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The map label for this gene is hscB

Identifier: 238921050

GI number: 238921050

Start: 3061299

End: 3061817

Strand: Reverse

Name: hscB

Synonym: NT01EI_3180

Alternate gene names: 238921050

Gene position: 3061817-3061299 (Counterclockwise)

Preceding gene: 238921051

Following gene: 238921049

Centisome position: 80.31

GC content: 57.42

Gene sequence:

>519_bases
ATGGACTATTTCACGCTTTTCGGGTTTCCGGCACGCTATGACGTGGATGGCAGCCTGCTCGCTGCGCGTTTTCAGGATCT
GCAGCGTCAGTTTCACCCCGACCGTTTCGTCACCGCGCCTGAGCGCGATCGCCTGCTGGCAATGCAGCAGGCGACAACCA
TCAATGACGCCTATCAGACGCTTAAACATCCCCTCAAGCGGGCCGAGTATCTGCTCTCTCTGCACGGTTTTGACATCAAT
AATGAACAGCAGACCTTGCGCGATACGGCTTTCCTGATAGAGCAGATGACCCTGCGCGAGGAGCTGGAGGTGCTGGAGCA
CCGTGCCGACGCCGATGAGGCGTTAATGAGCTTTTCCGACAAGGTCGCTAAAATGGTGCAGGTGCGCAGTGCTCAGATGA
TAAATGAGCTGGACTGTCAGGCATGGCCGCAGGCGGCGGACAGCGTGCGTAAGCTACGATTTCTGGACAGGCTCCAGCAG
CAGACCGAACAGCTGGAAGAGCGGCTGCTGGGGATGTAA

Upstream 100 bases:

>100_bases
TAACGTTTAACCCGCGCCCACGTCACCGGCGGGCGTCGCCTCTCCTTAATTAGCTGACGTCGGCGACGCCGCTTTTACGG
TATTAGCATCAGAGTACGGC

Downstream 100 bases:

>100_bases
CCCTTTTTGACGGATTAACGGAAGCGAACATGGCGTTATTACAAATCAGTGAGCCGGGACTGAGTGCTGCGCCGCATCAG
CGTCGTCTGGCGGCGGGCAT

Product: co-chaperone HscB

Products: NA

Alternate protein names: Hsc20

Number of amino acids: Translated: 172; Mature: 172

Protein sequence:

>172_residues
MDYFTLFGFPARYDVDGSLLAARFQDLQRQFHPDRFVTAPERDRLLAMQQATTINDAYQTLKHPLKRAEYLLSLHGFDIN
NEQQTLRDTAFLIEQMTLREELEVLEHRADADEALMSFSDKVAKMVQVRSAQMINELDCQAWPQAADSVRKLRFLDRLQQ
QTEQLEERLLGM

Sequences:

>Translated_172_residues
MDYFTLFGFPARYDVDGSLLAARFQDLQRQFHPDRFVTAPERDRLLAMQQATTINDAYQTLKHPLKRAEYLLSLHGFDIN
NEQQTLRDTAFLIEQMTLREELEVLEHRADADEALMSFSDKVAKMVQVRSAQMINELDCQAWPQAADSVRKLRFLDRLQQ
QTEQLEERLLGM
>Mature_172_residues
MDYFTLFGFPARYDVDGSLLAARFQDLQRQFHPDRFVTAPERDRLLAMQQATTINDAYQTLKHPLKRAEYLLSLHGFDIN
NEQQTLRDTAFLIEQMTLREELEVLEHRADADEALMSFSDKVAKMVQVRSAQMINELDCQAWPQAADSVRKLRFLDRLQQ
QTEQLEERLLGM

Specific function: Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward hscA

COG id: COG1076

COG function: function code O; DnaJ-domain-containing proteins 1

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 J domain

Homologues:

Organism=Homo sapiens, GI50301234, Length=112, Percent_Identity=39.2857142857143, Blast_Score=75, Evalue=2e-14,
Organism=Escherichia coli, GI1788876, Length=170, Percent_Identity=58.8235294117647, Blast_Score=202, Evalue=7e-54,
Organism=Caenorhabditis elegans, GI17541320, Length=138, Percent_Identity=25.3623188405797, Blast_Score=63, Evalue=8e-11,
Organism=Drosophila melanogaster, GI161084223, Length=171, Percent_Identity=25.1461988304094, Blast_Score=69, Evalue=1e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): HSCB_EDWI9 (C5BEU2)

Other databases:

- EMBL:   CP001600
- RefSeq:   YP_002934565.1
- GeneID:   7958698
- GenomeReviews:   CP001600_GR
- KEGG:   eic:NT01EI_3180
- OMA:   LNDAYQT
- ProtClustDB:   PRK05014
- HAMAP:   MF_00682
- InterPro:   IPR001623
- InterPro:   IPR009073
- InterPro:   IPR004640
- Gene3D:   G3DSA:1.10.287.110
- Gene3D:   G3DSA:1.20.1280.20
- SMART:   SM00271
- TIGRFAMs:   TIGR00714

Pfam domain/function: PF00226 DnaJ; PF07743 HSCB_C; SSF46565 DnaJ_N; SSF47144 HSC20_C

EC number: NA

Molecular weight: Translated: 20139; Mature: 20139

Theoretical pI: Translated: 4.78; Mature: 4.78

Prosite motif: PS00636 DNAJ_1; PS50076 DNAJ_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
4.1 %Met     (Translated Protein)
4.7 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
4.1 %Met     (Mature Protein)
4.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDYFTLFGFPARYDVDGSLLAARFQDLQRQFHPDRFVTAPERDRLLAMQQATTINDAYQT
CCCEEEECCCCCCCCCHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHH
LKHPLKRAEYLLSLHGFDINNEQQTLRDTAFLIEQMTLREELEVLEHRADADEALMSFSD
HHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHH
KVAKMVQVRSAQMINELDCQAWPQAADSVRKLRFLDRLQQQTEQLEERLLGM
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure
MDYFTLFGFPARYDVDGSLLAARFQDLQRQFHPDRFVTAPERDRLLAMQQATTINDAYQT
CCCEEEECCCCCCCCCHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHH
LKHPLKRAEYLLSLHGFDINNEQQTLRDTAFLIEQMTLREELEVLEHRADADEALMSFSD
HHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHH
KVAKMVQVRSAQMINELDCQAWPQAADSVRKLRFLDRLQQQTEQLEERLLGM
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA