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The map label for this gene is icd [H]

Identifier: 238920206

GI number: 238920206

Start: 2212715

End: 2213968

Strand: Reverse

Name: icd [H]

Synonym: NT01EI_2315

Alternate gene names: 238920206

Gene position: 2213968-2212715 (Counterclockwise)

Preceding gene: 238920214

Following gene: 238920203

Centisome position: 58.07

GC content: 59.41

Gene sequence:

>1254_bases
ATGGAAAGTAAAGTCGTTATTCCGGTCAACGGGCAGAAGATGAGCGCTGATGCACAGGGAAAGCTGAGCGTCCCGGCGAC
GCCGATTATTCCCTTTATCGAGGGCGATGGTATCGGGGTGGATGTGACACCGGCGATGATCAAGGTGGTGGATGCCGCCG
TCGCTAAGGCGTACCGCGGTGAGCGTCGGATCGCCTGGATGGAGATCTACACCGGAGAGAAGGCGACCCAGGTCTATGGT
CCTGATGTCTGGCTGCCCGATGAGACGCTGGATCTGATCCGTGAATACCGCGTAGCGATTAAGGGCCCCCTGACGACGCC
CGTCGGCGGCGGGATCCGCTCTCTCAACGTGGCGCTGCGCCAGCGGCTGGATCTGTATATCTGCCTGCGTCCGGTGCGCT
ATTACCAAGGGACGCCCAGCCCGGTCAAACAGCCGGAGCTGACGGACATGGTGATCTTCCGCGAAAACGCCGAGGATATT
TACGCCGGCATCGAGTGGAAAGCCGACAGCCCCGAGGCCAAAAAAGTCATCGATTTCCTGCGCGAAGAGATGGGCGTCAA
CAAGATCCGCTTCCCTGAGCACTGCGGCATCGGGGTGAAGCCGTGCTCCGAGCAGGGAACCCAACGCTTGGTGCGTGCGG
CGATCGAGTACGCTATCGCTAACGATCGCGACTCGGTGACTCTGGTGCACAAGGGCAATATCATGAAGTTTACCGAGGGG
GCCTTTAAGGACTGGGGATACCAGCTGGCGCGCGAGGAGTTTGGCGGCGAGCCTATTGACGGCGGCCCGTGGCTGGCGGT
GAAGAATCCGCGCAGCGGAAAAACCATCGTGATCAAGGATGTGATCGCCGATGCCTTCCTGCAGCAGATCCTGCTGCGTC
CGGCGGAGTATGACGTGATCGCCTGTATGAACCTGAACGGCGACTATATCTCCGATGCGTTGGCGGCACAGGTCGGCGGC
ATCGGTATCGCACCGGGCGCCAACATTGGCGACGCGTGTGCGCTGTTTGAGGCGACCCACGGCACTGCGCCGAAGTACGC
CGGCCAGGATAAGGTGAACCCCGGTTCGATTATCTTGTCTGCCGAAATGATGCTGCGTCACATGGGCTGGACGGAAGCGG
CGGACCTGATTGTTAAAGGTATGGAAGGGGCGATCGCCAATAAGACAGTGACCTATGACTTCGAACGTCTGATGGATGGC
GCTAAGTTGCTGAAATGCTCTGAGTTTGGCGACGCGGTCATCGACAATATGTGA

Upstream 100 bases:

>100_bases
ATGAAACAAAGTAAATCAAGGTGTAATTTTTATTAAATCAATCGGTTGGCGTCTGTTATTGCAGGCGTGGCCCGAGAGAG
CTACGCGGAGGGATAGGTTA

Downstream 100 bases:

>100_bases
TTTTTTCTGTTAACATATAGCCAACATAAATTGTTAATTTTATGTTGGCTTTTTGATCTGCACATCTTTCCCCAAAACTT
CCCCAAAACTCTTCCCCAAA

Product: isocitrate dehydrogenase

Products: NA

Alternate protein names: IDH; IDP; NADP(+)-specific ICDH; Oxalosuccinate decarboxylase [H]

Number of amino acids: Translated: 417; Mature: 417

Protein sequence:

>417_residues
MESKVVIPVNGQKMSADAQGKLSVPATPIIPFIEGDGIGVDVTPAMIKVVDAAVAKAYRGERRIAWMEIYTGEKATQVYG
PDVWLPDETLDLIREYRVAIKGPLTTPVGGGIRSLNVALRQRLDLYICLRPVRYYQGTPSPVKQPELTDMVIFRENAEDI
YAGIEWKADSPEAKKVIDFLREEMGVNKIRFPEHCGIGVKPCSEQGTQRLVRAAIEYAIANDRDSVTLVHKGNIMKFTEG
AFKDWGYQLAREEFGGEPIDGGPWLAVKNPRSGKTIVIKDVIADAFLQQILLRPAEYDVIACMNLNGDYISDALAAQVGG
IGIAPGANIGDACALFEATHGTAPKYAGQDKVNPGSIILSAEMMLRHMGWTEAADLIVKGMEGAIANKTVTYDFERLMDG
AKLLKCSEFGDAVIDNM

Sequences:

>Translated_417_residues
MESKVVIPVNGQKMSADAQGKLSVPATPIIPFIEGDGIGVDVTPAMIKVVDAAVAKAYRGERRIAWMEIYTGEKATQVYG
PDVWLPDETLDLIREYRVAIKGPLTTPVGGGIRSLNVALRQRLDLYICLRPVRYYQGTPSPVKQPELTDMVIFRENAEDI
YAGIEWKADSPEAKKVIDFLREEMGVNKIRFPEHCGIGVKPCSEQGTQRLVRAAIEYAIANDRDSVTLVHKGNIMKFTEG
AFKDWGYQLAREEFGGEPIDGGPWLAVKNPRSGKTIVIKDVIADAFLQQILLRPAEYDVIACMNLNGDYISDALAAQVGG
IGIAPGANIGDACALFEATHGTAPKYAGQDKVNPGSIILSAEMMLRHMGWTEAADLIVKGMEGAIANKTVTYDFERLMDG
AKLLKCSEFGDAVIDNM
>Mature_417_residues
MESKVVIPVNGQKMSADAQGKLSVPATPIIPFIEGDGIGVDVTPAMIKVVDAAVAKAYRGERRIAWMEIYTGEKATQVYG
PDVWLPDETLDLIREYRVAIKGPLTTPVGGGIRSLNVALRQRLDLYICLRPVRYYQGTPSPVKQPELTDMVIFRENAEDI
YAGIEWKADSPEAKKVIDFLREEMGVNKIRFPEHCGIGVKPCSEQGTQRLVRAAIEYAIANDRDSVTLVHKGNIMKFTEG
AFKDWGYQLAREEFGGEPIDGGPWLAVKNPRSGKTIVIKDVIADAFLQQILLRPAEYDVIACMNLNGDYISDALAAQVGG
IGIAPGANIGDACALFEATHGTAPKYAGQDKVNPGSIILSAEMMLRHMGWTEAADLIVKGMEGAIANKTVTYDFERLMDG
AKLLKCSEFGDAVIDNM

Specific function: Unknown

COG id: COG0538

COG function: function code C; Isocitrate dehydrogenases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the isocitrate and isopropylmalate dehydrogenases family [H]

Homologues:

Organism=Homo sapiens, GI5031777, Length=388, Percent_Identity=32.2164948453608, Blast_Score=178, Evalue=9e-45,
Organism=Homo sapiens, GI28178816, Length=389, Percent_Identity=26.9922879177378, Blast_Score=112, Evalue=9e-25,
Organism=Homo sapiens, GI28178821, Length=352, Percent_Identity=27.2727272727273, Blast_Score=110, Evalue=2e-24,
Organism=Homo sapiens, GI28178838, Length=303, Percent_Identity=29.3729372937294, Blast_Score=107, Evalue=2e-23,
Organism=Homo sapiens, GI4758582, Length=301, Percent_Identity=29.2358803986711, Blast_Score=105, Evalue=1e-22,
Organism=Homo sapiens, GI28178819, Length=181, Percent_Identity=31.4917127071823, Blast_Score=78, Evalue=1e-14,
Organism=Escherichia coli, GI1787381, Length=417, Percent_Identity=89.6882494004796, Blast_Score=774, Evalue=0.0,
Organism=Escherichia coli, GI1788101, Length=377, Percent_Identity=28.1167108753316, Blast_Score=104, Evalue=1e-23,
Organism=Escherichia coli, GI87081683, Length=402, Percent_Identity=25.1243781094527, Blast_Score=78, Evalue=1e-15,
Organism=Caenorhabditis elegans, GI71986051, Length=360, Percent_Identity=34.7222222222222, Blast_Score=181, Evalue=5e-46,
Organism=Caenorhabditis elegans, GI25144293, Length=388, Percent_Identity=27.0618556701031, Blast_Score=115, Evalue=6e-26,
Organism=Caenorhabditis elegans, GI17505779, Length=306, Percent_Identity=29.0849673202614, Blast_Score=106, Evalue=2e-23,
Organism=Caenorhabditis elegans, GI17550882, Length=393, Percent_Identity=24.6819338422392, Blast_Score=94, Evalue=2e-19,
Organism=Saccharomyces cerevisiae, GI6324709, Length=398, Percent_Identity=31.6582914572864, Blast_Score=167, Evalue=2e-42,
Organism=Saccharomyces cerevisiae, GI6322097, Length=367, Percent_Identity=29.1553133514986, Blast_Score=134, Evalue=4e-32,
Organism=Saccharomyces cerevisiae, GI6324291, Length=361, Percent_Identity=26.5927977839335, Blast_Score=120, Evalue=3e-28,
Organism=Drosophila melanogaster, GI24643270, Length=415, Percent_Identity=32.0481927710843, Blast_Score=185, Evalue=4e-47,
Organism=Drosophila melanogaster, GI24643268, Length=396, Percent_Identity=32.8282828282828, Blast_Score=185, Evalue=6e-47,
Organism=Drosophila melanogaster, GI24661184, Length=391, Percent_Identity=31.7135549872123, Blast_Score=175, Evalue=6e-44,
Organism=Drosophila melanogaster, GI161078639, Length=306, Percent_Identity=28.1045751633987, Blast_Score=112, Evalue=4e-25,
Organism=Drosophila melanogaster, GI161078635, Length=306, Percent_Identity=28.1045751633987, Blast_Score=112, Evalue=4e-25,
Organism=Drosophila melanogaster, GI161078637, Length=306, Percent_Identity=28.1045751633987, Blast_Score=112, Evalue=4e-25,
Organism=Drosophila melanogaster, GI161078633, Length=306, Percent_Identity=28.1045751633987, Blast_Score=112, Evalue=5e-25,
Organism=Drosophila melanogaster, GI24650122, Length=306, Percent_Identity=28.1045751633987, Blast_Score=112, Evalue=5e-25,
Organism=Drosophila melanogaster, GI20130355, Length=396, Percent_Identity=25.2525252525253, Blast_Score=96, Evalue=5e-20,
Organism=Drosophila melanogaster, GI281362242, Length=391, Percent_Identity=25.8312020460358, Blast_Score=79, Evalue=4e-15,
Organism=Drosophila melanogaster, GI24648872, Length=391, Percent_Identity=25.8312020460358, Blast_Score=79, Evalue=4e-15,

Paralogues:

None

Copy number: 8180 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 240 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 1480 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR019818
- InterPro:   IPR001804
- InterPro:   IPR004439 [H]

Pfam domain/function: PF00180 Iso_dh [H]

EC number: =1.1.1.42 [H]

Molecular weight: Translated: 45524; Mature: 45524

Theoretical pI: Translated: 4.93; Mature: 4.93

Prosite motif: PS00470 IDH_IMDH

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
3.4 %Met     (Translated Protein)
4.8 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
3.4 %Met     (Mature Protein)
4.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MESKVVIPVNGQKMSADAQGKLSVPATPIIPFIEGDGIGVDVTPAMIKVVDAAVAKAYRG
CCCCEEEEECCCEECCCCCCEEECCCCCCEEEECCCCCCEECHHHHHHHHHHHHHHHHCC
ERRIAWMEIYTGEKATQVYGPDVWLPDETLDLIREYRVAIKGPLTTPVGGGIRSLNVALR
CCEEEEEEEECCCCCEEECCCCCCCCHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHH
QRLDLYICLRPVRYYQGTPSPVKQPELTDMVIFRENAEDIYAGIEWKADSPEAKKVIDFL
HHCCEEEEEEEHHHHCCCCCCCCCCCCCEEEEEECCCCCEEECEEECCCCCHHHHHHHHH
REEMGVNKIRFPEHCGIGVKPCSEQGTQRLVRAAIEYAIANDRDSVTLVHKGNIMKFTEG
HHHHCCCCCCCCHHCCCCCCCCHHHHHHHHHHHHHHHHHCCCCCCEEEEECCCEEEECCC
AFKDWGYQLAREEFGGEPIDGGPWLAVKNPRSGKTIVIKDVIADAFLQQILLRPAEYDVI
HHHHHHHHHHHHHHCCCCCCCCCEEEECCCCCCCEEEEHHHHHHHHHHHHHCCCCCCCEE
ACMNLNGDYISDALAAQVGGIGIAPGANIGDACALFEATHGTAPKYAGQDKVNPGSIILS
EEEECCCHHHHHHHHHHHCCEECCCCCCCCCHHHHEECCCCCCCCCCCCCCCCCCCEEEE
AEMMLRHMGWTEAADLIVKGMEGAIANKTVTYDFERLMDGAKLLKCSEFGDAVIDNM
HHHHHHHCCCHHHHHHHHHCCCCCCCCCEEEEEHHHHHCHHHHEEHHHHCCHHHCCC
>Mature Secondary Structure
MESKVVIPVNGQKMSADAQGKLSVPATPIIPFIEGDGIGVDVTPAMIKVVDAAVAKAYRG
CCCCEEEEECCCEECCCCCCEEECCCCCCEEEECCCCCCEECHHHHHHHHHHHHHHHHCC
ERRIAWMEIYTGEKATQVYGPDVWLPDETLDLIREYRVAIKGPLTTPVGGGIRSLNVALR
CCEEEEEEEECCCCCEEECCCCCCCCHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHH
QRLDLYICLRPVRYYQGTPSPVKQPELTDMVIFRENAEDIYAGIEWKADSPEAKKVIDFL
HHCCEEEEEEEHHHHCCCCCCCCCCCCCEEEEEECCCCCEEECEEECCCCCHHHHHHHHH
REEMGVNKIRFPEHCGIGVKPCSEQGTQRLVRAAIEYAIANDRDSVTLVHKGNIMKFTEG
HHHHCCCCCCCCHHCCCCCCCCHHHHHHHHHHHHHHHHHCCCCCCEEEEECCCEEEECCC
AFKDWGYQLAREEFGGEPIDGGPWLAVKNPRSGKTIVIKDVIADAFLQQILLRPAEYDVI
HHHHHHHHHHHHHHCCCCCCCCCEEEECCCCCCCEEEEHHHHHHHHHHHHHCCCCCCCEE
ACMNLNGDYISDALAAQVGGIGIAPGANIGDACALFEATHGTAPKYAGQDKVNPGSIILS
EEEECCCHHHHHHHHHHHCCEECCCCCCCCCHHHHEECCCCCCCCCCCCCCCCCCCEEEE
AEMMLRHMGWTEAADLIVKGMEGAIANKTVTYDFERLMDGAKLLKCSEFGDAVIDNM
HHHHHHHCCCHHHHHHHHHCCCCCCCCCEEEEEHHHHHCHHHHEEHHHHCCHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 3112144; 8905232; 9278503; 9352899; 9298646; 2204109; 2682654; 10623532 [H]