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The map label for this gene is trxA [H]

Identifier: 238921823

GI number: 238921823

Start: 36948

End: 37259

Strand: Reverse

Name: trxA [H]

Synonym: EUBELI_20056

Alternate gene names: 238921823

Gene position: 37259-36948 (Counterclockwise)

Preceding gene: 238921824

Following gene: 238921822

Centisome position: 5.94

GC content: 37.5

Gene sequence:

>312_bases
ATGGAAATCAAACATGTAAAAGCAAGTGAATTCAATAATGAGGTACTTAAAGCGGATAAGCCGGTTCTTGTGGATTTCTG
GGCAGACTGGTGCGGACCATGCAAGATGTTAGGACCAGTTCTTGAACAGGTTGCAGCTAAGGTGGATGATGTTCAGATTG
TAAAGATTAATGTGGATGAGGAATCATCAGTTGCAGAGAAATATAATATTATGTCAATCCCTACATTACTTTTATTTAAG
AGTGGTGAGTGTGTGGCAAAGAGTGTTGGTTTTATAAGTGAAGGACAGGTAATGGAATTTATTGGTAAATAA

Upstream 100 bases:

>100_bases
TGGAATATTAAGCAGATGCTTGTGGAGATGAGAAGAGAAAAATTTGAATATATGCGGAGAAATATGAAATAATAATTATT
AAAGATAAAGGAGATAAGAT

Downstream 100 bases:

>100_bases
CATTAATACAGCCTGAAGTACTGATGAATACTGCATTTATAAAGGGGGAATATTTCACGATATTCCCCTTAAATTGTACA
AAATTAAATACTCTTGTTAA

Product: thioredoxin 1

Products: NA

Alternate protein names: Trx-1 [H]

Number of amino acids: Translated: 103; Mature: 103

Protein sequence:

>103_residues
MEIKHVKASEFNNEVLKADKPVLVDFWADWCGPCKMLGPVLEQVAAKVDDVQIVKINVDEESSVAEKYNIMSIPTLLLFK
SGECVAKSVGFISEGQVMEFIGK

Sequences:

>Translated_103_residues
MEIKHVKASEFNNEVLKADKPVLVDFWADWCGPCKMLGPVLEQVAAKVDDVQIVKINVDEESSVAEKYNIMSIPTLLLFK
SGECVAKSVGFISEGQVMEFIGK
>Mature_103_residues
MEIKHVKASEFNNEVLKADKPVLVDFWADWCGPCKMLGPVLEQVAAKVDDVQIVKINVDEESSVAEKYNIMSIPTLLLFK
SGECVAKSVGFISEGQVMEFIGK

Specific function: Participates in various redox reactions through the reversible oxidation of its active center dithiol to a disulfide and catalyzes dithiol-disulfide exchange reactions [H]

COG id: COG0526

COG function: function code OC; Thiol-disulfide isomerase and thioredoxins

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 thioredoxin domain [H]

Homologues:

Organism=Homo sapiens, GI21361403, Length=97, Percent_Identity=40.2061855670103, Blast_Score=84, Evalue=2e-17,
Organism=Homo sapiens, GI20070125, Length=77, Percent_Identity=35.0649350649351, Blast_Score=64, Evalue=2e-11,
Organism=Homo sapiens, GI50592994, Length=90, Percent_Identity=35.5555555555556, Blast_Score=64, Evalue=4e-11,
Organism=Escherichia coli, GI87082331, Length=101, Percent_Identity=48.5148514851485, Blast_Score=111, Evalue=7e-27,
Organism=Escherichia coli, GI1788936, Length=74, Percent_Identity=43.2432432432432, Blast_Score=78, Evalue=1e-16,
Organism=Caenorhabditis elegans, GI212646193, Length=93, Percent_Identity=40.8602150537634, Blast_Score=82, Evalue=5e-17,
Organism=Caenorhabditis elegans, GI17507705, Length=78, Percent_Identity=35.8974358974359, Blast_Score=72, Evalue=4e-14,
Organism=Caenorhabditis elegans, GI17509965, Length=67, Percent_Identity=47.7611940298507, Blast_Score=66, Evalue=4e-12,
Organism=Caenorhabditis elegans, GI71980562, Length=76, Percent_Identity=30.2631578947368, Blast_Score=62, Evalue=9e-11,
Organism=Saccharomyces cerevisiae, GI6321648, Length=83, Percent_Identity=45.7831325301205, Blast_Score=87, Evalue=4e-19,
Organism=Saccharomyces cerevisiae, GI6323072, Length=90, Percent_Identity=45.5555555555556, Blast_Score=84, Evalue=3e-18,
Organism=Saccharomyces cerevisiae, GI6319925, Length=87, Percent_Identity=37.9310344827586, Blast_Score=74, Evalue=4e-15,
Organism=Drosophila melanogaster, GI28573567, Length=95, Percent_Identity=36.8421052631579, Blast_Score=77, Evalue=2e-15,
Organism=Drosophila melanogaster, GI24639826, Length=81, Percent_Identity=41.9753086419753, Blast_Score=76, Evalue=4e-15,
Organism=Drosophila melanogaster, GI24664269, Length=90, Percent_Identity=41.1111111111111, Blast_Score=69, Evalue=5e-13,
Organism=Drosophila melanogaster, GI24639068, Length=92, Percent_Identity=29.3478260869565, Blast_Score=68, Evalue=1e-12,
Organism=Drosophila melanogaster, GI17648013, Length=76, Percent_Identity=40.7894736842105, Blast_Score=67, Evalue=2e-12,
Organism=Drosophila melanogaster, GI24583090, Length=76, Percent_Identity=40.7894736842105, Blast_Score=67, Evalue=2e-12,
Organism=Drosophila melanogaster, GI21358065, Length=96, Percent_Identity=32.2916666666667, Blast_Score=65, Evalue=1e-11,

Paralogues:

None

Copy number: 3,500 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005746
- InterPro:   IPR017936
- InterPro:   IPR012336
- InterPro:   IPR017937
- InterPro:   IPR013766
- InterPro:   IPR012335 [H]

Pfam domain/function: PF00085 Thioredoxin [H]

EC number: NA

Molecular weight: Translated: 11404; Mature: 11404

Theoretical pI: Translated: 4.52; Mature: 4.52

Prosite motif: PS00194 THIOREDOXIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.9 %Cys     (Translated Protein)
3.9 %Met     (Translated Protein)
6.8 %Cys+Met (Translated Protein)
2.9 %Cys     (Mature Protein)
3.9 %Met     (Mature Protein)
6.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MEIKHVKASEFNNEVLKADKPVLVDFWADWCGPCKMLGPVLEQVAAKVDDVQIVKINVDE
CCCCCCCCCCCCCHHHHCCCCEEEEEHHHHCCHHHHHHHHHHHHHHCCCCEEEEEEECCC
ESSVAEKYNIMSIPTLLLFKSGECVAKSVGFISEGQVMEFIGK
CHHHHHHHCHHCCCCEEEEECCCHHHHHCCCCCCCHHHHHHCC
>Mature Secondary Structure
MEIKHVKASEFNNEVLKADKPVLVDFWADWCGPCKMLGPVLEQVAAKVDDVQIVKINVDE
CCCCCCCCCCCCCHHHHCCCCEEEEEHHHHCCHHHHHHHHHHHHHHCCCCEEEEEEECCC
ESSVAEKYNIMSIPTLLLFKSGECVAKSVGFISEGQVMEFIGK
CHHHHHHHCHHCCCCEEEEECCCHHHHHCCCCCCCHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: Reduction reactions; participates in dithiol-disulfide exchange reactions [C]

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]