TAATTTTCGACCTAATTGCGTATGAACATACAGAATTATTCCATTGAAATATTTTTTATATCATATATAATTAAGATGGA
GCTGATAAAAAGCTTTGATA

Product: dihydroorotase

Products: NA

Alternate protein names: DHOase [H]

Number of amino acids: Translated: 728; Mature: 727

Protein sequence:

>728_residues
MGKVKVTSKNNQVKVQIRSSNGEQLNQNMAAYLSSVNVEGFLPFYIVTNSEGFTAEYGAAGFETAKDFFKNRVIDQNTFY
NFIDSSVKALSGMSAYNMEYGNVLVSLDTVLVESRTGRAMYLYYPVYGYNNGNFFNTFLGDVVSNMTTPSATDVSYIERL
NDMLRHPDSMSWDTLKEYADSVKVIIPNVPQMHPASYSEPVITPVQPINSGNAGKTCPVCGTYNALADAVFCSNCGNRLN
LDDINVSIVETEYKTCPACGFVNSPDSVFCAGCGIKMDEYKMPEDKQETDEKKEIQNTSILIKNGRVVDPVSGTDEVIDV
FIKNNVIEEIGHDINAADFNSEESDNIKIINADGMIVAPGLVDTHVHFRDPGFTYKEDIITGASAAARGGFTTVVCMANT
KPVVDNVETLRYIQEKGETTGIHVMQTATVTKELNGTELVDMEALADAGAAGFTDDGIPIMDEHVLVTAMKKAVELDLPI
SLHEEDPEFIIRPGVNQGKVSDQLGYGGASATAEDVMVARDCMLALNTGASVCIQHISSGNSVELVRLAKKLGADIHAEA
TPHHFTLTEDAVLKYGTNARMNPPLRTENDREKIIEGIKDGTIDMIVTDHAPHSEEEKAKPLENAPSGITGLETSLALGI
KSLVEPGHISLMKLIELMSKNPAEFYRMVPGSITKGASADIVIFGEKDLWTVNREDFASKACNSPFIGWELPGKVHYTIC
SGKIIYQA

Sequences:

>Translated_728_residues
MGKVKVTSKNNQVKVQIRSSNGEQLNQNMAAYLSSVNVEGFLPFYIVTNSEGFTAEYGAAGFETAKDFFKNRVIDQNTFY
NFIDSSVKALSGMSAYNMEYGNVLVSLDTVLVESRTGRAMYLYYPVYGYNNGNFFNTFLGDVVSNMTTPSATDVSYIERL
NDMLRHPDSMSWDTLKEYADSVKVIIPNVPQMHPASYSEPVITPVQPINSGNAGKTCPVCGTYNALADAVFCSNCGNRLN
LDDINVSIVETEYKTCPACGFVNSPDSVFCAGCGIKMDEYKMPEDKQETDEKKEIQNTSILIKNGRVVDPVSGTDEVIDV
FIKNNVIEEIGHDINAADFNSEESDNIKIINADGMIVAPGLVDTHVHFRDPGFTYKEDIITGASAAARGGFTTVVCMANT
KPVVDNVETLRYIQEKGETTGIHVMQTATVTKELNGTELVDMEALADAGAAGFTDDGIPIMDEHVLVTAMKKAVELDLPI
SLHEEDPEFIIRPGVNQGKVSDQLGYGGASATAEDVMVARDCMLALNTGASVCIQHISSGNSVELVRLAKKLGADIHAEA
TPHHFTLTEDAVLKYGTNARMNPPLRTENDREKIIEGIKDGTIDMIVTDHAPHSEEEKAKPLENAPSGITGLETSLALGI
KSLVEPGHISLMKLIELMSKNPAEFYRMVPGSITKGASADIVIFGEKDLWTVNREDFASKACNSPFIGWELPGKVHYTIC
SGKIIYQA
>Mature_727_residues
GKVKVTSKNNQVKVQIRSSNGEQLNQNMAAYLSSVNVEGFLPFYIVTNSEGFTAEYGAAGFETAKDFFKNRVIDQNTFYN
FIDSSVKALSGMSAYNMEYGNVLVSLDTVLVESRTGRAMYLYYPVYGYNNGNFFNTFLGDVVSNMTTPSATDVSYIERLN
DMLRHPDSMSWDTLKEYADSVKVIIPNVPQMHPASYSEPVITPVQPINSGNAGKTCPVCGTYNALADAVFCSNCGNRLNL
DDINVSIVETEYKTCPACGFVNSPDSVFCAGCGIKMDEYKMPEDKQETDEKKEIQNTSILIKNGRVVDPVSGTDEVIDVF
IKNNVIEEIGHDINAADFNSEESDNIKIINADGMIVAPGLVDTHVHFRDPGFTYKEDIITGASAAARGGFTTVVCMANTK
PVVDNVETLRYIQEKGETTGIHVMQTATVTKELNGTELVDMEALADAGAAGFTDDGIPIMDEHVLVTAMKKAVELDLPIS
LHEEDPEFIIRPGVNQGKVSDQLGYGGASATAEDVMVARDCMLALNTGASVCIQHISSGNSVELVRLAKKLGADIHAEAT
PHHFTLTEDAVLKYGTNARMNPPLRTENDREKIIEGIKDGTIDMIVTDHAPHSEEEKAKPLENAPSGITGLETSLALGIK
SLVEPGHISLMKLIELMSKNPAEFYRMVPGSITKGASADIVIFGEKDLWTVNREDFASKACNSPFIGWELPGKVHYTICS
GKIIYQA

Specific function: Involved In The Anaerobic Utilization Of Allantoin. [C]

COG id: COG0044

COG function: function code F; Dihydroorotase and related cyclic amidohydrolases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the DHOase family. Type 2 subfamily [H]

Homologues:

Organism=Homo sapiens, GI18105007, Length=419, Percent_Identity=27.6849642004773, Blast_Score=131, Evalue=2e-30,
Organism=Homo sapiens, GI4503051, Length=467, Percent_Identity=23.1263383297645, Blast_Score=85, Evalue=2e-16,
Organism=Homo sapiens, GI62422571, Length=465, Percent_Identity=23.2258064516129, Blast_Score=85, Evalue=2e-16,
Organism=Homo sapiens, GI19923821, Length=457, Percent_Identity=22.7571115973742, Blast_Score=80, Evalue=6e-15,
Organism=Escherichia coli, GI1786722, Length=442, Percent_Identity=28.7330316742081, Blast_Score=161, Evalue=1e-40,
Organism=Escherichia coli, GI87082175, Length=456, Percent_Identity=26.7543859649123, Blast_Score=121, Evalue=1e-28,
Organism=Caenorhabditis elegans, GI193204318, Length=371, Percent_Identity=28.8409703504043, Blast_Score=123, Evalue=4e-28,
Organism=Caenorhabditis elegans, GI86575075, Length=446, Percent_Identity=23.7668161434978, Blast_Score=91, Evalue=2e-18,
Organism=Saccharomyces cerevisiae, GI6322218, Length=394, Percent_Identity=27.4111675126904, Blast_Score=115, Evalue=2e-26,
Organism=Drosophila melanogaster, GI24642586, Length=380, Percent_Identity=27.3684210526316, Blast_Score=128, Evalue=2e-29,
Organism=Drosophila melanogaster, GI18859883, Length=477, Percent_Identity=24.3186582809224, Blast_Score=84, Evalue=3e-16,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006680
- InterPro:   IPR004722
- InterPro:   IPR002195
- InterPro:   IPR011059 [H]

Pfam domain/function: PF01979 Amidohydro_1 [H]

EC number: =3.5.2.3 [H]

Molecular weight: Translated: 79286; Mature: 79155

Theoretical pI: Translated: 4.53; Mature: 4.53

Prosite motif: PS00483 DIHYDROOROTASE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.8 %Cys     (Translated Protein)
3.3 %Met     (Translated Protein)
5.1 %Cys+Met (Translated Protein)
1.8 %Cys     (Mature Protein)
3.2 %Met     (Mature Protein)
5.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MGKVKVTSKNNQVKVQIRSSNGEQLNQNMAAYLSSVNVEGFLPFYIVTNSEGFTAEYGAA
CCCEEEECCCCEEEEEEECCCCHHHHHHHHHHHHHCCCCEEEEEEEEECCCCCEECCCCC
GFETAKDFFKNRVIDQNTFYNFIDSSVKALSGMSAYNMEYGNVLVSLDTVLVESRTGRAM
CHHHHHHHHHHCCCCCCHHHHHHHHHHHHHCCCCCCCEECCCEEEEEEEEEEECCCCCEE
YLYYPVYGYNNGNFFNTFLGDVVSNMTTPSATDVSYIERLNDMLRHPDSMSWDTLKEYAD
EEEEEEEECCCCCCHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHCCCCCCHHHHHHHHC
SVKVIIPNVPQMHPASYSEPVITPVQPINSGNAGKTCPVCGTYNALADAVFCSNCGNRLN
CEEEEECCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHCCCCCCC
LDDINVSIVETEYKTCPACGFVNSPDSVFCAGCGIKMDEYKMPEDKQETDEKKEIQNTSI
CCCCEEEEEEECCCCCCCCCCCCCCCCEEEEECCCCHHCCCCCCCHHHHHHHHHHCCCEE
LIKNGRVVDPVSGTDEVIDVFIKNNVIEEIGHDINAADFNSEESDNIKIINADGMIVAPG
EEECCEEECCCCCCHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCEEEEECCCEEEECC
LVDTHVHFRDPGFTYKEDIITGASAAARGGFTTVVCMANTKPVVDNVETLRYIQEKGETT
EEECEEEECCCCCCCHHHHHCCCCHHCCCCCEEEEEEECCCCCHHHHHHHHHHHHCCCCC
GIHVMQTATVTKELNGTELVDMEALADAGAAGFTDDGIPIMDEHVLVTAMKKAVELDLPI
CEEEEEEEEHHHCCCCCEEEEHHHHHCCCCCCCCCCCCCCCCCHHHHHHHHHHHEECCCE
SLHEEDPEFIIRPGVNQGKVSDQLGYGGASATAEDVMVARDCMLALNTGASVCIQHISSG
EECCCCCCEEEECCCCCCCCCHHCCCCCCCCCHHHHHHHHHHHEEECCCHHHHHHHHCCC
NSVELVRLAKKLGADIHAEATPHHFTLTEDAVLKYGTNARMNPPLRTENDREKIIEGIKD
CCCHHHHHHHHHCCCEECCCCCCEEEECCCHHHEECCCCCCCCCCCCCCHHHHHHHHCCC
GTIDMIVTDHAPHSEEEKAKPLENAPSGITGLETSLALGIKSLVEPGHISLMKLIELMSK
CCEEEEEECCCCCCCHHHCCCCCCCCCCCCCHHHHHHHHHHHHCCCCCHHHHHHHHHHCC
NPAEFYRMVPGSITKGASADIVIFGEKDLWTVNREDFASKACNSPFIGWELPGKVHYTIC
CHHHHHHHCCCCCCCCCCCCEEEECCCCEEEECHHHHHHHHCCCCCCCEECCCEEEEEEE
SGKIIYQA
CCEEEEEC
>Mature Secondary Structure 
GKVKVTSKNNQVKVQIRSSNGEQLNQNMAAYLSSVNVEGFLPFYIVTNSEGFTAEYGAA
CCEEEECCCCEEEEEEECCCCHHHHHHHHHHHHHCCCCEEEEEEEEECCCCCEECCCCC
GFETAKDFFKNRVIDQNTFYNFIDSSVKALSGMSAYNMEYGNVLVSLDTVLVESRTGRAM
CHHHHHHHHHHCCCCCCHHHHHHHHHHHHHCCCCCCCEECCCEEEEEEEEEEECCCCCEE
YLYYPVYGYNNGNFFNTFLGDVVSNMTTPSATDVSYIERLNDMLRHPDSMSWDTLKEYAD
EEEEEEEECCCCCCHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHCCCCCCHHHHHHHHC
SVKVIIPNVPQMHPASYSEPVITPVQPINSGNAGKTCPVCGTYNALADAVFCSNCGNRLN
CEEEEECCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHCCCCCCC
LDDINVSIVETEYKTCPACGFVNSPDSVFCAGCGIKMDEYKMPEDKQETDEKKEIQNTSI
CCCCEEEEEEECCCCCCCCCCCCCCCCEEEEECCCCHHCCCCCCCHHHHHHHHHHCCCEE
LIKNGRVVDPVSGTDEVIDVFIKNNVIEEIGHDINAADFNSEESDNIKIINADGMIVAPG
EEECCEEECCCCCCHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCEEEEECCCEEEECC
LVDTHVHFRDPGFTYKEDIITGASAAARGGFTTVVCMANTKPVVDNVETLRYIQEKGETT
EEECEEEECCCCCCCHHHHHCCCCHHCCCCCEEEEEEECCCCCHHHHHHHHHHHHCCCCC
GIHVMQTATVTKELNGTELVDMEALADAGAAGFTDDGIPIMDEHVLVTAMKKAVELDLPI
CEEEEEEEEHHHCCCCCEEEEHHHHHCCCCCCCCCCCCCCCCCHHHHHHHHHHHEECCCE
SLHEEDPEFIIRPGVNQGKVSDQLGYGGASATAEDVMVARDCMLALNTGASVCIQHISSG
EECCCCCCEEEECCCCCCCCCHHCCCCCCCCCHHHHHHHHHHHEEECCCHHHHHHHHCCC
NSVELVRLAKKLGADIHAEATPHHFTLTEDAVLKYGTNARMNPPLRTENDREKIIEGIKD
CCCHHHHHHHHHCCCEECCCCCCEEEECCCHHHEECCCCCCCCCCCCCCHHHHHHHHCCC
GTIDMIVTDHAPHSEEEKAKPLENAPSGITGLETSLALGIKSLVEPGHISLMKLIELMSK
CCEEEEEECCCCCCCHHHCCCCCCCCCCCCCHHHHHHHHHHHHCCCCCHHHHHHHHHHCC
NPAEFYRMVPGSITKGASADIVIFGEKDLWTVNREDFASKACNSPFIGWELPGKVHYTIC
CHHHHHHHCCCCCCCCCCCCEEEECCCCEEEECHHHHHHHHCCCCCCCEECCCEEEEEEE
SGKIIYQA
CCEEEEEC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA