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The map label for this gene is sdhB [H]

Identifier: 238920750

GI number: 238920750

Start: 2759674

End: 2760390

Strand: Reverse

Name: sdhB [H]

Synonym: NT01EI_2869

Alternate gene names: 238920750

Gene position: 2760390-2759674 (Counterclockwise)

Preceding gene: 238920751

Following gene: 238920749

Centisome position: 72.41

GC content: 60.95

Gene sequence:

>717_bases
ATGAAACTCGAATTCTCTGTTTACCGTTATAACCCGGACGTGGATAGCGCACCGCGCATGCAGGATTATACCCTGGAGGC
GGAAGAGGGGCGTGACATGATGCTGCTGGATGCGCTGATCCAGCTGAAAGAGCAGGACCCGACCCTGGCCTTTCGCCGCT
CCTGCCGCGAGGGGGTGTGCGGTTCGGATGGGGTCAACATGAACGGCCAAAACGGCCTGGCCTGCATCACCCCGCTCTCG
GCCCTGCGCCGTGGGGGAAAGAAAATCGTCATCCGCCCGCTGCCGGGACTGCCGGTGGTGCGCGATCTGGTGGTGGACAT
GGGGCAGTTTTATGCCCAGTACGAAAAGATCAAACCCTACCTGATTAACGATGGCCGAACGCCGCCGGCGCGTGAGCATC
TGCAGTCACCGGAGGAGCGCGCCAGGCTGGACGGGTTGTATGAGTGCATCCTGTGCGCCTGCTGCTCTACCGCCTGCCCA
TCCTTCTGGTGGAACCCGGACAAGTTTGTCGGTCCCTCCGGGCTGCTGGCGGCCTACCGTTTCCTGATCGATAGCCGCGA
CACGGCGACGACGCAGCGTCTCGACACGCTGGACGACGCTTTCAGTGTATTCCGTTGCCACGGCATCATGAATTGTGTCA
GCGTGTGCCCGAAGGGGCTAAATCCGACGCGTGCGATTGGTCACATTAAATCTATGCTGTTGCAGCGCGGAGCCTGA

Upstream 100 bases:

>100_bases
GAGTGAGAGCATGGTGCAACGCCGTGTCAACATGCAGCCCCGGCTGCGCGCGGCCTTCCCGCCGAAGGTGCGTACTTACT
GATTTGCCGAGGAGCAGGTA

Downstream 100 bases:

>100_bases
GGGATACACAGCATAGAATTCTGCGCGATACGCCGGATAATGGTTTCGCGCACTGTTCCGGTCGGAAGCGACGGGGACAG
TCAGGGAGGAGATAAGGCGC

Product: succinate dehydrogenase iron-sulfur subunit

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 238; Mature: 238

Protein sequence:

>238_residues
MKLEFSVYRYNPDVDSAPRMQDYTLEAEEGRDMMLLDALIQLKEQDPTLAFRRSCREGVCGSDGVNMNGQNGLACITPLS
ALRRGGKKIVIRPLPGLPVVRDLVVDMGQFYAQYEKIKPYLINDGRTPPAREHLQSPEERARLDGLYECILCACCSTACP
SFWWNPDKFVGPSGLLAAYRFLIDSRDTATTQRLDTLDDAFSVFRCHGIMNCVSVCPKGLNPTRAIGHIKSMLLQRGA

Sequences:

>Translated_238_residues
MKLEFSVYRYNPDVDSAPRMQDYTLEAEEGRDMMLLDALIQLKEQDPTLAFRRSCREGVCGSDGVNMNGQNGLACITPLS
ALRRGGKKIVIRPLPGLPVVRDLVVDMGQFYAQYEKIKPYLINDGRTPPAREHLQSPEERARLDGLYECILCACCSTACP
SFWWNPDKFVGPSGLLAAYRFLIDSRDTATTQRLDTLDDAFSVFRCHGIMNCVSVCPKGLNPTRAIGHIKSMLLQRGA
>Mature_238_residues
MKLEFSVYRYNPDVDSAPRMQDYTLEAEEGRDMMLLDALIQLKEQDPTLAFRRSCREGVCGSDGVNMNGQNGLACITPLS
ALRRGGKKIVIRPLPGLPVVRDLVVDMGQFYAQYEKIKPYLINDGRTPPAREHLQSPEERARLDGLYECILCACCSTACP
SFWWNPDKFVGPSGLLAAYRFLIDSRDTATTQRLDTLDDAFSVFRCHGIMNCVSVCPKGLNPTRAIGHIKSMLLQRGA

Specific function: Two distinct, membrane-bound, FAD-containing enzymes are responsible for the catalysis of fumarate and succinate interconversion; the fumarate reductase is used in anaerobic growth, and the succinate dehydrogenase is used in aerobic growth [H]

COG id: COG0479

COG function: function code C; Succinate dehydrogenase/fumarate reductase, Fe-S protein subunit

Gene ontology:

Cell location: Cell inner membrane; Peripheral membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 4Fe-4S ferredoxin-type domain [H]

Homologues:

Organism=Homo sapiens, GI115387094, Length=234, Percent_Identity=52.991452991453, Blast_Score=251, Evalue=5e-67,
Organism=Escherichia coli, GI1786943, Length=238, Percent_Identity=86.5546218487395, Blast_Score=445, Evalue=1e-126,
Organism=Escherichia coli, GI1790596, Length=233, Percent_Identity=38.6266094420601, Blast_Score=153, Evalue=9e-39,
Organism=Caenorhabditis elegans, GI17533915, Length=234, Percent_Identity=53.4188034188034, Blast_Score=252, Evalue=1e-67,
Organism=Saccharomyces cerevisiae, GI6322987, Length=231, Percent_Identity=52.8138528138528, Blast_Score=247, Evalue=1e-66,
Organism=Drosophila melanogaster, GI17137106, Length=235, Percent_Identity=53.6170212765957, Blast_Score=259, Evalue=1e-69,
Organism=Drosophila melanogaster, GI24643156, Length=233, Percent_Identity=52.7896995708155, Blast_Score=247, Evalue=5e-66,

Paralogues:

None

Copy number: 480 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR017896
- InterPro:   IPR017900
- InterPro:   IPR012675
- InterPro:   IPR001041
- InterPro:   IPR012285
- InterPro:   IPR009051
- InterPro:   IPR004489 [H]

Pfam domain/function: NA

EC number: =1.3.99.1 [H]

Molecular weight: Translated: 26597; Mature: 26597

Theoretical pI: Translated: 7.56; Mature: 7.56

Prosite motif: PS51085 2FE2S_FER_2 ; PS00198 4FE4S_FERREDOXIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

4.6 %Cys     (Translated Protein)
3.4 %Met     (Translated Protein)
8.0 %Cys+Met (Translated Protein)
4.6 %Cys     (Mature Protein)
3.4 %Met     (Mature Protein)
8.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKLEFSVYRYNPDVDSAPRMQDYTLEAEEGRDMMLLDALIQLKEQDPTLAFRRSCREGVC
CCEEEEEEEECCCCCCCCCCCCCEEECCCCCCHHHHHHHHHHHCCCCHHHHHHHHHCCCC
GSDGVNMNGQNGLACITPLSALRRGGKKIVIRPLPGLPVVRDLVVDMGQFYAQYEKIKPY
CCCCCCCCCCCCCHHHHHHHHHHCCCCEEEEECCCCCHHHHHHHHHHHHHHHHHHHCCCE
LINDGRTPPAREHLQSPEERARLDGLYECILCACCSTACPSFWWNPDKFVGPSGLLAAYR
EECCCCCCCHHHHHCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCHHHHHHHH
FLIDSRDTATTQRLDTLDDAFSVFRCHGIMNCVSVCPKGLNPTRAIGHIKSMLLQRGA
HHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHCCC
>Mature Secondary Structure
MKLEFSVYRYNPDVDSAPRMQDYTLEAEEGRDMMLLDALIQLKEQDPTLAFRRSCREGVC
CCEEEEEEEECCCCCCCCCCCCCEEECCCCCCHHHHHHHHHHHCCCCHHHHHHHHHCCCC
GSDGVNMNGQNGLACITPLSALRRGGKKIVIRPLPGLPVVRDLVVDMGQFYAQYEKIKPY
CCCCCCCCCCCCCHHHHHHHHHHCCCCEEEEECCCCCHHHHHHHHHHHHHHHHHHHCCCE
LINDGRTPPAREHLQSPEERARLDGLYECILCACCSTACPSFWWNPDKFVGPSGLLAAYR
EECCCCCCCHHHHHCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCHHHHHHHH
FLIDSRDTATTQRLDTLDDAFSVFRCHGIMNCVSVCPKGLNPTRAIGHIKSMLLQRGA
HHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 6388571; 8905232; 9278503; 6376123; 9298646 [H]