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The map label for this gene is selB [H]

Identifier: 238921329

GI number: 238921329

Start: 3366867

End: 3368744

Strand: Direct

Name: selB [H]

Synonym: NT01EI_3473

Alternate gene names: 238921329

Gene position: 3366867-3368744 (Clockwise)

Preceding gene: 238921328

Following gene: 238921330

Centisome position: 88.32

GC content: 67.78

Gene sequence:

>1878_bases
ATGATCATCGCCACCGCAGGACACGTTGATCACGGCAAAACCACCCTGCTGCGCGCCCTGACCGGCATCGATACCGATCG
CCTGCCGGAGGAGAAGCGCCGCGGCATGACCATCGATCTCGGCTATGCCTACCTGCCGCTGGCGGATGGGCGGGTACTGG
GATTTATTGACGTCCCCGGACATGAAAAATTTCTGGCCAATATGCTGGCCGGCATCGGCGGCATCCCACAGGCGCTGCTG
GTGGTCGCCTGTGACGACGGCGTGATGGCCCAGACCCGTGAGCACCTGCTGCTGCTGCGCCTGGCCGGACGACCCGGCCT
GACCGTGGCACTGACCAAATCCGGGCGGGTCGATGCACCGCGACGGGCGCAGGTGCGCGACCAGGTGCAGGCGCTGCTGG
CGGAGCAGGGCTGGCCAGACGCGGCGCTGTTCGAAACCGATGCCATGAGCGGTCAGGGCATCGAGGCGCTGCGCCACCAT
CTGTTGACCCTGAGCGCAGTCCCACCACAGGCCGATCGGCGCTTCCGCCTGGCCATCGATCGCGCCTTCAGCGTCAAGGG
CAGCGGGCTGGTTGTCACCGGTACAGCGCTGGCCGGAACGGTATGCTGCGGCGATACGCTGTGGCTGACCGGCTGCGATA
AGGCGGTACGGGTACGCACCCTGCACGCCCAAAACCGGGAGGCGCAGCGGGCACAGGCCGGTCAGCGCGTGGCCCTGAAC
CTCAGCGGTGACGTAGAAAAAAGCCAGATCCAGCGCGGCGACTGGCTGCTGGCGCAGCGACCCGCCGCAGCGGCAGCCCA
GCGGGTGCTGGTCGCAGTAGACAGCGTCGCACCGCTGCAGCACTGGCAGCCGCTGCATCTCCACCACGCCGCACGCCACA
TCACCGGGCGCCTCTCGCTGCTGGAAACCACCGCTGCGCCGCAGGCGCCGACCCTGGCCGAACTGGTGCTCGACACCCCC
CTCTGGCTGGCCGAGGATGACACCCTGATCCTGCGCGACATCGCCGCGCGCCACACCCTGGGCGCGGCACGGGTGCTACA
ACTGGAGGCACCGCGCCGCGGCAAGCGTCAGCCCGCCTTTTTGGAGACCCTGCGTCGCCTGGCTCAGGCCCGCGGCGACC
GTGAGGCGCTCAGCCTGCGCCTGCCCTCGGGCACCCTGAGCATCGCCAACCTGGCCTGGTCGCGCCAGCTGACGGAGGAG
TCCTGCCGGACGCTGCTGGCGCAGGACGATCTGCTGGTGGTCGGCGATCACCTGCTCTCCCGCACGACGGCGACGCGGCT
GCGTCAGCGGCTGCTGGATACCCTGGCGTACTATCATGCCCAGCACGGCGATCAGCTGGGCGTCGGGCGCGCCCGCCTGC
GACGCATGGCGCTGCCGACCGGGCCAGAGACGCTGGTATTTCATCTGATAGGCGAGCTGCTGGCCGAAGGCGCGCTATGC
AACAGCCGCGGCTGGCTGCATCTGCCACAGCACCGCCTGGCCATGACACCGCCGCAGCAGGCGCTGTGGCAGCGGGCGCA
GCCGCTGTTCGCCGACGATCCATGGTGGGTGCGCGATCTGGCCAATACCCTGAACGCCGATGAGAATGAGATGCGCCAGA
CGCTGCGCCAGGCGGCGCTGCTCGGGCATATCACCGCCGTGGTGCGCGATCGTTACTACCGCAACGAACGGCTCTACCAG
TTTGCCGAGCTGATCCGCCAACAGGATCACAGCCAGGGCAGCACCAATGCAGCTGACTTCCGCGATCAGCTCGGCGTAGG
CCGTAAGCTGGCAGTACAGATCCTGGAGTTCTTCGACCGCTGTGGCTTTACCCGGCGACGCGCCAACGACCATCTGCTGC
GCGATGCCGGTCTATTTTGCGCCGACGACAAAATGTAA

Upstream 100 bases:

>100_bases
CGCTGCCCTGTCCGGTCATCGGGCGACTGCAAGAGGGCAAACTGTGGCTCGATCTGCGCTGTCTGGACGATGAGCAGGCG
CTGCTCCAGGAGCTGTGCCA

Downstream 100 bases:

>100_bases
TCAATGAGTTATAAAAAAGTAAATAAAAGTGTGATCATGGGCAAATATTGACCGTATTTCGCTGTCTGCCGGTGCAATAT
CGCTTATGCTGGGAGGATGG

Product: selenocysteinyl-tRNA-specific translation factor

Products: NA

Alternate protein names: SelB translation factor [H]

Number of amino acids: Translated: 625; Mature: 625

Protein sequence:

>625_residues
MIIATAGHVDHGKTTLLRALTGIDTDRLPEEKRRGMTIDLGYAYLPLADGRVLGFIDVPGHEKFLANMLAGIGGIPQALL
VVACDDGVMAQTREHLLLLRLAGRPGLTVALTKSGRVDAPRRAQVRDQVQALLAEQGWPDAALFETDAMSGQGIEALRHH
LLTLSAVPPQADRRFRLAIDRAFSVKGSGLVVTGTALAGTVCCGDTLWLTGCDKAVRVRTLHAQNREAQRAQAGQRVALN
LSGDVEKSQIQRGDWLLAQRPAAAAAQRVLVAVDSVAPLQHWQPLHLHHAARHITGRLSLLETTAAPQAPTLAELVLDTP
LWLAEDDTLILRDIAARHTLGAARVLQLEAPRRGKRQPAFLETLRRLAQARGDREALSLRLPSGTLSIANLAWSRQLTEE
SCRTLLAQDDLLVVGDHLLSRTTATRLRQRLLDTLAYYHAQHGDQLGVGRARLRRMALPTGPETLVFHLIGELLAEGALC
NSRGWLHLPQHRLAMTPPQQALWQRAQPLFADDPWWVRDLANTLNADENEMRQTLRQAALLGHITAVVRDRYYRNERLYQ
FAELIRQQDHSQGSTNAADFRDQLGVGRKLAVQILEFFDRCGFTRRRANDHLLRDAGLFCADDKM

Sequences:

>Translated_625_residues
MIIATAGHVDHGKTTLLRALTGIDTDRLPEEKRRGMTIDLGYAYLPLADGRVLGFIDVPGHEKFLANMLAGIGGIPQALL
VVACDDGVMAQTREHLLLLRLAGRPGLTVALTKSGRVDAPRRAQVRDQVQALLAEQGWPDAALFETDAMSGQGIEALRHH
LLTLSAVPPQADRRFRLAIDRAFSVKGSGLVVTGTALAGTVCCGDTLWLTGCDKAVRVRTLHAQNREAQRAQAGQRVALN
LSGDVEKSQIQRGDWLLAQRPAAAAAQRVLVAVDSVAPLQHWQPLHLHHAARHITGRLSLLETTAAPQAPTLAELVLDTP
LWLAEDDTLILRDIAARHTLGAARVLQLEAPRRGKRQPAFLETLRRLAQARGDREALSLRLPSGTLSIANLAWSRQLTEE
SCRTLLAQDDLLVVGDHLLSRTTATRLRQRLLDTLAYYHAQHGDQLGVGRARLRRMALPTGPETLVFHLIGELLAEGALC
NSRGWLHLPQHRLAMTPPQQALWQRAQPLFADDPWWVRDLANTLNADENEMRQTLRQAALLGHITAVVRDRYYRNERLYQ
FAELIRQQDHSQGSTNAADFRDQLGVGRKLAVQILEFFDRCGFTRRRANDHLLRDAGLFCADDKM
>Mature_625_residues
MIIATAGHVDHGKTTLLRALTGIDTDRLPEEKRRGMTIDLGYAYLPLADGRVLGFIDVPGHEKFLANMLAGIGGIPQALL
VVACDDGVMAQTREHLLLLRLAGRPGLTVALTKSGRVDAPRRAQVRDQVQALLAEQGWPDAALFETDAMSGQGIEALRHH
LLTLSAVPPQADRRFRLAIDRAFSVKGSGLVVTGTALAGTVCCGDTLWLTGCDKAVRVRTLHAQNREAQRAQAGQRVALN
LSGDVEKSQIQRGDWLLAQRPAAAAAQRVLVAVDSVAPLQHWQPLHLHHAARHITGRLSLLETTAAPQAPTLAELVLDTP
LWLAEDDTLILRDIAARHTLGAARVLQLEAPRRGKRQPAFLETLRRLAQARGDREALSLRLPSGTLSIANLAWSRQLTEE
SCRTLLAQDDLLVVGDHLLSRTTATRLRQRLLDTLAYYHAQHGDQLGVGRARLRRMALPTGPETLVFHLIGELLAEGALC
NSRGWLHLPQHRLAMTPPQQALWQRAQPLFADDPWWVRDLANTLNADENEMRQTLRQAALLGHITAVVRDRYYRNERLYQ
FAELIRQQDHSQGSTNAADFRDQLGVGRKLAVQILEFFDRCGFTRRRANDHLLRDAGLFCADDKM

Specific function: Translation factor necessary for the incorporation of selenocysteine into proteins. It probably replaces EF-Tu for the insertion of selenocysteine directed by the UGA codon. SelB binds GTP and GDP [H]

COG id: COG3276

COG function: function code J; Selenocysteine-specific translation elongation factor

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the GTP-binding elongation factor family. SelB subfamily [H]

Homologues:

Organism=Homo sapiens, GI34147630, Length=293, Percent_Identity=32.7645051194539, Blast_Score=114, Evalue=4e-25,
Organism=Homo sapiens, GI223555963, Length=344, Percent_Identity=26.7441860465116, Blast_Score=91, Evalue=3e-18,
Organism=Homo sapiens, GI5729864, Length=344, Percent_Identity=26.7441860465116, Blast_Score=91, Evalue=3e-18,
Organism=Homo sapiens, GI54607086, Length=351, Percent_Identity=23.9316239316239, Blast_Score=90, Evalue=8e-18,
Organism=Homo sapiens, GI53729339, Length=224, Percent_Identity=29.4642857142857, Blast_Score=74, Evalue=3e-13,
Organism=Homo sapiens, GI53729337, Length=224, Percent_Identity=29.4642857142857, Blast_Score=74, Evalue=3e-13,
Organism=Homo sapiens, GI82546879, Length=329, Percent_Identity=25.8358662613982, Blast_Score=74, Evalue=4e-13,
Organism=Homo sapiens, GI194018522, Length=394, Percent_Identity=22.5888324873096, Blast_Score=72, Evalue=1e-12,
Organism=Homo sapiens, GI194097354, Length=394, Percent_Identity=22.5888324873096, Blast_Score=72, Evalue=1e-12,
Organism=Homo sapiens, GI194018520, Length=394, Percent_Identity=22.5888324873096, Blast_Score=72, Evalue=2e-12,
Organism=Escherichia coli, GI2367247, Length=619, Percent_Identity=61.2277867528271, Blast_Score=745, Evalue=0.0,
Organism=Escherichia coli, GI1790412, Length=284, Percent_Identity=31.6901408450704, Blast_Score=105, Evalue=8e-24,
Organism=Escherichia coli, GI1789737, Length=284, Percent_Identity=31.6901408450704, Blast_Score=105, Evalue=9e-24,
Organism=Caenorhabditis elegans, GI17556456, Length=291, Percent_Identity=32.9896907216495, Blast_Score=112, Evalue=9e-25,
Organism=Caenorhabditis elegans, GI25141371, Length=383, Percent_Identity=26.1096605744125, Blast_Score=108, Evalue=7e-24,
Organism=Caenorhabditis elegans, GI115532067, Length=304, Percent_Identity=26.6447368421053, Blast_Score=92, Evalue=1e-18,
Organism=Caenorhabditis elegans, GI115532065, Length=304, Percent_Identity=26.6447368421053, Blast_Score=92, Evalue=1e-18,
Organism=Caenorhabditis elegans, GI17552884, Length=411, Percent_Identity=25.0608272506083, Blast_Score=88, Evalue=1e-17,
Organism=Caenorhabditis elegans, GI17569207, Length=411, Percent_Identity=25.0608272506083, Blast_Score=88, Evalue=1e-17,
Organism=Caenorhabditis elegans, GI17506081, Length=265, Percent_Identity=26.4150943396226, Blast_Score=85, Evalue=1e-16,
Organism=Caenorhabditis elegans, GI71994658, Length=233, Percent_Identity=31.3304721030043, Blast_Score=79, Evalue=7e-15,
Organism=Saccharomyces cerevisiae, GI6324761, Length=301, Percent_Identity=30.5647840531561, Blast_Score=111, Evalue=4e-25,
Organism=Saccharomyces cerevisiae, GI6324550, Length=174, Percent_Identity=28.1609195402299, Blast_Score=66, Evalue=2e-11,
Organism=Drosophila melanogaster, GI19921738, Length=290, Percent_Identity=33.1034482758621, Blast_Score=118, Evalue=2e-26,
Organism=Drosophila melanogaster, GI281363316, Length=292, Percent_Identity=30.8219178082192, Blast_Score=117, Evalue=3e-26,
Organism=Drosophila melanogaster, GI17864358, Length=292, Percent_Identity=30.8219178082192, Blast_Score=117, Evalue=3e-26,
Organism=Drosophila melanogaster, GI19922690, Length=260, Percent_Identity=29.6153846153846, Blast_Score=95, Evalue=2e-19,
Organism=Drosophila melanogaster, GI28572034, Length=163, Percent_Identity=36.1963190184049, Blast_Score=80, Evalue=6e-15,
Organism=Drosophila melanogaster, GI45550900, Length=342, Percent_Identity=23.9766081871345, Blast_Score=78, Evalue=2e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR015190
- InterPro:   IPR015191
- InterPro:   IPR000795
- InterPro:   IPR004161
- InterPro:   IPR009000
- InterPro:   IPR004535
- InterPro:   IPR011991 [H]

Pfam domain/function: PF00009 GTP_EFTU; PF03144 GTP_EFTU_D2; PF09106 SelB-wing_2; PF09107 SelB-wing_3 [H]

EC number: NA

Molecular weight: Translated: 69128; Mature: 69128

Theoretical pI: Translated: 9.30; Mature: 9.30

Prosite motif: PS00301 EFACTOR_GTP

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
1.4 %Met     (Translated Protein)
2.7 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
1.4 %Met     (Mature Protein)
2.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIIATAGHVDHGKTTLLRALTGIDTDRLPEEKRRGMTIDLGYAYLPLADGRVLGFIDVPG
CEEEECCCCCCCHHHHHHHHHCCCCCCCCHHHHCCCEEEECEEEEEECCCCEEEEEECCC
HEKFLANMLAGIGGIPQALLVVACDDGVMAQTREHLLLLRLAGRPGLTVALTKSGRVDAP
HHHHHHHHHHCCCCCCCEEEEEECCCCHHHHHHHHEEEEEECCCCCEEEEEECCCCCCCC
RRAQVRDQVQALLAEQGWPDAALFETDAMSGQGIEALRHHLLTLSAVPPQADRRFRLAID
HHHHHHHHHHHHHHHCCCCCCCEEECCCCCCCCHHHHHHHHHEEECCCCCCCCEEEEEEE
RAFSVKGSGLVVTGTALAGTVCCGDTLWLTGCDKAVRVRTLHAQNREAQRAQAGQRVALN
HHEEECCCCEEEECHHHHHHEECCCCEEEECCCCHHEEEEHHHCCHHHHHHHCCCEEEEE
LSGDVEKSQIQRGDWLLAQRPAAAAAQRVLVAVDSVAPLQHWQPLHLHHAARHITGRLSL
ECCCCCHHHHHCCCEEEECCCHHHHHHHHHHHHCCCCCHHHCCCHHHHHHHHHHHHHHHH
LETTAAPQAPTLAELVLDTPLWLAEDDTLILRDIAARHTLGAARVLQLEAPRRGKRQPAF
HHHCCCCCCCHHHHHHHCCCCEECCCCCCHHHHHHHHHHHCHHHEEEECCCCCCCCCCHH
LETLRRLAQARGDREALSLRLPSGTLSIANLAWSRQLTEESCRTLLAQDDLLVVGDHLLS
HHHHHHHHHHCCCCCEEEEECCCCCEEHHHHHHHHHHHHHHHHHHHHCCCEEEECHHHHH
RTTATRLRQRLLDTLAYYHAQHGDQLGVGRARLRRMALPTGPETLVFHLIGELLAEGALC
HHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHCCCCCHHHHHHHHHHHHHHCCCEE
NSRGWLHLPQHRLAMTPPQQALWQRAQPLFADDPWWVRDLANTLNADENEMRQTLRQAAL
CCCCCEECCCCCCCCCCHHHHHHHHCCCCCCCCCHHHHHHHHHCCCCHHHHHHHHHHHHH
LGHITAVVRDRYYRNERLYQFAELIRQQDHSQGSTNAADFRDQLGVGRKLAVQILEFFDR
HHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHCCCHHHHHHHHHHHHH
CGFTRRRANDHLLRDAGLFCADDKM
CCCCHHCCCHHHHHHCCCEECCCCC
>Mature Secondary Structure
MIIATAGHVDHGKTTLLRALTGIDTDRLPEEKRRGMTIDLGYAYLPLADGRVLGFIDVPG
CEEEECCCCCCCHHHHHHHHHCCCCCCCCHHHHCCCEEEECEEEEEECCCCEEEEEECCC
HEKFLANMLAGIGGIPQALLVVACDDGVMAQTREHLLLLRLAGRPGLTVALTKSGRVDAP
HHHHHHHHHHCCCCCCCEEEEEECCCCHHHHHHHHEEEEEECCCCCEEEEEECCCCCCCC
RRAQVRDQVQALLAEQGWPDAALFETDAMSGQGIEALRHHLLTLSAVPPQADRRFRLAID
HHHHHHHHHHHHHHHCCCCCCCEEECCCCCCCCHHHHHHHHHEEECCCCCCCCEEEEEEE
RAFSVKGSGLVVTGTALAGTVCCGDTLWLTGCDKAVRVRTLHAQNREAQRAQAGQRVALN
HHEEECCCCEEEECHHHHHHEECCCCEEEECCCCHHEEEEHHHCCHHHHHHHCCCEEEEE
LSGDVEKSQIQRGDWLLAQRPAAAAAQRVLVAVDSVAPLQHWQPLHLHHAARHITGRLSL
ECCCCCHHHHHCCCEEEECCCHHHHHHHHHHHHCCCCCHHHCCCHHHHHHHHHHHHHHHH
LETTAAPQAPTLAELVLDTPLWLAEDDTLILRDIAARHTLGAARVLQLEAPRRGKRQPAF
HHHCCCCCCCHHHHHHHCCCCEECCCCCCHHHHHHHHHHHCHHHEEEECCCCCCCCCCHH
LETLRRLAQARGDREALSLRLPSGTLSIANLAWSRQLTEESCRTLLAQDDLLVVGDHLLS
HHHHHHHHHHCCCCCEEEEECCCCCEEHHHHHHHHHHHHHHHHHHHHCCCEEEECHHHHH
RTTATRLRQRLLDTLAYYHAQHGDQLGVGRARLRRMALPTGPETLVFHLIGELLAEGALC
HHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHCCCCCHHHHHHHHHHHHHHCCCEE
NSRGWLHLPQHRLAMTPPQQALWQRAQPLFADDPWWVRDLANTLNADENEMRQTLRQAAL
CCCCCEECCCCCCCCCCHHHHHHHHCCCCCCCCCHHHHHHHHHCCCCHHHHHHHHHHHHH
LGHITAVVRDRYYRNERLYQFAELIRQQDHSQGSTNAADFRDQLGVGRKLAVQILEFFDR
HHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHCCCHHHHHHHHHHHHH
CGFTRRRANDHLLRDAGLFCADDKM
CCCCHHCCCHHHHHHCCCEECCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 2531290; 8041620; 9278503; 2140572 [H]