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The map label for this gene is prpR [H]

Identifier: 238920068

GI number: 238920068

Start: 2100902

End: 2102851

Strand: Direct

Name: prpR [H]

Synonym: NT01EI_2173

Alternate gene names: 238920068

Gene position: 2100902-2102851 (Clockwise)

Preceding gene: 238920067

Following gene: 238920070

Centisome position: 55.11

GC content: 65.64

Gene sequence:

>1950_bases
ATGAGCGCCGAATTTCACTTTGCCTTTATCGCCCCCTACCCCCAGCTGGCGACTCTGGCGCGACAGCAGGCGGCGGCACT
GGGTTGCCGTCTGACGGTGATCGACGGTGCCTTTGACACCGTCGCCCGTCAGGTCGCGCGCCTGCCGGACGACATCTCGG
CGGTGATCAGCCGCGGTGGCACCGCCGAAAAAATCCGCCTGTATACGCTCAAGCCGGTGGTCTCCATCGAAACCAGCGCC
CTCGATCTGCTGACGCTGCTGCTGCCGCTGCGGGGAGAGGTCGCGCGGGTCGGCGTGATCAGCTACCGTCAGCCACTGCC
CGGGGTGGCGCCGATCGCCCAGGCGCTGGCGATGGAGATCCGTCAGGAGGTGTTCCATGGCCACGAGGATATCGACGCGC
TGCTGCTCAGCGAGGAGATTCGCGCCCTGGATGTCGTCATCGGTGGCATTCTGGTGGTGCGGGCGGCGCAGCGGCACGGC
GTGAGCGCGCGGCTGCTGACCGCCGACGACGACGCCATTTACCGGGCGCTGCATCAGGCGATGCTGCTGGCGCACGCGGA
AGATGAGAGCCGCAGGAAGGCCGCGCAGCTGGATACCATGCTGGCGACCATCGCCGAGGCACTGATCGTCACCGATGCGC
AGGATCGCATCATCCAGGTCAATCCGGCGGCGCTGACCATCCTGCGGCGCGAGCTGTCGGCGGTGATCGGCCGCGAGATC
CGCACGCTGATCCCGGATTCGCGCACCCGGGATGTGCTGAAGAGTCAGCGCAGCCAGCTGGGACAGGTGGTGGAGGTTAA
CGGCGATACCTTTATCGTTAACCGGGTACCCATCGTCAGCCAGGGACGCAGCCTCGGGGTGGTCTGCACCCTGTCGGCCT
CGCGCCTGATCCGCCACGCCGAGCACCGCCTGCGCCAGCAGGAGGGGCGGCGGCAGGGGTTCGTCGCGCGCTATGACTTT
GACGATATCCATACCGCCGACCCAAAGATGCAGGATATCAAAACGCTGGCGCGCCACTATGCTGCGACGCAGGCCAACGT
CTTAATCCAGGGGGAGTCGGGCACGGGCAAAGAGCTGTTTGCCCAGAGCCTGCACCGCAGCAGCGCGCGGCGCAGCCAGC
CCTTCGTGGCGATTAACTGCGCGGCGATCCCGGAGAACCTGCTGGAGAGCGAGCTGTTCGGCTATGTGGACGGCGCTTTC
ACCGGCGCCAATCGCAGGGGTAAGGCCGGGCTGTTCGAGCTGGCGCACGGCGGCACCCTGTTTCTGGACGAGATCGGCGA
GCTGCCGCTGAGTATGCAGACCAAGCTGCTGCGCGCCCTGCAGGAAAAGGAGATCATGCGCATCGGCGGCAGCGGGGTAC
TGCCGGTCGACGTGCGCATCATCACCGCCACCAACCAGGATCTGCGACGCCGGATCGACGAGCGGCTGTTCCGCGGCGAT
CTGTATTACCGGCTGAATACGCTGCACATCCTGCTGCCGCCGCTGCGTAGCCGCGACGACGATATCCGCCTGCTGGGGCG
CCACTTTCTGCAAACCCTCGGGTGCTGCCTCGACGGGGAGCAGGAAGCGGTGCTGCTGGCGGCGCTGTGCCGCCACCCGT
TTCACGGCAACGTCCGCGAGCTACGGGCCATCATCGAGCGCTTCGCCATCCTCTACCGGGTGTTCCCCGCCCTGACGCCG
ACCCAGATCCTGCAGCGCTATTGCCAGCCAGACGAGGCCGTCAGCGAGGCGGGCGGGCGCGGCGTCCTGACCTGCCGCAT
CCCGCTGCTGGACGACTTCAAACTCATGACCGGCCATTGCCAACGCCAAATCGTACAATATTATCTGGCGCGCAATCAGC
AGAATCAGCAGAAGGCGGCGCGCCAATTGAATATCAGCAAAATGAGTATCTACCGTCATATTCACGGCCAATCCCCGGAG
GCGGATCGCCACGACGCGTCCGAGCCATAA

Upstream 100 bases:

>100_bases
CGACGGGAAGTAGCGCCTCACGCCGGGCTGAGCCACGGGGGCCGCTCACGCGGCCCCTCTGCTGGCGGGCTCACCCGGTA
CCGTTGACCAAGGAGTTTCC

Downstream 100 bases:

>100_bases
CAAAGTTGTGACGCGCTACGCCGCGCCTGTTACCCCGGGGAGAATAAAGTGTGACCGGGGCGACAGCAGTGCGGCACATC
ACCTGGATACATATGATTCA

Product: propionate catabolism operon regulatory protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 649; Mature: 648

Protein sequence:

>649_residues
MSAEFHFAFIAPYPQLATLARQQAAALGCRLTVIDGAFDTVARQVARLPDDISAVISRGGTAEKIRLYTLKPVVSIETSA
LDLLTLLLPLRGEVARVGVISYRQPLPGVAPIAQALAMEIRQEVFHGHEDIDALLLSEEIRALDVVIGGILVVRAAQRHG
VSARLLTADDDAIYRALHQAMLLAHAEDESRRKAAQLDTMLATIAEALIVTDAQDRIIQVNPAALTILRRELSAVIGREI
RTLIPDSRTRDVLKSQRSQLGQVVEVNGDTFIVNRVPIVSQGRSLGVVCTLSASRLIRHAEHRLRQQEGRRQGFVARYDF
DDIHTADPKMQDIKTLARHYAATQANVLIQGESGTGKELFAQSLHRSSARRSQPFVAINCAAIPENLLESELFGYVDGAF
TGANRRGKAGLFELAHGGTLFLDEIGELPLSMQTKLLRALQEKEIMRIGGSGVLPVDVRIITATNQDLRRRIDERLFRGD
LYYRLNTLHILLPPLRSRDDDIRLLGRHFLQTLGCCLDGEQEAVLLAALCRHPFHGNVRELRAIIERFAILYRVFPALTP
TQILQRYCQPDEAVSEAGGRGVLTCRIPLLDDFKLMTGHCQRQIVQYYLARNQQNQQKAARQLNISKMSIYRHIHGQSPE
ADRHDASEP

Sequences:

>Translated_649_residues
MSAEFHFAFIAPYPQLATLARQQAAALGCRLTVIDGAFDTVARQVARLPDDISAVISRGGTAEKIRLYTLKPVVSIETSA
LDLLTLLLPLRGEVARVGVISYRQPLPGVAPIAQALAMEIRQEVFHGHEDIDALLLSEEIRALDVVIGGILVVRAAQRHG
VSARLLTADDDAIYRALHQAMLLAHAEDESRRKAAQLDTMLATIAEALIVTDAQDRIIQVNPAALTILRRELSAVIGREI
RTLIPDSRTRDVLKSQRSQLGQVVEVNGDTFIVNRVPIVSQGRSLGVVCTLSASRLIRHAEHRLRQQEGRRQGFVARYDF
DDIHTADPKMQDIKTLARHYAATQANVLIQGESGTGKELFAQSLHRSSARRSQPFVAINCAAIPENLLESELFGYVDGAF
TGANRRGKAGLFELAHGGTLFLDEIGELPLSMQTKLLRALQEKEIMRIGGSGVLPVDVRIITATNQDLRRRIDERLFRGD
LYYRLNTLHILLPPLRSRDDDIRLLGRHFLQTLGCCLDGEQEAVLLAALCRHPFHGNVRELRAIIERFAILYRVFPALTP
TQILQRYCQPDEAVSEAGGRGVLTCRIPLLDDFKLMTGHCQRQIVQYYLARNQQNQQKAARQLNISKMSIYRHIHGQSPE
ADRHDASEP
>Mature_648_residues
SAEFHFAFIAPYPQLATLARQQAAALGCRLTVIDGAFDTVARQVARLPDDISAVISRGGTAEKIRLYTLKPVVSIETSAL
DLLTLLLPLRGEVARVGVISYRQPLPGVAPIAQALAMEIRQEVFHGHEDIDALLLSEEIRALDVVIGGILVVRAAQRHGV
SARLLTADDDAIYRALHQAMLLAHAEDESRRKAAQLDTMLATIAEALIVTDAQDRIIQVNPAALTILRRELSAVIGREIR
TLIPDSRTRDVLKSQRSQLGQVVEVNGDTFIVNRVPIVSQGRSLGVVCTLSASRLIRHAEHRLRQQEGRRQGFVARYDFD
DIHTADPKMQDIKTLARHYAATQANVLIQGESGTGKELFAQSLHRSSARRSQPFVAINCAAIPENLLESELFGYVDGAFT
GANRRGKAGLFELAHGGTLFLDEIGELPLSMQTKLLRALQEKEIMRIGGSGVLPVDVRIITATNQDLRRRIDERLFRGDL
YYRLNTLHILLPPLRSRDDDIRLLGRHFLQTLGCCLDGEQEAVLLAALCRHPFHGNVRELRAIIERFAILYRVFPALTPT
QILQRYCQPDEAVSEAGGRGVLTCRIPLLDDFKLMTGHCQRQIVQYYLARNQQNQQKAARQLNISKMSIYRHIHGQSPEA
DRHDASEP

Specific function: Involved in the transcriptional regulation of the propionate catabolism operon [H]

COG id: COG3829

COG function: function code KT; Transcriptional regulator containing PAS, AAA-type ATPase, and DNA-binding domains

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 sigma-54 factor interaction domain [H]

Homologues:

Organism=Escherichia coli, GI1788550, Length=324, Percent_Identity=43.2098765432099, Blast_Score=242, Evalue=5e-65,
Organism=Escherichia coli, GI1786524, Length=286, Percent_Identity=46.1538461538462, Blast_Score=240, Evalue=2e-64,
Organism=Escherichia coli, GI1789233, Length=465, Percent_Identity=36.1290322580645, Blast_Score=233, Evalue=2e-62,
Organism=Escherichia coli, GI87082117, Length=253, Percent_Identity=48.6166007905138, Blast_Score=226, Evalue=4e-60,
Organism=Escherichia coli, GI1790299, Length=331, Percent_Identity=40.4833836858006, Blast_Score=214, Evalue=2e-56,
Organism=Escherichia coli, GI1790437, Length=311, Percent_Identity=40.5144694533762, Blast_Score=207, Evalue=1e-54,
Organism=Escherichia coli, GI87082152, Length=315, Percent_Identity=40.9523809523809, Blast_Score=206, Evalue=4e-54,
Organism=Escherichia coli, GI1789087, Length=239, Percent_Identity=46.0251046025105, Blast_Score=198, Evalue=8e-52,
Organism=Escherichia coli, GI1788905, Length=228, Percent_Identity=46.9298245614035, Blast_Score=194, Evalue=1e-50,
Organism=Escherichia coli, GI1787583, Length=437, Percent_Identity=33.1807780320366, Blast_Score=179, Evalue=4e-46,
Organism=Escherichia coli, GI87081872, Length=299, Percent_Identity=39.1304347826087, Blast_Score=177, Evalue=1e-45,
Organism=Escherichia coli, GI87081858, Length=398, Percent_Identity=28.643216080402, Blast_Score=138, Evalue=1e-33,
Organism=Escherichia coli, GI1789828, Length=242, Percent_Identity=35.9504132231405, Blast_Score=121, Evalue=1e-28,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003593
- InterPro:   IPR009057
- InterPro:   IPR002197
- InterPro:   IPR002078
- InterPro:   IPR012704
- InterPro:   IPR010524 [H]

Pfam domain/function: PF02954 HTH_8; PF06506 PrpR_N; PF00158 Sigma54_activat [H]

EC number: NA

Molecular weight: Translated: 72198; Mature: 72067

Theoretical pI: Translated: 8.48; Mature: 8.48

Prosite motif: PS50112 PAS ; PS00675 SIGMA54_INTERACT_1 ; PS00676 SIGMA54_INTERACT_2 ; PS50045 SIGMA54_INTERACT_4

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
1.4 %Met     (Translated Protein)
2.8 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
1.2 %Met     (Mature Protein)
2.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSAEFHFAFIAPYPQLATLARQQAAALGCRLTVIDGAFDTVARQVARLPDDISAVISRGG
CCCCEEEEEECCCHHHHHHHHHHHHHHCCEEEEECCHHHHHHHHHHHCCHHHHHHHHCCC
TAEKIRLYTLKPVVSIETSALDLLTLLLPLRGEVARVGVISYRQPLPGVAPIAQALAMEI
CCCEEEEEEECCEEEECHHHHHHHHHHHHCCCCHHHEEEHHCCCCCCCHHHHHHHHHHHH
RQEVFHGHEDIDALLLSEEIRALDVVIGGILVVRAAQRHGVSARLLTADDDAIYRALHQA
HHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEEECCHHHHHHHHHHH
MLLAHAEDESRRKAAQLDTMLATIAEALIVTDAQDRIIQVNPAALTILRRELSAVIGREI
HHHHHCCCHHHHHHHHHHHHHHHHHHHHHEECCCCCEEEECHHHHHHHHHHHHHHHHHHH
RTLIPDSRTRDVLKSQRSQLGQVVEVNGDTFIVNRVPIVSQGRSLGVVCTLSASRLIRHA
HHHCCCCHHHHHHHHHHHHCCCEEEECCCEEEEECCCCEECCCCEEEEEECCHHHHHHHH
EHRLRQQEGRRQGFVARYDFDDIHTADPKMQDIKTLARHYAATQANVLIQGESGTGKELF
HHHHHHHCCHHCCCEEEECCCCCCCCCCCHHHHHHHHHHHHHCCCCEEEECCCCCCHHHH
AQSLHRSSARRSQPFVAINCAAIPENLLESELFGYVDGAFTGANRRGKAGLFELAHGGTL
HHHHHHHHHHCCCCEEEEEEHHCCHHHHHHHHHHHHCCCCCCCCCCCCCCHHEECCCCEE
FLDEIGELPLSMQTKLLRALQEKEIMRIGGSGVLPVDVRIITATNQDLRRRIDERLFRGD
EHHHHCCCCHHHHHHHHHHHHHHHHHHCCCCCCEEEEEEEEEECCHHHHHHHHHHHHHCC
LYYRLNTLHILLPPLRSRDDDIRLLGRHFLQTLGCCLDGEQEAVLLAALCRHPFHGNVRE
CEEEEEEEEEEECCCCCCCHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHCCCCCCCHHH
LRAIIERFAILYRVFPALTPTQILQRYCQPDEAVSEAGGRGVLTCRIPLLDDFKLMTGHC
HHHHHHHHHHHHHHHHCCCHHHHHHHHCCCCHHHHHCCCCEEEEEECCCCCCHHHHHHHH
QRQIVQYYLARNQQNQQKAARQLNISKMSIYRHIHGQSPEADRHDASEP
HHHHHHHHHHHCCCHHHHHHHHHCHHHHHHHHHHCCCCCCCCCCCCCCC
>Mature Secondary Structure 
SAEFHFAFIAPYPQLATLARQQAAALGCRLTVIDGAFDTVARQVARLPDDISAVISRGG
CCCEEEEEECCCHHHHHHHHHHHHHHCCEEEEECCHHHHHHHHHHHCCHHHHHHHHCCC
TAEKIRLYTLKPVVSIETSALDLLTLLLPLRGEVARVGVISYRQPLPGVAPIAQALAMEI
CCCEEEEEEECCEEEECHHHHHHHHHHHHCCCCHHHEEEHHCCCCCCCHHHHHHHHHHHH
RQEVFHGHEDIDALLLSEEIRALDVVIGGILVVRAAQRHGVSARLLTADDDAIYRALHQA
HHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEEECCHHHHHHHHHHH
MLLAHAEDESRRKAAQLDTMLATIAEALIVTDAQDRIIQVNPAALTILRRELSAVIGREI
HHHHHCCCHHHHHHHHHHHHHHHHHHHHHEECCCCCEEEECHHHHHHHHHHHHHHHHHHH
RTLIPDSRTRDVLKSQRSQLGQVVEVNGDTFIVNRVPIVSQGRSLGVVCTLSASRLIRHA
HHHCCCCHHHHHHHHHHHHCCCEEEECCCEEEEECCCCEECCCCEEEEEECCHHHHHHHH
EHRLRQQEGRRQGFVARYDFDDIHTADPKMQDIKTLARHYAATQANVLIQGESGTGKELF
HHHHHHHCCHHCCCEEEECCCCCCCCCCCHHHHHHHHHHHHHCCCCEEEECCCCCCHHHH
AQSLHRSSARRSQPFVAINCAAIPENLLESELFGYVDGAFTGANRRGKAGLFELAHGGTL
HHHHHHHHHHCCCCEEEEEEHHCCHHHHHHHHHHHHCCCCCCCCCCCCCCHHEECCCCEE
FLDEIGELPLSMQTKLLRALQEKEIMRIGGSGVLPVDVRIITATNQDLRRRIDERLFRGD
EHHHHCCCCHHHHHHHHHHHHHHHHHHCCCCCCEEEEEEEEEECCHHHHHHHHHHHHHCC
LYYRLNTLHILLPPLRSRDDDIRLLGRHFLQTLGCCLDGEQEAVLLAALCRHPFHGNVRE
CEEEEEEEEEEECCCCCCCHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHCCCCCCCHHH
LRAIIERFAILYRVFPALTPTQILQRYCQPDEAVSEAGGRGVLTCRIPLLDDFKLMTGHC
HHHHHHHHHHHHHHHHCCCHHHHHHHHCCCCHHHHHCCCCEEEEEECCCCCCHHHHHHHH
QRQIVQYYLARNQQNQQKAARQLNISKMSIYRHIHGQSPEADRHDASEP
HHHHHHHHHHHCCCHHHHHHHHHCHHHHHHHHHHCCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9006051; 11677609 [H]