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The map label for this gene is fabR [H]

Identifier: 238921677

GI number: 238921677

Start: 3718906

End: 3719577

Strand: Reverse

Name: fabR [H]

Synonym: NT01EI_3838

Alternate gene names: 238921677

Gene position: 3719577-3718906 (Counterclockwise)

Preceding gene: 238921680

Following gene: 238921676

Centisome position: 97.57

GC content: 57.89

Gene sequence:

>672_bases
ATGGGCGTCAGGGCACAGCAAAAGGAACGGACTCGTCGTTCACTGATTGAGGCGGCATTTAATCAGCTCAGCGCTGAGCG
CAGCTTCGCCAGCCTGAGCCTGCGAGAGGTTTCGCGTGAGGCGGGGATCGCGCCCACGTCGTTTTATCGCCATTTTCGTG
ATGTGGATGAGCTGGGACTCACCATGGTGGACGAAAGCGGCCTGATGCTGCGTCAGCTGATGCGTCAGGCGCGTCAGCGT
ATCGCGAAGGGCGGCAGTGTGATCCGTACCTCGGTCGCGACCTTCATGGAGTTTATCGGTAATAATCCCAATGCGTTTCG
TCTGCTGCTGCGCGAGCGATCTGGAACTTCGGCCGCTTTTCGCGCCGCGGTACAGCGTGAAATTCAGCATTTTATTGCGG
AACTTGCCGACTATCTGGAAATCGAAAATCACATGCCGCGCAGCTTTACGGAAGCGCAGGCCGAGGCGATGGTCACCATT
GTCTTCAGCGCAGGTGCCGAGGCGTTAGATATCGACAGTGAGCAGCGCCGTCAGTTAGAGGAGCGCCTGGTGCTGCAGCT
GCGAATGATTTCCAAAGGGGTGTACTACTGGTATCGCCGCGAGCAGGAGAAAGCGCACTTGGTGCAGGCCGCAGCGACGG
CTATCGACGGCGGACATCATCACAAGTCATAG

Upstream 100 bases:

>100_bases
TAATTCAGCGTGACAGAGCTAAGTTTGGTATAGTGAGGCGGTGGTAGCCTATAAAGGCGCCGGCCGTAAAGCCGAACATG
AAGAGAATAATGGATAGAAT

Downstream 100 bases:

>100_bases
GGGAGGAGATGCGTAAACATCGTCTTGATATCGGAACATTGATCCTGTCAGCCGTGGCAGGGTTATCCATCAGCGGATCG
GAGCCTGTACATAAATTTGT

Product: DNA-binding transcriptional repressor FabR

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 223; Mature: 222

Protein sequence:

>223_residues
MGVRAQQKERTRRSLIEAAFNQLSAERSFASLSLREVSREAGIAPTSFYRHFRDVDELGLTMVDESGLMLRQLMRQARQR
IAKGGSVIRTSVATFMEFIGNNPNAFRLLLRERSGTSAAFRAAVQREIQHFIAELADYLEIENHMPRSFTEAQAEAMVTI
VFSAGAEALDIDSEQRRQLEERLVLQLRMISKGVYYWYRREQEKAHLVQAAATAIDGGHHHKS

Sequences:

>Translated_223_residues
MGVRAQQKERTRRSLIEAAFNQLSAERSFASLSLREVSREAGIAPTSFYRHFRDVDELGLTMVDESGLMLRQLMRQARQR
IAKGGSVIRTSVATFMEFIGNNPNAFRLLLRERSGTSAAFRAAVQREIQHFIAELADYLEIENHMPRSFTEAQAEAMVTI
VFSAGAEALDIDSEQRRQLEERLVLQLRMISKGVYYWYRREQEKAHLVQAAATAIDGGHHHKS
>Mature_222_residues
GVRAQQKERTRRSLIEAAFNQLSAERSFASLSLREVSREAGIAPTSFYRHFRDVDELGLTMVDESGLMLRQLMRQARQRI
AKGGSVIRTSVATFMEFIGNNPNAFRLLLRERSGTSAAFRAAVQREIQHFIAELADYLEIENHMPRSFTEAQAEAMVTIV
FSAGAEALDIDSEQRRQLEERLVLQLRMISKGVYYWYRREQEKAHLVQAAATAIDGGHHHKS

Specific function: Represses the transcription of fabB, involved in unsaturated fatty acid (UFA) biosynthesis. By controlling UFA production, fabR directly influences the physical properties of the membrane bilayer [H]

COG id: COG1309

COG function: function code K; Transcriptional regulator

Gene ontology:

Cell location: Cytoplasmic [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 HTH tetR-type DNA-binding domain [H]

Homologues:

Organism=Escherichia coli, GI145693209, Length=208, Percent_Identity=92.3076923076923, Blast_Score=394, Evalue=1e-111,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR009057
- InterPro:   IPR015893
- InterPro:   IPR001647 [H]

Pfam domain/function: PF00440 TetR_N [H]

EC number: NA

Molecular weight: Translated: 25399; Mature: 25268

Theoretical pI: Translated: 9.77; Mature: 9.77

Prosite motif: PS50977 HTH_TETR_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
3.6 %Met     (Translated Protein)
3.6 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
3.2 %Met     (Mature Protein)
3.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MGVRAQQKERTRRSLIEAAFNQLSAERSFASLSLREVSREAGIAPTSFYRHFRDVDELGL
CCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHCC
TMVDESGLMLRQLMRQARQRIAKGGSVIRTSVATFMEFIGNNPNAFRLLLRERSGTSAAF
EEECCCCHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHCCCCHHHHHHHHHCCCCHHHH
RAAVQREIQHFIAELADYLEIENHMPRSFTEAQAEAMVTIVFSAGAEALDIDSEQRRQLE
HHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHH
ERLVLQLRMISKGVYYWYRREQEKAHLVQAAATAIDGGHHHKS
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCC
>Mature Secondary Structure 
GVRAQQKERTRRSLIEAAFNQLSAERSFASLSLREVSREAGIAPTSFYRHFRDVDELGL
CCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHCC
TMVDESGLMLRQLMRQARQRIAKGGSVIRTSVATFMEFIGNNPNAFRLLLRERSGTSAAF
EEECCCCHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHCCCCHHHHHHHHHCCCCHHHH
RAAVQREIQHFIAELADYLEIENHMPRSFTEAQAEAMVTIVFSAGAEALDIDSEQRRQLE
HHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHH
ERLVLQLRMISKGVYYWYRREQEKAHLVQAAATAIDGGHHHKS
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA