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The map label for this gene is sspH2 [H]

Identifier: 238920246

GI number: 238920246

Start: 2257161

End: 2258957

Strand: Reverse

Name: sspH2 [H]

Synonym: NT01EI_2355

Alternate gene names: 238920246

Gene position: 2258957-2257161 (Counterclockwise)

Preceding gene: 238920247

Following gene: 238920245

Centisome position: 59.25

GC content: 56.65

Gene sequence:

>1797_bases
ATGCAAAATGACACCCTGCTGGATGTCTATGGCCCATCACTGACCAGCCTGCCGCCGCTGCCGCCCGGACTGCAGACGCT
GGTGGTCTATAAAACCTCACTGACCAGCCTACCGCCGCTACCGCCCGGGCTGCAAGTGCTGGAGGTTCGTAATACCCGAT
TGACCAGCCTGCCACAACTGCCCTCCGAACTGCAGACGCTGAATGTCTATAAGACCTCACTGAGCAACCTACCGCAGCTG
CCCGACGGGCTGCGGGCACTGATAGTTTCTGACACCTCACTGAGCAGCCTGCCATCGCTACCCTCCAGACTGCGGACTGT
GATCGTACATTGCCCCTCACTGACCAGCCTGCAGCAATTGCCCGATGGACTGCTGAGACTGGATGTCTCTGGCGTCCCAC
TGGCCGATCTGCCGCAACTGCCCTCCGGACTGCAGGAGCTGGATGTCTCTAATACCTCACTGAGCAGCCTACCGCCGCAG
CTGCCCGACGGACTGCAGGCGCTGGATGTCTCTAATACCTCACTGAGCAGCCTACCGCCGCAGCTGCCCGACGGACTGCA
GACGCTGCAGGCCTTTAACACCTCACTGACCGGCCTACCTCCGCTGCCCTCCGGACTGCAAGTACTGATGGTCTCTGATA
CCCCGCTGAGCAGCCTGCCGCCGCTGCCCTCCAGACTGCGGGTGTTGGATGCCTCTCGCACTTCGCTGACTAATCTGCCG
GAAAATATCATCAGTTTGCCCCAGAGTGCAACGGTCAGTCTGCGGAATAATCCCCTGTCAGAGCATACGATCCAGGCATT
GCGTGACATGACCAATGCGTCCGACTATCAGGGGCCCCGGATAGATTTTGATATGGGCGCCTCTTCAGTACCTCTGGAAA
CCAGAGCCCTGCACTTGGCGGTGGCTGACTGGCTGACGCCAGCGACAGAGGGCGAGGCGGCTTCCGCTGACAGATGGCAG
TCCATCGGGAAGGAAGAGGATGCCGCCGCCTTCAGCAGTTTCCTCGACCAGCTAAAAGCGACGCAACATAACCAGGCTGC
CGATTTTCGTATGCAGATAGCCGCCTGGCTCACCCAGCTGGAGCAGGATGATGAGCTAAGAGCCAAAACCTTCGCCATGG
CAATGGAGTCAACGTCAAGCTGTGAGGACAGGGTCACATTGGCGATGAACAATATGAAAAGCGTGCAACTGGTTCATAAT
GCTGAAAAAGGTGAGTTCGATAGTGATATCCCGGGGCTGGTGGCGGTGGGTCGTGAAATGTTCCGCCTAGAGAAGCTAGA
GCTGATTGCCCGTGAGAAGGTAAAAACACTACGCGTTGTCGATGAGATTGAGGTTTTTCTGGGCTATCAGAACAAACTGA
AAAAATCACTGGAGCTGACCGGCATAACCGAAGAGATGCGATTTTTTGGTGTATCCGGTATTACTGAGTCAGACCTTCAG
GCTGCTGAAATTCAGGTGAAGACCGCCGAGAATAGCCAGTTCAGGGAGTGGATACTGCGGTGGGAGCCGTTGCACAACGT
GCTAAAGCGTACAGCGTCGGACCACTGGGAAACGCTTACTGACAAGAAAAGGCAGGATTATGAGCGTGAATACCAAGAAT
TATATGACACAGAGCTGGAACCGGCAGGTCTGGGCGGTGACCTAGAGGCTGAACGAACTATCGGTGCAAGAGCGATGGCG
AGCGCAGAAAAAGCATTTCAGCAAGGCTTACGCCCGCGGGCAGAGCAGTTGCTGGCCGGGCATCTGGGGCCCCGGTGGTC
GTTAGCTGAGTCCTCTGTATATCATTCTCTGGCGTGA

Upstream 100 bases:

>100_bases
AGCGGAAGAGTATGAGGCTGCGTGGTCAGAATGGGAAAGGGCTGCGCCGCCAGAAGAGGCAGCAGACCGTGCCAATACTG
TGTGGAAGCTACGTCACTGC

Downstream 100 bases:

>100_bases
ACGTGCGGTAACCGTGAGCGGTGGCCGGAATTTTTCCGGCCACCGGGCGGCGTTGGACAAGCGCCCGCGCGTCAGTCACC
CCACACTTTTGCATGCAAGA

Product: leucine-rich repeat protein

Products: NA

Alternate protein names: Salmonella secreted protein H2; Secreted effector protein sspH2 [H]

Number of amino acids: Translated: 598; Mature: 598

Protein sequence:

>598_residues
MQNDTLLDVYGPSLTSLPPLPPGLQTLVVYKTSLTSLPPLPPGLQVLEVRNTRLTSLPQLPSELQTLNVYKTSLSNLPQL
PDGLRALIVSDTSLSSLPSLPSRLRTVIVHCPSLTSLQQLPDGLLRLDVSGVPLADLPQLPSGLQELDVSNTSLSSLPPQ
LPDGLQALDVSNTSLSSLPPQLPDGLQTLQAFNTSLTGLPPLPSGLQVLMVSDTPLSSLPPLPSRLRVLDASRTSLTNLP
ENIISLPQSATVSLRNNPLSEHTIQALRDMTNASDYQGPRIDFDMGASSVPLETRALHLAVADWLTPATEGEAASADRWQ
SIGKEEDAAAFSSFLDQLKATQHNQAADFRMQIAAWLTQLEQDDELRAKTFAMAMESTSSCEDRVTLAMNNMKSVQLVHN
AEKGEFDSDIPGLVAVGREMFRLEKLELIAREKVKTLRVVDEIEVFLGYQNKLKKSLELTGITEEMRFFGVSGITESDLQ
AAEIQVKTAENSQFREWILRWEPLHNVLKRTASDHWETLTDKKRQDYEREYQELYDTELEPAGLGGDLEAERTIGARAMA
SAEKAFQQGLRPRAEQLLAGHLGPRWSLAESSVYHSLA

Sequences:

