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The map label for this gene is aas [H]

Identifier: 238921126

GI number: 238921126

Start: 3143626

End: 3145785

Strand: Reverse

Name: aas [H]

Synonym: NT01EI_3265

Alternate gene names: 238921126

Gene position: 3145785-3143626 (Counterclockwise)

Preceding gene: 238921146

Following gene: 238921125

Centisome position: 82.52

GC content: 63.19

Gene sequence:

>2160_bases
ATGCTGTACCGATTCCTCGGCGTGCTGCTGAAAATGTTGTTCCGTATTCGTCTGACCGGCTTCGGTCAGTGTCTCGATCA
CCCGAAGCTGTTAATCGTTCCCAACCACGTCTCCTTTTTGGATGGTGTCCTGCTGACGCTGTATCTGCCGGTTCGGCCGG
TGTTTGCTGTCTACAGTTCGATAGCCGACAGCTGGCTGATGCGCCTGGTTGGGCGTTTTGTCGATATCGTCGCTCTGGAT
CCGCGTAAGCCGATGGCGATCAAACGGTTAATTCGCTTGGTTGAGCAGGGAAGGCCGGTGGTGATCTTTCCTGAGGGACG
TATCACCGTGAGCGGATCGCTGATGAAGATCTATGACGGTGCGGCGTTTGTGGCGGCCCGCTCCGGCGCAGCCCTGCTGC
CGGTACGCATTGAGGGGGCTGAGTTCAGCCACTTTGGCCGTCTGAAAGGGCTGTTTCCTCTGCGCCTGCTGCCGCCGATC
TCCCTTCATCTGCTGCCGGTGACGCATCTGGCGATGCCGCAGGCCGCGCGGGCGCGTGATCGGCGCCTGCTGGCCGGTGA
ACGCCTGCGCGACATTATGATGCGTGCCCGTCTGGACGCGCAGCCGATGACCACGCTGTTTGCCGCCTATCTGTCGGCGA
TGCGGCGCTATGGGGCAGGCAGCCGTGCGATCGATGACATTAACCTGCGTGAGGACAGCTACCGTGGGCTGCTGAAAAAG
AGCCTCGCCGTCAGCCGGATCCTGCAGCGTTTTACCTGCGAGAATGAGCACGTTGGTCTGCTGCTGCCTAACGCCACCGT
CACGGCGGCGGCGATCCTGGGGGCGACGCTGCGCAATCGGGTGCCGGCGATGCTGAACTACACCGCCGGCGCTGCCGGGC
TGCGCAATGCCCTGCTGGCCGCCGGGATCGATACCGTGGTCACCTCGCGGCAGTTTTTGCAAAAGGCGCGTCTGGAGCCG
TTGCCTCAGCTGGTGGACGGCGCACGCTGGGTCTATCTGGAGGATCTGCGGGATACGCTAGGGTGGCGGGATAAGCTCTG
GGTGTTGTGGCATCGGGTGTTCCCCCACGGTGCCATGCTTCCGCGCCAGCCTGACGATGCGGCGCTGATCCTGTTTACCT
CCGGTTCAGAGGGAGCGCCCAAAGGGGTAGTACACTCTCACCGTAGCCTGTTGGCCAACGTGGAGCAGATCCGCTGCGTA
GCGGATTTTACCCCGCGCGATCGCTTTATGTCGGCGCTGCCGCTGTTTCACGCCTTTGGGCTGACGGTGGGGCTGCTGAC
GCCGCTGCTGTGCGGCAGCCGGGTCTTTCTGTATCCCAGTCCGCTGCACTACCGCATGGTGCCGGAGATGGTTTATGACC
GAAACTGCACCGTGCTGTTTGCCACCTCGACGTTCCTGGGACACTACGCGCGTTTCGCTCATCCCTATGACTTTGCCCGG
CTGCGCTATGTGGTTGCCGGCGCAGAGAAGCTGGCGCCGGAGACGGCCCGGCTGTGGTTTGAGAAGTTTGGCATCCGTAT
TCTTGAGGGATACGGGGTGACCGAGTGTGCGCCGGTGGTGGCGATCAATGTGCCGATGGCGACCCGCACCGGCAGCGTCG
GCTGCATTCTGCCGGGAATGGAGGCGCGGCTGATCCCGGTGGCGGGGATCGCGCAGGGTGGTTGTCTGCAGCTGCGTGGC
CCCAATATTATGAAAGGCTACCTGCGGATCGAGGCGCCGGGGGTCCTGGTGCCGCCGCAGGCGGCGAACGTACAGGGTGA
GATGGAGGCGGGCTGGTACGATACTGGCGATATTGTGACGCTGGACGCACAAGGCTATTGCACGATTATCGGACGCCTCA
AGCGGTTTGCCAAACTGGCAGGGGAAATGGTGTCGCTGGAGCGTGTTGAACAGCTGGCGCGCGCGGCGTCGCCGCAGGGC
GAACATGCCGCCAGCGCGCGGAGCGATCGACTCAAGGGAGAGGCGCTGGTGCTGTTTACCACCGATGTCGGGCTGGGGCG
GGAGCAGCTGTTGGCGGCGGCCCGCGCCAGCGGTGCCCCTGAGCTGGCGGTGGCACGGGATATTCGCTATCTGAAGGCCC
TGCCGCTGTTGGGCAGTGGCAAGGTGGACTTTGTGACGCTGCGCCGTATGGCAGCATCTGAGGATAGCGTGGATGGATGA

Upstream 100 bases:

>100_bases
CGGGTCCGGGCGCAGATATTCCCGCCTGTGCAGTTTGCTGCGCTTCTGGCATCGGGTAGTATGCTAGCCGTGCTATCCTG
CCGCACATAGGGAGATGTCC

Downstream 100 bases:

>100_bases
GACACAGTGCACCGCCGTCGACGGGAGCGGACGGGGAATGCGGGCGGTTTTTGTGGCGCAGTTTTTCTCTGCGTTTGGCG
ACAATGCCCTGCTGTTTGTG

Product: bifunctional acyl-[acyl carrier protein] synthetase/2-acylglycerophosphoethanolamine acyltransferase

Products: NA

Alternate protein names: 2-acylglycerophosphoethanolamine acyltransferase; 2-acyl-GPE acyltransferase; Acyl-[acyl-carrier-protein]--phospholipid O-acyltransferase; Acyl-[acyl-carrier-protein] synthetase; Acyl-ACP synthetase; Long-chain-fatty-acid--[acyl-carrier-protein] ligase [H]

Number of amino acids: Translated: 719; Mature: 719

Protein sequence:

>719_residues
MLYRFLGVLLKMLFRIRLTGFGQCLDHPKLLIVPNHVSFLDGVLLTLYLPVRPVFAVYSSIADSWLMRLVGRFVDIVALD
PRKPMAIKRLIRLVEQGRPVVIFPEGRITVSGSLMKIYDGAAFVAARSGAALLPVRIEGAEFSHFGRLKGLFPLRLLPPI
SLHLLPVTHLAMPQAARARDRRLLAGERLRDIMMRARLDAQPMTTLFAAYLSAMRRYGAGSRAIDDINLREDSYRGLLKK
SLAVSRILQRFTCENEHVGLLLPNATVTAAAILGATLRNRVPAMLNYTAGAAGLRNALLAAGIDTVVTSRQFLQKARLEP
LPQLVDGARWVYLEDLRDTLGWRDKLWVLWHRVFPHGAMLPRQPDDAALILFTSGSEGAPKGVVHSHRSLLANVEQIRCV
ADFTPRDRFMSALPLFHAFGLTVGLLTPLLCGSRVFLYPSPLHYRMVPEMVYDRNCTVLFATSTFLGHYARFAHPYDFAR
LRYVVAGAEKLAPETARLWFEKFGIRILEGYGVTECAPVVAINVPMATRTGSVGCILPGMEARLIPVAGIAQGGCLQLRG
PNIMKGYLRIEAPGVLVPPQAANVQGEMEAGWYDTGDIVTLDAQGYCTIIGRLKRFAKLAGEMVSLERVEQLARAASPQG
EHAASARSDRLKGEALVLFTTDVGLGREQLLAAARASGAPELAVARDIRYLKALPLLGSGKVDFVTLRRMAASEDSVDG

Sequences:

>Translated_719_residues
MLYRFLGVLLKMLFRIRLTGFGQCLDHPKLLIVPNHVSFLDGVLLTLYLPVRPVFAVYSSIADSWLMRLVGRFVDIVALD
PRKPMAIKRLIRLVEQGRPVVIFPEGRITVSGSLMKIYDGAAFVAARSGAALLPVRIEGAEFSHFGRLKGLFPLRLLPPI
SLHLLPVTHLAMPQAARARDRRLLAGERLRDIMMRARLDAQPMTTLFAAYLSAMRRYGAGSRAIDDINLREDSYRGLLKK
SLAVSRILQRFTCENEHVGLLLPNATVTAAAILGATLRNRVPAMLNYTAGAAGLRNALLAAGIDTVVTSRQFLQKARLEP
LPQLVDGARWVYLEDLRDTLGWRDKLWVLWHRVFPHGAMLPRQPDDAALILFTSGSEGAPKGVVHSHRSLLANVEQIRCV
ADFTPRDRFMSALPLFHAFGLTVGLLTPLLCGSRVFLYPSPLHYRMVPEMVYDRNCTVLFATSTFLGHYARFAHPYDFAR
LRYVVAGAEKLAPETARLWFEKFGIRILEGYGVTECAPVVAINVPMATRTGSVGCILPGMEARLIPVAGIAQGGCLQLRG
PNIMKGYLRIEAPGVLVPPQAANVQGEMEAGWYDTGDIVTLDAQGYCTIIGRLKRFAKLAGEMVSLERVEQLARAASPQG
EHAASARSDRLKGEALVLFTTDVGLGREQLLAAARASGAPELAVARDIRYLKALPLLGSGKVDFVTLRRMAASEDSVDG
>Mature_719_residues
MLYRFLGVLLKMLFRIRLTGFGQCLDHPKLLIVPNHVSFLDGVLLTLYLPVRPVFAVYSSIADSWLMRLVGRFVDIVALD
PRKPMAIKRLIRLVEQGRPVVIFPEGRITVSGSLMKIYDGAAFVAARSGAALLPVRIEGAEFSHFGRLKGLFPLRLLPPI
SLHLLPVTHLAMPQAARARDRRLLAGERLRDIMMRARLDAQPMTTLFAAYLSAMRRYGAGSRAIDDINLREDSYRGLLKK
SLAVSRILQRFTCENEHVGLLLPNATVTAAAILGATLRNRVPAMLNYTAGAAGLRNALLAAGIDTVVTSRQFLQKARLEP
LPQLVDGARWVYLEDLRDTLGWRDKLWVLWHRVFPHGAMLPRQPDDAALILFTSGSEGAPKGVVHSHRSLLANVEQIRCV
ADFTPRDRFMSALPLFHAFGLTVGLLTPLLCGSRVFLYPSPLHYRMVPEMVYDRNCTVLFATSTFLGHYARFAHPYDFAR
LRYVVAGAEKLAPETARLWFEKFGIRILEGYGVTECAPVVAINVPMATRTGSVGCILPGMEARLIPVAGIAQGGCLQLRG
PNIMKGYLRIEAPGVLVPPQAANVQGEMEAGWYDTGDIVTLDAQGYCTIIGRLKRFAKLAGEMVSLERVEQLARAASPQG
EHAASARSDRLKGEALVLFTTDVGLGREQLLAAARASGAPELAVARDIRYLKALPLLGSGKVDFVTLRRMAASEDSVDG

Specific function: Plays a role in lysophospholipid acylation. Transfers fatty acids to the 1-position via an enzyme-bound acyl-ACP intermediate in the presence of ATP and magnesium. Its physiological function is to regenerate phosphatidylethanolamine from 2-acyl-glycero-3-

COG id: COG0318

COG function: function code IQ; Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: In the C-terminal section; belongs to the ATP- dependent AMP-binding enzyme family [H]

Homologues:

Organism=Homo sapiens, GI156151445, Length=365, Percent_Identity=26.027397260274, Blast_Score=97, Evalue=6e-20,
Organism=Homo sapiens, GI187761345, Length=544, Percent_Identity=25.5514705882353, Blast_Score=92, Evalue=1e-18,
Organism=Homo sapiens, GI187761343, Length=544, Percent_Identity=25.5514705882353, Blast_Score=92, Evalue=1e-18,
Organism=Homo sapiens, GI57165412, Length=336, Percent_Identity=27.3809523809524, Blast_Score=91, Evalue=3e-18,
Organism=Homo sapiens, GI57165410, Length=336, Percent_Identity=27.3809523809524, Blast_Score=91, Evalue=4e-18,
Organism=Homo sapiens, GI42544132, Length=432, Percent_Identity=23.3796296296296, Blast_Score=84, Evalue=6e-16,
Organism=Escherichia coli, GI1789201, Length=718, Percent_Identity=64.6239554317549, Blast_Score=956, Evalue=0.0,
Organism=Escherichia coli, GI1788107, Length=361, Percent_Identity=29.0858725761773, Blast_Score=127, Evalue=2e-30,
Organism=Escherichia coli, GI145693145, Length=362, Percent_Identity=28.7292817679558, Blast_Score=116, Evalue=5e-27,
Organism=Escherichia coli, GI1790505, Length=457, Percent_Identity=23.6323851203501, Blast_Score=77, Evalue=5e-15,
Organism=Escherichia coli, GI1788595, Length=277, Percent_Identity=29.6028880866426, Blast_Score=70, Evalue=5e-13,
Organism=Caenorhabditis elegans, GI17558820, Length=300, Percent_Identity=29, Blast_Score=112, Evalue=8e-25,
Organism=Caenorhabditis elegans, GI32563687, Length=297, Percent_Identity=28.2828282828283, Blast_Score=101, Evalue=2e-21,
Organism=Caenorhabditis elegans, GI71994694, Length=371, Percent_Identity=26.6846361185984, Blast_Score=100, Evalue=5e-21,
Organism=Caenorhabditis elegans, GI71994690, Length=371, Percent_Identity=26.6846361185984, Blast_Score=100, Evalue=5e-21,
Organism=Caenorhabditis elegans, GI71994703, Length=371, Percent_Identity=26.6846361185984, Blast_Score=99, Evalue=6e-21,
Organism=Caenorhabditis elegans, GI17560308, Length=375, Percent_Identity=26.1333333333333, Blast_Score=87, Evalue=4e-17,
Organism=Caenorhabditis elegans, GI17531443, Length=286, Percent_Identity=26.9230769230769, Blast_Score=81, Evalue=2e-15,
Organism=Caenorhabditis elegans, GI71985884, Length=362, Percent_Identity=25.1381215469613, Blast_Score=80, Evalue=3e-15,
Organism=Caenorhabditis elegans, GI17559526, Length=398, Percent_Identity=24.3718592964824, Blast_Score=70, Evalue=4e-12,
Organism=Saccharomyces cerevisiae, GI6319699, Length=349, Percent_Identity=24.0687679083095, Blast_Score=94, Evalue=8e-20,
Organism=Saccharomyces cerevisiae, GI6320852, Length=342, Percent_Identity=25.4385964912281, Blast_Score=85, Evalue=4e-17,
Organism=Saccharomyces cerevisiae, GI6319264, Length=393, Percent_Identity=26.2086513994911, Blast_Score=71, Evalue=5e-13,
Organism=Drosophila melanogaster, GI21355181, Length=541, Percent_Identity=23.6598890942699, Blast_Score=109, Evalue=7e-24,
Organism=Drosophila melanogaster, GI18859661, Length=304, Percent_Identity=26.9736842105263, Blast_Score=100, Evalue=3e-21,
Organism=Drosophila melanogaster, GI24581924, Length=357, Percent_Identity=24.6498599439776, Blast_Score=87, Evalue=3e-17,
Organism=Drosophila melanogaster, GI19922652, Length=279, Percent_Identity=27.5985663082437, Blast_Score=79, Evalue=1e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002123
- InterPro:   IPR020845
- InterPro:   IPR000873 [H]

Pfam domain/function: PF01553 Acyltransferase; PF00501 AMP-binding [H]

EC number: =2.3.1.40; =6.2.1.20 [H]

Molecular weight: Translated: 79081; Mature: 79081

Theoretical pI: Translated: 10.20; Mature: 10.20

Prosite motif: PS00455 AMP_BINDING

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
2.9 %Met     (Translated Protein)
4.2 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
2.9 %Met     (Mature Protein)
4.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLYRFLGVLLKMLFRIRLTGFGQCLDHPKLLIVPNHVSFLDGVLLTLYLPVRPVFAVYSS
CHHHHHHHHHHHHHHHHHCCCHHHCCCCCEEEECCCHHHHHHHHHHHHHHHHHHHHHHHH
IADSWLMRLVGRFVDIVALDPRKPMAIKRLIRLVEQGRPVVIFPEGRITVSGSLMKIYDG
HHHHHHHHHHHHHHEEEEECCCCCHHHHHHHHHHHCCCCEEEECCCEEEECCCEEEEECC
AAFVAARSGAALLPVRIEGAEFSHFGRLKGLFPLRLLPPISLHLLPVTHLAMPQAARARD
EEEEEECCCCEEEEEEECCCCCHHHHHHCCCCCEECCCCCCEEEEEHHHHHCCCHHHHHH
RRLLAGERLRDIMMRARLDAQPMTTLFAAYLSAMRRYGAGSRAIDDINLREDSYRGLLKK
HHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCHHHHHHHHH
SLAVSRILQRFTCENEHVGLLLPNATVTAAAILGATLRNRVPAMLNYTAGAAGLRNALLA
HHHHHHHHHHHCCCCCCEEEEECCCHHHHHHHHHHHHHHCCCHHEECCCCHHHHHHHHHH
AGIDTVVTSRQFLQKARLEPLPQLVDGARWVYLEDLRDTLGWRDKLWVLWHRVFPHGAML
HHHHHHHHHHHHHHHHCCCCCHHHHCCCCEEEHHHHHHHCCCCHHHHHHHHHHCCCCCCC
PRQPDDAALILFTSGSEGAPKGVVHSHRSLLANVEQIRCVADFTPRDRFMSALPLFHAFG
CCCCCCCEEEEEECCCCCCCCHHHHHHHHHHHHHHHHEEEECCCCHHHHHHHHHHHHHHH
LTVGLLTPLLCGSRVFLYPSPLHYRMVPEMVYDRNCTVLFATSTFLGHYARFAHPYDFAR
HHHHHHHHHHHCCEEEEECCCCCHHHCHHHHHCCCCEEEEEEHHHHHHHHHHCCCHHHHH
LRYVVAGAEKLAPETARLWFEKFGIRILEGYGVTECAPVVAINVPMATRTGSVGCILPGM
HHHHHHCHHHHCCHHHHHHHHHHCCEEEECCCCCCCCCEEEEECCCEECCCCCEEEECCC
EARLIPVAGIAQGGCLQLRGPNIMKGYLRIEAPGVLVPPQAANVQGEMEAGWYDTGDIVT
CCEEEEEECCCCCCEEEECCCCEEEEEEEEECCCEEECCCCCCCCCCCCCCEECCCCEEE
LDAQGYCTIIGRLKRFAKLAGEMVSLERVEQLARAASPQGEHAASARSDRLKGEALVLFT
ECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHCCCCCEEEEEE
TDVGLGREQLLAAARASGAPELAVARDIRYLKALPLLGSGKVDFVTLRRMAASEDSVDG
ECCCCCHHHHHHHHHCCCCCCHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHCCCCCCCC
>Mature Secondary Structure
MLYRFLGVLLKMLFRIRLTGFGQCLDHPKLLIVPNHVSFLDGVLLTLYLPVRPVFAVYSS
CHHHHHHHHHHHHHHHHHCCCHHHCCCCCEEEECCCHHHHHHHHHHHHHHHHHHHHHHHH
IADSWLMRLVGRFVDIVALDPRKPMAIKRLIRLVEQGRPVVIFPEGRITVSGSLMKIYDG
HHHHHHHHHHHHHHEEEEECCCCCHHHHHHHHHHHCCCCEEEECCCEEEECCCEEEEECC
AAFVAARSGAALLPVRIEGAEFSHFGRLKGLFPLRLLPPISLHLLPVTHLAMPQAARARD
EEEEEECCCCEEEEEEECCCCCHHHHHHCCCCCEECCCCCCEEEEEHHHHHCCCHHHHHH
RRLLAGERLRDIMMRARLDAQPMTTLFAAYLSAMRRYGAGSRAIDDINLREDSYRGLLKK
HHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCHHHHHHHHH
SLAVSRILQRFTCENEHVGLLLPNATVTAAAILGATLRNRVPAMLNYTAGAAGLRNALLA
HHHHHHHHHHHCCCCCCEEEEECCCHHHHHHHHHHHHHHCCCHHEECCCCHHHHHHHHHH
AGIDTVVTSRQFLQKARLEPLPQLVDGARWVYLEDLRDTLGWRDKLWVLWHRVFPHGAML
HHHHHHHHHHHHHHHHCCCCCHHHHCCCCEEEHHHHHHHCCCCHHHHHHHHHHCCCCCCC
PRQPDDAALILFTSGSEGAPKGVVHSHRSLLANVEQIRCVADFTPRDRFMSALPLFHAFG
CCCCCCCEEEEEECCCCCCCCHHHHHHHHHHHHHHHHEEEECCCCHHHHHHHHHHHHHHH
LTVGLLTPLLCGSRVFLYPSPLHYRMVPEMVYDRNCTVLFATSTFLGHYARFAHPYDFAR
HHHHHHHHHHHCCEEEEECCCCCHHHCHHHHHCCCCEEEEEEHHHHHHHHHHCCCHHHHH
LRYVVAGAEKLAPETARLWFEKFGIRILEGYGVTECAPVVAINVPMATRTGSVGCILPGM
HHHHHHCHHHHCCHHHHHHHHHHCCEEEECCCCCCCCCEEEEECCCEECCCCCEEEECCC
EARLIPVAGIAQGGCLQLRGPNIMKGYLRIEAPGVLVPPQAANVQGEMEAGWYDTGDIVT
CCEEEEEECCCCCCEEEECCCCEEEEEEEEECCCEEECCCCCCCCCCCCCCEECCCCEEE
LDAQGYCTIIGRLKRFAKLAGEMVSLERVEQLARAASPQGEHAASARSDRLKGEALVLFT
ECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHCCCCCEEEEEE
TDVGLGREQLLAAARASGAPELAVARDIRYLKALPLLGSGKVDFVTLRRMAASEDSVDG
ECCCCCHHHHHHHHHCCCCCCHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: NA