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The map label for this gene is uvrB

Identifier: 238920712

GI number: 238920712

Start: 2716225

End: 2718243

Strand: Reverse

Name: uvrB

Synonym: NT01EI_2825

Alternate gene names: 238920712

Gene position: 2718243-2716225 (Counterclockwise)

Preceding gene: 238920713

Following gene: 238920711

Centisome position: 71.3

GC content: 62.7

Gene sequence:

>2019_bases
ATGAGTAAAACCTTCAAACTGCATTCCGCCTTTCAGCCTTCCGGCGATCAACCTGAGGCGATCCGTCGCCTGGAAGAGGG
GTTGGAGGACGGTCTGGCGCATCAGACCCTGCTGGGGGTGACCGGCTCAGGCAAGACGTTTACCATCGCCAATGTGATCG
CCGATCTTAACCGGCCGACCATGGTGATGGCGCCCAACAAGACGCTGGCTGCCCAGCTGTACGGCGAGATGAAGCAGTTC
TTTCCGGAGAATGCGGTGGAGTACTTTGTCTCCTACTACGATTACTACCAGCCGGAAGCCTATGTGCCCAGCTCGGATAC
CTTTATCGAAAAGGACGCATCGGTCAACGAGCACATTGAGCAGATGCGCCTGTCGGCCACCAAGGCACTGCTGGAGCGGC
GCGACGTGGTGGTGGTCGCCTCGGTTTCCGCGATTTACGGCCTGGGCGATCCCGATCTGTACCTGAAAATGATGCTGCAT
CTGACACAGGGGATGCTGATCGATCAGCGCAGCATTCTGCGCCGCCTCTCCGAGCTGCAGTATGTCCGTAACGATCAGGC
GTTCGCGCGCGGGACCTTTCGGGTACGCGGCGAGGTGATCGACATCTTCCCGGCGGAGGCCGACGATGAGGCGCTTCGGG
TGGAGCTGTTTGATGACGAGGTGGAGCGTCTGTCGCTGTTCGATCCTCTCACCGGACAGCTGCTGCGCACGGTGCCGCGC
TTTACCGTCTACCCGAAGACTCACTATGTGACCCCGCGCGAACGCATCCTGCAGGCGATGGAGGCGATCCGCGCCGAGCT
GGCGATGCGCCGTCAGTCGCTGCTGGCCAGTAACAAGCTGCTGGAAGAGCAGCGTCTGGCCCAGCGCACCCAGTTCGATT
TGGAGATGATGAACGAGCTGGGCTACTGTTCGGGGATCGAGAACTACTCCCGCTATCTCTCCGGACGCGGGCCCGGCGAG
CCGCCGCCGACCCTGTTTGACTACCTGCCGGCGGACGGCCTGCTGGTGATCGATGAGTCCCATGTGACTATCCCGCAGAT
CGGCGGGATGTACCGCGGTGACCGGGCGCGTAAAGAGACGCTGGTGGAGTATGGCTTCCGCCTGCCATCGGCGCTGGATA
ACCGGCCGCTGCGTTTTGAGGAGTTTGAGGCGCTGGCACCGCAGACCATCTATGTGTCGGCGACCCCGGGCAACTACGAG
CTGGATAAGTCGGGCGGCGAGGTGATCGACCAGGTGGTGCGCCCGACGGGACTGCTCGATCCGCTGATCGAGGTGCGCCC
GGTGGCGACCCAGGTGGACGATCTGCTGTCGGAGATCAATCTGCGCGCCGCCATCGGTGAGCGGGTGCTGGTGACCACCC
TGACCAAGCGCATGGCCGAAGATTTGACCGAGTATCTGGAAGAGCACGGCGTGCGGGTGCGCTACCTGCACTCCGATATC
GACACCGTCGAGCGGATGGAGATCATCCGCGATCTGCGCCTGGGCGAGTTTGACGCGCTGGTGGGGATCAACCTGCTGCG
CGAGGGGCTGGATATGCCGGAGGTGTCGCTGGTGGCGATTCTGGACGCGGACAAGGAAGGCTTCCTGCGCTCGGAGCGCT
CGCTGATCCAGACCATTGGCCGGGCGGCGCGTAACCTGAACGGCAAGGCGATCCTCTATGCCGACAAAATCACCCCGTCG
ATGGCGCGGGCGATCGGGGAGACGGAGCGCCGCCGCGAGCGTCAGCAGGCATTTAACCTGGCGCACGGCATCACGCCGCA
GGCGCTGAACAAGAAGGTCACGGATATCCTGCAGCTGGGCGATGGCCCGGTACGTAGCCGGACGAAAGGGGCGCGCGGAC
AGCGTGCGGCAGAGCCTCATCCAGACTACCACACGCTGTCGGCGAAGCAGATCGAGCAGCAGATCCAGCGCTTGGAGACG
CAGATGTACCAACATGCCCAGAACCTGGAGTTTGAGCAGGCCGCGGCCCTGCGCGACGAGATCCATATTCTGCGCGAGCA
GTTTAAGAATGCGTCCTAG

Upstream 100 bases:

>100_bases
GTAAGTATCCAGTAATATAGCCGGTTCACACAATAATCCGGTGCAGAGCAGCACGGTTCTTCTGCCAGCGTGCCGCCGCC
GCGTAATGGGGTAGTGAGCC

Downstream 100 bases:

>100_bases
GCGCACAGCTTTTGCTTGCCCGGCGGCTCCTGTGCCGTTAGGGTAAGCCCCCTTTTATGCCAAGCGGAGACACTATGAAC
CCATCACGCGATCCCCTGCA

Product: excinuclease ABC subunit B

Products: NA

Alternate protein names: Protein uvrB; Excinuclease ABC subunit B

Number of amino acids: Translated: 672; Mature: 671

Protein sequence:

>672_residues
MSKTFKLHSAFQPSGDQPEAIRRLEEGLEDGLAHQTLLGVTGSGKTFTIANVIADLNRPTMVMAPNKTLAAQLYGEMKQF
FPENAVEYFVSYYDYYQPEAYVPSSDTFIEKDASVNEHIEQMRLSATKALLERRDVVVVASVSAIYGLGDPDLYLKMMLH
LTQGMLIDQRSILRRLSELQYVRNDQAFARGTFRVRGEVIDIFPAEADDEALRVELFDDEVERLSLFDPLTGQLLRTVPR
FTVYPKTHYVTPRERILQAMEAIRAELAMRRQSLLASNKLLEEQRLAQRTQFDLEMMNELGYCSGIENYSRYLSGRGPGE
PPPTLFDYLPADGLLVIDESHVTIPQIGGMYRGDRARKETLVEYGFRLPSALDNRPLRFEEFEALAPQTIYVSATPGNYE
LDKSGGEVIDQVVRPTGLLDPLIEVRPVATQVDDLLSEINLRAAIGERVLVTTLTKRMAEDLTEYLEEHGVRVRYLHSDI
DTVERMEIIRDLRLGEFDALVGINLLREGLDMPEVSLVAILDADKEGFLRSERSLIQTIGRAARNLNGKAILYADKITPS
MARAIGETERRRERQQAFNLAHGITPQALNKKVTDILQLGDGPVRSRTKGARGQRAAEPHPDYHTLSAKQIEQQIQRLET
QMYQHAQNLEFEQAAALRDEIHILREQFKNAS

Sequences:

>Translated_672_residues
MSKTFKLHSAFQPSGDQPEAIRRLEEGLEDGLAHQTLLGVTGSGKTFTIANVIADLNRPTMVMAPNKTLAAQLYGEMKQF
FPENAVEYFVSYYDYYQPEAYVPSSDTFIEKDASVNEHIEQMRLSATKALLERRDVVVVASVSAIYGLGDPDLYLKMMLH
LTQGMLIDQRSILRRLSELQYVRNDQAFARGTFRVRGEVIDIFPAEADDEALRVELFDDEVERLSLFDPLTGQLLRTVPR
FTVYPKTHYVTPRERILQAMEAIRAELAMRRQSLLASNKLLEEQRLAQRTQFDLEMMNELGYCSGIENYSRYLSGRGPGE
PPPTLFDYLPADGLLVIDESHVTIPQIGGMYRGDRARKETLVEYGFRLPSALDNRPLRFEEFEALAPQTIYVSATPGNYE
LDKSGGEVIDQVVRPTGLLDPLIEVRPVATQVDDLLSEINLRAAIGERVLVTTLTKRMAEDLTEYLEEHGVRVRYLHSDI
DTVERMEIIRDLRLGEFDALVGINLLREGLDMPEVSLVAILDADKEGFLRSERSLIQTIGRAARNLNGKAILYADKITPS
MARAIGETERRRERQQAFNLAHGITPQALNKKVTDILQLGDGPVRSRTKGARGQRAAEPHPDYHTLSAKQIEQQIQRLET
QMYQHAQNLEFEQAAALRDEIHILREQFKNAS
>Mature_671_residues
SKTFKLHSAFQPSGDQPEAIRRLEEGLEDGLAHQTLLGVTGSGKTFTIANVIADLNRPTMVMAPNKTLAAQLYGEMKQFF
PENAVEYFVSYYDYYQPEAYVPSSDTFIEKDASVNEHIEQMRLSATKALLERRDVVVVASVSAIYGLGDPDLYLKMMLHL
TQGMLIDQRSILRRLSELQYVRNDQAFARGTFRVRGEVIDIFPAEADDEALRVELFDDEVERLSLFDPLTGQLLRTVPRF
TVYPKTHYVTPRERILQAMEAIRAELAMRRQSLLASNKLLEEQRLAQRTQFDLEMMNELGYCSGIENYSRYLSGRGPGEP
PPTLFDYLPADGLLVIDESHVTIPQIGGMYRGDRARKETLVEYGFRLPSALDNRPLRFEEFEALAPQTIYVSATPGNYEL
DKSGGEVIDQVVRPTGLLDPLIEVRPVATQVDDLLSEINLRAAIGERVLVTTLTKRMAEDLTEYLEEHGVRVRYLHSDID
TVERMEIIRDLRLGEFDALVGINLLREGLDMPEVSLVAILDADKEGFLRSERSLIQTIGRAARNLNGKAILYADKITPSM
ARAIGETERRRERQQAFNLAHGITPQALNKKVTDILQLGDGPVRSRTKGARGQRAAEPHPDYHTLSAKQIEQQIQRLETQ
MYQHAQNLEFEQAAALRDEIHILREQFKNAS

Specific function: The UvrABC repair system catalyzes the recognition and processing of DNA lesions. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. Upon binding of the uvrA(2)B(2) complex to a putative damaged site, the DNA

COG id: COG0556

COG function: function code L; Helicase subunit of the DNA excision repair complex

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 UVR domain

Homologues:

Organism=Escherichia coli, GI1786996, Length=673, Percent_Identity=85.7355126300149, Blast_Score=1159, Evalue=0.0,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): UVRB_EDWI9 (C5BEJ2)

Other databases:

- EMBL:   CP001600
- RefSeq:   YP_002934227.1
- GeneID:   7959473
- GenomeReviews:   CP001600_GR
- KEGG:   eic:NT01EI_2825
- OMA:   AAQLCNE
- ProtClustDB:   PRK05298
- GO:   GO:0005737
- HAMAP:   MF_00204
- InterPro:   IPR014001
- InterPro:   IPR001650
- InterPro:   IPR014021
- InterPro:   IPR006935
- InterPro:   IPR001943
- InterPro:   IPR004807
- InterPro:   IPR009055
- SMART:   SM00487
- SMART:   SM00490
- TIGRFAMs:   TIGR00631

Pfam domain/function: PF00271 Helicase_C; PF04851 ResIII; PF02151 UVR; SSF46600 UvrB_C

EC number: NA

Molecular weight: Translated: 76115; Mature: 75984

Theoretical pI: Translated: 5.07; Mature: 5.07

Prosite motif: PS51192 HELICASE_ATP_BIND_1; PS51194 HELICASE_CTER; PS50151 UVR

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.1 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
2.8 %Cys+Met (Translated Protein)
0.1 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
2.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSKTFKLHSAFQPSGDQPEAIRRLEEGLEDGLAHQTLLGVTGSGKTFTIANVIADLNRPT
CCCCEECCCCCCCCCCCHHHHHHHHHHHHHCHHHHHHEEECCCCCEEEHHHHHHHCCCCE
MVMAPNKTLAAQLYGEMKQFFPENAVEYFVSYYDYYQPEAYVPSSDTFIEKDASVNEHIE
EEECCCHHHHHHHHHHHHHHCCHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCHHHHHH
QMRLSATKALLERRDVVVVASVSAIYGLGDPDLYLKMMLHLTQGMLIDQRSILRRLSELQ
HHHHHHHHHHHHHCCEEEEEEHHHHHCCCCHHHHHHHHHHHHHCHHCCHHHHHHHHHHHH
YVRNDQAFARGTFRVRGEVIDIFPAEADDEALRVELFDDEVERLSLFDPLTGQLLRTVPR
HHHCCHHHHCCEEEEECEEEEEECCCCCCCEEEEEEEHHHHHHHHHCCCHHHHHHHHCCC
FTVYPKTHYVTPRERILQAMEAIRAELAMRRQSLLASNKLLEEQRLAQRTQFDLEMMNEL
CEECCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHC
GYCSGIENYSRYLSGRGPGEPPPTLFDYLPADGLLVIDESHVTIPQIGGMYRGDRARKET
HHHCCHHHHHHHHCCCCCCCCCCHHHHCCCCCCEEEEECCCCCCCCCCCCCCCCHHHHHH
LVEYGFRLPSALDNRPLRFEEFEALAPQTIYVSATPGNYELDKSGGEVIDQVVRPTGLLD
HHHHHCCCCHHHCCCCCCHHHHHHCCCCEEEEEECCCCCEECCCCHHHHHHHHCCCCHHH
PLIEVRPVATQVDDLLSEINLRAAIGERVLVTTLTKRMAEDLTEYLEEHGVRVRYLHSDI
HHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHCCCEEEEECCHH
DTVERMEIIRDLRLGEFDALVGINLLREGLDMPEVSLVAILDADKEGFLRSERSLIQTIG
HHHHHHHHHHHHCCCCHHHHHHHHHHHHCCCCCCEEEEEEEECCCHHHHHHHHHHHHHHH
RAARNLNGKAILYADKITPSMARAIGETERRRERQQAFNLAHGITPQALNKKVTDILQLG
HHHHCCCCCEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHCC
DGPVRSRTKGARGQRAAEPHPDYHTLSAKQIEQQIQRLETQMYQHAQNLEFEQAAALRDE
CCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHH
IHILREQFKNAS
HHHHHHHHCCCC
>Mature Secondary Structure 
SKTFKLHSAFQPSGDQPEAIRRLEEGLEDGLAHQTLLGVTGSGKTFTIANVIADLNRPT
CCCEECCCCCCCCCCCHHHHHHHHHHHHHCHHHHHHEEECCCCCEEEHHHHHHHCCCCE
MVMAPNKTLAAQLYGEMKQFFPENAVEYFVSYYDYYQPEAYVPSSDTFIEKDASVNEHIE
EEECCCHHHHHHHHHHHHHHCCHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCHHHHHH
QMRLSATKALLERRDVVVVASVSAIYGLGDPDLYLKMMLHLTQGMLIDQRSILRRLSELQ
HHHHHHHHHHHHHCCEEEEEEHHHHHCCCCHHHHHHHHHHHHHCHHCCHHHHHHHHHHHH
YVRNDQAFARGTFRVRGEVIDIFPAEADDEALRVELFDDEVERLSLFDPLTGQLLRTVPR
HHHCCHHHHCCEEEEECEEEEEECCCCCCCEEEEEEEHHHHHHHHHCCCHHHHHHHHCCC
FTVYPKTHYVTPRERILQAMEAIRAELAMRRQSLLASNKLLEEQRLAQRTQFDLEMMNEL
CEECCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHC
GYCSGIENYSRYLSGRGPGEPPPTLFDYLPADGLLVIDESHVTIPQIGGMYRGDRARKET
HHHCCHHHHHHHHCCCCCCCCCCHHHHCCCCCCEEEEECCCCCCCCCCCCCCCCHHHHHH
LVEYGFRLPSALDNRPLRFEEFEALAPQTIYVSATPGNYELDKSGGEVIDQVVRPTGLLD
HHHHHCCCCHHHCCCCCCHHHHHHCCCCEEEEEECCCCCEECCCCHHHHHHHHCCCCHHH
PLIEVRPVATQVDDLLSEINLRAAIGERVLVTTLTKRMAEDLTEYLEEHGVRVRYLHSDI
HHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHCCCEEEEECCHH
DTVERMEIIRDLRLGEFDALVGINLLREGLDMPEVSLVAILDADKEGFLRSERSLIQTIG
HHHHHHHHHHHHCCCCHHHHHHHHHHHHCCCCCCEEEEEEEECCCHHHHHHHHHHHHHHH
RAARNLNGKAILYADKITPSMARAIGETERRRERQQAFNLAHGITPQALNKKVTDILQLG
HHHHCCCCCEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHCC
DGPVRSRTKGARGQRAAEPHPDYHTLSAKQIEQQIQRLETQMYQHAQNLEFEQAAALRDE
CCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHH
IHILREQFKNAS
HHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: Hydrolase; Acting on ester bonds [C]

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA