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The map label for this gene is menA [H]

Identifier: 238921642

GI number: 238921642

Start: 3676727

End: 3677644

Strand: Reverse

Name: menA [H]

Synonym: NT01EI_3797

Alternate gene names: 238921642

Gene position: 3677644-3676727 (Counterclockwise)

Preceding gene: 238921643

Following gene: 238921641

Centisome position: 96.47

GC content: 59.15

Gene sequence:

>918_bases
ATGACTTCATTAACCCCGATCAGCCGGCCTCGAGCCTGGCTGGAAAGCCTGCGTCTGCGTACGCTGCCGCTGGCGCTGGC
ATCGATAGTGACCGGATCGGCCATCGCCGCTTGGCAGCAAACCTTTAATCTCGGCATCGCTCTGCTCGCGCTGCTGACGG
CGGCGCTGTTGCAGATCCTCTCCAATCTGGCCAACGACTACGGCGACGCCGTCAAGGGCAGTGATACCCCGGAGCGCATT
GGGCCGCTGCGCGGTATGCAAAAAGGTGTGATCACCCAGGCTCAGATGAAGCGGGCCTTGATCATCACCGTGCTGCTGAC
CATCGCCTCCGGCGTCGCGCTGATCGCCGTCGCCTGCCAAAAACCCCAGGATATCATTGGATTCTTGTTACTCGGCCTGA
TGGCTATCATCGCCGCCATCACTTACACCGTCGGTACCCGGCCCTATGGCTATATCGGCCTAGGCGATATCTCGGTGCTG
ATCTTTTTTGGCTGGCTGAGCGTTGCCGGTACCTACTACCTGCAGGCGGGCACCTTTAACCGCGTGGTGATGCTACCGGC
AACGGCCTGCGGTCTGTTGGCCGCGGCGGTACTGAATATCAATAACCTGCGGGATATCGAAAACGATGCCCGCAACGGTA
AAAACACCCTGGCTGTACGCCTGGGGCCACACATCGCCCGCTACTACCACGTAGCCCTGCTGGGCGGCGCGGTACTGTGT
CTGGCACTGTTTGCCCTGTTAGATCTGCATAGTCTGGTGGGCTGGCTATTTGTGCTGGCTGTTCCCATGCTGTACCGCCA
TGCCAGCTATGTCCTGCACCAACGCTCGCCGGAGGCCATGCGGCCCATGTTGGAAAATATGGTGAAAAGCGCCCTATTGA
CCAATCTGCTCTTTGCCATCGGTACCGTACTGAGTTAA

Upstream 100 bases:

>100_bases
ACAGCTAACGGTTTGTTAAGATAAACACATGAGATAACCCGGCAACGGGCCGTTCAGCGCATTGCTGAGGGTCGCATGCC
CTAGTGACTGAAACCATATA

Downstream 100 bases:

>100_bases
TCCCTTTTGCAGCAGTATCCCCCGCGTTTCACGCGGGGGATACTGCTGCTTTTGCAAACAGCCACATTAAAGGGATATAC
TGATACCCCCCTGCGGCAAC

Product: 1,4-dihydroxy-2-naphthoate octaprenyltransferase

Products: NA

Alternate protein names: DHNA-octaprenyltransferase [H]

Number of amino acids: Translated: 305; Mature: 304

Protein sequence:

>305_residues
MTSLTPISRPRAWLESLRLRTLPLALASIVTGSAIAAWQQTFNLGIALLALLTAALLQILSNLANDYGDAVKGSDTPERI
GPLRGMQKGVITQAQMKRALIITVLLTIASGVALIAVACQKPQDIIGFLLLGLMAIIAAITYTVGTRPYGYIGLGDISVL
IFFGWLSVAGTYYLQAGTFNRVVMLPATACGLLAAAVLNINNLRDIENDARNGKNTLAVRLGPHIARYYHVALLGGAVLC
LALFALLDLHSLVGWLFVLAVPMLYRHASYVLHQRSPEAMRPMLENMVKSALLTNLLFAIGTVLS

Sequences:

