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The map label for this gene is gor [H]

Identifier: 238921588

GI number: 238921588

Start: 3626966

End: 3628318

Strand: Direct

Name: gor [H]

Synonym: NT01EI_3741

Alternate gene names: 238921588

Gene position: 3626966-3628318 (Clockwise)

Preceding gene: 238921587

Following gene: 238921591

Centisome position: 95.14

GC content: 60.24

Gene sequence:

>1353_bases
ATGACTAAACATTATGACTATCTCGCCATCGGCGGCGGCAGCGGCGGTATCGCCTCCATCAATCGGGCGGCGATGTACGG
CCGCAAGTGTGCGCTGATCGAAGCCAAAGCGCTGGGCGGCACCTGCGTCAACGTGGGCTGCGTTCCGAAGAAAGTGATGT
GGCACGCCGCGCAGATCGCTGAAGCCATCAAACTATATGGCCCGGATTATGGTTTTGACACCACGCTCAACCGTTTCGAC
TGGCAGCGCCTGATCGACAGCCGCAGCGCCTATATTGAGCGTATTCATCAGTCCTATCAGCGCGGTCTGGGAAATAACAA
AGTCGACGTTATCCAGGGAGTTACCACCTTTATTGACGCCCACACGATCGATGTCAACGGCGAGCGTATCAGCGCCGACC
ATATCCTCATCGCCTCCGGGGGACGGCCAGCGCACCCGGATATCCCGGGCGCAGAATATGGCATCGACTCCGACGGATTC
TTTGCCCTTGACGCGCTGCCACAGCGCGTCGCCATCGTCGGCGCCGGTTATATCGCGGTCGAGATCGCCGGGGTGCTCAA
CGCGTTGGGCGCAGAAACCCACCTGTTCGTCCGCAGGCATGCGCCGCTACGCAGCTTTGACAGCCTGATCGTCGATACCC
TGTTGGAGGTGATGCACAGCGAAGGGCCTCAGCTGCATACCCACAGCGTGCCGCAGTCAGTGGTTAAAAATGCGGACGGC
AGCCTGACGCTGATGCTGGAAAACGGCCATAGCCAGACCGTCGATTGTCTGATCTGGGCCATTGGCCGCGATCCGAATAC
CGACCGCCTCAATCTGGGGGCTGCCGGGGTCACTACCGACGCCAACGGCTATATTCCGGTTGATGCGTTCCAGAATACCA
ACGTTCCCGGCATCTACGCCGTCGGGGACAATACCGGCGCCGTCGAGCTGACGCCGGTCGCTGTCGCCGCCGGGCGCCGC
CTCTCTGAGCGTCTGTTCAACAATAAGCCGCAGGAGCACCTGGATTACAGCAATATCCCCACCGTGGTCTTCAGCCACCC
GCCGATCGGCACCGTGGGACTGAGCGAAGCGCAGGCGCGTGCGCAGTACGGCGATGAACAGATTAAGGTCTACACCTCCT
CATTTACCGCCATGTATAGCGCGGTCACCCAGCACCGTCAGCCGTGTCGCATGAAGCTGGTGTGCCAGGGGGCGGATGAA
CGGATCGTCGGGATCCACGGGATCGGCTTCGGTATGGATGAAATGCTGCAGGGCTTCGCCGTGGCGCTGAAGATGGGCGC
CACTAAGCGGGACTTTGACAATACCGTGGCCATCCATCCGACGGCCTCTGAAGAGTTTGTTACCATGCGTTAA

Upstream 100 bases:

>100_bases
CGGAGCAATCCTGCAATAGCCGCGGTATCTCGCCATCCTGCCTCCGGCAGAGAGGCATTGCGGGGCAAATCCGATTTGTT
GATAACGCGAAGACATCCCT

Downstream 100 bases:

>100_bases
CCCGATGTCACGCTACGGGCCAGCCCTCGCCGGCCCGTATGGCGTTGGCACGCTTATGCCGGGCGCGACGCCTGACTCTC
TGGCAATGTAAATAGGGCAA

Product: glutathione reductase

Products: NA

Alternate protein names: GR; GRase [H]

Number of amino acids: Translated: 450; Mature: 449

Protein sequence:

>450_residues
MTKHYDYLAIGGGSGGIASINRAAMYGRKCALIEAKALGGTCVNVGCVPKKVMWHAAQIAEAIKLYGPDYGFDTTLNRFD
WQRLIDSRSAYIERIHQSYQRGLGNNKVDVIQGVTTFIDAHTIDVNGERISADHILIASGGRPAHPDIPGAEYGIDSDGF
FALDALPQRVAIVGAGYIAVEIAGVLNALGAETHLFVRRHAPLRSFDSLIVDTLLEVMHSEGPQLHTHSVPQSVVKNADG
SLTLMLENGHSQTVDCLIWAIGRDPNTDRLNLGAAGVTTDANGYIPVDAFQNTNVPGIYAVGDNTGAVELTPVAVAAGRR
LSERLFNNKPQEHLDYSNIPTVVFSHPPIGTVGLSEAQARAQYGDEQIKVYTSSFTAMYSAVTQHRQPCRMKLVCQGADE
RIVGIHGIGFGMDEMLQGFAVALKMGATKRDFDNTVAIHPTASEEFVTMR

Sequences:

>Translated_450_residues
MTKHYDYLAIGGGSGGIASINRAAMYGRKCALIEAKALGGTCVNVGCVPKKVMWHAAQIAEAIKLYGPDYGFDTTLNRFD
WQRLIDSRSAYIERIHQSYQRGLGNNKVDVIQGVTTFIDAHTIDVNGERISADHILIASGGRPAHPDIPGAEYGIDSDGF
FALDALPQRVAIVGAGYIAVEIAGVLNALGAETHLFVRRHAPLRSFDSLIVDTLLEVMHSEGPQLHTHSVPQSVVKNADG
SLTLMLENGHSQTVDCLIWAIGRDPNTDRLNLGAAGVTTDANGYIPVDAFQNTNVPGIYAVGDNTGAVELTPVAVAAGRR
LSERLFNNKPQEHLDYSNIPTVVFSHPPIGTVGLSEAQARAQYGDEQIKVYTSSFTAMYSAVTQHRQPCRMKLVCQGADE
RIVGIHGIGFGMDEMLQGFAVALKMGATKRDFDNTVAIHPTASEEFVTMR
>Mature_449_residues
TKHYDYLAIGGGSGGIASINRAAMYGRKCALIEAKALGGTCVNVGCVPKKVMWHAAQIAEAIKLYGPDYGFDTTLNRFDW
QRLIDSRSAYIERIHQSYQRGLGNNKVDVIQGVTTFIDAHTIDVNGERISADHILIASGGRPAHPDIPGAEYGIDSDGFF
ALDALPQRVAIVGAGYIAVEIAGVLNALGAETHLFVRRHAPLRSFDSLIVDTLLEVMHSEGPQLHTHSVPQSVVKNADGS
LTLMLENGHSQTVDCLIWAIGRDPNTDRLNLGAAGVTTDANGYIPVDAFQNTNVPGIYAVGDNTGAVELTPVAVAAGRRL
SERLFNNKPQEHLDYSNIPTVVFSHPPIGTVGLSEAQARAQYGDEQIKVYTSSFTAMYSAVTQHRQPCRMKLVCQGADER
IVGIHGIGFGMDEMLQGFAVALKMGATKRDFDNTVAIHPTASEEFVTMR

Specific function: Maintains high levels of reduced glutathione in the cytosol [H]

COG id: COG1249

COG function: function code C; Pyruvate/2-oxoglutarate dehydrogenase complex, dihydrolipoamide dehydrogenase (E3) component, and related enzymes

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family [H]

Homologues:

Organism=Homo sapiens, GI50301238, Length=459, Percent_Identity=53.3769063180828, Blast_Score=464, Evalue=1e-131,
Organism=Homo sapiens, GI22035672, Length=474, Percent_Identity=38.6075949367089, Blast_Score=276, Evalue=2e-74,
Organism=Homo sapiens, GI33519430, Length=457, Percent_Identity=36.3238512035011, Blast_Score=258, Evalue=9e-69,
Organism=Homo sapiens, GI33519428, Length=457, Percent_Identity=36.3238512035011, Blast_Score=258, Evalue=9e-69,
Organism=Homo sapiens, GI33519426, Length=457, Percent_Identity=36.3238512035011, Blast_Score=258, Evalue=9e-69,
Organism=Homo sapiens, GI148277065, Length=457, Percent_Identity=36.3238512035011, Blast_Score=258, Evalue=9e-69,
Organism=Homo sapiens, GI148277071, Length=457, Percent_Identity=36.3238512035011, Blast_Score=258, Evalue=9e-69,
Organism=Homo sapiens, GI291045266, Length=459, Percent_Identity=32.6797385620915, Blast_Score=235, Evalue=8e-62,
Organism=Homo sapiens, GI291045268, Length=459, Percent_Identity=29.6296296296296, Blast_Score=194, Evalue=1e-49,
Organism=Homo sapiens, GI91199540, Length=458, Percent_Identity=29.0393013100437, Blast_Score=171, Evalue=1e-42,
Organism=Escherichia coli, GI1789915, Length=450, Percent_Identity=80.4444444444444, Blast_Score=753, Evalue=0.0,
Organism=Escherichia coli, GI1786307, Length=453, Percent_Identity=29.3598233995585, Blast_Score=161, Evalue=7e-41,
Organism=Escherichia coli, GI87082354, Length=454, Percent_Identity=28.4140969162996, Blast_Score=154, Evalue=1e-38,
Organism=Escherichia coli, GI87081717, Length=453, Percent_Identity=26.4900662251656, Blast_Score=132, Evalue=4e-32,
Organism=Caenorhabditis elegans, GI71983419, Length=450, Percent_Identity=55.7777777777778, Blast_Score=463, Evalue=1e-130,
Organism=Caenorhabditis elegans, GI71983429, Length=450, Percent_Identity=55.7777777777778, Blast_Score=462, Evalue=1e-130,
Organism=Caenorhabditis elegans, GI17557007, Length=472, Percent_Identity=35.8050847457627, Blast_Score=281, Evalue=5e-76,
Organism=Caenorhabditis elegans, GI71982272, Length=481, Percent_Identity=33.6798336798337, Blast_Score=223, Evalue=1e-58,
Organism=Caenorhabditis elegans, GI32565766, Length=459, Percent_Identity=28.7581699346405, Blast_Score=171, Evalue=7e-43,
Organism=Saccharomyces cerevisiae, GI6325166, Length=467, Percent_Identity=49.2505353319058, Blast_Score=424, Evalue=1e-119,
Organism=Saccharomyces cerevisiae, GI6321091, Length=471, Percent_Identity=27.6008492569002, Blast_Score=140, Evalue=5e-34,
Organism=Saccharomyces cerevisiae, GI6325240, Length=470, Percent_Identity=25.3191489361702, Blast_Score=117, Evalue=3e-27,
Organism=Drosophila melanogaster, GI24640553, Length=469, Percent_Identity=40.0852878464819, Blast_Score=297, Evalue=1e-80,
Organism=Drosophila melanogaster, GI24640549, Length=469, Percent_Identity=40.0852878464819, Blast_Score=296, Evalue=2e-80,
Organism=Drosophila melanogaster, GI24640551, Length=469, Percent_Identity=40.0852878464819, Blast_Score=296, Evalue=3e-80,
Organism=Drosophila melanogaster, GI17737741, Length=472, Percent_Identity=37.2881355932203, Blast_Score=276, Evalue=2e-74,
Organism=Drosophila melanogaster, GI21358499, Length=467, Percent_Identity=29.1220556745182, Blast_Score=169, Evalue=4e-42,

Paralogues:

None

Copy number: 650 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR016156
- InterPro:   IPR013027
- InterPro:   IPR006322
- InterPro:   IPR004099
- InterPro:   IPR012999
- InterPro:   IPR001327 [H]

Pfam domain/function: PF00070 Pyr_redox; PF07992 Pyr_redox_2; PF02852 Pyr_redox_dim [H]

EC number: =1.8.1.7 [H]