>Translated_598_residues
MQNDTLLDVYGPSLTSLPPLPPGLQTLVVYKTSLTSLPPLPPGLQVLEVRNTRLTSLPQLPSELQTLNVYKTSLSNLPQL
PDGLRALIVSDTSLSSLPSLPSRLRTVIVHCPSLTSLQQLPDGLLRLDVSGVPLADLPQLPSGLQELDVSNTSLSSLPPQ
LPDGLQALDVSNTSLSSLPPQLPDGLQTLQAFNTSLTGLPPLPSGLQVLMVSDTPLSSLPPLPSRLRVLDASRTSLTNLP
ENIISLPQSATVSLRNNPLSEHTIQALRDMTNASDYQGPRIDFDMGASSVPLETRALHLAVADWLTPATEGEAASADRWQ
SIGKEEDAAAFSSFLDQLKATQHNQAADFRMQIAAWLTQLEQDDELRAKTFAMAMESTSSCEDRVTLAMNNMKSVQLVHN
AEKGEFDSDIPGLVAVGREMFRLEKLELIAREKVKTLRVVDEIEVFLGYQNKLKKSLELTGITEEMRFFGVSGITESDLQ
AAEIQVKTAENSQFREWILRWEPLHNVLKRTASDHWETLTDKKRQDYEREYQELYDTELEPAGLGGDLEAERTIGARAMA
SAEKAFQQGLRPRAEQLLAGHLGPRWSLAESSVYHSLA
>Mature_598_residues
MQNDTLLDVYGPSLTSLPPLPPGLQTLVVYKTSLTSLPPLPPGLQVLEVRNTRLTSLPQLPSELQTLNVYKTSLSNLPQL
PDGLRALIVSDTSLSSLPSLPSRLRTVIVHCPSLTSLQQLPDGLLRLDVSGVPLADLPQLPSGLQELDVSNTSLSSLPPQ
LPDGLQALDVSNTSLSSLPPQLPDGLQTLQAFNTSLTGLPPLPSGLQVLMVSDTPLSSLPPLPSRLRVLDASRTSLTNLP
ENIISLPQSATVSLRNNPLSEHTIQALRDMTNASDYQGPRIDFDMGASSVPLETRALHLAVADWLTPATEGEAASADRWQ
SIGKEEDAAAFSSFLDQLKATQHNQAADFRMQIAAWLTQLEQDDELRAKTFAMAMESTSSCEDRVTLAMNNMKSVQLVHN
AEKGEFDSDIPGLVAVGREMFRLEKLELIAREKVKTLRVVDEIEVFLGYQNKLKKSLELTGITEEMRFFGVSGITESDLQ
AAEIQVKTAENSQFREWILRWEPLHNVLKRTASDHWETLTDKKRQDYEREYQELYDTELEPAGLGGDLEAERTIGARAMA
SAEKAFQQGLRPRAEQLLAGHLGPRWSLAESSVYHSLA

Specific function: Effector proteins function to alter host cell physiology and promote bacterial survival in host tissues. This protein is an E3 ubiquitin ligase that interferes with host's ubiquitination pathway. Contributes to virulence in calves [H]

COG id: COG4886

COG function: function code S; Leucine-rich repeat (LRR) protein

Gene ontology:

Cell location: Secreted. Host cytoplasm. Host apical cell membrane; Peripheral membrane protein; Cytoplasmic side. Note=Secreted via type III secretion system 2 (SPI-2 TTSS), and delivered into the host cytoplasm. Localizes at the periphery of the host cell, specificall

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Contains 12 LRR (leucine-rich) repeats [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001611 [H]

Pfam domain/function: PF00560 LRR_1 [H]

EC number: NA

Molecular weight: Translated: 65651; Mature: 65651

Theoretical pI: Translated: 4.58; Mature: 4.58

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
2.3 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
2.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MQNDTLLDVYGPSLTSLPPLPPGLQTLVVYKTSLTSLPPLPPGLQVLEVRNTRLTSLPQL
CCCCCEEEECCCCCCCCCCCCCCCCEEEEEEHHHCCCCCCCCCCEEEEECCCHHHCCCCC
PSELQTLNVYKTSLSNLPQLPDGLRALIVSDTSLSSLPSLPSRLRTVIVHCPSLTSLQQL
HHHHHHHHHHHHHHHCCCCCCCCCEEEEECCCCHHHCCCHHHHHHHHHHCCCCHHHHHHC
PDGLLRLDVSGVPLADLPQLPSGLQELDVSNTSLSSLPPQLPDGLQALDVSNTSLSSLPP
CCHHEEECCCCCCCCCCCCCCCCHHHHCCCCCCHHHCCCCCCCCCCEECCCCCCHHHCCC
QLPDGLQTLQAFNTSLTGLPPLPSGLQVLMVSDTPLSSLPPLPSRLRVLDASRTSLTNLP
CCCHHHHHHHHHCCCCCCCCCCCCCCEEEEECCCCCCCCCCCHHHHHHHCCCHHHHHHCC
ENIISLPQSATVSLRNNPLSEHTIQALRDMTNASDYQGPRIDFDMGASSVPLETRALHLA
HHHHHCCCCCEEEECCCCCHHHHHHHHHHHCCCCCCCCCCEECCCCCCCCCCHHHHHHHH
VADWLTPATEGEAASADRWQSIGKEEDAAAFSSFLDQLKATQHNQAADFRMQIAAWLTQL
HHHHCCCCCCCCCCCHHHHHHCCCHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHH
EQDDELRAKTFAMAMESTSSCEDRVTLAMNNMKSVQLVHNAEKGEFDSDIPGLVAVGREM
CCCCHHHHHHHHHHHHCCCCHHHHHHHHHCCCCHHHHEECCCCCCCCCCCCHHHHHHHHH
FRLEKLELIAREKVKTLRVVDEIEVFLGYQNKLKKSLELTGITEEMRFFGVSGITESDLQ
HHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHCCCHHHHHHHCCCCCCCCCCC
AAEIQVKTAENSQFREWILRWEPLHNVLKRTASDHWETLTDKKRQDYEREYQELYDTELE
EEEEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCC
PAGLGGDLEAERTIGARAMASAEKAFQQGLRPRAEQLLAGHLGPRWSLAESSVYHSLA
CCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHCCCCCCCHHHHHHHHHCC
>Mature Secondary Structure
MQNDTLLDVYGPSLTSLPPLPPGLQTLVVYKTSLTSLPPLPPGLQVLEVRNTRLTSLPQL
CCCCCEEEECCCCCCCCCCCCCCCCEEEEEEHHHCCCCCCCCCCEEEEECCCHHHCCCCC
PSELQTLNVYKTSLSNLPQLPDGLRALIVSDTSLSSLPSLPSRLRTVIVHCPSLTSLQQL
HHHHHHHHHHHHHHHCCCCCCCCCEEEEECCCCHHHCCCHHHHHHHHHHCCCCHHHHHHC
PDGLLRLDVSGVPLADLPQLPSGLQELDVSNTSLSSLPPQLPDGLQALDVSNTSLSSLPP
CCHHEEECCCCCCCCCCCCCCCCHHHHCCCCCCHHHCCCCCCCCCCEECCCCCCHHHCCC
QLPDGLQTLQAFNTSLTGLPPLPSGLQVLMVSDTPLSSLPPLPSRLRVLDASRTSLTNLP
CCCHHHHHHHHHCCCCCCCCCCCCCCEEEEECCCCCCCCCCCHHHHHHHCCCHHHHHHCC
ENIISLPQSATVSLRNNPLSEHTIQALRDMTNASDYQGPRIDFDMGASSVPLETRALHLA
HHHHHCCCCCEEEECCCCCHHHHHHHHHHHCCCCCCCCCCEECCCCCCCCCCHHHHHHHH
VADWLTPATEGEAASADRWQSIGKEEDAAAFSSFLDQLKATQHNQAADFRMQIAAWLTQL
HHHHCCCCCCCCCCCHHHHHHCCCHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHH
EQDDELRAKTFAMAMESTSSCEDRVTLAMNNMKSVQLVHNAEKGEFDSDIPGLVAVGREM
CCCCHHHHHHHHHHHHCCCCHHHHHHHHHCCCCHHHHEECCCCCCCCCCCCHHHHHHHHH
FRLEKLELIAREKVKTLRVVDEIEVFLGYQNKLKKSLELTGITEEMRFFGVSGITESDLQ
HHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHCCCHHHHHHHCCCCCCCCCCC
AAEIQVKTAENSQFREWILRWEPLHNVLKRTASDHWETLTDKKRQDYEREYQELYDTELE
EEEEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCC
PAGLGGDLEAERTIGARAMASAEKAFQQGLRPRAEQLLAGHLGPRWSLAESSVYHSLA
CCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHCCCCCCCHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 10564523; 10861017 [H]