>Translated_305_residues
MTSLTPISRPRAWLESLRLRTLPLALASIVTGSAIAAWQQTFNLGIALLALLTAALLQILSNLANDYGDAVKGSDTPERI
GPLRGMQKGVITQAQMKRALIITVLLTIASGVALIAVACQKPQDIIGFLLLGLMAIIAAITYTVGTRPYGYIGLGDISVL
IFFGWLSVAGTYYLQAGTFNRVVMLPATACGLLAAAVLNINNLRDIENDARNGKNTLAVRLGPHIARYYHVALLGGAVLC
LALFALLDLHSLVGWLFVLAVPMLYRHASYVLHQRSPEAMRPMLENMVKSALLTNLLFAIGTVLS
>Mature_304_residues
TSLTPISRPRAWLESLRLRTLPLALASIVTGSAIAAWQQTFNLGIALLALLTAALLQILSNLANDYGDAVKGSDTPERIG
PLRGMQKGVITQAQMKRALIITVLLTIASGVALIAVACQKPQDIIGFLLLGLMAIIAAITYTVGTRPYGYIGLGDISVLI
FFGWLSVAGTYYLQAGTFNRVVMLPATACGLLAAAVLNINNLRDIENDARNGKNTLAVRLGPHIARYYHVALLGGAVLCL
ALFALLDLHSLVGWLFVLAVPMLYRHASYVLHQRSPEAMRPMLENMVKSALLTNLLFAIGTVLS

Specific function: Conversion of 1,4-dihydroxy-2-naphthoate (DHNA) to dimethylmenaquinone (DMK). Attaches octaprenylpyrophosphate, a membrane-bound 40-carbon side chain to DHNA. The conversion of DHNA to DMK proceeds in three stages:the removal of the carboxyl group of DHNA

COG id: COG1575

COG function: function code H; 1,4-dihydroxy-2-naphthoate octaprenyltransferase

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the menA family [H]

Homologues:

Organism=Homo sapiens, GI7019551, Length=297, Percent_Identity=25.9259259259259, Blast_Score=65, Evalue=6e-11,
Organism=Escherichia coli, GI1790365, Length=299, Percent_Identity=69.5652173913043, Blast_Score=410, Evalue=1e-116,
Organism=Drosophila melanogaster, GI17737429, Length=215, Percent_Identity=28.3720930232558, Blast_Score=77, Evalue=2e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004657
- InterPro:   IPR000537 [H]

Pfam domain/function: PF01040 UbiA [H]

EC number: =2.5.1.74 [H]

Molecular weight: Translated: 32747; Mature: 32615

Theoretical pI: Translated: 9.98; Mature: 9.98

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
3.0 %Met     (Translated Protein)
3.9 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
3.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTSLTPISRPRAWLESLRLRTLPLALASIVTGSAIAAWQQTFNLGIALLALLTAALLQIL
CCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
SNLANDYGDAVKGSDTPERIGPLRGMQKGVITQAQMKRALIITVLLTIASGVALIAVACQ
HHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHC
KPQDIIGFLLLGLMAIIAAITYTVGTRPYGYIGLGDISVLIFFGWLSVAGTYYLQAGTFN
CHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEHHHHHHHHHHHHHHHHHHHHEECCCCC
RVVMLPATACGLLAAAVLNINNLRDIENDARNGKNTLAVRLGPHIARYYHVALLGGAVLC
CEEEEHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEEECHHHHHHHHHHHHHHHHHH
LALFALLDLHSLVGWLFVLAVPMLYRHASYVLHQRSPEAMRPMLENMVKSALLTNLLFAI
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHH
GTVLS
HHHCC
>Mature Secondary Structure 
TSLTPISRPRAWLESLRLRTLPLALASIVTGSAIAAWQQTFNLGIALLALLTAALLQIL
CCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
SNLANDYGDAVKGSDTPERIGPLRGMQKGVITQAQMKRALIITVLLTIASGVALIAVACQ
HHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHC
KPQDIIGFLLLGLMAIIAAITYTVGTRPYGYIGLGDISVLIFFGWLSVAGTYYLQAGTFN
CHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEHHHHHHHHHHHHHHHHHHHHEECCCCC
RVVMLPATACGLLAAAVLNINNLRDIENDARNGKNTLAVRLGPHIARYYHVALLGGAVLC
CEEEEHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEEECHHHHHHHHHHHHHHHHHH
LALFALLDLHSLVGWLFVLAVPMLYRHASYVLHQRSPEAMRPMLENMVKSALLTNLLFAI
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHH
GTVLS
HHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 9573170; 8346018; 9278503 [H]