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The map label for this gene is modE [H]

Identifier: 238920726

GI number: 238920726

Start: 2730688

End: 2731479

Strand: Direct

Name: modE [H]

Synonym: NT01EI_2839

Alternate gene names: 238920726

Gene position: 2730688-2731479 (Clockwise)

Preceding gene: 238920720

Following gene: 238920727

Centisome position: 71.63

GC content: 61.99

Gene sequence:

>792_bases
ATGCAAGCCGATATTTTACTCACCCTTAAACTACAGGATCGTCTGTTTGCCGATCCGCGCCGCATCGAGCTGCTCAAACA
GGTGCGTCATACCGGATCCATCAGCCAGGGAGCCAGGCTGGCCGGGATCAGCTATAAAAGCGCCTGGGATGCCATCAATG
AAATGAACCAGCTGGCGGACGACGAGATCGTCAAGCGTGCCACCGGCGGCAAAGGTGGCGGCGGCGCCCGGCTGACCCGC
TACGGCGAGCGCCTGATAGCGCTGTACGATCTGCTGGAACAAATCCAACAGAAAGCCTTCGACGTACTGAAAACCGACGA
TCTGCCTCTAGACAGTCTGCTGGCGGCGATCGCCCGCTTCTCCCTGCAGACCAGCGCCCGCAACCAGTTTTTCGGCACCG
TCATCGAGCGCGGAGAGGAGTCGGTCCAGCAACACCTGCTGGTGCAGCTGGCAGACGGAAAGACCTGTCTGCGCGCCGCC
GTAACCGCCCAGAGCGCCCGTCGCCTGGCACTGCGGCCGGGTAAAGAGGTGCTGGTGCTGATCAAGGCACCCTGGATCCG
CCTGTGCATCGACAACGCCCTGTGCGGCGCCGCCGACAATGCGCTGAGCGGCCAGGTCAGCCATATTCAGGCCGGCAGCG
ACAACAGCGAGGTGTTGATCGCGCTGCCCGGCGGTGAAACCCTGTGCGCCACCGTCGATAACCGCACCATGAGCCAGCTG
CACCTGAACGTCGGCATGCCGATCAATGCCCTGTTTAACGCCGATCGGGTCATTATCGCCACCCTGACGTAA

Upstream 100 bases:

>100_bases
CGATAGCGTTTGGCATTGTTCAATCCGTGCGATACTCGCGGTTTGCCTGACGGGTGCCGGATCAGCCACAATAAGGGGGG
CATCAATGCGAGGAGCCGCC

Downstream 100 bases:

>100_bases
AACGCTGTGTGCCCCGGGGCAGACCTCTCCCCTCCCCGGTCTGCCCTGTCCGGCGTTTAACGGCGGTTTACCCCGCCGTG
ATAACATAATTGAAAACAAA

Product: DNA-binding transcriptional regulator ModE

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 263; Mature: 263

Protein sequence:

>263_residues
MQADILLTLKLQDRLFADPRRIELLKQVRHTGSISQGARLAGISYKSAWDAINEMNQLADDEIVKRATGGKGGGGARLTR
YGERLIALYDLLEQIQQKAFDVLKTDDLPLDSLLAAIARFSLQTSARNQFFGTVIERGEESVQQHLLVQLADGKTCLRAA
VTAQSARRLALRPGKEVLVLIKAPWIRLCIDNALCGAADNALSGQVSHIQAGSDNSEVLIALPGGETLCATVDNRTMSQL
HLNVGMPINALFNADRVIIATLT

Sequences:

>Translated_263_residues
MQADILLTLKLQDRLFADPRRIELLKQVRHTGSISQGARLAGISYKSAWDAINEMNQLADDEIVKRATGGKGGGGARLTR
YGERLIALYDLLEQIQQKAFDVLKTDDLPLDSLLAAIARFSLQTSARNQFFGTVIERGEESVQQHLLVQLADGKTCLRAA
VTAQSARRLALRPGKEVLVLIKAPWIRLCIDNALCGAADNALSGQVSHIQAGSDNSEVLIALPGGETLCATVDNRTMSQL
HLNVGMPINALFNADRVIIATLT
>Mature_263_residues
MQADILLTLKLQDRLFADPRRIELLKQVRHTGSISQGARLAGISYKSAWDAINEMNQLADDEIVKRATGGKGGGGARLTR
YGERLIALYDLLEQIQQKAFDVLKTDDLPLDSLLAAIARFSLQTSARNQFFGTVIERGEESVQQHLLVQLADGKTCLRAA
VTAQSARRLALRPGKEVLVLIKAPWIRLCIDNALCGAADNALSGQVSHIQAGSDNSEVLIALPGGETLCATVDNRTMSQL
HLNVGMPINALFNADRVIIATLT

Specific function: The modE-Mo complex acts as a repressor of the modABC operon, involved in the transport of molybdate. Upon binding molybdate, the conformation of the protein changes, promoting dimerization of ModE-Mo. The protein dimer is then competent to bind a DNA reg

COG id: COG2005

COG function: function code R; N-terminal domain of molybdenum-binding protein

Gene ontology:

Cell location: Cytoplasmic [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the modE family [H]

Homologues:

Organism=Escherichia coli, GI1786976, Length=264, Percent_Identity=67.0454545454545, Blast_Score=299, Evalue=2e-82,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000847
- InterPro:   IPR004606
- InterPro:   IPR008995
- InterPro:   IPR003725
- InterPro:   IPR016462
- InterPro:   IPR005116
- InterPro:   IPR011991 [H]

Pfam domain/function: PF00126 HTH_1; PF03459 TOBE [H]

EC number: NA

Molecular weight: Translated: 28552; Mature: 28552

Theoretical pI: Translated: 7.97; Mature: 7.97

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.5 %Cys     (Translated Protein)
1.5 %Met     (Translated Protein)
3.0 %Cys+Met (Translated Protein)
1.5 %Cys     (Mature Protein)
1.5 %Met     (Mature Protein)
3.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MQADILLTLKLQDRLFADPRRIELLKQVRHTGSISQGARLAGISYKSAWDAINEMNQLAD
CCCCEEEEEEECHHHCCCHHHHHHHHHHHHCCCCCCCCEEECCCHHHHHHHHHHHHHHHH
DEIVKRATGGKGGGGARLTRYGERLIALYDLLEQIQQKAFDVLKTDDLPLDSLLAAIARF
HHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHH
SLQTSARNQFFGTVIERGEESVQQHLLVQLADGKTCLRAAVTAQSARRLALRPGKEVLVL
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHCCCCCEEEEE
IKAPWIRLCIDNALCGAADNALSGQVSHIQAGSDNSEVLIALPGGETLCATVDNRTMSQL
EECCHHHHHHHHHHCCCCCCCCCCCCEEEECCCCCCEEEEEECCCCEEEEEECCCCEEHE
HLNVGMPINALFNADRVIIATLT
EEECCCCHHHHCCCCEEEEEEEC
>Mature Secondary Structure
MQADILLTLKLQDRLFADPRRIELLKQVRHTGSISQGARLAGISYKSAWDAINEMNQLAD
CCCCEEEEEEECHHHCCCHHHHHHHHHHHHCCCCCCCCEEECCCHHHHHHHHHHHHHHHH
DEIVKRATGGKGGGGARLTRYGERLIALYDLLEQIQQKAFDVLKTDDLPLDSLLAAIARF
HHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHH
SLQTSARNQFFGTVIERGEESVQQHLLVQLADGKTCLRAAVTAQSARRLALRPGKEVLVL
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHCCCCCEEEEE
IKAPWIRLCIDNALCGAADNALSGQVSHIQAGSDNSEVLIALPGGETLCATVDNRTMSQL
EECCHHHHHHHHHHCCCCCCCCCCCCEEEECCCCCCEEEEEECCCCEEEEEECCCCEEHE
HLNVGMPINALFNADRVIIATLT
EEECCCCHHHHCCCCEEEEEEEC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11586360; 12142430 [H]