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The map label for this gene is thrS

Identifier: 238919782

GI number: 238919782

Start: 1815689

End: 1817617

Strand: Direct

Name: thrS

Synonym: NT01EI_1886

Alternate gene names: 238919782

Gene position: 1815689-1817617 (Clockwise)

Preceding gene: 238919781

Following gene: 238919783

Centisome position: 47.63

GC content: 55.42

Gene sequence:

>1929_bases
ATGCCTGTTATTACGCTTCCTGACGGCAGTCAGCGTCATTTCGACCATCCCGTATCTGTCATGGACATCGCCCGCGATAT
CGGCCCGGGTCTGGCAAAAGCCTGTATCGCCGGTCGCGTCAACGGTGAGCTGGTCGACGCCTGCGATTTAATCGATGCCG
ACGCAACGGTCGCCATCATTACCGCCAAGGATCAGGAAGGGGTAGACATTCTGCGTCACTCCTGTGCCCATCTGCTGGGG
CATGCCATCAAGCAGCTGTGGCCACAAACCAAAATGGCCATCGGCCCGGTAATCGACAACGGCTTCTACTATGATGTCGA
TTTGGATCACACGCTGACCCAGGAAGATCTCGAGCGCCTGGATAAGCGTATGCATGAGCTGGCGGAAAAAGACTACGACG
TCATCAAGAAAAAAGTCAGCTGGCAAGAGGCACGTGACGCTTTTGTCGCGCGCGATGAGCTGTACAAAGTGGCGATCCTC
GACGAGAACATCAGTCACGACGATCGCCCCGGCCTGTACCATCATGAAGAGTATCTCGACATGTGTCGTGGTCCGCACGT
GCCGAATATGCGCTTCTGTCACCACTTCAAGCTGCAGAAGTCTTCCGGCGCCTACTGGCGCGGCGACAGCGATAATAAGA
TGCTGCAGCGCATCTATGGTACCGCTTGGGCAGACAAGAAGCAGCTGAACGCCTATCTGCAGCGTCTGGAAGAGGCGGCC
AAGCGTGACCATCGCAAGATCGGTAAACAGCTCGACCTGTACCATATGCAGGAAGAAGCGCCGGGCATGGTGTTCTGGCA
CAATGACGGCTGGACTATCTTCCGCGAGCTGGAAGCGTTTGTTCGCATGAAGCTGAAAGAGTACCAGTACCAGGAGGTGA
AGGGTCCGTTTATGATGGACCGCGTGCTGTGGGAGAAAACCGGCCACTGGGAAAACTACAAGGATGCCATGTTCACCACC
TCATCAGAGAACCGTGAATACTGCATCAAGCCGATGAACTGCCCGGGCCACGTGCAGATCTTCAACCAGGGGCTGAAGTC
CTACCGCGATCTGCCGCTGCGCATGGCCGAGTTTGGCAGCTGCCACCGCAACGAGCCGTCGGGCTCCCTGCACGGCCTGA
TGCGCGTCCGTGGCTTTACCCAGGACGATGCGCACATTTTCTGTACCGAAGAGCAGATCCGCGACGAGGTCAACAGCTGC
ATTAAGATGGTGTACGACATGTACAGCACCTTCGGCTTTGAAAAAATCGTGGTGAAGCTGTCTACCCGTCCGGAGAAGCG
TATCGGCAGCGATGAAATCTGGGATCGCGCGGAAGAGGACCTGGCCGCAGCGCTGCAGGAGAACGGGATTCCGTTTGAAT
ATCAGCCGGGTGAGGGCGCCTTCTACGGACCGAAGATCGAGTTTACCCTGCATGATTGCTTGGATCGCGCTTGGCAGTGT
GGTACCGTGCAGCTCGACTTCTCTCTTCCGGGTCGTCTGAGCGCCTCTTACGTTGGCGAAAACAACGAACGTGTGGTGCC
GGTGATGATCCACCGGGCCATCCTGGGGTCCATGGAGCGTTTTATCGGCATTCTGACCGAAGAGTTTGCCGGCTTCTTCC
CAACGTGGCTGGCGCCGGTACAGGCCGTAGTGATGAATATCACCGATTCTCAGGCTGAATATGTCGAAGAATTGAGCAAA
AAACTGCAGGCCGCCGGTATTCGCGTAAAATCAGACTTGAGAAACGAGAAGATTGGCTTTAAAATTCGCGAACATACTTT
ACGTCGCGTCCCCTATATGCTGGTTTGCGGTGACAAAGAAGTCGAAGCCGGCAAAGTGGCAGTGCGTACACGCCGTGGTA
AAGACCTGGGCGTAATGAGCATTGACGACGTAATCAAGAAGCTGCAGCAAGAGATTCGCAGCCGTAGTCTTCATCAGTTG
GAGGAATAA

Upstream 100 bases:

>100_bases
TAAGTAGAGCAGGAACGCACCGGCAATCCCTGAAACTCAACAAAACTTTTTTCTATATGTGACCTGTCGTGTGGGTCACC
ACTGTAGATAAGGAATTCAA

Downstream 100 bases:

>100_bases
GGTATTAAAGGCGGAAAACGAGTTCAAACGGCGCGTCCTAATCGTATTAACGGGGAAATTCGCGCCCAAGAGGTTCGCTT
GACAGGTGTGGATGGCGAGC

Product: threonyl-tRNA synthetase

Products: NA

Alternate protein names: Threonine--tRNA ligase; ThrRS

Number of amino acids: Translated: 642; Mature: 641

Protein sequence:

>642_residues
MPVITLPDGSQRHFDHPVSVMDIARDIGPGLAKACIAGRVNGELVDACDLIDADATVAIITAKDQEGVDILRHSCAHLLG
HAIKQLWPQTKMAIGPVIDNGFYYDVDLDHTLTQEDLERLDKRMHELAEKDYDVIKKKVSWQEARDAFVARDELYKVAIL
DENISHDDRPGLYHHEEYLDMCRGPHVPNMRFCHHFKLQKSSGAYWRGDSDNKMLQRIYGTAWADKKQLNAYLQRLEEAA
KRDHRKIGKQLDLYHMQEEAPGMVFWHNDGWTIFRELEAFVRMKLKEYQYQEVKGPFMMDRVLWEKTGHWENYKDAMFTT
SSENREYCIKPMNCPGHVQIFNQGLKSYRDLPLRMAEFGSCHRNEPSGSLHGLMRVRGFTQDDAHIFCTEEQIRDEVNSC
IKMVYDMYSTFGFEKIVVKLSTRPEKRIGSDEIWDRAEEDLAAALQENGIPFEYQPGEGAFYGPKIEFTLHDCLDRAWQC
GTVQLDFSLPGRLSASYVGENNERVVPVMIHRAILGSMERFIGILTEEFAGFFPTWLAPVQAVVMNITDSQAEYVEELSK
KLQAAGIRVKSDLRNEKIGFKIREHTLRRVPYMLVCGDKEVEAGKVAVRTRRGKDLGVMSIDDVIKKLQQEIRSRSLHQL
EE

Sequences:

>Translated_642_residues
MPVITLPDGSQRHFDHPVSVMDIARDIGPGLAKACIAGRVNGELVDACDLIDADATVAIITAKDQEGVDILRHSCAHLLG
HAIKQLWPQTKMAIGPVIDNGFYYDVDLDHTLTQEDLERLDKRMHELAEKDYDVIKKKVSWQEARDAFVARDELYKVAIL
DENISHDDRPGLYHHEEYLDMCRGPHVPNMRFCHHFKLQKSSGAYWRGDSDNKMLQRIYGTAWADKKQLNAYLQRLEEAA
KRDHRKIGKQLDLYHMQEEAPGMVFWHNDGWTIFRELEAFVRMKLKEYQYQEVKGPFMMDRVLWEKTGHWENYKDAMFTT
SSENREYCIKPMNCPGHVQIFNQGLKSYRDLPLRMAEFGSCHRNEPSGSLHGLMRVRGFTQDDAHIFCTEEQIRDEVNSC
IKMVYDMYSTFGFEKIVVKLSTRPEKRIGSDEIWDRAEEDLAAALQENGIPFEYQPGEGAFYGPKIEFTLHDCLDRAWQC
GTVQLDFSLPGRLSASYVGENNERVVPVMIHRAILGSMERFIGILTEEFAGFFPTWLAPVQAVVMNITDSQAEYVEELSK
KLQAAGIRVKSDLRNEKIGFKIREHTLRRVPYMLVCGDKEVEAGKVAVRTRRGKDLGVMSIDDVIKKLQQEIRSRSLHQL
EE
>Mature_641_residues
PVITLPDGSQRHFDHPVSVMDIARDIGPGLAKACIAGRVNGELVDACDLIDADATVAIITAKDQEGVDILRHSCAHLLGH
AIKQLWPQTKMAIGPVIDNGFYYDVDLDHTLTQEDLERLDKRMHELAEKDYDVIKKKVSWQEARDAFVARDELYKVAILD
ENISHDDRPGLYHHEEYLDMCRGPHVPNMRFCHHFKLQKSSGAYWRGDSDNKMLQRIYGTAWADKKQLNAYLQRLEEAAK
RDHRKIGKQLDLYHMQEEAPGMVFWHNDGWTIFRELEAFVRMKLKEYQYQEVKGPFMMDRVLWEKTGHWENYKDAMFTTS
SENREYCIKPMNCPGHVQIFNQGLKSYRDLPLRMAEFGSCHRNEPSGSLHGLMRVRGFTQDDAHIFCTEEQIRDEVNSCI
KMVYDMYSTFGFEKIVVKLSTRPEKRIGSDEIWDRAEEDLAAALQENGIPFEYQPGEGAFYGPKIEFTLHDCLDRAWQCG
TVQLDFSLPGRLSASYVGENNERVVPVMIHRAILGSMERFIGILTEEFAGFFPTWLAPVQAVVMNITDSQAEYVEELSKK
LQAAGIRVKSDLRNEKIGFKIREHTLRRVPYMLVCGDKEVEAGKVAVRTRRGKDLGVMSIDDVIKKLQQEIRSRSLHQLE
E

Specific function: Thrs Is Also A Translational Repressor Protein, It Controls The Translation Of Its Own Gene By Binding To Its mRNA. [C]

COG id: COG0441

COG function: function code J; Threonyl-tRNA synthetase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-II aminoacyl-tRNA synthetase family

Homologues:

Organism=Homo sapiens, GI38202255, Length=648, Percent_Identity=38.4259259259259, Blast_Score=445, Evalue=1e-125,
Organism=Homo sapiens, GI38570111, Length=622, Percent_Identity=37.620578778135, Blast_Score=437, Evalue=1e-122,
Organism=Homo sapiens, GI20070344, Length=628, Percent_Identity=35.9872611464968, Blast_Score=387, Evalue=1e-107,
Organism=Escherichia coli, GI1788013, Length=642, Percent_Identity=89.0965732087227, Blast_Score=1221, Evalue=0.0,
Organism=Caenorhabditis elegans, GI71984192, Length=631, Percent_Identity=38.0348652931854, Blast_Score=455, Evalue=1e-128,
Organism=Caenorhabditis elegans, GI71984184, Length=631, Percent_Identity=38.0348652931854, Blast_Score=455, Evalue=1e-128,
Organism=Saccharomyces cerevisiae, GI6322112, Length=658, Percent_Identity=37.3860182370821, Blast_Score=430, Evalue=1e-121,
Organism=Saccharomyces cerevisiae, GI6322654, Length=398, Percent_Identity=38.1909547738693, Blast_Score=299, Evalue=1e-81,
Organism=Drosophila melanogaster, GI24583842, Length=630, Percent_Identity=39.8412698412698, Blast_Score=486, Evalue=1e-137,
Organism=Drosophila melanogaster, GI28574141, Length=630, Percent_Identity=39.8412698412698, Blast_Score=486, Evalue=1e-137,
Organism=Drosophila melanogaster, GI24583839, Length=630, Percent_Identity=39.8412698412698, Blast_Score=486, Evalue=1e-137,

Paralogues:

None

Copy number: 700 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): SYT_EDWI9 (C5B846)

Other databases:

- EMBL:   CP001600
- RefSeq:   YP_002933297.1
- ProteinModelPortal:   C5B846
- GeneID:   7961197
- GenomeReviews:   CP001600_GR
- KEGG:   eic:NT01EI_1886
- OMA:   TAKDPEC
- ProtClustDB:   PRK00413
- GO:   GO:0005737
- HAMAP:   MF_00184_B
- InterPro:   IPR002314
- InterPro:   IPR006195
- InterPro:   IPR004154
- InterPro:   IPR012675
- InterPro:   IPR004095
- InterPro:   IPR012676
- InterPro:   IPR002320
- InterPro:   IPR018163
- InterPro:   IPR012947
- Gene3D:   G3DSA:3.40.50.800
- Gene3D:   G3DSA:3.10.20.30
- PRINTS:   PR01047
- SMART:   SM00863
- TIGRFAMs:   TIGR00418

Pfam domain/function: PF03129 HGTP_anticodon; PF02824 TGS; PF00587 tRNA-synt_2b; PF07973 tRNA_SAD; SSF52954 Anticodon_bd; SSF81271 TGS-like; SSF55186 Thr/Ala-tRNA-synth_IIc_edit

EC number: =6.1.1.3

Molecular weight: Translated: 73940; Mature: 73809

Theoretical pI: Translated: 6.22; Mature: 6.22

Prosite motif: PS50862 AA_TRNA_LIGASE_II

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.0 %Cys     (Translated Protein)
3.6 %Met     (Translated Protein)
5.6 %Cys+Met (Translated Protein)
2.0 %Cys     (Mature Protein)
3.4 %Met     (Mature Protein)
5.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPVITLPDGSQRHFDHPVSVMDIARDIGPGLAKACIAGRVNGELVDACDLIDADATVAII
CCEEECCCCCCCCCCCCHHHHHHHHHHCHHHHHHHHHCCCCCCHHHHHHHCCCCCEEEEE
TAKDQEGVDILRHSCAHLLGHAIKQLWPQTKMAIGPVIDNGFYYDVDLDHTLTQEDLERL
EECCCCCHHHHHHHHHHHHHHHHHHHCCHHHHHHCCEECCCEEEEECCCCCCCHHHHHHH
DKRMHELAEKDYDVIKKKVSWQEARDAFVARDELYKVAILDENISHDDRPGLYHHEEYLD
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEEEEEECCCCCCCCCCCCCCHHHHH
MCRGPHVPNMRFCHHFKLQKSSGAYWRGDSDNKMLQRIYGTAWADKKQLNAYLQRLEEAA
HHCCCCCCCCHHHHEEEEECCCCCEECCCCHHHHHHHHHHHHCCCHHHHHHHHHHHHHHH
KRDHRKIGKQLDLYHMQEEAPGMVFWHNDGWTIFRELEAFVRMKLKEYQYQEVKGPFMMD
HHHHHHHCCHHHHHHHHCCCCCEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHCCCHHHH
RVLWEKTGHWENYKDAMFTTSSENREYCIKPMNCPGHVQIFNQGLKSYRDLPLRMAEFGS
HHHHHHCCCCCCCCCCEEECCCCCCCEEEECCCCCCHHHHHHHHHHHHHCCCHHHHHHCC
CHRNEPSGSLHGLMRVRGFTQDDAHIFCTEEQIRDEVNSCIKMVYDMYSTFGFEKIVVKL
CCCCCCCHHHHHHHHHCCCCCCCCEEEECHHHHHHHHHHHHHHHHHHHHHCCHHHEEEEE
STRPEKRIGSDEIWDRAEEDLAAALQENGIPFEYQPGEGAFYGPKIEFTLHDCLDRAWQC
CCCCCCCCCCHHHHHHHHHHHHHHHHHCCCCEEEECCCCCEECCEEEEEHHHHHHHHHCC
GTVQLDFSLPGRLSASYVGENNERVVPVMIHRAILGSMERFIGILTEEFAGFFPTWLAPV
CEEEEECCCCCCCCHHCCCCCCCEEHHHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHH
QAVVMNITDSQAEYVEELSKKLQAAGIRVKSDLRNEKIGFKIREHTLRRVPYMLVCGDKE
HHHHHHCCCHHHHHHHHHHHHHHHCCCHHHHHHCCCCCCCCHHHHHHHHCCEEEEECCCC
VEAGKVAVRTRRGKDLGVMSIDDVIKKLQQEIRSRSLHQLEE
CCCCCEEEEECCCCCCCCCCHHHHHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure 
PVITLPDGSQRHFDHPVSVMDIARDIGPGLAKACIAGRVNGELVDACDLIDADATVAII
CEEECCCCCCCCCCCCHHHHHHHHHHCHHHHHHHHHCCCCCCHHHHHHHCCCCCEEEEE
TAKDQEGVDILRHSCAHLLGHAIKQLWPQTKMAIGPVIDNGFYYDVDLDHTLTQEDLERL
EECCCCCHHHHHHHHHHHHHHHHHHHCCHHHHHHCCEECCCEEEEECCCCCCCHHHHHHH
DKRMHELAEKDYDVIKKKVSWQEARDAFVARDELYKVAILDENISHDDRPGLYHHEEYLD
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEEEEEECCCCCCCCCCCCCCHHHHH
MCRGPHVPNMRFCHHFKLQKSSGAYWRGDSDNKMLQRIYGTAWADKKQLNAYLQRLEEAA
HHCCCCCCCCHHHHEEEEECCCCCEECCCCHHHHHHHHHHHHCCCHHHHHHHHHHHHHHH
KRDHRKIGKQLDLYHMQEEAPGMVFWHNDGWTIFRELEAFVRMKLKEYQYQEVKGPFMMD
HHHHHHHCCHHHHHHHHCCCCCEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHCCCHHHH
RVLWEKTGHWENYKDAMFTTSSENREYCIKPMNCPGHVQIFNQGLKSYRDLPLRMAEFGS
HHHHHHCCCCCCCCCCEEECCCCCCCEEEECCCCCCHHHHHHHHHHHHHCCCHHHHHHCC
CHRNEPSGSLHGLMRVRGFTQDDAHIFCTEEQIRDEVNSCIKMVYDMYSTFGFEKIVVKL
CCCCCCCHHHHHHHHHCCCCCCCCEEEECHHHHHHHHHHHHHHHHHHHHHCCHHHEEEEE
STRPEKRIGSDEIWDRAEEDLAAALQENGIPFEYQPGEGAFYGPKIEFTLHDCLDRAWQC
CCCCCCCCCCHHHHHHHHHHHHHHHHHCCCCEEEECCCCCEECCEEEEEHHHHHHHHHCC
GTVQLDFSLPGRLSASYVGENNERVVPVMIHRAILGSMERFIGILTEEFAGFFPTWLAPV
CEEEEECCCCCCCCHHCCCCCCCEEHHHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHH
QAVVMNITDSQAEYVEELSKKLQAAGIRVKSDLRNEKIGFKIREHTLRRVPYMLVCGDKE
HHHHHHCCCHHHHHHHHHHHHHHHCCCHHHHHHCCCCCCCCHHHHHHHHCCEEEEECCCC
VEAGKVAVRTRRGKDLGVMSIDDVIKKLQQEIRSRSLHQLEE
CCCCCEEEEECCCCCCCCCCHHHHHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA