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The map label for this gene is pyrC

Identifier: 238920273

GI number: 238920273

Start: 2281700

End: 2282746

Strand: Direct

Name: pyrC

Synonym: NT01EI_2383

Alternate gene names: 238920273

Gene position: 2281700-2282746 (Clockwise)

Preceding gene: 238920271

Following gene: 238920274

Centisome position: 59.85

GC content: 63.42

Gene sequence:

>1047_bases
ATGACCGTAATGCAGCACACCCTGAAGATCCGCCGCCCTGACGATTGGCACCTCCATCTGCGCGATGATGCGATGCTGCA
CAGCGTGTTACCCTACACCAGCCGCCACTTTTCCCGGGCTGTGGTGATGCCCAACCTGGTTCCGCCGATCACCTCCGTGG
AGCAGTGCATCGCCTATCGCCAGCGCATTCTCGACGCCGTGCCTCAGGGGCACGCGTTTACCCCACTGATGACCTGCTAT
CTGACCGATGCCCTCTCGGTAGACACGTTGATGCACGGCCAGCGGGAAGGCGTATTCACCGCCGCCAAGCTGTATCCGGC
CAACGCCACCACCAACTCGGCCTGCGGCGTCACCTCCATTCCCGGACTGTATCCGCTGTTTGAGGCGATGCAGCAGAGCG
GCATGCCGCTGTTGATCCACGGTGAGGTCACCCAGGCGGATATCGACATCTTCGATCGCGAGGCTCGCTTTATCGAGCAG
GTGATGCTGCCGCTGCGCCGCGACTTCCCCGAGCTGCGCATCGTCTTTGAGCACATCACCACCCGCGAGGCGGCCCAGTT
TGTCGCCGAAGGCGATCGCTATCTGGCGGCAACCATTACCCCGCAGCACCTGATGTTCAACCGCAACCACATGCTGGTCG
GCGGGATTCACCCGCACCTGTACTGCCTGCCGATCCTCAAGCGCAGCGTGCACCAGCAGGCGCTGCGCAAGGCGGCCACC
AGCGGGCAGACCTGTTTCTTCCTCGGTACCGACTCCGCGCCGCACCTGCGCGGGCGCAAAGAGTCAGCCTGCGGCTGCGC
CGGGGTCTTCAACGCGCCGACGGCGCTACAGGCCTACGCAACGGTCTTTGAAGAGGAGCAGGCGCTGCAGCATCTGGAGG
CTTTCTGTTCGCTGAACGGACCGGCTTTCTATGGACTCCCGGCCAATGAGGCGTATATTGAGCTGGCACAGGAGCCTGCG
TCTGTCGTCGACAGCATCGCCAGCGGCGATGAAACCCTGACCCCCTTCCTGGCAGGGGAAACGCTGCGATGGTCGGTACG
CGCGTAG

Upstream 100 bases:

>100_bases
CGCCCGGCACAGAAATGTTCACTGCGCCCTGGCGCCCTGCCCTTGCGGCGGCCAGAAGCCTGCGCAGTCCATCAGACATA
TCCACCAGCCGGAGTCCGTA

Downstream 100 bases:

>100_bases
GCTCAGGACACTATTTACTCCGGCCTGTCCCTTAGGACAGGCCTTTTTGTTGGTAGCCGTGAGGGAGAATATGACCGCAA
CACCGCTACTGGCGCTCAAT

Product: dihydroorotase

Products: NA

Alternate protein names: DHOase

Number of amino acids: Translated: 348; Mature: 347

Protein sequence:

>348_residues
MTVMQHTLKIRRPDDWHLHLRDDAMLHSVLPYTSRHFSRAVVMPNLVPPITSVEQCIAYRQRILDAVPQGHAFTPLMTCY
LTDALSVDTLMHGQREGVFTAAKLYPANATTNSACGVTSIPGLYPLFEAMQQSGMPLLIHGEVTQADIDIFDREARFIEQ
VMLPLRRDFPELRIVFEHITTREAAQFVAEGDRYLAATITPQHLMFNRNHMLVGGIHPHLYCLPILKRSVHQQALRKAAT
SGQTCFFLGTDSAPHLRGRKESACGCAGVFNAPTALQAYATVFEEEQALQHLEAFCSLNGPAFYGLPANEAYIELAQEPA
SVVDSIASGDETLTPFLAGETLRWSVRA

Sequences:

>Translated_348_residues
MTVMQHTLKIRRPDDWHLHLRDDAMLHSVLPYTSRHFSRAVVMPNLVPPITSVEQCIAYRQRILDAVPQGHAFTPLMTCY
LTDALSVDTLMHGQREGVFTAAKLYPANATTNSACGVTSIPGLYPLFEAMQQSGMPLLIHGEVTQADIDIFDREARFIEQ
VMLPLRRDFPELRIVFEHITTREAAQFVAEGDRYLAATITPQHLMFNRNHMLVGGIHPHLYCLPILKRSVHQQALRKAAT
SGQTCFFLGTDSAPHLRGRKESACGCAGVFNAPTALQAYATVFEEEQALQHLEAFCSLNGPAFYGLPANEAYIELAQEPA
SVVDSIASGDETLTPFLAGETLRWSVRA
>Mature_347_residues
TVMQHTLKIRRPDDWHLHLRDDAMLHSVLPYTSRHFSRAVVMPNLVPPITSVEQCIAYRQRILDAVPQGHAFTPLMTCYL
TDALSVDTLMHGQREGVFTAAKLYPANATTNSACGVTSIPGLYPLFEAMQQSGMPLLIHGEVTQADIDIFDREARFIEQV
MLPLRRDFPELRIVFEHITTREAAQFVAEGDRYLAATITPQHLMFNRNHMLVGGIHPHLYCLPILKRSVHQQALRKAATS
GQTCFFLGTDSAPHLRGRKESACGCAGVFNAPTALQAYATVFEEEQALQHLEAFCSLNGPAFYGLPANEAYIELAQEPAS
VVDSIASGDETLTPFLAGETLRWSVRA

Specific function: Pyrimidine biosynthesis; third step. [C]

COG id: COG0418

COG function: function code F; Dihydroorotase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the DHOase family. Type 1 subfamily

Homologues:

Organism=Escherichia coli, GI1787301, Length=347, Percent_Identity=70.028818443804, Blast_Score=516, Evalue=1e-147,
Organism=Saccharomyces cerevisiae, GI6323452, Length=357, Percent_Identity=34.733893557423, Blast_Score=183, Evalue=4e-47,

Paralogues:

None

Copy number: 340 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): PYRC_EDWI9 (C5BA73)

Other databases:

- EMBL:   CP001600
- RefSeq:   YP_002933788.1
- GeneID:   7960558
- GenomeReviews:   CP001600_GR
- KEGG:   eic:NT01EI_2383
- OMA:   KESACGC
- ProtClustDB:   PRK05451
- HAMAP:   MF_00219
- InterPro:   IPR006680
- InterPro:   IPR004721
- InterPro:   IPR002195
- PIRSF:   PIRSF001237
- TIGRFAMs:   TIGR00856

Pfam domain/function: PF01979 Amidohydro_1

EC number: =3.5.2.3

Molecular weight: Translated: 38672; Mature: 38541

Theoretical pI: Translated: 6.50; Mature: 6.50

Prosite motif: PS00482 DIHYDROOROTASE_1; PS00483 DIHYDROOROTASE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.3 %Cys     (Translated Protein)
3.2 %Met     (Translated Protein)
5.5 %Cys+Met (Translated Protein)
2.3 %Cys     (Mature Protein)
2.9 %Met     (Mature Protein)
5.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTVMQHTLKIRRPDDWHLHLRDDAMLHSVLPYTSRHFSRAVVMPNLVPPITSVEQCIAYR
CCCCHHHHEECCCCCCEEEECCHHHHHHHCCHHHHHHHHEEECCCCCCCHHHHHHHHHHH
QRILDAVPQGHAFTPLMTCYLTDALSVDTLMHGQREGVFTAAKLYPANATTNSACGVTSI
HHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCEEEEEEEECCCCCCCCCCCCCC
PGLYPLFEAMQQSGMPLLIHGEVTQADIDIFDREARFIEQVMLPLRRDFPELRIVFEHIT
CCHHHHHHHHHHCCCCEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHH
TREAAQFVAEGDRYLAATITPQHLMFNRNHMLVGGIHPHLYCLPILKRSVHQQALRKAAT
HHHHHHHHHCCCCEEEEEECHHHHEECCCEEEEECCCCHHHHHHHHHHHHHHHHHHHHHC
SGQTCFFLGTDSAPHLRGRKESACGCAGVFNAPTALQAYATVFEEEQALQHLEAFCSLNG
CCCEEEEEECCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCC
PAFYGLPANEAYIELAQEPASVVDSIASGDETLTPFLAGETLRWSVRA
CEEECCCCCHHHHHHHHHHHHHHHHHHCCCCCCCHHHCCCCEEEEECC
>Mature Secondary Structure 
TVMQHTLKIRRPDDWHLHLRDDAMLHSVLPYTSRHFSRAVVMPNLVPPITSVEQCIAYR
CCCHHHHEECCCCCCEEEECCHHHHHHHCCHHHHHHHHEEECCCCCCCHHHHHHHHHHH
QRILDAVPQGHAFTPLMTCYLTDALSVDTLMHGQREGVFTAAKLYPANATTNSACGVTSI
HHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCEEEEEEEECCCCCCCCCCCCCC
PGLYPLFEAMQQSGMPLLIHGEVTQADIDIFDREARFIEQVMLPLRRDFPELRIVFEHIT
CCHHHHHHHHHHCCCCEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHH
TREAAQFVAEGDRYLAATITPQHLMFNRNHMLVGGIHPHLYCLPILKRSVHQQALRKAAT
HHHHHHHHHCCCCEEEEEECHHHHEECCCEEEEECCCCHHHHHHHHHHHHHHHHHHHHHC
SGQTCFFLGTDSAPHLRGRKESACGCAGVFNAPTALQAYATVFEEEQALQHLEAFCSLNG
CCCEEEEEECCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCC
PAFYGLPANEAYIELAQEPASVVDSIASGDETLTPFLAGETLRWSVRA
CEEECCCCCHHHHHHHHHHHHHHHHHHCCCCCCCHHHCCCCEEEEECC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA