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The map label for this gene is rnc [H]

Identifier: 238920905

GI number: 238920905

Start: 2921310

End: 2921990

Strand: Reverse

Name: rnc [H]

Synonym: NT01EI_3032

Alternate gene names: 238920905

Gene position: 2921990-2921310 (Counterclockwise)

Preceding gene: 238920906

Following gene: 238920904

Centisome position: 76.65

GC content: 59.18

Gene sequence:

>681_bases
ATGAACCCCATCGTAATAAACCGGCTTCAGCGTAAGCTGGGCTACACTTTTAGACAGCATGATCTGCTGATGCAGGCGTT
GACCCACCGCAGCGCCAGCAGTAAACATAATGAACGGCTTGAGTTTCTGGGTGACTCGATCCTGAGTTTTGTGATTGCTA
ACGCGCTCTATCACCGCTTCCCGCGCGTGGATGAAGGCGATATGAGCCGGATGCGCGCCACGCTGGTGCGCGGCAACACC
CTGGCCGAAATGGCGCGCGAGTTCGATCTGGGCGAGTGTCTGCGTCTGGGGCCGGGAGAGTTGAAGAGCGGTGGTTTTCG
CCGTGAGTCTATCCTGGCGGATACCGTAGAGGCGCTGATCGGCGGTATTTTCCTCGACAGCGATATTCAGACCATTGAGC
GTCTGATCCTCGACTGGTATCGCTCCCGCCTGGAGGAGATCAGCCCGGGCGACAAGCAGAAAGATCCCAAGACACGTTTA
CAGGAGTTTCTGCAGGGGCGCCATCTACCGCTGCCCTCCTATCTGGTGGTACAGGTGCGCGGTGAGGCGCACGACCAGGA
GTTTACCATTCACTGCCAGGTCAGCGGGCTGTCCGCGCCGGTAGTTGGTGTCGGCTCCAGCCGGCGCAAGGCCGAGCAGG
CCGCCGCCGAGCAGGCGTTAAAACAGTTGGAGCTTGAATGA

Upstream 100 bases:

>100_bases
GGGGCCACTGCAAACGAAACAGCTTTGGATTGGCTTATGGCAAGGCAGGCCTGTTCCGTATGCTGCGGTTTTTGACGCAT
TCTGAATTTATTGGTATCTC

Downstream 100 bases:

>100_bases
GCGAAGAAAAAACCTACTGCGGCTTTATTGCCATCGTTGGCCGTCCCAATGTCGGTAAGTCAACGTTACTGAACCAGTTG
CTGGGGCAAAAAATTTCCAT

Product: ribonuclease III

Products: NA

Alternate protein names: Ribonuclease III; RNase III [H]

Number of amino acids: Translated: 226; Mature: 226

Protein sequence:

>226_residues
MNPIVINRLQRKLGYTFRQHDLLMQALTHRSASSKHNERLEFLGDSILSFVIANALYHRFPRVDEGDMSRMRATLVRGNT
LAEMAREFDLGECLRLGPGELKSGGFRRESILADTVEALIGGIFLDSDIQTIERLILDWYRSRLEEISPGDKQKDPKTRL
QEFLQGRHLPLPSYLVVQVRGEAHDQEFTIHCQVSGLSAPVVGVGSSRRKAEQAAAEQALKQLELE

Sequences:

>Translated_226_residues
MNPIVINRLQRKLGYTFRQHDLLMQALTHRSASSKHNERLEFLGDSILSFVIANALYHRFPRVDEGDMSRMRATLVRGNT
LAEMAREFDLGECLRLGPGELKSGGFRRESILADTVEALIGGIFLDSDIQTIERLILDWYRSRLEEISPGDKQKDPKTRL
QEFLQGRHLPLPSYLVVQVRGEAHDQEFTIHCQVSGLSAPVVGVGSSRRKAEQAAAEQALKQLELE
>Mature_226_residues
MNPIVINRLQRKLGYTFRQHDLLMQALTHRSASSKHNERLEFLGDSILSFVIANALYHRFPRVDEGDMSRMRATLVRGNT
LAEMAREFDLGECLRLGPGELKSGGFRRESILADTVEALIGGIFLDSDIQTIERLILDWYRSRLEEISPGDKQKDPKTRL
QEFLQGRHLPLPSYLVVQVRGEAHDQEFTIHCQVSGLSAPVVGVGSSRRKAEQAAAEQALKQLELE

Specific function: Digests double-stranded RNA. Involved in the processing of ribosomal RNA precursors and of some mRNAs [H]

COG id: COG0571

COG function: function code K; dsRNA-specific ribonuclease

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 RNase III domain [H]

Homologues:

Organism=Homo sapiens, GI155030234, Length=230, Percent_Identity=28.2608695652174, Blast_Score=95, Evalue=4e-20,
Organism=Homo sapiens, GI155030236, Length=230, Percent_Identity=28.2608695652174, Blast_Score=95, Evalue=6e-20,
Organism=Escherichia coli, GI1788920, Length=226, Percent_Identity=91.1504424778761, Blast_Score=412, Evalue=1e-117,
Organism=Caenorhabditis elegans, GI193202651, Length=227, Percent_Identity=30.8370044052863, Blast_Score=97, Evalue=8e-21,
Organism=Caenorhabditis elegans, GI17506883, Length=227, Percent_Identity=30.8370044052863, Blast_Score=97, Evalue=8e-21,
Organism=Saccharomyces cerevisiae, GI6323895, Length=203, Percent_Identity=28.5714285714286, Blast_Score=67, Evalue=2e-12,
Organism=Drosophila melanogaster, GI17137682, Length=230, Percent_Identity=27.3913043478261, Blast_Score=82, Evalue=4e-16,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001159
- InterPro:   IPR014720
- InterPro:   IPR000999
- InterPro:   IPR011907 [H]

Pfam domain/function: PF00035 dsrm; PF00636 Ribonuclease_3 [H]

EC number: =3.1.26.3 [H]

Molecular weight: Translated: 25565; Mature: 25565

Theoretical pI: Translated: 7.22; Mature: 7.22

Prosite motif: PS50137 DS_RBD ; PS00517 RNASE_3_1 ; PS50142 RNASE_3_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
3.1 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
3.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNPIVINRLQRKLGYTFRQHDLLMQALTHRSASSKHNERLEFLGDSILSFVIANALYHRF
CCCHHHHHHHHHHCCHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHC
PRVDEGDMSRMRATLVRGNTLAEMAREFDLGECLRLGPGELKSGGFRRESILADTVEALI
CCCCCCHHHHHHHHHHCCHHHHHHHHHCCHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHH
GGIFLDSDIQTIERLILDWYRSRLEEISPGDKQKDPKTRLQEFLQGRHLPLPSYLVVQVR
HHHHCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHCCCCCCCCCEEEEEEC
GEAHDQEFTIHCQVSGLSAPVVGVGSSRRKAEQAAAEQALKQLELE
CCCCCCEEEEEEEECCCCCCEEECCCCHHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure
MNPIVINRLQRKLGYTFRQHDLLMQALTHRSASSKHNERLEFLGDSILSFVIANALYHRF
CCCHHHHHHHHHHCCHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHC
PRVDEGDMSRMRATLVRGNTLAEMAREFDLGECLRLGPGELKSGGFRRESILADTVEALI
CCCCCCHHHHHHHHHHCCHHHHHHHHHCCHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHH
GGIFLDSDIQTIERLILDWYRSRLEEISPGDKQKDPKTRLQEFLQGRHLPLPSYLVVQVR
HHHHCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHCCCCCCCCCEEEEEEC
GEAHDQEFTIHCQVSGLSAPVVGVGSSRRKAEQAAAEQALKQLELE
CCCCCCEEEEEEEECCCCCCEEECCCCHHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA