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The map label for this gene is degP [H]

Identifier: 238920969

GI number: 238920969

Start: 2987740

End: 2989155

Strand: Reverse

Name: degP [H]

Synonym: NT01EI_3099

Alternate gene names: 238920969

Gene position: 2989155-2987740 (Counterclockwise)

Preceding gene: 238920970

Following gene: 238920959

Centisome position: 78.41

GC content: 59.25

Gene sequence:

>1416_bases
ATGAAAAAAACCACTTTAGTATTGAGTGCCGTTGCATTGAGTCTGGGAATGGCGCTGAGCCCGATGTCGGCCAGCGCGGC
AGAGACCTCTTCCGCCACCACTGCCCAGGCGCTGCCGAGCCTGGCACCAATGCTGGAGAAAGTGATGCCGTCCGTGGTCA
GCATCAACGTTGAGGGCAGTGCGACCGTCAATAACAGCCGCGTGCCGCCGCAGTTCCAGCAGTTCTTTGGCGAAGACTCT
CCACTGTGCCAGCCAGGCTCACCGTTCGGCGGTTCGCCGATGTGTCAGGGTGGCGGTAATGCGCCGTCCAAAGAGCGCTT
TAAGGCGCTGGGCTCCGGGGTGATTATCGACGCGGGTAAAGGCTATGTCGTTACCAATAACCACGTTGTGGCCAACGCCG
ACAGTATTAAGGTTCAGCTGAGTGACGGTCGCCGCTTTGACGCTAAAGTGATCGGCACCGATCCGCGCACCGATATCGCA
CTGATCCAGCTGAAGGATGCCAAGAACCTGACCGCCATCAAGATGGCTGACTCCGATCGGCTGCGCGTGGGCGACTATGC
AGTGGCGATCGGTAACCCCTACGGATTGGGTGAGACCGTCACCTCCGGCATCGTTTCCGCGCTGGGCCGCAGCGGTCTGA
ACGTGGAAAACTACGAAAACTTTATTCAGACCGACGCGGCGATTAACCGCGGTAATTCCGGCGGCGCGCTGGTGAATCTG
AACGGCGATCTCATCGGGATCAACACCGCCATTCTGGCACCGGACGGTGGCAACATCGGCATCGGTTTTGCCATTCCGAG
TAACATGGTGAAAAACCTGACCGGTCAGATGGTGGAGTATGGTCAGGTGAAACGCGGTGAGCTGGGGATCATGGGGACCG
AGCTGAACTCTGAGCTGGCGAAGGCGATGAAGATCGACGCCCAGCGCGGTGCCTTTATCAGCCAGGTGTTGCCGAAGTCA
GCCGCCGCGAAGGCCGGGCTGAAAGCCGGTGATGTCATCGTCTCCCTGAACGGGAAGAACATCTCCAGCTTTGCCTCCTT
CCGCGCTGAAATTGGCACCATGCCGGTCGGCAGCAAGCTGGCGCTGGGGATTATCCGCAACGGTAAGCCGATGAACGTGG
AGGTGACTCTGGAGCAGAGCGCGCAGAGCCAGGTAGCCTCTGACAACATCTTCAGCGGTATCGAAGGGGCTGAGCTGAAC
AACGCCGCTGGTGGCAAGGGCGTGAAGGTGGATAACGTGAAGAAAGGCTCCACCGCTGCGCGTATCGGCCTGCAGAAGGG
CGACGTGATCCTGGGCGTGAACCAGCAGGCGATCGCCAACATCGGCGAGCTGCGTAAAATTCTGGATGCCAAGCCGCCGG
TGCTGGCGTTGAACATCCAGCGTGGCGACAATACCCTGTATCTGCTGATGCAGTAA

Upstream 100 bases:

>100_bases
TATCACCGTCACGGTGATAGCGGCGCCTTCTGGCACAACGCCGTTCAGCGCCGCTGAATGAATCCGTTTTATCGTTGCTA
ATACGAGAGAAAATCGTGCT

Downstream 100 bases:

>100_bases
TCTCCCACGAGCCACCTGGATATCGGGCGGCGCATCCGGAAAGACGAATACCCCGTGAGCGTATTGCCCACGGGGTATTT
TTTTATCCTCATCTCACTGC

Product: serine endoprotease

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 471; Mature: 471

Protein sequence:

>471_residues
MKKTTLVLSAVALSLGMALSPMSASAAETSSATTAQALPSLAPMLEKVMPSVVSINVEGSATVNNSRVPPQFQQFFGEDS
PLCQPGSPFGGSPMCQGGGNAPSKERFKALGSGVIIDAGKGYVVTNNHVVANADSIKVQLSDGRRFDAKVIGTDPRTDIA
LIQLKDAKNLTAIKMADSDRLRVGDYAVAIGNPYGLGETVTSGIVSALGRSGLNVENYENFIQTDAAINRGNSGGALVNL
NGDLIGINTAILAPDGGNIGIGFAIPSNMVKNLTGQMVEYGQVKRGELGIMGTELNSELAKAMKIDAQRGAFISQVLPKS
AAAKAGLKAGDVIVSLNGKNISSFASFRAEIGTMPVGSKLALGIIRNGKPMNVEVTLEQSAQSQVASDNIFSGIEGAELN
NAAGGKGVKVDNVKKGSTAARIGLQKGDVILGVNQQAIANIGELRKILDAKPPVLALNIQRGDNTLYLLMQ

Sequences:

>Translated_471_residues
MKKTTLVLSAVALSLGMALSPMSASAAETSSATTAQALPSLAPMLEKVMPSVVSINVEGSATVNNSRVPPQFQQFFGEDS
PLCQPGSPFGGSPMCQGGGNAPSKERFKALGSGVIIDAGKGYVVTNNHVVANADSIKVQLSDGRRFDAKVIGTDPRTDIA
LIQLKDAKNLTAIKMADSDRLRVGDYAVAIGNPYGLGETVTSGIVSALGRSGLNVENYENFIQTDAAINRGNSGGALVNL
NGDLIGINTAILAPDGGNIGIGFAIPSNMVKNLTGQMVEYGQVKRGELGIMGTELNSELAKAMKIDAQRGAFISQVLPKS
AAAKAGLKAGDVIVSLNGKNISSFASFRAEIGTMPVGSKLALGIIRNGKPMNVEVTLEQSAQSQVASDNIFSGIEGAELN
NAAGGKGVKVDNVKKGSTAARIGLQKGDVILGVNQQAIANIGELRKILDAKPPVLALNIQRGDNTLYLLMQ
>Mature_471_residues
MKKTTLVLSAVALSLGMALSPMSASAAETSSATTAQALPSLAPMLEKVMPSVVSINVEGSATVNNSRVPPQFQQFFGEDS
PLCQPGSPFGGSPMCQGGGNAPSKERFKALGSGVIIDAGKGYVVTNNHVVANADSIKVQLSDGRRFDAKVIGTDPRTDIA
LIQLKDAKNLTAIKMADSDRLRVGDYAVAIGNPYGLGETVTSGIVSALGRSGLNVENYENFIQTDAAINRGNSGGALVNL
NGDLIGINTAILAPDGGNIGIGFAIPSNMVKNLTGQMVEYGQVKRGELGIMGTELNSELAKAMKIDAQRGAFISQVLPKS
AAAKAGLKAGDVIVSLNGKNISSFASFRAEIGTMPVGSKLALGIIRNGKPMNVEVTLEQSAQSQVASDNIFSGIEGAELN
NAAGGKGVKVDNVKKGSTAARIGLQKGDVILGVNQQAIANIGELRKILDAKPPVLALNIQRGDNTLYLLMQ

Specific function: Serine protease that is required at high temperature. Involved in the degradation of damaged proteins. Shared specificity with hhoA/degQ [H]

COG id: COG0265

COG function: function code O; Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain

Gene ontology:

Cell location: Periplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 2 PDZ (DHR) domains [H]

Homologues:

Organism=Homo sapiens, GI4506141, Length=250, Percent_Identity=41.2, Blast_Score=162, Evalue=5e-40,
Organism=Homo sapiens, GI24308541, Length=318, Percent_Identity=32.0754716981132, Blast_Score=147, Evalue=2e-35,
Organism=Homo sapiens, GI22129776, Length=248, Percent_Identity=35.0806451612903, Blast_Score=141, Evalue=2e-33,
Organism=Homo sapiens, GI7019477, Length=288, Percent_Identity=34.7222222222222, Blast_Score=136, Evalue=5e-32,
Organism=Escherichia coli, GI1786356, Length=474, Percent_Identity=78.6919831223629, Blast_Score=716, Evalue=0.0,
Organism=Escherichia coli, GI1789629, Length=475, Percent_Identity=57.0526315789474, Blast_Score=525, Evalue=1e-150,
Organism=Escherichia coli, GI1789630, Length=285, Percent_Identity=40, Blast_Score=200, Evalue=2e-52,
Organism=Drosophila melanogaster, GI24646839, Length=290, Percent_Identity=33.7931034482759, Blast_Score=132, Evalue=5e-31,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001478
- InterPro:   IPR009003
- InterPro:   IPR011782
- InterPro:   IPR001254
- InterPro:   IPR001940 [H]

Pfam domain/function: PF00595 PDZ; PF00089 Trypsin [H]

EC number: 3.4.21.- [C]

Molecular weight: Translated: 48675; Mature: 48675

Theoretical pI: Translated: 9.45; Mature: 9.45

Prosite motif: PS50106 PDZ

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
3.0 %Met     (Translated Protein)
3.4 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
3.0 %Met     (Mature Protein)
3.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKKTTLVLSAVALSLGMALSPMSASAAETSSATTAQALPSLAPMLEKVMPSVVSINVEGS
CCCHHHHHHHHHHHHCCEECCCCCCCCCCCCCHHHHHHHHHHHHHHHHCCCEEEEEECCC
ATVNNSRVPPQFQQFFGEDSPLCQPGSPFGGSPMCQGGGNAPSKERFKALGSGVIIDAGK
EEECCCCCCHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHCCCEEEECCC
GYVVTNNHVVANADSIKVQLSDGRRFDAKVIGTDPRTDIALIQLKDAKNLTAIKMADSDR
CEEEECCEEEECCCEEEEEECCCCEEEEEEECCCCCCCEEEEEEECCCCEEEEEECCCCC
LRVGDYAVAIGNPYGLGETVTSGIVSALGRSGLNVENYENFIQTDAAINRGNSGGALVNL
EEECCEEEEECCCCCCCHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHCCCCCCCEEEEE
NGDLIGINTAILAPDGGNIGIGFAIPSNMVKNLTGQMVEYGQVKRGELGIMGTELNSELA
CCCEEEEEEEEECCCCCCEEEEEECCHHHHHHHHHHHHHHCCCCCCCEEEEECCHHHHHH
KAMKIDAQRGAFISQVLPKSAAAKAGLKAGDVIVSLNGKNISSFASFRAEIGTMPVGSKL
HHHHCCCCCCHHHHHHCCHHHHHHCCCCCCCEEEEECCCCHHHHHHHHHHHCCCCCCCCE
ALGIIRNGKPMNVEVTLEQSAQSQVASDNIFSGIEGAELNNAAGGKGVKVDNVKKGSTAA
EEEEEECCCCEEEEEEECCCHHHHHHCCHHHCCCCCCCCCCCCCCCCEEECCCCCCCCCE
RIGLQKGDVILGVNQQAIANIGELRKILDAKPPVLALNIQRGDNTLYLLMQ
EEECCCCCEEEECCHHHHHHHHHHHHHHCCCCCEEEEEEEECCCEEEEEEC
>Mature Secondary Structure
MKKTTLVLSAVALSLGMALSPMSASAAETSSATTAQALPSLAPMLEKVMPSVVSINVEGS
CCCHHHHHHHHHHHHCCEECCCCCCCCCCCCCHHHHHHHHHHHHHHHHCCCEEEEEECCC
ATVNNSRVPPQFQQFFGEDSPLCQPGSPFGGSPMCQGGGNAPSKERFKALGSGVIIDAGK
EEECCCCCCHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHCCCEEEECCC
GYVVTNNHVVANADSIKVQLSDGRRFDAKVIGTDPRTDIALIQLKDAKNLTAIKMADSDR
CEEEECCEEEECCCEEEEEECCCCEEEEEEECCCCCCCEEEEEEECCCCEEEEEECCCCC
LRVGDYAVAIGNPYGLGETVTSGIVSALGRSGLNVENYENFIQTDAAINRGNSGGALVNL
EEECCEEEEECCCCCCCHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHCCCCCCCEEEEE
NGDLIGINTAILAPDGGNIGIGFAIPSNMVKNLTGQMVEYGQVKRGELGIMGTELNSELA
CCCEEEEEEEEECCCCCCEEEEEECCHHHHHHHHHHHHHHCCCCCCCEEEEECCHHHHHH
KAMKIDAQRGAFISQVLPKSAAAKAGLKAGDVIVSLNGKNISSFASFRAEIGTMPVGSKL
HHHHCCCCCCHHHHHHCCHHHHHHCCCCCCCEEEEECCCCHHHHHHHHHHHCCCCCCCCE
ALGIIRNGKPMNVEVTLEQSAQSQVASDNIFSGIEGAELNNAAGGKGVKVDNVKKGSTAA
EEEEEECCCCEEEEEEECCCHHHHHHCCHHHCCCCCCCCCCCCCCCCEEECCCCCCCCCE
RIGLQKGDVILGVNQQAIANIGELRKILDAKPPVLALNIQRGDNTLYLLMQ
EEECCCCCEEEECCHHHHHHHHHHHHHHCCCCCEEEEEEEECCCEEEEEEC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: Serine endopeptidases [C]

General reaction: Hydrolase; Acting on peptide bonds (Peptidases) [C]

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 1645840; 11677609 [H]