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The map label for this gene is lysA [H]

Identifier: 238921148

GI number: 238921148

Start: 3169283

End: 3170542

Strand: Reverse

Name: lysA [H]

Synonym: NT01EI_3289

Alternate gene names: 238921148

Gene position: 3170542-3169283 (Counterclockwise)

Preceding gene: 238921155

Following gene: 238921147

Centisome position: 83.17

GC content: 61.75

Gene sequence:

>1260_bases
ATGCCCTATCCCCTGAATCAGGCCGGTTATGCCCTGAATGACACGCTGCTTTCCGCTCTGCCGGGCCGCTTTGGTACACC
GCTGTGGGTTTATGACGCAGCGTTGATCGAACGCCAGATAGCCTCTCTACGCACCTTCGACACCATTCGCTTCGCTCAGA
AAGCCTGCTCCAACCTGCATATTCTGCGACTGATGCGTCAGGCCGGTGTGAAGGTGGATGCGGTATCGCTGGGGGAGATT
GAGCGGGCGCTGATGGCGGGGTTCCGTCCGGACGCTGACGATGAGGAGATCGTCTTTACCGCCGACGTGATCGATGAGGC
GACGCTGGATCGGATCTGTGCATTGGGGATCACGGTTAACGCCGGATCCTGTGACATGCTGCGTCAGCTGGGCTGCAGGG
CATCCGGCCATCCGGTCTGGCTGCGTATCAACCCGGGTTTTGGCCACGGCCACAGCCAGAAGACCAATACCGGCGGAGAA
AACAGCAAGCACGGTATCTGGTATCAGGATTTGGCACAGGCGTTGGCCCTGATCGATACTTACGGCCTGCGTCTGGTCGG
CCTGCATATGCACATTGGCTCCGGCGTGGATTATGACCACCTGGCCCGGGTCTGCGATACGCTGGCCAACCAGGCGATCG
CGCTGGGGCGCGACATTCAGGCGATTTCAGCCGGTGGGGGACTCAGCATCCCCTACCGCGACGGCGACGCGTCGGTGGAC
GTCAGGCACTACTACGGGCTGTGGGATGCCGCGCGGCGGCGTATCGCTGAACATCTGGGGCATCCGGTGCGTCTGGAGAT
CGAGCCGGGACGCTATCTGGTGGCGCAGTCCGGTGTACTGCTGGCGCAGGTGCGGGCAGTGAAGTCGATGGGAGCGCGCC
ATTTTGTTCTGGCGGACGCCGGGTTTAACGATCTGATGCGCCCGGCAATGTACGGCAGCCATCACCATATTTCACTGCTG
CCTCAGGATGGTCGCGACGTCACGACGCCGTGTATCGAAACGGTGGTGGGGGGACCGCTGTGTGAGTCGGGTGATGTGTT
TACCCAGCGTGAAGGGGGGAGGGTAACCTCGTGTGCGCTGCCGGCGGTGCAGGTGGGAGACTGGCTGGTGTTTCACGATA
CCGGCGCCTACGGCGCATCGATGTCCTCCAACTATAACAGTCGTCCGCTGCTGCCGGAGGTGCTGGTGGAGGGGGACTCG
GTTCGGCTGATCCGTCGGCGCCAGCGAATGGATGAGCTATTGGCGCTGGAGCAAATATAA

Upstream 100 bases:

>100_bases
CATATCATAAATGAATAGACTTGTGACAAATAGATATTTTTTATTCTCTCTGGGCGCTGCTACATAGAGGGTAATGCTGA
TTTTTCCGGAGCCTTTTACC

Downstream 100 bases:

>100_bases
TAACTCCAGGTATTGTTCCGTGGCATAGCTCTCAAATTAAACGTATTAAATTGTTGCCTTATGTTTCACAGACCAACAAT
AACGTTATTTAACTAATGAG

Product: diaminopimelate decarboxylase

Products: NA

Alternate protein names: DAP decarboxylase [H]

Number of amino acids: Translated: 419; Mature: 418

Protein sequence:

>419_residues
MPYPLNQAGYALNDTLLSALPGRFGTPLWVYDAALIERQIASLRTFDTIRFAQKACSNLHILRLMRQAGVKVDAVSLGEI
ERALMAGFRPDADDEEIVFTADVIDEATLDRICALGITVNAGSCDMLRQLGCRASGHPVWLRINPGFGHGHSQKTNTGGE
NSKHGIWYQDLAQALALIDTYGLRLVGLHMHIGSGVDYDHLARVCDTLANQAIALGRDIQAISAGGGLSIPYRDGDASVD
VRHYYGLWDAARRRIAEHLGHPVRLEIEPGRYLVAQSGVLLAQVRAVKSMGARHFVLADAGFNDLMRPAMYGSHHHISLL
PQDGRDVTTPCIETVVGGPLCESGDVFTQREGGRVTSCALPAVQVGDWLVFHDTGAYGASMSSNYNSRPLLPEVLVEGDS
VRLIRRRQRMDELLALEQI

Sequences:

>Translated_419_residues
MPYPLNQAGYALNDTLLSALPGRFGTPLWVYDAALIERQIASLRTFDTIRFAQKACSNLHILRLMRQAGVKVDAVSLGEI
ERALMAGFRPDADDEEIVFTADVIDEATLDRICALGITVNAGSCDMLRQLGCRASGHPVWLRINPGFGHGHSQKTNTGGE
NSKHGIWYQDLAQALALIDTYGLRLVGLHMHIGSGVDYDHLARVCDTLANQAIALGRDIQAISAGGGLSIPYRDGDASVD
VRHYYGLWDAARRRIAEHLGHPVRLEIEPGRYLVAQSGVLLAQVRAVKSMGARHFVLADAGFNDLMRPAMYGSHHHISLL
PQDGRDVTTPCIETVVGGPLCESGDVFTQREGGRVTSCALPAVQVGDWLVFHDTGAYGASMSSNYNSRPLLPEVLVEGDS
VRLIRRRQRMDELLALEQI
>Mature_418_residues
PYPLNQAGYALNDTLLSALPGRFGTPLWVYDAALIERQIASLRTFDTIRFAQKACSNLHILRLMRQAGVKVDAVSLGEIE
RALMAGFRPDADDEEIVFTADVIDEATLDRICALGITVNAGSCDMLRQLGCRASGHPVWLRINPGFGHGHSQKTNTGGEN
SKHGIWYQDLAQALALIDTYGLRLVGLHMHIGSGVDYDHLARVCDTLANQAIALGRDIQAISAGGGLSIPYRDGDASVDV
RHYYGLWDAARRRIAEHLGHPVRLEIEPGRYLVAQSGVLLAQVRAVKSMGARHFVLADAGFNDLMRPAMYGSHHHISLLP
QDGRDVTTPCIETVVGGPLCESGDVFTQREGGRVTSCALPAVQVGDWLVFHDTGAYGASMSSNYNSRPLLPEVLVEGDSV
RLIRRRQRMDELLALEQI

Specific function: Lysine biosynthesis; last step. [C]

COG id: COG0019

COG function: function code E; Diaminopimelate decarboxylase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the Orn/Lys/Arg decarboxylase class-II family [H]

Homologues:

Organism=Escherichia coli, GI1789203, Length=411, Percent_Identity=68.8564476885645, Blast_Score=590, Evalue=1e-170,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR009006
- InterPro:   IPR002986
- InterPro:   IPR022643
- InterPro:   IPR022657
- InterPro:   IPR022644
- InterPro:   IPR022653
- InterPro:   IPR000183 [H]

Pfam domain/function: PF02784 Orn_Arg_deC_N; PF00278 Orn_DAP_Arg_deC [H]

EC number: =4.1.1.20 [H]

Molecular weight: Translated: 45740; Mature: 45609

Theoretical pI: Translated: 6.51; Mature: 6.51

Prosite motif: PS00878 ODR_DC_2_1 ; PS00879 ODR_DC_2_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.9 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
4.3 %Cys+Met (Translated Protein)
1.9 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
4.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPYPLNQAGYALNDTLLSALPGRFGTPLWVYDAALIERQIASLRTFDTIRFAQKACSNLH
CCCCCCCCCCHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHH
ILRLMRQAGVKVDAVSLGEIERALMAGFRPDADDEEIVFTADVIDEATLDRICALGITVN
HHHHHHHCCCEEEEECHHHHHHHHHHCCCCCCCCCCEEEEHHHHHHHHHHHHHHEEEEEC
AGSCDMLRQLGCRASGHPVWLRINPGFGHGHSQKTNTGGENSKHGIWYQDLAQALALIDT
CCCHHHHHHHCCCCCCCEEEEEECCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHH
YGLRLVGLHMHIGSGVDYDHLARVCDTLANQAIALGRDIQAISAGGGLSIPYRDGDASVD
CCCEEEEEEEEECCCCCHHHHHHHHHHHHHHHHHHCCCCEEEECCCCCCCCCCCCCCCEE
VRHYYGLWDAARRRIAEHLGHPVRLEIEPGRYLVAQSGVLLAQVRAVKSMGARHFVLADA
HHHHHHHHHHHHHHHHHHCCCCEEEEECCCEEEEECCCHHHHHHHHHHHCCCCEEEEECC
GFNDLMRPAMYGSHHHISLLPQDGRDVTTPCIETVVGGPLCESGDVFTQREGGRVTSCAL
CHHHHHHHHHCCCCCEEEECCCCCCCCCHHHHHHHHCCCCCCCCCCEEECCCCEEEEECC
PAVQVGDWLVFHDTGAYGASMSSNYNSRPLLPEVLVEGDSVRLIRRRQRMDELLALEQI
CCEECCCEEEEECCCCCCCCCCCCCCCCCCCHHHHHCCCHHHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure 
PYPLNQAGYALNDTLLSALPGRFGTPLWVYDAALIERQIASLRTFDTIRFAQKACSNLH
CCCCCCCCCHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHH
ILRLMRQAGVKVDAVSLGEIERALMAGFRPDADDEEIVFTADVIDEATLDRICALGITVN
HHHHHHHCCCEEEEECHHHHHHHHHHCCCCCCCCCCEEEEHHHHHHHHHHHHHHEEEEEC
AGSCDMLRQLGCRASGHPVWLRINPGFGHGHSQKTNTGGENSKHGIWYQDLAQALALIDT
CCCHHHHHHHCCCCCCCEEEEEECCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHH
YGLRLVGLHMHIGSGVDYDHLARVCDTLANQAIALGRDIQAISAGGGLSIPYRDGDASVD
CCCEEEEEEEEECCCCCHHHHHHHHHHHHHHHHHHCCCCEEEECCCCCCCCCCCCCCCEE
VRHYYGLWDAARRRIAEHLGHPVRLEIEPGRYLVAQSGVLLAQVRAVKSMGARHFVLADA
HHHHHHHHHHHHHHHHHHCCCCEEEEECCCEEEEECCCHHHHHHHHHHHCCCCEEEEECC
GFNDLMRPAMYGSHHHISLLPQDGRDVTTPCIETVVGGPLCESGDVFTQREGGRVTSCAL
CHHHHHHHHHCCCCCEEEECCCCCCCCCHHHHHHHHCCCCCCCCCCEEECCCCEEEEECC
PAVQVGDWLVFHDTGAYGASMSSNYNSRPLLPEVLVEGDSVRLIRRRQRMDELLALEQI
CCEECCCEEEEECCCCCCCCCCCCCCCCCCCHHHHHCCCHHHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 6350601; 9278503 [H]