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The map label for this gene is glmU

Identifier: 238921745

GI number: 238921745

Start: 3791583

End: 3792953

Strand: Direct

Name: glmU

Synonym: NT01EI_3914

Alternate gene names: 238921745

Gene position: 3791583-3792953 (Clockwise)

Preceding gene: 238921744

Following gene: 238921746

Centisome position: 99.46

GC content: 58.86

Gene sequence:

>1371_bases
ATGTCGACATCTCCATTAAGCGTGGTCATCCTTGCCGCCGGTAAAGGAACCCGCATGTATTCCGATCTTCCTAAGGTGTT
GCATCCGCTGGCAGGTAAGCCGATGGTGCAGCATGTTATTGATAGCGCGCTGACGCTGGGCGCCCGTCAGGTACATCTGG
TATATGGACACGGCGGTGATCTGCTGAAGGCCCATCTGTCTGGCCAGCCGCTGAACTGGGTGCTGCAGGCTCAGCAGCTG
GGCACCGGCCATGCCATGCAGCAGGCGGCGCCTGATTTTTCCGACGATGAAGATATCCTGATGCTGTACGGCGATGTGCC
GCTGATTTCGGCCGCGACGTTGCAGCGCCTGATCGCGGCGAAGCCCCAGGGGGGAATCGGTCTACTGACGGTAAAACTGG
ACGATCCGAGCGGCTATGGCCGCATTGTGCGTCATCACGACCGCGTAGTGGGGATCGTCGAACATAAGGATGCCAGCGAA
GCGCAGCGTCGTATCAATGAGATCAACACCGGCATTCTGGTGGCCAACGGCGTGGATCTGAAGCGCTGGCTGGCCCGTCT
GGATAACAACAATGCTCAGGGTGAGTTCTATATTACCGATATTATCGCCATGGCCCATCAGGAAGGGAGGCAGATTGCGG
CAGTACATCCCGAACGCCTGAGCGAGGTGGAGGGGGTTAACAACCGCCTGCAGCTTTCCGCCCTGGAACGGGCCTATCAG
CAGCAGCAGGCGCAGCGTTTGCTGCTGGCTGGCGTAATGCTAACCGATCCGGCCCGCTTCGATCTGCGCGGAGAGCTGGT
ACACGGACGCGATGTGGTGATCGATACCAACGTGATTATCGAAGGCAAAGTGACGCTGGGAAACCGGGTTCATATCGGCA
GCGGCTGTGTGCTGAAAGATTGCCAGATCGCCGATGATAGTGTGATTAGTCCCTATACGGTGATTGAGGGTGCCCGGCTG
GCGCAGGCTTGTACCGTGGGGCCCTTTGCCCGTCTGCGCCCCGGCGCCTGCCTCGATGCGGAGGCGCACGTGGGTAACTT
TGTTGAAATGAAGAAGGCGCACCTGGGGCGCGGCTCTAAGGCGGGTCATCTGAGTTATCTGGGTGATGCGGAGATCGGCG
CAGGGGTGAATATCGGCGCAGGGACTATTACCTGTAACTATGATGGCGCCAATAAACACCAGACGGTGATCGGTGATGAT
GTCTTCGTTGGTTCAGACAGTCAGCTGGTGGCGCCGGTTACCGTTGGCCGTGGTGCGACGATCGCGGCCGGTACGACGGT
CACCAAAAATGTGGGTGACGGAGAGCTGGTGCTCAGTCGGGTGAAACAGGTACAGCTCAGCGGCTGGGAGCGGCCGGTGA
AGAAAAAATGA

Upstream 100 bases:

>100_bases
TACATCTGACCTGCGCGCGTTTTGAGTAGAGAAATATGTAGTAATCCCGCCACTGAACGGGTTTACTTTACCCCATCAAT
TTGAATGGATCAGATTGCTT

Downstream 100 bases:

>100_bases
TCGCGATCGCTGCAGCCTGACGGCTGCAGCGGTTTTTCCCTGTGCCCCGACGAGGGACACAGGGAAAAAAATAATAAAGA
TCCCGCTAAAGGGATCAGCC

Product: bifunctional N-acetylglucosamine-1-phosphate uridyltransferase/glucosamine-1-phosphate acetyltransferase

Products: NA

Alternate protein names: UDP-N-acetylglucosamine pyrophosphorylase; N-acetylglucosamine-1-phosphate uridyltransferase; Glucosamine-1-phosphate N-acetyltransferase

Number of amino acids: Translated: 456; Mature: 455

Protein sequence:

>456_residues
MSTSPLSVVILAAGKGTRMYSDLPKVLHPLAGKPMVQHVIDSALTLGARQVHLVYGHGGDLLKAHLSGQPLNWVLQAQQL
GTGHAMQQAAPDFSDDEDILMLYGDVPLISAATLQRLIAAKPQGGIGLLTVKLDDPSGYGRIVRHHDRVVGIVEHKDASE
AQRRINEINTGILVANGVDLKRWLARLDNNNAQGEFYITDIIAMAHQEGRQIAAVHPERLSEVEGVNNRLQLSALERAYQ
QQQAQRLLLAGVMLTDPARFDLRGELVHGRDVVIDTNVIIEGKVTLGNRVHIGSGCVLKDCQIADDSVISPYTVIEGARL
AQACTVGPFARLRPGACLDAEAHVGNFVEMKKAHLGRGSKAGHLSYLGDAEIGAGVNIGAGTITCNYDGANKHQTVIGDD
VFVGSDSQLVAPVTVGRGATIAAGTTVTKNVGDGELVLSRVKQVQLSGWERPVKKK

Sequences:

>Translated_456_residues
MSTSPLSVVILAAGKGTRMYSDLPKVLHPLAGKPMVQHVIDSALTLGARQVHLVYGHGGDLLKAHLSGQPLNWVLQAQQL
GTGHAMQQAAPDFSDDEDILMLYGDVPLISAATLQRLIAAKPQGGIGLLTVKLDDPSGYGRIVRHHDRVVGIVEHKDASE
AQRRINEINTGILVANGVDLKRWLARLDNNNAQGEFYITDIIAMAHQEGRQIAAVHPERLSEVEGVNNRLQLSALERAYQ
QQQAQRLLLAGVMLTDPARFDLRGELVHGRDVVIDTNVIIEGKVTLGNRVHIGSGCVLKDCQIADDSVISPYTVIEGARL
AQACTVGPFARLRPGACLDAEAHVGNFVEMKKAHLGRGSKAGHLSYLGDAEIGAGVNIGAGTITCNYDGANKHQTVIGDD
VFVGSDSQLVAPVTVGRGATIAAGTTVTKNVGDGELVLSRVKQVQLSGWERPVKKK
>Mature_455_residues
STSPLSVVILAAGKGTRMYSDLPKVLHPLAGKPMVQHVIDSALTLGARQVHLVYGHGGDLLKAHLSGQPLNWVLQAQQLG
TGHAMQQAAPDFSDDEDILMLYGDVPLISAATLQRLIAAKPQGGIGLLTVKLDDPSGYGRIVRHHDRVVGIVEHKDASEA
QRRINEINTGILVANGVDLKRWLARLDNNNAQGEFYITDIIAMAHQEGRQIAAVHPERLSEVEGVNNRLQLSALERAYQQ
QQAQRLLLAGVMLTDPARFDLRGELVHGRDVVIDTNVIIEGKVTLGNRVHIGSGCVLKDCQIADDSVISPYTVIEGARLA
QACTVGPFARLRPGACLDAEAHVGNFVEMKKAHLGRGSKAGHLSYLGDAEIGAGVNIGAGTITCNYDGANKHQTVIGDDV
FVGSDSQLVAPVTVGRGATIAAGTTVTKNVGDGELVLSRVKQVQLSGWERPVKKK

Specific function: Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-GlcNAc. Responsible for the acetylation of Glc-N-1-P to give GlcNAc-1-P and for the uridyl transfer from UTP to GlcNAc-1-P which produces UDP-GlcNAc

COG id: COG1207

COG function: function code M; N-acetylglucosamine-1-phosphate uridyltransferase (contains nucleotidyltransferase and I-patch acetyltransferase domains)

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: In the C-terminal section; belongs to the transferase hexapeptide repeat family

Homologues:

Organism=Escherichia coli, GI1790168, Length=456, Percent_Identity=78.2894736842105, Blast_Score=729, Evalue=0.0,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): GLMU_EDWI9 (C5BF42)

Other databases:

- EMBL:   CP001600
- RefSeq:   YP_002935260.1
- ProteinModelPortal:   C5BF42
- GeneID:   7961480
- GenomeReviews:   CP001600_GR
- KEGG:   eic:NT01EI_3914
- OMA:   GSKVNHL
- ProtClustDB:   PRK09451
- GO:   GO:0005737
- HAMAP:   MF_01631
- InterPro:   IPR005882
- InterPro:   IPR018357
- InterPro:   IPR005835
- InterPro:   IPR011004
- TIGRFAMs:   TIGR01173

Pfam domain/function: PF00483 NTP_transferase; SSF51161 Trimer_LpxA_like

EC number: =2.7.7.23; =2.3.1.157

Molecular weight: Translated: 48716; Mature: 48585

Theoretical pI: Translated: 7.30; Mature: 7.30

Prosite motif: PS00101 HEXAPEP_TRANSFERASES

Important sites: ACT_SITE 363-363 BINDING 76-76 BINDING 140-140 BINDING 154-154 BINDING 169-169 BINDING 387-387 BINDING 405-405 BINDING 423-423 BINDING 440-440

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
2.9 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
1.5 %Met     (Mature Protein)
2.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSTSPLSVVILAAGKGTRMYSDLPKVLHPLAGKPMVQHVIDSALTLGARQVHLVYGHGGD
CCCCCEEEEEEECCCCCCHHHHHHHHHHHCCCCHHHHHHHHHHHHCCCEEEEEEEECCCC
LLKAHLSGQPLNWVLQAQQLGTGHAMQQAAPDFSDDEDILMLYGDVPLISAATLQRLIAA
EEEEECCCCCCEEEEEEHHCCCCHHHHHCCCCCCCCCCEEEEECCCCHHHHHHHHHHHHC
KPQGGIGLLTVKLDDPSGYGRIVRHHDRVVGIVEHKDASEAQRRINEINTGILVANGVDL
CCCCCEEEEEEEECCCCCCCHHEEECCEEEEEEECCCHHHHHHHHHHCCCCEEEECCCCH
KRWLARLDNNNAQGEFYITDIIAMAHQEGRQIAAVHPERLSEVEGVNNRLQLSALERAYQ
HHHHHHHCCCCCCCEEEHHHHHHHHHHCCCEEEEECHHHHHHHHCCCCHHHHHHHHHHHH
QQQAQRLLLAGVMLTDPARFDLRGELVHGRDVVIDTNVIIEGKVTLGNRVHIGSGCVLKD
HHHHHHHHHHHEEECCCCCCCEEEEEECCCEEEEECCEEEEEEEEECCEEEECCCCEEEC
CQIADDSVISPYTVIEGARLAQACTVGPFARLRPGACLDAEAHVGNFVEMKKAHLGRGSK
CCCCCCCCCCCHHHHCCCHHHHHHCCCCHHHCCCCCCCCCHHHCCHHHHHHHHHCCCCCC
AGHLSYLGDAEIGAGVNIGAGTITCNYDGANKHQTVIGDDVFVGSDSQLVAPVTVGRGAT
CCCEEEECCCCCCCCCEECCCEEEEECCCCCCCCEEECCEEEECCCCCEEEEEEECCCCE
IAAGTTVTKNVGDGELVLSRVKQVQLSGWERPVKKK
EEECCEEECCCCCHHHHHHHHHHHHHCCCCCCCCCC
>Mature Secondary Structure 
STSPLSVVILAAGKGTRMYSDLPKVLHPLAGKPMVQHVIDSALTLGARQVHLVYGHGGD
CCCCEEEEEEECCCCCCHHHHHHHHHHHCCCCHHHHHHHHHHHHCCCEEEEEEEECCCC
LLKAHLSGQPLNWVLQAQQLGTGHAMQQAAPDFSDDEDILMLYGDVPLISAATLQRLIAA
EEEEECCCCCCEEEEEEHHCCCCHHHHHCCCCCCCCCCEEEEECCCCHHHHHHHHHHHHC
KPQGGIGLLTVKLDDPSGYGRIVRHHDRVVGIVEHKDASEAQRRINEINTGILVANGVDL
CCCCCEEEEEEEECCCCCCCHHEEECCEEEEEEECCCHHHHHHHHHHCCCCEEEECCCCH
KRWLARLDNNNAQGEFYITDIIAMAHQEGRQIAAVHPERLSEVEGVNNRLQLSALERAYQ
HHHHHHHCCCCCCCEEEHHHHHHHHHHCCCEEEEECHHHHHHHHCCCCHHHHHHHHHHHH
QQQAQRLLLAGVMLTDPARFDLRGELVHGRDVVIDTNVIIEGKVTLGNRVHIGSGCVLKD
HHHHHHHHHHHEEECCCCCCCEEEEEECCCEEEEECCEEEEEEEEECCEEEECCCCEEEC
CQIADDSVISPYTVIEGARLAQACTVGPFARLRPGACLDAEAHVGNFVEMKKAHLGRGSK
CCCCCCCCCCCHHHHCCCHHHHHHCCCCHHHCCCCCCCCCHHHCCHHHHHHHHHCCCCCC
AGHLSYLGDAEIGAGVNIGAGTITCNYDGANKHQTVIGDDVFVGSDSQLVAPVTVGRGAT
CCCEEEECCCCCCCCCEECCCEEEEECCCCCCCCEEECCEEEECCCCCEEEEEEECCCCE
IAAGTTVTKNVGDGELVLSRVKQVQLSGWERPVKKK
EEECCEEECCCCCHHHHHHHHHHHHHCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA