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The map label for this gene is gyrA [H]

Identifier: 238920518

GI number: 238920518

Start: 2521579

End: 2524215

Strand: Reverse

Name: gyrA [H]

Synonym: NT01EI_2630

Alternate gene names: 238920518

Gene position: 2524215-2521579 (Counterclockwise)

Preceding gene: 238920523

Following gene: 238920517

Centisome position: 66.21

GC content: 60.71

Gene sequence:

>2637_bases
ATGAGCGACCTTGCCAGAGAGATTACGCCGGTCAATATCGAAGAAGAGTTGAAAAACTCATATCTGGATTACGCCATGTC
CGTTATCGTCGGTCGTGCGCTGCCGGATGTTCGGGATGGCCTGAAGCCGGTACACCGTCGCGTCCTGTTTGCGATGAACG
TACTGGGCAATGACTGGAACAAACCATACAAAAAATCGGCCCGCGTGGTCGGTGACGTTATCGGTAAATATCACCCACAC
GGTGACAGCGCGGTTTATGACACTATCGTGCGTATGGCGCAGCCCTTCTCCCTGCGTTATATGCTGGTCGACGGCCAGGG
TAACTTTGGCTCCATCGACGGCGACTCCGCGGCGGCGATGCGTTACACCGAAGTGCGCATGGCGAAGATTGCTCATGAGC
TGTTGGCCGATCTGGACAAAGAGACGGTGGACTATGTGCCCAACTACGACGGCACCGAACAGATCCCCGACGTCCTGCCG
ACCAAGGTGCCCAACCTGCTGGTCAACGGCTCTGCCGGTATCGCGGTGGGGATGGCGACCAACATTCCTCCCCATAACCT
GACTGAGGTGATCAACGGCTGCCTGGCCTATATCGATGATGAGAACATCACCATCGAAGGGCTGATGGAGCATATTCCGG
GGCCAGATTTCCCGACGGCGGCGATCATCAACGGGCGCCGCGGCATTGAAGAGGCCTATCGCACCGGGCGCGGCAAGATC
TACGTGCGTGCGCGCGCCGAGATCGAGGTCGACGATAAAAATAGCCGCGAAACCATCGTGGTGCATGAGATCCCCTATCA
GGTCAACAAGGCGCGTCTGATCGAGAAAATCGCCGAGCTGGTGAAGGAGAAGCGCGTCGAGGGCATCAGTGCCCTGCGCG
ATGAGTCTGATAAGGATGGGATGCGCATCGTTATCGAAGTCAAGCGCGACGCGGTGGGTGAGGTGGTGCTGAATAACCTC
TACTCGCAGACCCAGATGCAGGTCTCTTTCGGGATTAATATGGTGGCGCTGCACCAGGGACAGCCGAAGCTGCTGACCCT
GAAGGAGTGTCTGGAAGCCTTTGTGCGCCACCGCCGTGAGGTGGTGACCCGCCGCACCATCTTTGAACTGCGCAAGGCGC
GCGGGCGTGCCCACATCTTGGAAGGCCTGGCCATTGCGCTGGTCAACATCGATCCGATCATTGAGTTGATCCGCCGTGCG
CCGACGCCCGCCGAGGCCAAGGCCGCGCTGGTTTCCCAGGCCTGGGCGCTGGGCAACGTAGCGGCGATGCTGGCGCGCGC
CGGCGACGATGCCGCGCGTCCGGAGTGGCTGGAGCCGCAGTATGGCATCCGCGACGGCCATTATCACCTGACGGAGCAGC
AGGCGCAGGCGATCCTGGATCTGCGTCTGCAGAAACTGACCGGCCTGGAGCACGAGAAGCTGCTGGATGAGTACAAGGCG
CTGCTGGAGCAGATCGCCGCGCTGATCTTCATTCTACAAAGCCCGGAGCGCCTGATGGAGGTGATCCGCGAAGAGCTGAT
CGCCATCCGCGAGCAGTTTGGCGATGCGCGCCGCACCGAGATCACCGCCAACACGGCGGATATCAATATCGAAGATCTGA
TCGAGCAGGAAGACGTGGTGGTGACCCTGTCGCATCAGGGCTACGTGAAGTACCAGCCGCTGAGCGACTATGAGGCCCAG
CGTCGCGGCGGTAAGGGCAAGTCTGCCGCACGGATTAAAGAAGAGGACTTTATCGATCGGCTGCTGGTGGCCAATACCCA
CGACACCATCCTGTGCTTCTCCAGCCGGGGGCGCATGTACTGGATGAAGGTATATCAGCTGCCGGAAGCCAGTCGCGGTG
CCCGCGGTCGTCCGATCATCAACCTGTTGCCACTGGAAGCCGACGAACGTATCACCGCTATCCTGCCGGTGCGTGAGTAT
GCTGAAGGGGTCAATGTGTTTATGGCTACCGCCAGCGGCACGGTGAAGAAGACGGCGCTGGCCGAGTTCAGCCGTCCGCG
TGCCGCCGGGATTATCGCGGTGAACCTTAACGACGGTGATGAGCTGATCGGGGTCGATCTGACCGATGGCAACGACGAGG
TGATGCTGTTCTCCGCCGCCGGTAAAGTGGTGCGCTTCAAGGAGGATGCCGTGCGTGCCATGGGGCGCACCGCGACCGGG
GTGCGAGGCATCAAGCTGGCCGGGGACGATCGCGTGGTATCGCTGATCGTACCGCACGGTGAGGGGGCTATCCTGACCGT
GACCCAGAACGGCTACGGCAAACGCAGCAGCGTGGCCGAGTACCCGACCAAGTCACGTGCGACTCAGGGGGTTATCTCTA
TCAAGGTGACTGAGCGTAACGGCAGCGTCGTCGGCGCGGTGCAGGTCGAGGACAGCGATCAGATCATGATGATCACCGAT
GCCGGTACCCTGGTGCGTACCCGCGTTTCTGAGGTCAGCATCGTCGGGCGCAATACGCAGGGGGTTATCCTAATCCGTAC
CGCCGAGGACGAGCACGTGGTGGGGCTGCAGCGGGTCGTTGAACCGGTTGACGACGAAGATCTGGACAGCATCGACGGCA
GCGCCGCGGAGGGTGACGATGAGATCGTGCCGGAAGTGGAGAGCGATGACGATGCCGCCGAGGATGACGCTGAATAA

