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The map label for this gene is grxD [H]

Identifier: 238920001

GI number: 238920001

Start: 2026694

End: 2027038

Strand: Reverse

Name: grxD [H]

Synonym: NT01EI_2105

Alternate gene names: 238920001

Gene position: 2027038-2026694 (Counterclockwise)

Preceding gene: 238920003

Following gene: 238919997

Centisome position: 53.17

GC content: 59.13

Gene sequence:

>345_bases
ATGACCACTATTGAAAAGATTCAGCGCCAGATCGCCGAGAACCCGATTATCCTGTACATGAAAGGCTCACCGAAGCTGCC
GAGCTGCGGCTTTTCAGCGCAGGCGGTACAGGCGCTGTCTGCCTGCGGCGAGCGCTTTGCCTACGTGGATATTCTGCAGA
ACCCGGACATCCGCGCCGAGTTGCCGAAGTTTGCTGACTGGCCAACCTTTCCGCAGCTGTGGGTAGAGGGTGAGCTGATC
GGTGGGTGTGACATCATACTGGAGATGTATCAGCGCGGCGAGCTGCAGACGCTGATCAAAGAGGCTGCGGCCCGTCACGG
CTCAGCAGCGCAGGACAACGGCTGA

Upstream 100 bases:

>100_bases
CATCTGTGCCTCATCCCTTGTCTGCAAAGGTCGGCGCAGGCAATAATGATAATATACTGCGTTACCGCTATAACACTGGA
TATTTAAGGAAGTAGAGACC

Downstream 100 bases:

>100_bases
CAGCGCGGCACCAGGCCATGTAAAAAGGCGCCGAAGGGCGCCTTTTGTGTATCGGCAGGGGCCGTTTGCTAGAGGATCAT
CGCTGCCGCCCAGCCGAAGC

Product: hypothetical protein

Products: NA

Alternate protein names: Grx4; Monothiol glutaredoxin [H]

Number of amino acids: Translated: 114; Mature: 113

Protein sequence:

>114_residues
MTTIEKIQRQIAENPIILYMKGSPKLPSCGFSAQAVQALSACGERFAYVDILQNPDIRAELPKFADWPTFPQLWVEGELI
GGCDIILEMYQRGELQTLIKEAAARHGSAAQDNG

Sequences:

>Translated_114_residues
MTTIEKIQRQIAENPIILYMKGSPKLPSCGFSAQAVQALSACGERFAYVDILQNPDIRAELPKFADWPTFPQLWVEGELI
GGCDIILEMYQRGELQTLIKEAAARHGSAAQDNG
>Mature_113_residues
TTIEKIQRQIAENPIILYMKGSPKLPSCGFSAQAVQALSACGERFAYVDILQNPDIRAELPKFADWPTFPQLWVEGELIG
GCDIILEMYQRGELQTLIKEAAARHGSAAQDNG

Specific function: Monothiol glutaredoxin involved in the biogenesis of iron-sulfur clusters [H]

COG id: COG0278

COG function: function code O; Glutaredoxin-related protein

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 glutaredoxin domain [H]

Homologues:

Organism=Homo sapiens, GI42516576, Length=98, Percent_Identity=36.734693877551, Blast_Score=92, Evalue=8e-20,
Organism=Homo sapiens, GI95113651, Length=97, Percent_Identity=41.2371134020619, Blast_Score=88, Evalue=1e-18,
Organism=Escherichia coli, GI1787943, Length=111, Percent_Identity=85.5855855855856, Blast_Score=206, Evalue=3e-55,
Organism=Caenorhabditis elegans, GI17556042, Length=107, Percent_Identity=29.9065420560748, Blast_Score=84, Evalue=2e-17,
Organism=Caenorhabditis elegans, GI71988153, Length=84, Percent_Identity=36.9047619047619, Blast_Score=80, Evalue=1e-16,
Organism=Caenorhabditis elegans, GI71988159, Length=98, Percent_Identity=34.6938775510204, Blast_Score=77, Evalue=1e-15,
Organism=Saccharomyces cerevisiae, GI6325198, Length=107, Percent_Identity=42.9906542056075, Blast_Score=97, Evalue=8e-22,
Organism=Saccharomyces cerevisiae, GI6321022, Length=74, Percent_Identity=54.0540540540541, Blast_Score=93, Evalue=1e-20,
Organism=Saccharomyces cerevisiae, GI6320303, Length=83, Percent_Identity=46.9879518072289, Blast_Score=91, Evalue=4e-20,
Organism=Drosophila melanogaster, GI24642023, Length=101, Percent_Identity=40.5940594059406, Blast_Score=98, Evalue=8e-22,
Organism=Drosophila melanogaster, GI19921242, Length=96, Percent_Identity=38.5416666666667, Blast_Score=86, Evalue=5e-18,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002109
- InterPro:   IPR014434
- InterPro:   IPR004480
- InterPro:   IPR012336
- InterPro:   IPR012335 [H]

Pfam domain/function: PF00462 Glutaredoxin [H]

EC number: NA

Molecular weight: Translated: 12595; Mature: 12463

Theoretical pI: Translated: 4.61; Mature: 4.61

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.6 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
5.3 %Cys+Met (Translated Protein)
2.7 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
4.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTTIEKIQRQIAENPIILYMKGSPKLPSCGFSAQAVQALSACGERFAYVDILQNPDIRAE
CCHHHHHHHHHCCCCEEEEECCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCC
LPKFADWPTFPQLWVEGELIGGCDIILEMYQRGELQTLIKEAAARHGSAAQDNG
CCCCCCCCCCCHHEECCCCCCHHHHHHHHHHCCHHHHHHHHHHHHCCCCCCCCC
>Mature Secondary Structure 
TTIEKIQRQIAENPIILYMKGSPKLPSCGFSAQAVQALSACGERFAYVDILQNPDIRAE
CHHHHHHHHHCCCCEEEEECCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCC
LPKFADWPTFPQLWVEGELIGGCDIILEMYQRGELQTLIKEAAARHGSAAQDNG
CCCCCCCCCCCHHEECCCCCCHHHHHHHHHHCCHHHHHHHHHHHHCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]