| Definition | Edwardsiella ictaluri 93-146 chromosome, complete genome. |
|---|---|
| Accession | NC_012779 |
| Length | 3,812,315 |
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The map label for this gene is dkgA [H]
Identifier: 238921397
GI number: 238921397
Start: 3442311
End: 3443141
Strand: Direct
Name: dkgA [H]
Synonym: NT01EI_3541
Alternate gene names: 238921397
Gene position: 3442311-3443141 (Clockwise)
Preceding gene: 238921393
Following gene: 238921402
Centisome position: 90.29
GC content: 58.0
Gene sequence:
>831_bases ATGTCCATCCCTCCCTTTATTACGCTGAATGATGGTAACCGCATTCCCCAGCTGGGACTCGGCGTATGGCAGGTCAGTGA TACGCTGGCCCGTAACGTGGTCGGCGAGGCGCTGCGCATCGGCTATCGCGCCATTGATACCGCCGCGATCTATGGCAACG AGAGTGGCGTCGGCCAGGCGCTGCAGCAAAGTGGCCTGACCCGGAATTCGCTGTTTATCACCACCAAGCTGTGGAATGCG GATCATATGGCGGTCGATAAGGCGTTTCACGACAGCCTGCACAAGCTGCACCTTGAGTATGTTGATCTGTACCTGATCCA CTGGCCGATGGCGCTGCAGGATACCTTTGTTCATGCCTGGCGTCGGCTGATCGACCTGCGGCGCCAGGGATTGGTGAAAA GCATCGGGGTTTGCAACTTCAATATTGTCCATCTCCAGCGCCTGCTGGATGAAACCGGCGTGGTGCCGAGCATCAACCAA ATTGAGCTACACCCGCTGATGCAGCAGCGGGAGCTGCAGTCATGGAATAGCCACAACGGCATTGCCACAGAGGCCTGGAG CCCGCTGGCACAGGGGGGAAAGGGCGTATTTGACGCGGAACTGATCCATCGTTTGGCGGCAAAATACAACAAGACACCGG CGCAGATCGTGATCCGCTGGCATTTGGACAGCGGGAGGATAGTGATCCCCAAAACGGTCTCGGCGATGCGCCTGAGGGAA AATATCGCCGTATTTGACTTTACGCTGGAGACGAGCGAACGGGCGCAGATCGCCCGCTTGGAGTGCGGCAAGCGATTAGG CTCCGATCCCGCCACCTATATGCGCCTGTAG
Upstream 100 bases:
>100_bases CGGTGCACCACCTCTACGCGGCGGCTCCATAGCTGAGATGAATATGCTAAGGTGCAAATCTGACGGTCTATTCCCTACCC ATCCGCAACGGAGATGCCCC
Downstream 100 bases:
>100_bases GCGGTGAGCGCAGCCCTGATGCTAAGGCATCAGGGCTGTCGGAAAAGGCGTTAGCGCGGCTTTTTGGCCTGCCCGGCAGG GCGCGCCGGACGGGCGTTGC
Product: 2,5-diketo-D-gluconate reductase A
Products: NA
Alternate protein names: 2,5-DKG reductase A; 2,5-DKGR A; 25DKGR-A; AKR5C [H]
Number of amino acids: Translated: 276; Mature: 275
Protein sequence:
>276_residues MSIPPFITLNDGNRIPQLGLGVWQVSDTLARNVVGEALRIGYRAIDTAAIYGNESGVGQALQQSGLTRNSLFITTKLWNA DHMAVDKAFHDSLHKLHLEYVDLYLIHWPMALQDTFVHAWRRLIDLRRQGLVKSIGVCNFNIVHLQRLLDETGVVPSINQ IELHPLMQQRELQSWNSHNGIATEAWSPLAQGGKGVFDAELIHRLAAKYNKTPAQIVIRWHLDSGRIVIPKTVSAMRLRE NIAVFDFTLETSERAQIARLECGKRLGSDPATYMRL
Sequences:
>Translated_276_residues MSIPPFITLNDGNRIPQLGLGVWQVSDTLARNVVGEALRIGYRAIDTAAIYGNESGVGQALQQSGLTRNSLFITTKLWNA DHMAVDKAFHDSLHKLHLEYVDLYLIHWPMALQDTFVHAWRRLIDLRRQGLVKSIGVCNFNIVHLQRLLDETGVVPSINQ IELHPLMQQRELQSWNSHNGIATEAWSPLAQGGKGVFDAELIHRLAAKYNKTPAQIVIRWHLDSGRIVIPKTVSAMRLRE NIAVFDFTLETSERAQIARLECGKRLGSDPATYMRL >Mature_275_residues SIPPFITLNDGNRIPQLGLGVWQVSDTLARNVVGEALRIGYRAIDTAAIYGNESGVGQALQQSGLTRNSLFITTKLWNAD HMAVDKAFHDSLHKLHLEYVDLYLIHWPMALQDTFVHAWRRLIDLRRQGLVKSIGVCNFNIVHLQRLLDETGVVPSINQI ELHPLMQQRELQSWNSHNGIATEAWSPLAQGGKGVFDAELIHRLAAKYNKTPAQIVIRWHLDSGRIVIPKTVSAMRLREN IAVFDFTLETSERAQIARLECGKRLGSDPATYMRL
Specific function: Catalyzes the reduction of 2,5-diketo-D-gluconic acid (25DKG) to 2-keto-L-gulonic acid (2KLG) [H]
COG id: COG0656
COG function: function code R; Aldo/keto reductases, related to diketogulonate reductase
Gene ontology:
Cell location: Cytoplasm [H]
Metaboloic importance: Non_Essential [C]
Operon status: Not Known
Operon components: None
Similarity: Belongs to the aldo/keto reductase family [H]
Homologues:
Organism=Homo sapiens, GI24497577, Length=287, Percent_Identity=34.8432055749129, Blast_Score=185, Evalue=4e-47, Organism=Homo sapiens, GI5174391, Length=287, Percent_Identity=34.8432055749129, Blast_Score=185, Evalue=4e-47, Organism=Homo sapiens, GI223468663, Length=286, Percent_Identity=36.013986013986, Blast_Score=181, Evalue=4e-46, Organism=Homo sapiens, GI93277124, Length=305, Percent_Identity=35.7377049180328, Blast_Score=170, Evalue=1e-42, Organism=Homo sapiens, GI291291012, Length=262, Percent_Identity=35.4961832061069, Blast_Score=158, Evalue=5e-39, Organism=Homo sapiens, GI5174695, Length=300, Percent_Identity=32.6666666666667, Blast_Score=156, Evalue=2e-38, Organism=Homo sapiens, GI4502049, Length=279, Percent_Identity=35.84229390681, Blast_Score=151, Evalue=6e-37, Organism=Homo sapiens, GI310109922, Length=271, Percent_Identity=34.6863468634686, Blast_Score=150, Evalue=1e-36, Organism=Homo sapiens, GI24497585, Length=289, Percent_Identity=34.2560553633218, Blast_Score=150, Evalue=2e-36, Organism=Homo sapiens, GI5453543, Length=289, Percent_Identity=32.5259515570934, Blast_Score=149, Evalue=3e-36, Organism=Homo sapiens, GI310109920, Length=289, Percent_Identity=32.5259515570934, Blast_Score=149, Evalue=3e-36, Organism=Homo sapiens, GI45446745, Length=289, Percent_Identity=32.5259515570934, Blast_Score=148, Evalue=5e-36, Organism=Homo sapiens, GI4503285, Length=289, Percent_Identity=32.5259515570934, Blast_Score=148, Evalue=5e-36, Organism=Homo sapiens, GI24497583, Length=293, Percent_Identity=31.740614334471, Blast_Score=146, Evalue=2e-35, Organism=Homo sapiens, GI300116273, Length=278, Percent_Identity=32.7338129496403, Blast_Score=144, Evalue=1e-34, Organism=Homo sapiens, GI300116271, Length=280, Percent_Identity=30.3571428571429, Blast_Score=122, Evalue=3e-28, Organism=Homo sapiens, GI310109924, Length=139, Percent_Identity=33.8129496402878, Blast_Score=82, Evalue=5e-16, Organism=Homo sapiens, GI310109926, Length=126, Percent_Identity=36.5079365079365, Blast_Score=82, Evalue=7e-16, Organism=Homo sapiens, GI207028673, Length=126, Percent_Identity=36.5079365079365, Blast_Score=81, Evalue=8e-16, Organism=Escherichia coli, GI87082198, Length=273, Percent_Identity=60.4395604395604, Blast_Score=352, Evalue=2e-98, Organism=Escherichia coli, GI1786400, Length=259, Percent_Identity=39.3822393822394, Blast_Score=188, Evalue=3e-49, Organism=Escherichia coli, GI1788081, Length=277, Percent_Identity=29.6028880866426, Blast_Score=100, Evalue=2e-22, Organism=Caenorhabditis elegans, GI17537077, Length=286, Percent_Identity=34.6153846153846, Blast_Score=169, Evalue=1e-42, Organism=Caenorhabditis