Upstream 100 bases:

>100_bases
GTGGTATCATTATCGTCTTCGTCATCGTGTATGCGCCTGGTTCTACTCGATGTATTTAGGGTAGCGGCAGATGAATAATT
AGTAGAGGGATAGCAGCTCC

Downstream 100 bases:

>100_bases
GCGTTGATACAGGTGTCAAAAGGGTCGGTCACTCCGGCCCTTTTTTATGCCGGAGGCCCGTCCGGATAGAGATTGACGCT
GTTACGTCTGGCTCCCCCTG

Product: DNA gyrase subunit A

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 878; Mature: 877

Protein sequence:

>878_residues
MSDLAREITPVNIEEELKNSYLDYAMSVIVGRALPDVRDGLKPVHRRVLFAMNVLGNDWNKPYKKSARVVGDVIGKYHPH
GDSAVYDTIVRMAQPFSLRYMLVDGQGNFGSIDGDSAAAMRYTEVRMAKIAHELLADLDKETVDYVPNYDGTEQIPDVLP
TKVPNLLVNGSAGIAVGMATNIPPHNLTEVINGCLAYIDDENITIEGLMEHIPGPDFPTAAIINGRRGIEEAYRTGRGKI
YVRARAEIEVDDKNSRETIVVHEIPYQVNKARLIEKIAELVKEKRVEGISALRDESDKDGMRIVIEVKRDAVGEVVLNNL
YSQTQMQVSFGINMVALHQGQPKLLTLKECLEAFVRHRREVVTRRTIFELRKARGRAHILEGLAIALVNIDPIIELIRRA
PTPAEAKAALVSQAWALGNVAAMLARAGDDAARPEWLEPQYGIRDGHYHLTEQQAQAILDLRLQKLTGLEHEKLLDEYKA
LLEQIAALIFILQSPERLMEVIREELIAIREQFGDARRTEITANTADINIEDLIEQEDVVVTLSHQGYVKYQPLSDYEAQ
RRGGKGKSAARIKEEDFIDRLLVANTHDTILCFSSRGRMYWMKVYQLPEASRGARGRPIINLLPLEADERITAILPVREY
AEGVNVFMATASGTVKKTALAEFSRPRAAGIIAVNLNDGDELIGVDLTDGNDEVMLFSAAGKVVRFKEDAVRAMGRTATG
VRGIKLAGDDRVVSLIVPHGEGAILTVTQNGYGKRSSVAEYPTKSRATQGVISIKVTERNGSVVGAVQVEDSDQIMMITD
AGTLVRTRVSEVSIVGRNTQGVILIRTAEDEHVVGLQRVVEPVDDEDLDSIDGSAAEGDDEIVPEVESDDDAAEDDAE

Sequences:

>Translated_878_residues
MSDLAREITPVNIEEELKNSYLDYAMSVIVGRALPDVRDGLKPVHRRVLFAMNVLGNDWNKPYKKSARVVGDVIGKYHPH
GDSAVYDTIVRMAQPFSLRYMLVDGQGNFGSIDGDSAAAMRYTEVRMAKIAHELLADLDKETVDYVPNYDGTEQIPDVLP
TKVPNLLVNGSAGIAVGMATNIPPHNLTEVINGCLAYIDDENITIEGLMEHIPGPDFPTAAIINGRRGIEEAYRTGRGKI
YVRARAEIEVDDKNSRETIVVHEIPYQVNKARLIEKIAELVKEKRVEGISALRDESDKDGMRIVIEVKRDAVGEVVLNNL
YSQTQMQVSFGINMVALHQGQPKLLTLKECLEAFVRHRREVVTRRTIFELRKARGRAHILEGLAIALVNIDPIIELIRRA
PTPAEAKAALVSQAWALGNVAAMLARAGDDAARPEWLEPQYGIRDGHYHLTEQQAQAILDLRLQKLTGLEHEKLLDEYKA
LLEQIAALIFILQSPERLMEVIREELIAIREQFGDARRTEITANTADINIEDLIEQEDVVVTLSHQGYVKYQPLSDYEAQ
RRGGKGKSAARIKEEDFIDRLLVANTHDTILCFSSRGRMYWMKVYQLPEASRGARGRPIINLLPLEADERITAILPVREY
AEGVNVFMATASGTVKKTALAEFSRPRAAGIIAVNLNDGDELIGVDLTDGNDEVMLFSAAGKVVRFKEDAVRAMGRTATG
VRGIKLAGDDRVVSLIVPHGEGAILTVTQNGYGKRSSVAEYPTKSRATQGVISIKVTERNGSVVGAVQVEDSDQIMMITD
AGTLVRTRVSEVSIVGRNTQGVILIRTAEDEHVVGLQRVVEPVDDEDLDSIDGSAAEGDDEIVPEVESDDDAAEDDAE
>Mature_877_residues
SDLAREITPVNIEEELKNSYLDYAMSVIVGRALPDVRDGLKPVHRRVLFAMNVLGNDWNKPYKKSARVVGDVIGKYHPHG
DSAVYDTIVRMAQPFSLRYMLVDGQGNFGSIDGDSAAAMRYTEVRMAKIAHELLADLDKETVDYVPNYDGTEQIPDVLPT
KVPNLLVNGSAGIAVGMATNIPPHNLTEVINGCLAYIDDENITIEGLMEHIPGPDFPTAAIINGRRGIEEAYRTGRGKIY
VRARAEIEVDDKNSRETIVVHEIPYQVNKARLIEKIAELVKEKRVEGISALRDESDKDGMRIVIEVKRDAVGEVVLNNLY
SQTQMQVSFGINMVALHQGQPKLLTLKECLEAFVRHRREVVTRRTIFELRKARGRAHILEGLAIALVNIDPIIELIRRAP
TPAEAKAALVSQAWALGNVAAMLARAGDDAARPEWLEPQYGIRDGHYHLTEQQAQAILDLRLQKLTGLEHEKLLDEYKAL
LEQIAALIFILQSPERLMEVIREELIAIREQFGDARRTEITANTADINIEDLIEQEDVVVTLSHQGYVKYQPLSDYEAQR
RGGKGKSAARIKEEDFIDRLLVANTHDTILCFSSRGRMYWMKVYQLPEASRGARGRPIINLLPLEADERITAILPVREYA
EGVNVFMATASGTVKKTALAEFSRPRAAGIIAVNLNDGDELIGVDLTDGNDEVMLFSAAGKVVRFKEDAVRAMGRTATGV
RGIKLAGDDRVVSLIVPHGEGAILTVTQNGYGKRSSVAEYPTKSRATQGVISIKVTERNGSVVGAVQVEDSDQIMMITDA
GTLVRTRVSEVSIVGRNTQGVILIRTAEDEHVVGLQRVVEPVDDEDLDSIDGSAAEGDDEIVPEVESDDDAAEDDAE

Specific function: DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings [H]

COG id: COG0188

COG function: function code L; Type IIA topoisomerase (DNA gyrase/topo II, topoisomerase IV), A subunit

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the topoisomerase gyrA/parC subunit family [H]

Homologues:

Organism=Homo sapiens, GI19913408, Length=341, Percent_Identity=26.6862170087977, Blast_Score=82, Evalue=3e-15,
Organism=Homo sapiens, GI19913406, Length=356, Percent_Identity=26.123595505618, Blast_Score=79, Evalue=2e-14,
Organism=Escherichia coli, GI1788562, Length=875, Percent_Identity=86.5142857142857, Blast_Score=1552, Evalue=0.0,
Organism=Escherichia coli, GI1789396, Length=715, Percent_Identity=36.3636363636364, Blast_Score=399, Evalue=1e-112,
Organism=Caenorhabditis elegans, GI17535065, Length=286, Percent_Identity=28.6713286713287, Blast_Score=75, Evalue=2e-13,
Organism=Caenorhabditis elegans, GI212645657, Length=285, Percent_Identity=28.4210526315789, Blast_Score=74, Evalue=3e-13,
Organism=Caenorhabditis elegans, GI212645845, Length=201, Percent_Identity=29.8507462686567, Blast_Score=68, Evalue=2e-11,
Organism=Saccharomyces cerevisiae, GI6324241, Length=182, Percent_Identity=31.3186813186813, Blast_Score=77, Evalue=1e-14,
Organism=Drosophila melanogaster, GI17136538, Length=180, Percent_Identity=31.1111111111111, Blast_Score=69, Evalue=2e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR020899
- InterPro:   IPR005743
- InterPro:   IPR006691
- InterPro:   IPR002205
- InterPro:   IPR013758
- InterPro:   IPR013757
- InterPro:   IPR013760 [H]

Pfam domain/function: PF03989 DNA_gyraseA_C; PF00521 DNA_topoisoIV [H]

EC number: =5.99.1.3 [H]

Molecular weight: Translated: 96947; Mature: 96815

Theoretical pI: Translated: 4.84; Mature: 4.84

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
2.7 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
2.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSDLAREITPVNIEEELKNSYLDYAMSVIVGRALPDVRDGLKPVHRRVLFAMNVLGNDWN
CCCHHHHCCCCCHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHCCCCC
KPYKKSARVVGDVIGKYHPHGDSAVYDTIVRMAQPFSLRYMLVDGQGNFGSIDGDSAAAM
CCHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHCCCCEEEEEEEECCCCCCCCCCCCHHHH
RYTEVRMAKIAHELLADLDKETVDYVPNYDGTEQIPDVLPTKVPNLLVNGSAGIAVGMAT
HHHHHHHHHHHHHHHHHCCHHHHHCCCCCCCHHHHHHHCCCCCCCEEEECCCCEEEEEEC
NIPPHNLTEVINGCLAYIDDENITIEGLMEHIPGPDFPTAAIINGRRGIEEAYRTGRGKI
CCCCCHHHHHHHHHEEEECCCCEEHHHHHHHCCCCCCCCEEEECCCCCHHHHHHCCCCEE
YVRARAEIEVDDKNSRETIVVHEIPYQVNKARLIEKIAELVKEKRVEGISALRDESDKDG
EEEEEEEEEECCCCCCCEEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCC
MRIVIEVKRDAVGEVVLNNLYSQTQMQVSFGINMVALHQGQPKLLTLKECLEAFVRHRRE
CEEEEEECCHHHHHHHHHHHHHHHEEEEEECCEEEEEECCCCCEEHHHHHHHHHHHHHHH
VVTRRTIFELRKARGRAHILEGLAIALVNIDPIIELIRRAPTPAEAKAALVSQAWALGNV
HHHHHHHHHHHHHCCHHHHHHHHEEEEECHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHH
AAMLARAGDDAARPEWLEPQYGIRDGHYHLTEQQAQAILDLRLQKLTGLEHEKLLDEYKA
HHHHHHCCCCCCCCCCCCCCCCCCCCCEEECHHHHHHHHHHHHHHHCCCCHHHHHHHHHH
LLEQIAALIFILQSPERLMEVIREELIAIREQFGDARRTEITANTADINIEDLIEQEDVV
HHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHCCCCCCEEECCCCCCCHHHHHCCCCEE
VTLSHQGYVKYQPLSDYEAQRRGGKGKSAARIKEEDFIDRLLVANTHDTILCFSSRGRMY
EEEECCCEEEECCCCCHHHHHCCCCCCCHHHCCHHHHHHHHHHCCCCCEEEEECCCCCEE
WMKVYQLPEASRGARGRPIINLLPLEADERITAILPVREYAEGVNVFMATASGTVKKTAL
EEEEEECCCCCCCCCCCCEEEEECCCCCCCEEEEECHHHHHCCCEEEEEECCCCHHHHHH
AEFSRPRAAGIIAVNLNDGDELIGVDLTDGNDEVMLFSAAGKVVRFKEDAVRAMGRTATG
HHCCCCCCCEEEEEEECCCCEEEEEEEECCCCCEEEEECCCCEEEEHHHHHHHHCCCCCC
VRGIKLAGDDRVVSLIVPHGEGAILTVTQNGYGKRSSVAEYPTKSRATQGVISIKVTERN
CCEEEEECCCEEEEEEEECCCCEEEEEECCCCCCCCCHHHCCCCCCCCCCEEEEEEEECC
GSVVGAVQVEDSDQIMMITDAGTLVRTRVSEVSIVGRNTQGVILIRTAEDEHVVGLQRVV
CCEEEEEEECCCCCEEEEECCCHHHHHHHHEEEEEECCCCCEEEEEECCCCHHHHHHHHH
EPVDDEDLDSIDGSAAEGDDEIVPEVESDDDAAEDDAE
CCCCCCCCHHCCCCCCCCCCCCCCCCCCCCCCCCCCCC
>Mature Secondary Structure 
SDLAREITPVNIEEELKNSYLDYAMSVIVGRALPDVRDGLKPVHRRVLFAMNVLGNDWN
CCHHHHCCCCCHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHCCCCC
KPYKKSARVVGDVIGKYHPHGDSAVYDTIVRMAQPFSLRYMLVDGQGNFGSIDGDSAAAM
CCHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHCCCCEEEEEEEECCCCCCCCCCCCHHHH
RYTEVRMAKIAHELLADLDKETVDYVPNYDGTEQIPDVLPTKVPNLLVNGSAGIAVGMAT
HHHHHHHHHHHHHHHHHCCHHHHHCCCCCCCHHHHHHHCCCCCCCEEEECCCCEEEEEEC
NIPPHNLTEVINGCLAYIDDENITIEGLMEHIPGPDFPTAAIINGRRGIEEAYRTGRGKI
CCCCCHHHHHHHHHEEEECCCCEEHHHHHHHCCCCCCCCEEEECCCCCHHHHHHCCCCEE
YVRARAEIEVDDKNSRETIVVHEIPYQVNKARLIEKIAELVKEKRVEGISALRDESDKDG
EEEEEEEEEECCCCCCCEEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCC
MRIVIEVKRDAVGEVVLNNLYSQTQMQVSFGINMVALHQGQPKLLTLKECLEAFVRHRRE
CEEEEEECCHHHHHHHHHHHHHHHEEEEEECCEEEEEECCCCCEEHHHHHHHHHHHHHHH
VVTRRTIFELRKARGRAHILEGLAIALVNIDPIIELIRRAPTPAEAKAALVSQAWALGNV
HHHHHHHHHHHHHCCHHHHHHHHEEEEECHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHH
AAMLARAGDDAARPEWLEPQYGIRDGHYHLTEQQAQAILDLRLQKLTGLEHEKLLDEYKA
HHHHHHCCCCCCCCCCCCCCCCCCCCCEEECHHHHHHHHHHHHHHHCCCCHHHHHHHHHH
LLEQIAALIFILQSPERLMEVIREELIAIREQFGDARRTEITANTADINIEDLIEQEDVV
HHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHCCCCCCEEECCCCCCCHHHHHCCCCEE
VTLSHQGYVKYQPLSDYEAQRRGGKGKSAARIKEEDFIDRLLVANTHDTILCFSSRGRMY
EEEECCCEEEECCCCCHHHHHCCCCCCCHHHCCHHHHHHHHHHCCCCCEEEEECCCCCEE
WMKVYQLPEASRGARGRPIINLLPLEADERITAILPVREYAEGVNVFMATASGTVKKTAL
EEEEEECCCCCCCCCCCCEEEEECCCCCCCEEEEECHHHHHCCCEEEEEECCCCHHHHHH
AEFSRPRAAGIIAVNLNDGDELIGVDLTDGNDEVMLFSAAGKVVRFKEDAVRAMGRTATG
HHCCCCCCCEEEEEEECCCCEEEEEEEECCCCCEEEEECCCCEEEEHHHHHHHHCCCCCC
VRGIKLAGDDRVVSLIVPHGEGAILTVTQNGYGKRSSVAEYPTKSRATQGVISIKVTERN
CCEEEEECCCEEEEEEEECCCCEEEEEECCCCCCCCCHHHCCCCCCCCCCEEEEEEEECC
GSVVGAVQVEDSDQIMMITDAGTLVRTRVSEVSIVGRNTQGVILIRTAEDEHVVGLQRVV
CCEEEEEEECCCCCEEEEECCCHHHHHHHHEEEEEECCCCCEEEEEECCCCHHHHHHHHH
EPVDDEDLDSIDGSAAEGDDEIVPEVESDDDAAEDDAE
CCCCCCCCHHCCCCCCCCCCCCCCCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11677609; 8849216 [H]