Click here to switch to the map view.

The map label for this gene is cytR [H]

Identifier: 238921646

GI number: 238921646

Start: 3680802

End: 3681821

Strand: Reverse

Name: cytR [H]

Synonym: NT01EI_3801

Alternate gene names: 238921646

Gene position: 3681821-3680802 (Counterclockwise)

Preceding gene: 238921647

Following gene: 238921645

Centisome position: 96.58

GC content: 58.33

Gene sequence:

>1020_bases
TTGGAAGAGAAGCAAATGAACGCCACCATGAAAGATGTGGCGGAGTATGCCGGCGTATCAACCGCAACGGTATCGCGAGC
GCTGATGAATCCAGAGAAGGTGTCGGCCGCCACGCGACAAAAGGTAGAGCAGGCTGCTTTAGCCGTCGGATATGCCCCTC
ATACGCTGACCCGCAGTAACAAGCGCGGTGAGTCACGCACTATCCTGGTGATCGTCCCGGACATCTGCGATCCGTTTTTT
GCTGAAGTGATCCAGGGGATCGAGCGTACCGCCGCCGAGCACGGCTATCTGGTTCTGCTCGGCGACTGCGCTCAGCAGAT
ACAGCAGGAAAAAACTTTCGTTAACCTGATCATCACCAAGCAGATCGATGGCATGCTGCTGCTTGGATCCAATATCCCCT
TCGATGCCAGTAAGGAAGAACAGCGCAATCTACCACCCATGGTGATGGCCAATGAGTTTGCGCCGGAGCTGGAGCTGCCG
ACGGTGCATATTGACAACCTGACCGCCGCCTTCAAGGCCGTGCTCTATCTGCATGATCTGGGCCACCAGCGGATAGGCTG
CCTCGCCGGTCCAGAGCACATGCCGCTGAGCCAATACCGCCTGCAGGGATATATCCAGGCGTTACGCCGCTGTGGCCTCA
GCGAAACGGGCTACGTAGCGCATGGCGATTTTACCTTCGAGGCCGGCGCCAAGGCGCTGGCGCAGGTGATGGCGCAGCCG
CAGCCACCCACGGCACTGTTTTGTCACAGCGATGTGATGGCGATAGGCGCGTTGTCACAGGCGAAGCGGCTTGGGATCAA
GGTGCCAGAGGAGCTGTCTATCATCGGTTTCGATGACATCCGATTGGCGCAGTACGCCGATCCACCGCTGACAACTGTGG
CGCAGCCCCGCTATCAGATTGGCCGAGAGGCTATGCTGCTATTGCTGGAGCAGCTACATCACCATCGTGTGGTCAGCGGT
TCGTGCCTGCTGGAGAGCGAACTCATCATCCGCGGTAGTACGGCTGTTCCGAAACGCTAG

Upstream 100 bases:

>100_bases
GAACAGAGCTATCGCTGGCGCAATCGTTACCTTCGCCGCGGGATAATGATCGGGAAGTCATATCATCGCGCCAGCATGGA
CTGACGCAAGGAGAAACGCG

Downstream 100 bases:

>100_bases
TGAATTGAATCCGAGTTCAGTAACATGGCGTTCTGATATTGACTATTCAGTTGTAGTGAAACGACAGTGGCACAAAGAGA
CTATGTGAGCAGTGGGCGCG

Product: DNA-binding transcriptional regulator CytR

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 339; Mature: 339

Protein sequence:

>339_residues
MEEKQMNATMKDVAEYAGVSTATVSRALMNPEKVSAATRQKVEQAALAVGYAPHTLTRSNKRGESRTILVIVPDICDPFF
AEVIQGIERTAAEHGYLVLLGDCAQQIQQEKTFVNLIITKQIDGMLLLGSNIPFDASKEEQRNLPPMVMANEFAPELELP
TVHIDNLTAAFKAVLYLHDLGHQRIGCLAGPEHMPLSQYRLQGYIQALRRCGLSETGYVAHGDFTFEAGAKALAQVMAQP
QPPTALFCHSDVMAIGALSQAKRLGIKVPEELSIIGFDDIRLAQYADPPLTTVAQPRYQIGREAMLLLLEQLHHHRVVSG
SCLLESELIIRGSTAVPKR

Sequences:

>Translated_339_residues
MEEKQMNATMKDVAEYAGVSTATVSRALMNPEKVSAATRQKVEQAALAVGYAPHTLTRSNKRGESRTILVIVPDICDPFF
AEVIQGIERTAAEHGYLVLLGDCAQQIQQEKTFVNLIITKQIDGMLLLGSNIPFDASKEEQRNLPPMVMANEFAPELELP
TVHIDNLTAAFKAVLYLHDLGHQRIGCLAGPEHMPLSQYRLQGYIQALRRCGLSETGYVAHGDFTFEAGAKALAQVMAQP
QPPTALFCHSDVMAIGALSQAKRLGIKVPEELSIIGFDDIRLAQYADPPLTTVAQPRYQIGREAMLLLLEQLHHHRVVSG
SCLLESELIIRGSTAVPKR
>Mature_339_residues
MEEKQMNATMKDVAEYAGVSTATVSRALMNPEKVSAATRQKVEQAALAVGYAPHTLTRSNKRGESRTILVIVPDICDPFF
AEVIQGIERTAAEHGYLVLLGDCAQQIQQEKTFVNLIITKQIDGMLLLGSNIPFDASKEEQRNLPPMVMANEFAPELELP
TVHIDNLTAAFKAVLYLHDLGHQRIGCLAGPEHMPLSQYRLQGYIQALRRCGLSETGYVAHGDFTFEAGAKALAQVMAQP
QPPTALFCHSDVMAIGALSQAKRLGIKVPEELSIIGFDDIRLAQYADPPLTTVAQPRYQIGREAMLLLLEQLHHHRVVSG
SCLLESELIIRGSTAVPKR

Specific function: This protein negatively controls the transcription initiation of genes such as deoCABD, udp, and cdd encoding catabolizing enzymes and nupC, nupG, and tsx encoding transporting and pore-forming proteins. Binds cytidine and adenosine as effectors [H]

COG id: COG1609

COG function: function code K; Transcriptional regulators

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 HTH lacI-type DNA-binding domain [H]

Homologues:

Organism=Escherichia coli, GI1790369, Length=334, Percent_Identity=74.251497005988, Blast_Score=514, Evalue=1e-147,
Organism=Escherichia coli, GI1787948, Length=332, Percent_Identity=33.1325301204819, Blast_Score=201, Evalue=8e-53,
Organism=Escherichia coli, GI1790194, Length=329, Percent_Identity=34.9544072948328, Blast_Score=196, Evalue=2e-51,
Organism=Escherichia coli, GI1788474, Length=303, Percent_Identity=33.6633663366337, Blast_Score=168, Evalue=5e-43,
Organism=Escherichia coli, GI1789202, Length=290, Percent_Identity=33.1034482758621, Blast_Score=167, Evalue=1e-42,
Organism=Escherichia coli, GI1789068, Length=344, Percent_Identity=31.1046511627907, Blast_Score=137, Evalue=9e-34,
Organism=Escherichia coli, GI48994940, Length=301, Percent_Identity=29.9003322259136, Blast_Score=136, Evalue=2e-33,
Organism=Escherichia coli, GI1786540, Length=336, Percent_Identity=27.9761904761905, Blast_Score=119, Evalue=3e-28,
Organism=Escherichia coli, GI1790715, Length=315, Percent_Identity=25.7142857142857, Blast_Score=114, Evalue=9e-27,
Organism=Escherichia coli, GI1787580, Length=324, Percent_Identity=27.1604938271605, Blast_Score=114, Evalue=1e-26,
Organism=Escherichia coli, GI1787906, Length=337, Percent_Identity=24.9258160237389, Blast_Score=103, Evalue=2e-23,
Organism=Escherichia coli, GI1789456, Length=337, Percent_Identity=26.4094955489614, Blast_Score=93, Evalue=2e-20,
Organism=Escherichia coli, GI1786268, Length=312, Percent_Identity=23.7179487179487, Blast_Score=72, Evalue=5e-14,
Organism=Escherichia coli, GI1790689, Length=312, Percent_Identity=25.9615384615385, Blast_Score=68, Evalue=7e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000843
- InterPro:   IPR010982
- InterPro:   IPR001761 [H]

Pfam domain/function: PF00356 LacI; PF00532 Peripla_BP_1 [H]

EC number: NA

Molecular weight: Translated: 37206; Mature: 37206

Theoretical pI: Translated: 6.44; Mature: 6.44

Prosite motif: PS00356 HTH_LACI_1 ; PS50932 HTH_LACI_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.8 %Cys     (Translated Protein)
3.2 %Met     (Translated Protein)
5.0 %Cys+Met (Translated Protein)
1.8 %Cys     (Mature Protein)
3.2 %Met     (Mature Protein)
5.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MEEKQMNATMKDVAEYAGVSTATVSRALMNPEKVSAATRQKVEQAALAVGYAPHTLTRSN
CCCHHHHHHHHHHHHHCCCHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHCCCCCHHCCCC
KRGESRTILVIVPDICDPFFAEVIQGIERTAAEHGYLVLLGDCAQQIQQEKTFVNLIITK
CCCCCCEEEEEECCCCCHHHHHHHHHHHHHHHHCCEEEEEHHHHHHHHHHHHHEEEEEEE
QIDGMLLLGSNIPFDASKEEQRNLPPMVMANEFAPELELPTVHIDNLTAAFKAVLYLHDL
CCCCEEEECCCCCCCCCCHHHHCCCCEEEECCCCCCCCCCEEEECHHHHHHHHHHHHHHH
GHQRIGCLAGPEHMPLSQYRLQGYIQALRRCGLSETGYVAHGDFTFEAGAKALAQVMAQP
CCCCEECCCCCCCCCHHHHHHHHHHHHHHHCCCCCCCEEEECCEEHHHHHHHHHHHHCCC
QPPTALFCHSDVMAIGALSQAKRLGIKVPEELSIIGFDDIRLAQYADPPLTTVAQPRYQI
CCCCEEEECCHHHHHHHHHHHHHCCCCCCCCCEEEECCCEEHHHCCCCCCCHHCCCHHHH
GREAMLLLLEQLHHHRVVSGSCLLESELIIRGSTAVPKR
HHHHHHHHHHHHHHHCCCCCCEEEECCEEEECCCCCCCC
>Mature Secondary Structure
MEEKQMNATMKDVAEYAGVSTATVSRALMNPEKVSAATRQKVEQAALAVGYAPHTLTRSN
CCCHHHHHHHHHHHHHCCCHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHCCCCCHHCCCC
KRGESRTILVIVPDICDPFFAEVIQGIERTAAEHGYLVLLGDCAQQIQQEKTFVNLIITK
CCCCCCEEEEEECCCCCHHHHHHHHHHHHHHHHCCEEEEEHHHHHHHHHHHHHEEEEEEE
QIDGMLLLGSNIPFDASKEEQRNLPPMVMANEFAPELELPTVHIDNLTAAFKAVLYLHDL
CCCCEEEECCCCCCCCCCHHHHCCCCEEEECCCCCCCCCCEEEECHHHHHHHHHHHHHHH
GHQRIGCLAGPEHMPLSQYRLQGYIQALRRCGLSETGYVAHGDFTFEAGAKALAQVMAQP
CCCCEECCCCCCCCCHHHHHHHHHHHHHHHCCCCCCCEEEECCEEHHHHHHHHHHHHCCC
QPPTALFCHSDVMAIGALSQAKRLGIKVPEELSIIGFDDIRLAQYADPPLTTVAQPRYQI
CCCCEEEECCHHHHHHHHHHHHHCCCCCCCCCEEEECCCEEHHHCCCCCCCHHCCCHHHH
GREAMLLLLEQLHHHRVVSGSCLLESELIIRGSTAVPKR
HHHHHHHHHHHHHHHCCCCCCEEEECCEEEECCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]