elegans, GI71998625, Length=256, Percent_Identity=35.15625, Blast_Score=167, Evalue=6e-42, Organism=Caenorhabditis elegans, GI17537075, Length=300, Percent_Identity=34.3333333333333, Blast_Score=166, Evalue=1e-41, Organism=Caenorhabditis elegans, GI17564128, Length=298, Percent_Identity=36.241610738255, Blast_Score=161, Evalue=3e-40, Organism=Caenorhabditis elegans, GI17550248, Length=292, Percent_Identity=33.2191780821918, Blast_Score=157, Evalue=7e-39, Organism=Caenorhabditis elegans, GI17566692, Length=282, Percent_Identity=34.0425531914894, Blast_Score=154, Evalue=6e-38, Organism=Caenorhabditis elegans, GI17561300, Length=272, Percent_Identity=33.0882352941176, Blast_Score=147, Evalue=6e-36, Organism=Caenorhabditis elegans, GI17552492, Length=275, Percent_Identity=31.6363636363636, Blast_Score=145, Evalue=3e-35, Organism=Caenorhabditis elegans, GI17561298, Length=272, Percent_Identity=30.1470588235294, Blast_Score=140, Evalue=8e-34, Organism=Caenorhabditis elegans, GI17537079, Length=304, Percent_Identity=26.6447368421053, Blast_Score=136, Evalue=1e-32, Organism=Caenorhabditis elegans, GI17538386, Length=270, Percent_Identity=29.2592592592593, Blast_Score=134, Evalue=4e-32, Organism=Caenorhabditis elegans, GI17562292, Length=279, Percent_Identity=31.1827956989247, Blast_Score=134, Evalue=6e-32, Organism=Saccharomyces cerevisiae, GI6324694, Length=288, Percent_Identity=37.5, Blast_Score=201, Evalue=7e-53, Organism=Saccharomyces cerevisiae, GI6320576, Length=282, Percent_Identity=36.8794326241135, Blast_Score=188, Evalue=1e-48, Organism=Saccharomyces cerevisiae, GI6322556, Length=262, Percent_Identity=33.206106870229, Blast_Score=158, Evalue=8e-40, Organism=Saccharomyces cerevisiae, GI6319625, Length=279, Percent_Identity=34.0501792114695, Blast_Score=158, Evalue=9e-40, Organism=Saccharomyces cerevisiae, GI6321896, Length=317, Percent_Identity=29.6529968454259, Blast_Score=138, Evalue=9e-34, Organism=Saccharomyces cerevisiae, GI6320079, Length=282, Percent_Identity=31.9148936170213, Blast_Score=125, Evalue=7e-30, Organism=Drosophila melanogaster, GI24644950, Length=302, Percent_Identity=36.0927152317881, Blast_Score=183, Evalue=1e-46, Organism=Drosophila melanogaster, GI24662789, Length=308, Percent_Identity=36.038961038961, Blast_Score=180, Evalue=9e-46, Organism=Drosophila melanogaster, GI20129731, Length=291, Percent_Identity=36.426116838488, Blast_Score=177, Evalue=1e-44, Organism=Drosophila melanogaster, GI221378297, Length=322, Percent_Identity=33.8509316770186, Blast_Score=175, Evalue=3e-44, Organism=Drosophila melanogaster, GI24657054, Length=298, Percent_Identity=35.9060402684564, Blast_Score=172, Evalue=3e-43, Organism=Drosophila melanogaster, GI21356425, Length=294, Percent_Identity=34.0136054421769, Blast_Score=167, Evalue=7e-42, Organism=Drosophila melanogaster, GI24663317, Length=297, Percent_Identity=32.3232323232323, Blast_Score=164, Evalue=4e-41, Organism=Drosophila