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The map label for this gene is lolC [H]

Identifier: 238920222

GI number: 238920222

Start: 2229567

End: 2230769

Strand: Reverse

Name: lolC [H]

Synonym: NT01EI_2331

Alternate gene names: 238920222

Gene position: 2230769-2229567 (Counterclockwise)

Preceding gene: 238920224

Following gene: 238920221

Centisome position: 58.51

GC content: 63.92

Gene sequence:

>1203_bases
ATGCATCAACCTGTCGCCCTATTTATTGGCCTGCGCTATATGCGCGGGCGCGCCTCGGACCGCTTCGGGCGGTTTGTGTC
CTGGCTGTCTACCATCGGCATTACGCTGGGAGTGATGGCGCTGGTCACCGTGCTGTCGGTGATGAACGGATTTGAGCGCG
ATCTGGAGCAGAGCATTTTAAACCTGATGCCGCAGGCGGTGGTGACCACCCCGCAGGGGCAGCTGGACCCCGCCCGCTAT
CCGGCATCGCTGCTGCAGGGGCTGCCCGGCGTACACCGGGCGGCGCCGCTGACCACCGGCGATGTGGTGCTGCAGAGCCC
GCACAGCGTGGGTGTCGGCGTGATGATCGGCGTCAATCCTGACGAGGCCGATCCCCTGGACCGCTATCTGAACGGCGTTA
GCCAAAGCGCGCTGCAACCGGGCCAGTACCGCGCTATCCTCGGCAGCCAGCTGGCCGCCGAGCTCGGCGTCAAGGCCGGT
GACCGGGTGCGTCTGATGGTGCCGAGCGCCAGCCAGTTTACCCCGATGGGGCGGATTCCCAGCCAGCGTATCTTTACCGT
GATCGGTACCTTTAACGCCGACAGCGAGGTGGATCAGACGCAGCTGCTGGTTAACCAGCAGGATGCCTCGCGGCTGATGC
GCTATCCGCTGGGTCACATCAGCGGCTGGCGTCTGTTTATGGATCGCCCGCTGGATATCGAGGCACTGGTGGCGCACGCA
CTGCCCGACGGACTGGTATGGCAGGACTGGCGCGCCCGCAAGGGTGAGCTGTTCCAGGCGGTGAAGATGGAGAAAAATAT
GATGGGGCTGCTGCTCAGCCTGATCATCGCCGTGGCCGCCTTCAATATCATTACGTCGCTGGGGCTGCTGGTGATGGAGA
AGCAGGGCGAGGTGGCCATTCTGCAGACCCAGGGGCTGACCCGGCGCCAGATCATGAGCGTCTTTATGGTGCAGGGCGCC
AGCGCCGGGATCATCGGATCGCTGCTGGGGGCTCTGCTGGGAGCCCTGCTGGCCAGCCAGCTGAATACCCTGCTGCCGGG
GTTGGGCGATATGCTCGGCGGCGGCACGCTGCCGGTCGATATTCACGCAGGTCAGGTGGTGACCATTGCGCTGGTGGCCA
TGCTGCTCTCCCTGCTGTCAACGATTTATCCTTCATGGCGCGCCGCCGCCGTTCATCCTGCCGAGGCATTACGTTATGAG
TAA

Upstream 100 bases:

>100_bases
CGCGGGTTTCTGCGGCGGCGGGCGTGGAGATGACCATTGTGATAACCTGTTCACAGACATATACTTGCCAATCACTTTGC
GCATTGCAAGAAAGAGAGCC

Downstream 100 bases:

>100_bases
CCCTTCATCCCGGGCTCCCGCACTGCTACAGTGCAAGGGACTGAGCAAAAGCTACCAGGAGGGCAAACTGAGCACCGACG
TTCTGCGTCAGGTCTCGTTT

Product: outer membrane-specific lipoprotein transporter subunit LolC

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 400; Mature: 400

Protein sequence:

>400_residues
MHQPVALFIGLRYMRGRASDRFGRFVSWLSTIGITLGVMALVTVLSVMNGFERDLEQSILNLMPQAVVTTPQGQLDPARY
PASLLQGLPGVHRAAPLTTGDVVLQSPHSVGVGVMIGVNPDEADPLDRYLNGVSQSALQPGQYRAILGSQLAAELGVKAG
DRVRLMVPSASQFTPMGRIPSQRIFTVIGTFNADSEVDQTQLLVNQQDASRLMRYPLGHISGWRLFMDRPLDIEALVAHA
LPDGLVWQDWRARKGELFQAVKMEKNMMGLLLSLIIAVAAFNIITSLGLLVMEKQGEVAILQTQGLTRRQIMSVFMVQGA
SAGIIGSLLGALLGALLASQLNTLLPGLGDMLGGGTLPVDIHAGQVVTIALVAMLLSLLSTIYPSWRAAAVHPAEALRYE

Sequences:

>Translated_400_residues
MHQPVALFIGLRYMRGRASDRFGRFVSWLSTIGITLGVMALVTVLSVMNGFERDLEQSILNLMPQAVVTTPQGQLDPARY
PASLLQGLPGVHRAAPLTTGDVVLQSPHSVGVGVMIGVNPDEADPLDRYLNGVSQSALQPGQYRAILGSQLAAELGVKAG
DRVRLMVPSASQFTPMGRIPSQRIFTVIGTFNADSEVDQTQLLVNQQDASRLMRYPLGHISGWRLFMDRPLDIEALVAHA
LPDGLVWQDWRARKGELFQAVKMEKNMMGLLLSLIIAVAAFNIITSLGLLVMEKQGEVAILQTQGLTRRQIMSVFMVQGA
SAGIIGSLLGALLGALLASQLNTLLPGLGDMLGGGTLPVDIHAGQVVTIALVAMLLSLLSTIYPSWRAAAVHPAEALRYE
>Mature_400_residues
MHQPVALFIGLRYMRGRASDRFGRFVSWLSTIGITLGVMALVTVLSVMNGFERDLEQSILNLMPQAVVTTPQGQLDPARY
PASLLQGLPGVHRAAPLTTGDVVLQSPHSVGVGVMIGVNPDEADPLDRYLNGVSQSALQPGQYRAILGSQLAAELGVKAG
DRVRLMVPSASQFTPMGRIPSQRIFTVIGTFNADSEVDQTQLLVNQQDASRLMRYPLGHISGWRLFMDRPLDIEALVAHA
LPDGLVWQDWRARKGELFQAVKMEKNMMGLLLSLIIAVAAFNIITSLGLLVMEKQGEVAILQTQGLTRRQIMSVFMVQGA
SAGIIGSLLGALLGALLASQLNTLLPGLGDMLGGGTLPVDIHAGQVVTIALVAMLLSLLSTIYPSWRAAAVHPAEALRYE

Specific function: Part of an ATP-dependent transport system lolCDE responsible for the release of lipoproteins targeted to the outer membrane from the inner membrane. Such a release is dependent of the sorting-signal (absence of an Asp at position 2 of the mature lipoprote

COG id: COG4591

COG function: function code M; ABC-type transport system, involved in lipoprotein release, permease component

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ABC-4 integral membrane protein family. LolC/E subfamily [H]

Homologues:

Organism=Escherichia coli, GI1787360, Length=400, Percent_Identity=71.75, Blast_Score=549, Evalue=1e-157,
Organism=Escherichia coli, GI1787362, Length=413, Percent_Identity=29.2978208232446, Blast_Score=148, Evalue=7e-37,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003838
- InterPro:   IPR011925 [H]

Pfam domain/function: PF02687 FtsX [H]

EC number: NA

Molecular weight: Translated: 43042; Mature: 43042

Theoretical pI: Translated: 7.95; Mature: 7.95

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
4.5 %Met     (Translated Protein)
4.5 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
4.5 %Met     (Mature Protein)
4.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MHQPVALFIGLRYMRGRASDRFGRFVSWLSTIGITLGVMALVTVLSVMNGFERDLEQSIL
CCCCHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
NLMPQAVVTTPQGQLDPARYPASLLQGLPGVHRAAPLTTGDVVLQSPHSVGVGVMIGVNP
HHCCHHHEECCCCCCCHHCCHHHHHHCCCCCHHCCCCCCCCCEEECCCCCCEEEEEECCC
DEADPLDRYLNGVSQSALQPGQYRAILGSQLAAELGVKAGDRVRLMVPSASQFTPMGRIP
CCCCHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHCCCCCCEEEEEECCCHHCCCCCCCC
SQRIFTVIGTFNADSEVDQTQLLVNQQDASRLMRYPLGHISGWRLFMDRPLDIEALVAHA
CHHHEEEEECCCCCCCCHHHHHHHHHHHHHHHHHCCCCCCCCCCEEECCCCCHHHHHHHH
LPDGLVWQDWRARKGELFQAVKMEKNMMGLLLSLIIAVAAFNIITSLGLLVMEKQGEVAI
CCCCCCCCHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEECCCCEEE
LQTQGLTRRQIMSVFMVQGASAGIIGSLLGALLGALLASQLNTLLPGLGDMLGGGTLPVD
EECCCCCHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHCCCCCEEE
IHAGQVVTIALVAMLLSLLSTIYPSWRAAAVHPAEALRYE
ECCCHHHHHHHHHHHHHHHHHHCCCCCCHHCCHHHHHCCC
>Mature Secondary Structure
MHQPVALFIGLRYMRGRASDRFGRFVSWLSTIGITLGVMALVTVLSVMNGFERDLEQSIL
CCCCHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
NLMPQAVVTTPQGQLDPARYPASLLQGLPGVHRAAPLTTGDVVLQSPHSVGVGVMIGVNP
HHCCHHHEECCCCCCCHHCCHHHHHHCCCCCHHCCCCCCCCCEEECCCCCCEEEEEECCC
DEADPLDRYLNGVSQSALQPGQYRAILGSQLAAELGVKAGDRVRLMVPSASQFTPMGRIP
CCCCHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHCCCCCCEEEEEECCCHHCCCCCCCC
SQRIFTVIGTFNADSEVDQTQLLVNQQDASRLMRYPLGHISGWRLFMDRPLDIEALVAHA
CHHHEEEEECCCCCCCCHHHHHHHHHHHHHHHHHCCCCCCCCCCEEECCCCCHHHHHHHH
LPDGLVWQDWRARKGELFQAVKMEKNMMGLLLSLIIAVAAFNIITSLGLLVMEKQGEVAI
CCCCCCCCHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEECCCCEEE
LQTQGLTRRQIMSVFMVQGASAGIIGSLLGALLGALLASQLNTLLPGLGDMLGGGTLPVD
EECCCCCHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHCCCCCEEE
IHAGQVVTIALVAMLLSLLSTIYPSWRAAAVHPAEALRYE
ECCCHHHHHHHHHHHHHHHHHHCCCCCCHHCCHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]