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The map label for this gene is nei [H]

Identifier: 238920756

GI number: 238920756

Start: 2764795

End: 2765670

Strand: Reverse

Name: nei [H]

Synonym: NT01EI_2874

Alternate gene names: 238920756

Gene position: 2765670-2764795 (Counterclockwise)

Preceding gene: 238920759

Following gene: 238920754

Centisome position: 72.55

GC content: 63.24

Gene sequence:

>876_bases
ATGCCGGAAGGACCAGAAATTCGCCGGGTGGCAGATGAACTGCGCGCCGCGGTTGGGGGAGGAACGCTGACCCAGGTCTG
GTTTGGCGTGCCGTCTCTTCAGCGGCACGCCGCTGGACTGGTCGGTTGCCGGGTTACGACGATTGAGGCGCGTGGCAAAG
CGCTGCTGATTCACTTTTCCAACGGTGTGAGCATGTACAGTCATAATCAGCTGTACGGCATCTGGCGGGTGGCCGCCACT
GGCCAGATACCACCGACGTCGCGCTCGCTGCGCGTGCGCCTGGAGACCGCCGAGCGGGCTATTTTGCTTTATAGCGCCTC
CGATATTCAGCTGGCGCCGCGGGCGCAGATCCTTCGCCATCCTTTTTTACTGCGGATTGGCCCCGATGTACTGGATCCCG
CCCTGACGGAGGTGCAGGTGCGAGAGCGTCTGTGTTCGCCAGCGTTTCGCCGTCGTCAGCTGGGTGCCCTGCTGCTGGAT
CAGCGCTTTCTGGCGGGACTGGGTAACTACCTGAGGGTGGAGATCCTGTGGCAGGTGGAGCTGCCGCCGCAGCGGCGGGC
GACGGATCTGACCCCAGCGCAGCTGACATCGCTCTGCCATGCGTTGCTGGCAGTGCCGCGTCTCTCCTATGTAACGCGTG
GTCAGATCGATACGGGCCGCCATCACGGGACGCTGTTCCGTTTTCGGGTATTTCAGCGTGAGGGGGAGTCATGTGAACGT
TGCGGGACGACCCTCATCCGTGCACAGGTGGCGTCGCGTCCGTTTTACGGCTGTCCGGGCTGTCAGGGTGGGTTGGAGGA
CACATCGGGTAACGCGAAAACCGGCGGGAGCCGCTCCCGCCGGGGAATGATTAACGCTGGTTCAGCCGTGAGCTGA

Upstream 100 bases:

>100_bases
TACCACTTACGTATACCCGACTCGATACGGTGCTCAGGTCTGCGCAGGGGAGGATCCATTTTCGGCCACGTTGCCTAACA
TATGCAATCAGGGGGAATAA

Downstream 100 bases:

>100_bases
AGTCACGGCGCGTATAGCCGGTATACAGCTGGCGCGGGCGGGCGATCTTCAGACCATCCTCGTGCATTTCATTCCAGTGG
GCTATCCAGCCGACGGTACG

Product: endonuclease VIII

Products: NA

Alternate protein names: DNA glycosylase/AP lyase Nei; DNA-(apurinic or apyrimidinic site) lyase Nei; Endonuclease VIII [H]

Number of amino acids: Translated: 291; Mature: 290

Protein sequence:

>291_residues
MPEGPEIRRVADELRAAVGGGTLTQVWFGVPSLQRHAAGLVGCRVTTIEARGKALLIHFSNGVSMYSHNQLYGIWRVAAT
GQIPPTSRSLRVRLETAERAILLYSASDIQLAPRAQILRHPFLLRIGPDVLDPALTEVQVRERLCSPAFRRRQLGALLLD
QRFLAGLGNYLRVEILWQVELPPQRRATDLTPAQLTSLCHALLAVPRLSYVTRGQIDTGRHHGTLFRFRVFQREGESCER
CGTTLIRAQVASRPFYGCPGCQGGLEDTSGNAKTGGSRSRRGMINAGSAVS

Sequences:

>Translated_291_residues
MPEGPEIRRVADELRAAVGGGTLTQVWFGVPSLQRHAAGLVGCRVTTIEARGKALLIHFSNGVSMYSHNQLYGIWRVAAT
GQIPPTSRSLRVRLETAERAILLYSASDIQLAPRAQILRHPFLLRIGPDVLDPALTEVQVRERLCSPAFRRRQLGALLLD
QRFLAGLGNYLRVEILWQVELPPQRRATDLTPAQLTSLCHALLAVPRLSYVTRGQIDTGRHHGTLFRFRVFQREGESCER
CGTTLIRAQVASRPFYGCPGCQGGLEDTSGNAKTGGSRSRRGMINAGSAVS
>Mature_290_residues
PEGPEIRRVADELRAAVGGGTLTQVWFGVPSLQRHAAGLVGCRVTTIEARGKALLIHFSNGVSMYSHNQLYGIWRVAATG
QIPPTSRSLRVRLETAERAILLYSASDIQLAPRAQILRHPFLLRIGPDVLDPALTEVQVRERLCSPAFRRRQLGALLLDQ
RFLAGLGNYLRVEILWQVELPPQRRATDLTPAQLTSLCHALLAVPRLSYVTRGQIDTGRHHGTLFRFRVFQREGESCERC
GTTLIRAQVASRPFYGCPGCQGGLEDTSGNAKTGGSRSRRGMINAGSAVS

Specific function: Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized pyrimidines, such as thymine glycol, 5,6-dihydrouracil and 5,6-dihydrothy

COG id: COG0266

COG function: function code L; Formamidopyrimidine-DNA glycosylase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 FPG-type zinc finger [H]

Homologues:

Organism=Escherichia coli, GI1786932, Length=262, Percent_Identity=62.2137404580153, Blast_Score=352, Evalue=1e-98,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR015886
- InterPro:   IPR015887
- InterPro:   IPR012319
- InterPro:   IPR010979
- InterPro:   IPR000214
- InterPro:   IPR010663 [H]

Pfam domain/function: PF01149 Fapy_DNA_glyco; PF06831 H2TH; PF06827 zf-FPG_IleRS [H]

EC number: =4.2.99.18 [H]

Molecular weight: Translated: 31971; Mature: 31840

Theoretical pI: Translated: 10.88; Mature: 10.88

Prosite motif: PS51066 ZF_FPG_2 ; PS51068 FPG_CAT

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.4 %Cys     (Translated Protein)
1.0 %Met     (Translated Protein)
3.4 %Cys+Met (Translated Protein)
2.4 %Cys     (Mature Protein)
0.7 %Met     (Mature Protein)
3.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPEGPEIRRVADELRAAVGGGTLTQVWFGVPSLQRHAAGLVGCRVTTIEARGKALLIHFS
CCCCHHHHHHHHHHHHHHCCCHHHHHHHCCCHHHHHHHHEEEEEEEEEECCCCEEEEEEC
NGVSMYSHNQLYGIWRVAATGQIPPTSRSLRVRLETAERAILLYSASDIQLAPRAQILRH
CCCEEEECCCEEEEEEEEECCCCCCCCCEEEEEEEECCEEEEEEECCCCCCCCHHHHHHC
PFLLRIGPDVLDPALTEVQVRERLCSPAFRRRQLGALLLDQRFLAGLGNYLRVEILWQVE
CEEEEECCHHHCHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHCCCCEEEEEEEEEEC
LPPQRRATDLTPAQLTSLCHALLAVPRLSYVTRGQIDTGRHHGTLFRFRVFQREGESCER
CCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCEEEEEEEEHHCCCHHHH
CGTTLIRAQVASRPFYGCPGCQGGLEDTSGNAKTGGSRSRRGMINAGSAVS
HHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCC
>Mature Secondary Structure 
PEGPEIRRVADELRAAVGGGTLTQVWFGVPSLQRHAAGLVGCRVTTIEARGKALLIHFS
CCCHHHHHHHHHHHHHHCCCHHHHHHHCCCHHHHHHHHEEEEEEEEEECCCCEEEEEEC
NGVSMYSHNQLYGIWRVAATGQIPPTSRSLRVRLETAERAILLYSASDIQLAPRAQILRH
CCCEEEECCCEEEEEEEEECCCCCCCCCEEEEEEEECCEEEEEEECCCCCCCCHHHHHHC
PFLLRIGPDVLDPALTEVQVRERLCSPAFRRRQLGALLLDQRFLAGLGNYLRVEILWQVE
CEEEEECCHHHCHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHCCCCEEEEEEEEEEC
LPPQRRATDLTPAQLTSLCHALLAVPRLSYVTRGQIDTGRHHGTLFRFRVFQREGESCER
CCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCEEEEEEEEHHCCCHHHH
CGTTLIRAQVASRPFYGCPGCQGGLEDTSGNAKTGGSRSRRGMINAGSAVS
HHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA