Click here to switch to the map view.

The map label for this gene is lpxK

Identifier: 238920341

GI number: 238920341

Start: 2340389

End: 2341384

Strand: Reverse

Name: lpxK

Synonym: NT01EI_2451

Alternate gene names: 238920341

Gene position: 2341384-2340389 (Counterclockwise)

Preceding gene: 238920342

Following gene: 238920340

Centisome position: 61.42

GC content: 65.66

Gene sequence:

>996_bases
ATGATCGCGCGGATCTGGTCTGGGCGCTCGCCGCTGTATCTGCTGCTGCTGCCTCTCTCTTGGCTGTATGGCCTGGTGGC
GCTGCTGCGTCGTCAGGCCTATCGCCGCGGTTGGATCCGGGTCTGGCGGGCGCCGCTGCCGCTGGTGGTAGTGGGGAATC
TGACTGCCGGTGGCAATGGTAAGACGCCGCTGGTTATCTGGCTGGTAGAGCAGCTGCAACGACGTGGCTACCGGGTTGGC
GTGGTATCGCGCGGCTACGGTGGCCGGGCCACATGCTATCCATTGGTGCTGGGACCGGATACCCGCAGCGTGGAGTGTGG
CGATGAGCCGCTGCTGATAGCCCAGCGCACCGGCGCCCGGGTCGCGGTGGCACCACAGCGTAGCGCAGCGGTACAGGCGT
TGCTGGCTCAGGAGCCGCTGGACGTGGTGATCACCGACGATGGCCTGCAGCACTATGCACTGGCGCGCGATATGGAGCTG
GTAGTGATCGACGGCGAGCGCCGCTTTGGTAACGGCTGGTGGCTGCCGGCCGGACCGATGCGCGAGCGGGCTGCCCGGCT
ATGCAGCGTCGATGCGGTGATCGTCAACGGAGGCCTCCCCCGAACCGGCGAGATCCCGATGGCGCTGACTGGCCATACGC
TGGTCAATCTGCGCAGTGGAGAGCGGCGTGTGGCGGGGCAATTTGTGACGCCGGTTGTTGCCATGGCTGGAATAGGGCAT
CCACCGCGTTTTTTTCATACTCTGACCCAGCTGGGAATCCCGCTGCAGGCGACCCATGCCTTTGCCGACCATCAGGCGTA
TCAGGCACAGGTGCTGGCGGCGCTGACGCCGCAGGCGCAGCCGTTGCTGATGACCGAAAAAGATGCAGTGAAATGCCGTG
CCTTTGCCCAAGATAACTGGTGGTATTTGCCGGTCAGCGCTACGCTGCCCGCGGAGGCTGGTGATCGCCTGCTGGCGCGC
ATCGCCGCGCTGGTTGCAGCCCAGCCGCGCGGGTAG

Upstream 100 bases:

>100_bases
TGGTGGTGGAGGACGGCTGTATTGTGGAGCGCGGCAACCATCGTACATTGCTGGATAACGATGGCGTTTACGCCCAGCTC
TACCGGATGCAGTTCGGACA

Downstream 100 bases:

>100_bases
GGCCGTCCGCGGCGGCGGACGGGCTCCGCTGCCCGGGGGCGCCGATCGTTTAGGTAGTGAATATTTAAAAAGGGAAATTT
TTAGGCAAAAAACGGCTTGC

Product: tetraacyldisaccharide 4'-kinase

Products: NA

Alternate protein names: Lipid A 4'-kinase

Number of amino acids: Translated: 331; Mature: 331

Protein sequence:

>331_residues
MIARIWSGRSPLYLLLLPLSWLYGLVALLRRQAYRRGWIRVWRAPLPLVVVGNLTAGGNGKTPLVIWLVEQLQRRGYRVG
VVSRGYGGRATCYPLVLGPDTRSVECGDEPLLIAQRTGARVAVAPQRSAAVQALLAQEPLDVVITDDGLQHYALARDMEL
VVIDGERRFGNGWWLPAGPMRERAARLCSVDAVIVNGGLPRTGEIPMALTGHTLVNLRSGERRVAGQFVTPVVAMAGIGH
PPRFFHTLTQLGIPLQATHAFADHQAYQAQVLAALTPQAQPLLMTEKDAVKCRAFAQDNWWYLPVSATLPAEAGDRLLAR
IAALVAAQPRG

Sequences:

>Translated_331_residues
MIARIWSGRSPLYLLLLPLSWLYGLVALLRRQAYRRGWIRVWRAPLPLVVVGNLTAGGNGKTPLVIWLVEQLQRRGYRVG
VVSRGYGGRATCYPLVLGPDTRSVECGDEPLLIAQRTGARVAVAPQRSAAVQALLAQEPLDVVITDDGLQHYALARDMEL
VVIDGERRFGNGWWLPAGPMRERAARLCSVDAVIVNGGLPRTGEIPMALTGHTLVNLRSGERRVAGQFVTPVVAMAGIGH
PPRFFHTLTQLGIPLQATHAFADHQAYQAQVLAALTPQAQPLLMTEKDAVKCRAFAQDNWWYLPVSATLPAEAGDRLLAR
IAALVAAQPRG
>Mature_331_residues
MIARIWSGRSPLYLLLLPLSWLYGLVALLRRQAYRRGWIRVWRAPLPLVVVGNLTAGGNGKTPLVIWLVEQLQRRGYRVG
VVSRGYGGRATCYPLVLGPDTRSVECGDEPLLIAQRTGARVAVAPQRSAAVQALLAQEPLDVVITDDGLQHYALARDMEL
VVIDGERRFGNGWWLPAGPMRERAARLCSVDAVIVNGGLPRTGEIPMALTGHTLVNLRSGERRVAGQFVTPVVAMAGIGH
PPRFFHTLTQLGIPLQATHAFADHQAYQAQVLAALTPQAQPLLMTEKDAVKCRAFAQDNWWYLPVSATLPAEAGDRLLAR
IAALVAAQPRG

Specific function: Transfers the gamma-phosphate of ATP to the 4'-position of a tetraacyldisaccharide 1-phosphate intermediate (termed DS-1- P) to form tetraacyldisaccharide 1,4'-bis-phosphate (lipid IVA)

COG id: COG1663

COG function: function code M; Tetraacyldisaccharide-1-P 4'-kinase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the lpxK family

Homologues:

Organism=Escherichia coli, GI1787144, Length=329, Percent_Identity=63.2218844984802, Blast_Score=407, Evalue=1e-115,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): LPXK_EDWI9 (C5BAE1)

Other databases:

- EMBL:   CP001600
- RefSeq:   YP_002933856.1
- GeneID:   7959183
- GenomeReviews:   CP001600_GR
- KEGG:   eic:NT01EI_2451
- OMA:   VILMDDG
- ProtClustDB:   CLSK2813320
- HAMAP:   MF_00409
- InterPro:   IPR003758
- TIGRFAMs:   TIGR00682

Pfam domain/function: PF02606 LpxK

EC number: =2.7.1.130

Molecular weight: Translated: 36114; Mature: 36114

Theoretical pI: Translated: 10.39; Mature: 10.39

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
3.0 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
3.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIARIWSGRSPLYLLLLPLSWLYGLVALLRRQAYRRGWIRVWRAPLPLVVVGNLTAGGNG
CEEEEECCCCCEEEEHHHHHHHHHHHHHHHHHHHHCCHHEEECCCCCEEEEEEEECCCCC
KTPLVIWLVEQLQRRGYRVGVVSRGYGGRATCYPLVLGPDTRSVECGDEPLLIAQRTGAR
CCCEEEHHHHHHHHCCCEEEEEECCCCCCCEEEEEEECCCCCCEECCCCCEEEEECCCCE
VAVAPQRSAAVQALLAQEPLDVVITDDGLQHYALARDMELVVIDGERRFGNGWWLPAGPM
EEECCCHHHHHHHHHHCCCCEEEEECCCCHHHHHHCCCEEEEEECCEEECCEEECCCCHH
RERAARLCSVDAVIVNGGLPRTGEIPMALTGHTLVNLRSGERRVAGQFVTPVVAMAGIGH
HHHHHHHHCCCEEEEECCCCCCCCCCEEEECCEEEEECCCCCHHHHHHHHHHHHHHCCCC
PPRFFHTLTQLGIPLQATHAFADHQAYQAQVLAALTPQAQPLLMTEKDAVKCRAFAQDNW
CHHHHHHHHHHCCCEEHHHHHHHHHHHHHHHHHHCCCCCCEEEEECCCCEEEEEEECCCE
WYLPVSATLPAEAGDRLLARIAALVAAQPRG
EEEEEECCCCCCHHHHHHHHHHHHHHCCCCC
>Mature Secondary Structure
MIARIWSGRSPLYLLLLPLSWLYGLVALLRRQAYRRGWIRVWRAPLPLVVVGNLTAGGNG
CEEEEECCCCCEEEEHHHHHHHHHHHHHHHHHHHHCCHHEEECCCCCEEEEEEEECCCCC
KTPLVIWLVEQLQRRGYRVGVVSRGYGGRATCYPLVLGPDTRSVECGDEPLLIAQRTGAR
CCCEEEHHHHHHHHCCCEEEEEECCCCCCCEEEEEEECCCCCCEECCCCCEEEEECCCCE
VAVAPQRSAAVQALLAQEPLDVVITDDGLQHYALARDMELVVIDGERRFGNGWWLPAGPM
EEECCCHHHHHHHHHHCCCCEEEEECCCCHHHHHHCCCEEEEEECCEEECCEEECCCCHH
RERAARLCSVDAVIVNGGLPRTGEIPMALTGHTLVNLRSGERRVAGQFVTPVVAMAGIGH
HHHHHHHHCCCEEEEECCCCCCCCCCEEEECCEEEEECCCCCHHHHHHHHHHHHHHCCCC
PPRFFHTLTQLGIPLQATHAFADHQAYQAQVLAALTPQAQPLLMTEKDAVKCRAFAQDNW
CHHHHHHHHHHCCCEEHHHHHHHHHHHHHHHHHHCCCCCCEEEEECCCCEEEEEEECCCE
WYLPVSATLPAEAGDRLLARIAALVAAQPRG
EEEEEECCCCCCHHHHHHHHHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA