Click here to switch to the map view.

The map label for this gene is atpB

Identifier: 238921737

GI number: 238921737

Start: 3784782

End: 3785600

Strand: Direct

Name: atpB

Synonym: NT01EI_3906

Alternate gene names: 238921737

Gene position: 3784782-3785600 (Clockwise)

Preceding gene: 238921736

Following gene: 238921738

Centisome position: 99.28

GC content: 52.01

Gene sequence:

>819_bases
ATGTCTGCAGGAGAAATCTCTACGCCACAAGAGTACATCGGTCATCATCTGAACAACCTTCAGTTGGATCTGCGTACTTT
TGAGCTGGTGAATCCGCACGATGGTCCAGCATCTTTCTGGACGCTGAACATCGACTCCATGTTTTTCTCTGTGGTTCTGG
GCCTGATATTTTTGGCTCTGTTCCGTAAGGTCGCCAAGAATGCAACCAGCGGCGTACCGGGTAAGTTTCAGACCGCCGTT
GAGCTGATTATCGGCTTCGTCGATGGCAGTGTGCGCGACATGTATCACGGCAAGAGCAAGCTGATCGCACCGCTGGCTCT
GACCATCTTCGTCTGGGTCTTCCTGATGAACCTGATGGATCTGGTTCCCATCGATTTCCTGCCGTATATCGCTGAGCATT
GGATGGGGCTTCCTGCGCTGCGCGTGGTACCGTCGGCGGATGTCAATATCACCCTGTCGATGGCGCTTGGGGTGTTTATC
CTGATCCTGTTCTACAGCATTAAGATGAAAGGGGTGGGGGGCTTCGTTAAGGAGTTGACTCTGCAGCCGTTCAATCATCC
TGTCTTTATTCCCGTCAACCTGATTCTGGAAGGCGTCAGCCTGTTGTCCAAGCCGGTCTCCCTCGGTTTGCGACTGTTCG
GTAACATGTATGCCGGCGAGCTGATTTTCATCCTGATTGCCGGTCTGTTGCCGTGGTGGTCACAGTGGTTGCTCAACGTT
CCATGGGCTATTTTCCACATCCTGATTATTACGCTTCAAGCCTTTATCTTCATGGTTCTGACGATCGTCTATCTGTCGAT
GGCGTCTGAAGAGCACTGA

Upstream 100 bases:

>100_bases
ACTTACATTGCGGTGCTGGTGGTGCAGGTAGCAGCGCCGGCATTTATTAGTCGTAATTAAAACAGTTACCGTATTAACTA
CTTAAAGGGTAAGAGGCATC

Downstream 100 bases:

>100_bases
TTATTTTTTAACAACACTACTGCGTTTAACTGAAATAAACTGGAGACTGTCATGGAAAACCTGAGTATGGATCTGCTGTA
CATGGCTGCCGCTGTGATGA

Product: ATP synthase F0, A subunit

Products: ADP; phosphate; H+

Alternate protein names: ATP synthase F0 sector subunit a; F-ATPase subunit 6

Number of amino acids: Translated: 272; Mature: 271

Protein sequence:

>272_residues
MSAGEISTPQEYIGHHLNNLQLDLRTFELVNPHDGPASFWTLNIDSMFFSVVLGLIFLALFRKVAKNATSGVPGKFQTAV
ELIIGFVDGSVRDMYHGKSKLIAPLALTIFVWVFLMNLMDLVPIDFLPYIAEHWMGLPALRVVPSADVNITLSMALGVFI
LILFYSIKMKGVGGFVKELTLQPFNHPVFIPVNLILEGVSLLSKPVSLGLRLFGNMYAGELIFILIAGLLPWWSQWLLNV
PWAIFHILIITLQAFIFMVLTIVYLSMASEEH

Sequences:

>Translated_272_residues
MSAGEISTPQEYIGHHLNNLQLDLRTFELVNPHDGPASFWTLNIDSMFFSVVLGLIFLALFRKVAKNATSGVPGKFQTAV
ELIIGFVDGSVRDMYHGKSKLIAPLALTIFVWVFLMNLMDLVPIDFLPYIAEHWMGLPALRVVPSADVNITLSMALGVFI
LILFYSIKMKGVGGFVKELTLQPFNHPVFIPVNLILEGVSLLSKPVSLGLRLFGNMYAGELIFILIAGLLPWWSQWLLNV
PWAIFHILIITLQAFIFMVLTIVYLSMASEEH
>Mature_271_residues
SAGEISTPQEYIGHHLNNLQLDLRTFELVNPHDGPASFWTLNIDSMFFSVVLGLIFLALFRKVAKNATSGVPGKFQTAVE
LIIGFVDGSVRDMYHGKSKLIAPLALTIFVWVFLMNLMDLVPIDFLPYIAEHWMGLPALRVVPSADVNITLSMALGVFIL
ILFYSIKMKGVGGFVKELTLQPFNHPVFIPVNLILEGVSLLSKPVSLGLRLFGNMYAGELIFILIAGLLPWWSQWLLNVP
WAIFHILIITLQAFIFMVLTIVYLSMASEEH

Specific function: Key component of the proton channel; it plays a direct role in the translocation of protons across the membrane

COG id: COG0356

COG function: function code C; F0F1-type ATP synthase, subunit a

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ATPase A chain family

Homologues:

Organism=Escherichia coli, GI1790176, Length=270, Percent_Identity=89.2592592592593, Blast_Score=467, Evalue=1e-133,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): ATP6_EDWI9 (C5BF34)

Other databases:

- EMBL:   CP001600
- RefSeq:   YP_002935252.1
- GeneID:   7961472
- GenomeReviews:   CP001600_GR
- KEGG:   eic:NT01EI_3906
- OMA:   HGHETSA
- ProtClustDB:   CLSK2813768
- HAMAP:   MF_01393
- InterPro:   IPR000568
- InterPro:   IPR023011
- Gene3D:   G3DSA:1.20.120.220
- PANTHER:   PTHR11410
- PRINTS:   PR00123
- TIGRFAMs:   TIGR01131

Pfam domain/function: PF00119 ATP-synt_A; SSF81336 ATPase_F0_A

EC number: 3.6.3.14

Molecular weight: Translated: 30417; Mature: 30286

Theoretical pI: Translated: 6.51; Mature: 6.51

Prosite motif: PS00449 ATPASE_A

Important sites: NA

Signals:

None

Transmembrane regions:

HASH(0x20dc8ac4)-; HASH(0x1a27c8e8)-; HASH(0x20823600)-; HASH(0x2044e660)-; HASH(0x20ac9814)-;

Cys/Met content:

0.0 %Cys     (Translated Protein)
4.0 %Met     (Translated Protein)
4.0 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
3.7 %Met     (Mature Protein)
3.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSAGEISTPQEYIGHHLNNLQLDLRTFELVNPHDGPASFWTLNIDSMFFSVVLGLIFLAL
CCCCCCCCCHHHHHHHHCCCEEEHHHEEEECCCCCCCCEEEEEHHHHHHHHHHHHHHHHH
FRKVAKNATSGVPGKFQTAVELIIGFVDGSVRDMYHGKSKLIAPLALTIFVWVFLMNLMD
HHHHHHHCCCCCCCHHHHHHHHHHHHHCCHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHH
LVPIDFLPYIAEHWMGLPALRVVPSADVNITLSMALGVFILILFYSIKMKGVGGFVKELT
HCCHHHHHHHHHHHCCCCHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCHHHHHHH
LQPFNHPVFIPVNLILEGVSLLSKPVSLGLRLFGNMYAGELIFILIAGLLPWWSQWLLNV
CCCCCCCEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHC
PWAIFHILIITLQAFIFMVLTIVYLSMASEEH
CHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCH
>Mature Secondary Structure 
SAGEISTPQEYIGHHLNNLQLDLRTFELVNPHDGPASFWTLNIDSMFFSVVLGLIFLAL
CCCCCCCCHHHHHHHHCCCEEEHHHEEEECCCCCCCCEEEEEHHHHHHHHHHHHHHHHH
FRKVAKNATSGVPGKFQTAVELIIGFVDGSVRDMYHGKSKLIAPLALTIFVWVFLMNLMD
HHHHHHHCCCCCCCHHHHHHHHHHHHHCCHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHH
LVPIDFLPYIAEHWMGLPALRVVPSADVNITLSMALGVFILILFYSIKMKGVGGFVKELT
HCCHHHHHHHHHHHCCCCHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCHHHHHHH
LQPFNHPVFIPVNLILEGVSLLSKPVSLGLRLFGNMYAGELIFILIAGLLPWWSQWLLNV
CCCCCCCEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHC
PWAIFHILIITLQAFIFMVLTIVYLSMASEEH
CHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCH

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: Borate; diphosphate; HCO3- [C]

Metal ions: Co2+; Fe2+; Mn2+; Zn2+ [C]

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: ATP; H2O; H+

Specific reaction: ATP + H2O + H+(in) = ADP + phosphate + H+(out)

General reaction: Phosphorous acid anhydride hydrolysis [C]

Inhibitor: Ca2+; CN-; Efrapeptin; Ethidiumbromide; Guanidines analogs; Oligomycin; Quercetin; Trialkyl tin derivatives; Venturicidin [C]

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: NA