melanogaster, GI45553081, Length=297, Percent_Identity=34.6801346801347, Blast_Score=164, Evalue=6e-41, Organism=Drosophila melanogaster, GI24662781, Length=294, Percent_Identity=36.3945578231293, Blast_Score=157, Evalue=1e-38, Organism=Drosophila melanogaster, GI24662785, Length=294, Percent_Identity=36.734693877551, Blast_Score=155, Evalue=2e-38, Organism=Drosophila melanogaster, GI281366140, Length=258, Percent_Identity=34.8837209302326, Blast_Score=138, Evalue=5e-33,
Paralogues:
None
Copy number: NA
Swissprot (AC and ID): NA
Other databases:
- InterPro: IPR001395 - InterPro: IPR018170 - InterPro: IPR020471 - InterPro: IPR023210 [H]
Pfam domain/function: PF00248 Aldo_ket_red [H]
EC number: =1.1.1.274 [H]
Molecular weight: Translated: 31130; Mature: 30999
Theoretical pI: Translated: 9.08; Mature: 9.08
Prosite motif: PS00798 ALDOKETO_REDUCTASE_1 ; PS00062 ALDOKETO_REDUCTASE_2 ; PS00063 ALDOKETO_REDUCTASE_3
Important sites: NA
Signals:
None
Transmembrane regions:
None
Cys/Met content:
0.7 %Cys (Translated Protein) 2.2 %Met (Translated Protein) 2.9 %Cys+Met (Translated Protein) 0.7 %Cys (Mature Protein) 1.8 %Met (Mature Protein) 2.5 %Cys+Met (Mature Protein)
Secondary structure:
>Translated Secondary Structure MSIPPFITLNDGNRIPQLGLGVWQVSDTLARNVVGEALRIGYRAIDTAAIYGNESGVGQA CCCCCEEEECCCCCCCHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHEEEECCCCCHHHH LQQSGLTRNSLFITTKLWNADHMAVDKAFHDSLHKLHLEYVDLYLIHWPMALQDTFVHAW HHHCCCCCCEEEEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHEECCHHHHHHHHHHH RRLIDLRRQGLVKSIGVCNFNIVHLQRLLDETGVVPSINQIELHPLMQQRELQSWNSHNG HHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHCCCCCCCCCEEHHHHHHHHHHHCCCCCCC IATEAWSPLAQGGKGVFDAELIHRLAAKYNKTPAQIVIRWHLDSGRIVIPKTVSAMRLRE CCHHHCCHHHCCCCCCCHHHHHHHHHHHHCCCCEEEEEEEEECCCCEEECCCHHHHHHHC NIAVFDFTLETSERAQIARLECGKRLGSDPATYMRL CCEEEEEEECCCCHHHHHHHHHHHHCCCCCHHHHCC >Mature Secondary Structure SIPPFITLNDGNRIPQLGLGVWQVSDTLARNVVGEALRIGYRAIDTAAIYGNESGVGQA CCCCEEEECCCCCCCHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHEEEECCCCCHHHH LQQSGLTRNSLFITTKLWNADHMAVDKAFHDSLHKLHLEYVDLYLIHWPMALQDTFVHAW HHHCCCCCCEEEEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHEECCHHHHHHHHHHH RRLIDLRRQGLVKSIGVCNFNIVHLQRLLDETGVVPSINQIELHPLMQQRELQSWNSHNG HHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHCCCCCCCCCEEHHHHHHHHHHHCCCCCCC IATEAWSPLAQGGKGVFDAELIHRLAAKYNKTPAQIVIRWHLDSGRIVIPKTVSAMRLRE CCHHHCCHHHCCCCCCCHHHHHHHHHHHHCCCCEEEEEEEEECCCCEEECCCHHHHHHHC NIAVFDFTLETSERAQIARLECGKRLGSDPATYMRL CCEEEEEEECCCCHHHHHHHHHHHHCCCCCHHHHCC
PDB accession: NA
Resolution: NA
Structure class: Unstructured
Cofactors: NA
Metal ions: NA
Kcat value (1/min): NA
Specific activity: NA
Km value (mM): NA
Substrates: NA
Specific reaction: NA
General reaction: NA
Inhibitor: NA
Structure determination priority: 10.0
TargetDB status: NA
Availability: NA
References: 11586360; 12142430 [H]