Molecular weight: Translated: 48559; Mature: 48427

Theoretical pI: Translated: 6.36; Mature: 6.36

Prosite motif: PS00076 PYRIDINE_REDOX_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
3.8 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
3.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTKHYDYLAIGGGSGGIASINRAAMYGRKCALIEAKALGGTCVNVGCVPKKVMWHAAQIA
CCCCEEEEEEECCCCCCHHHHHHHHCCCEEEEEEEECCCCEEEECCCCCHHHHHHHHHHH
EAIKLYGPDYGFDTTLNRFDWQRLIDSRSAYIERIHQSYQRGLGNNKVDVIQGVTTFIDA
HHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHEE
HTIDVNGERISADHILIASGGRPAHPDIPGAEYGIDSDGFFALDALPQRVAIVGAGYIAV
EEEECCCCEEECCEEEEECCCCCCCCCCCCCCCCCCCCCEEEECCCCCEEEEEECCHHHH
EIAGVLNALGAETHLFVRRHAPLRSFDSLIVDTLLEVMHSEGPQLHTHSVPQSVVKNADG
HHHHHHHHHCCCEEEEEEECCCHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHCCCC
SLTLMLENGHSQTVDCLIWAIGRDPNTDRLNLGAAGVTTDANGYIPVDAFQNTNVPGIYA
CEEEEEECCCCCEEEEEEEEECCCCCCCEEECCCCCEEECCCCEEEECCCCCCCCCEEEE
VGDNTGAVELTPVAVAAGRRLSERLFNNKPQEHLDYSNIPTVVFSHPPIGTVGLSEAQAR
ECCCCCEEEEEEHHHHHHHHHHHHHHCCCCHHHCCCCCCCEEEECCCCCCCCCCHHHHHH
AQYGDEQIKVYTSSFTAMYSAVTQHRQPCRMKLVCQGADERIVGIHGIGFGMDEMLQGFA
HHCCCCEEEEEEHHHHHHHHHHHHCCCCCEEEEEEECCCCEEEEEEECCCCHHHHHHHHH
VALKMGATKRDFDNTVAIHPTASEEFVTMR
HHHHCCCCCCCCCCEEEEECCCCCCEEEEC
>Mature Secondary Structure 
TKHYDYLAIGGGSGGIASINRAAMYGRKCALIEAKALGGTCVNVGCVPKKVMWHAAQIA
CCCEEEEEEECCCCCCHHHHHHHHCCCEEEEEEEECCCCEEEECCCCCHHHHHHHHHHH
EAIKLYGPDYGFDTTLNRFDWQRLIDSRSAYIERIHQSYQRGLGNNKVDVIQGVTTFIDA
HHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHEE
HTIDVNGERISADHILIASGGRPAHPDIPGAEYGIDSDGFFALDALPQRVAIVGAGYIAV
EEEECCCCEEECCEEEEECCCCCCCCCCCCCCCCCCCCCEEEECCCCCEEEEEECCHHHH
EIAGVLNALGAETHLFVRRHAPLRSFDSLIVDTLLEVMHSEGPQLHTHSVPQSVVKNADG
HHHHHHHHHCCCEEEEEEECCCHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHCCCC
SLTLMLENGHSQTVDCLIWAIGRDPNTDRLNLGAAGVTTDANGYIPVDAFQNTNVPGIYA
CEEEEEECCCCCEEEEEEEEECCCCCCCEEECCCCCEEECCCCEEEECCCCCCCCCEEEE
VGDNTGAVELTPVAVAAGRRLSERLFNNKPQEHLDYSNIPTVVFSHPPIGTVGLSEAQAR
ECCCCCEEEEEEHHHHHHHHHHHHHHCCCCHHHCCCCCCCEEEECCCCCCCCCCHHHHHH
AQYGDEQIKVYTSSFTAMYSAVTQHRQPCRMKLVCQGADERIVGIHGIGFGMDEMLQGFA
HHCCCCEEEEEEHHHHHHHHHHHHCCCCCEEEEEEECCCCEEEEEEECCCCHHHHHHHHH
VALKMGATKRDFDNTVAIHPTASEEFVTMR
HHHHCCCCCCCCCCEEEEECCCCCCEEEEC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 3521741; 8041620; 9278503; 2006135; 8061609 [H]