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The map label for this gene is cobD [H]

Identifier: 238919744

GI number: 238919744

Start: 1784596

End: 1785672

Strand: Reverse

Name: cobD [H]

Synonym: NT01EI_1848

Alternate gene names: 238919744

Gene position: 1785672-1784596 (Counterclockwise)

Preceding gene: 238919753

Following gene: 238919742

Centisome position: 46.84

GC content: 64.62

Gene sequence:

>1077_bases
ATGTTACACAGCCAGCACGGCGGCGACGTTATCGGCGTCGCAGAGCGCCTGGGCGTCAGCGCACTCAACCTCACCGACTT
CAGCGCCAATATTAATCCCCTGGGTATGCCTGACAGCCTGCGTCAGGCCCTGCATCACCACCTGTCGTTGGCCCAGCCCT
ATCCCGATATTGAATACCGCGCGCTGTACCGTGCTCTGGCTGACCATCACGGGGTTGACGCCGGATGGATCGTCGCCGGC
AACGGCGAGACGGAGCTGATTTTTGCCCTGGCCGATGCCCTGCGTCCGCGGCGTGCCTTGCTGCTGACGCCCGGCTTTGC
CGAGTATCGGCGGGCGCTGCAGCGGGTGGGCTGCGCCATTCAGACCCACCCGCTCAAGGCCGGGAACGGATTTCAGGTGG
ATGAGGATCTGCTGGCAGCGCTGACGGCCGATCTGGACTGCCTCTTTATCTGCACGCCCAATAACCCGACCGGACTCACC
CCCGATCCCGCTCTGCTGCTGGTGCTGGCGGAGCGCTGTCAGCACCTGGGCATCCGCCTGATCGTCGATGAGGCCTTTTG
GGACTTCATCACCGATGAGGCGGGGATGATCCCGCAGCTGGCACGCTTTTCCTGCCTCTGTGTGCTGCGCTCCCTGACCA
AGTTTTACGCCATCGCCGGGCTGCGCCTGGGTTACCTGCTGAGCGCCGATGCATCACTGACCGCGCGGCTGCGGGCGCGA
CAGATGCCCTGGAGCATCAATGCCTTTGCCGCACTGGCCGGCGAGGTCGTGTTGCGCGACCGCGCCTATCAGCAGGCCAC
CCATCGCTGGCTGGCGCAGGAGCGCCCTTTTCTGTACTCGGCGCTGGCGGCGCTGCCGTCGCTTCAGGTGTGGCCCGGTC
GCGCCAACTATCTGTTTCTGCGCTGCGACCGCCCACAGATATGTCTACAGCAGGCCCTGCTGTCTCACGGCCTGTTGATC
CGCCGCTGCGCTGACTATCCGGGACTGGATCCGCGTTATTATCGGGTTTGCGTGCGCCTGCGTTCCGATAATCTGCGGCT
GATCGCCGCCCTGCGTACATGCCTCTGCGCAGGCTGA

Upstream 100 bases:

>100_bases
GCGCAGAATGTATCCGATCAGGGGCGCCCCATTAACCGAGGGCGCCGGTGCCCGCCGTGACGGCGATGCGGGGCACCGGC
CTCCCTTTTGGAGCACCGCG

Downstream 100 bases:

>100_bases
CGCACGCCTGCTCCCCCGCCGTGAACCGGGCCGGAGTAGGTCTGTCATGACACGCAGGCCCGATGGCGACGCCGCCATAC
TGGTCGCACCGATCGCGGCA

Product: threonine-phosphate decarboxylase

Products: NA

Alternate protein names: L-threonine-O-3-phosphate decarboxylase [H]

Number of amino acids: Translated: 358; Mature: 358

Protein sequence:

>358_residues
MLHSQHGGDVIGVAERLGVSALNLTDFSANINPLGMPDSLRQALHHHLSLAQPYPDIEYRALYRALADHHGVDAGWIVAG
NGETELIFALADALRPRRALLLTPGFAEYRRALQRVGCAIQTHPLKAGNGFQVDEDLLAALTADLDCLFICTPNNPTGLT
PDPALLLVLAERCQHLGIRLIVDEAFWDFITDEAGMIPQLARFSCLCVLRSLTKFYAIAGLRLGYLLSADASLTARLRAR
QMPWSINAFAALAGEVVLRDRAYQQATHRWLAQERPFLYSALAALPSLQVWPGRANYLFLRCDRPQICLQQALLSHGLLI
RRCADYPGLDPRYYRVCVRLRSDNLRLIAALRTCLCAG

Sequences:

>Translated_358_residues
MLHSQHGGDVIGVAERLGVSALNLTDFSANINPLGMPDSLRQALHHHLSLAQPYPDIEYRALYRALADHHGVDAGWIVAG
NGETELIFALADALRPRRALLLTPGFAEYRRALQRVGCAIQTHPLKAGNGFQVDEDLLAALTADLDCLFICTPNNPTGLT
PDPALLLVLAERCQHLGIRLIVDEAFWDFITDEAGMIPQLARFSCLCVLRSLTKFYAIAGLRLGYLLSADASLTARLRAR
QMPWSINAFAALAGEVVLRDRAYQQATHRWLAQERPFLYSALAALPSLQVWPGRANYLFLRCDRPQICLQQALLSHGLLI
RRCADYPGLDPRYYRVCVRLRSDNLRLIAALRTCLCAG
>Mature_358_residues
MLHSQHGGDVIGVAERLGVSALNLTDFSANINPLGMPDSLRQALHHHLSLAQPYPDIEYRALYRALADHHGVDAGWIVAG
NGETELIFALADALRPRRALLLTPGFAEYRRALQRVGCAIQTHPLKAGNGFQVDEDLLAALTADLDCLFICTPNNPTGLT
PDPALLLVLAERCQHLGIRLIVDEAFWDFITDEAGMIPQLARFSCLCVLRSLTKFYAIAGLRLGYLLSADASLTARLRAR
QMPWSINAFAALAGEVVLRDRAYQQATHRWLAQERPFLYSALAALPSLQVWPGRANYLFLRCDRPQICLQQALLSHGLLI
RRCADYPGLDPRYYRVCVRLRSDNLRLIAALRTCLCAG

Specific function: Decarboxylates L-threonine-O-3-phosphate to yield (R)-1- amino-2-propanol O-2-phosphate, the precursor for the linkage between the nucleotide loop and the corrin ring in cobalamin [H]

COG id: COG0079

COG function: function code E; Histidinol-phosphate/aromatic aminotransferase and cobyric acid decarboxylase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family [H]

Homologues:

Organism=Escherichia coli, GI1788332, Length=310, Percent_Identity=26.7741935483871, Blast_Score=92, Evalue=5e-20,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004839
- InterPro:   IPR005860
- InterPro:   IPR004838
- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422 [H]

Pfam domain/function: PF00155 Aminotran_1_2 [H]

EC number: =4.1.1.81 [H]

Molecular weight: Translated: 39687; Mature: 39687

Theoretical pI: Translated: 8.02; Mature: 8.02

Prosite motif: PS00105 AA_TRANSFER_CLASS_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

3.4 %Cys     (Translated Protein)
1.1 %Met     (Translated Protein)
4.5 %Cys+Met (Translated Protein)
3.4 %Cys     (Mature Protein)
1.1 %Met     (Mature Protein)
4.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLHSQHGGDVIGVAERLGVSALNLTDFSANINPLGMPDSLRQALHHHLSLAQPYPDIEYR
CCCCCCCCCEEEHHHHHCCEEEEEEECCCCCCCCCCCHHHHHHHHHHHHHCCCCCCHHHH
ALYRALADHHGVDAGWIVAGNGETELIFALADALRPRRALLLTPGFAEYRRALQRVGCAI
HHHHHHHHHCCCCCCEEEECCCCCEEHHHHHHHCCCCCEEEECCCHHHHHHHHHHHCCEE
QTHPLKAGNGFQVDEDLLAALTADLDCLFICTPNNPTGLTPDPALLLVLAERCQHLGIRL
EECCCCCCCCCCCCHHHHHHHHCCCCEEEEECCCCCCCCCCCHHHHHHHHHHHHHCCEEE
IVDEAFWDFITDEAGMIPQLARFSCLCVLRSLTKFYAIAGLRLGYLLSADASLTARLRAR
EEHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEECCCHHHHHHHHH
QMPWSINAFAALAGEVVLRDRAYQQATHRWLAQERPFLYSALAALPSLQVWPGRANYLFL
CCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHCCCCEECCCCCCEEEE
RCDRPQICLQQALLSHGLLIRRCADYPGLDPRYYRVCVRLRSDNLRLIAALRTCLCAG
ECCCHHHHHHHHHHHCCHHHHHHCCCCCCCHHHHHHEEECCCCCCHHHHHHHHHHCCC
>Mature Secondary Structure
MLHSQHGGDVIGVAERLGVSALNLTDFSANINPLGMPDSLRQALHHHLSLAQPYPDIEYR
CCCCCCCCCEEEHHHHHCCEEEEEEECCCCCCCCCCCHHHHHHHHHHHHHCCCCCCHHHH
ALYRALADHHGVDAGWIVAGNGETELIFALADALRPRRALLLTPGFAEYRRALQRVGCAI
HHHHHHHHHCCCCCCEEEECCCCCEEHHHHHHHCCCCCEEEECCCHHHHHHHHHHHCCEE
QTHPLKAGNGFQVDEDLLAALTADLDCLFICTPNNPTGLTPDPALLLVLAERCQHLGIRL
EECCCCCCCCCCCCHHHHHHHHCCCCEEEEECCCCCCCCCCCHHHHHHHHHHHHHCCEEE
IVDEAFWDFITDEAGMIPQLARFSCLCVLRSLTKFYAIAGLRLGYLLSADASLTARLRAR
EEHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEECCCHHHHHHHHH
QMPWSINAFAALAGEVVLRDRAYQQATHRWLAQERPFLYSALAALPSLQVWPGRANYLFL
CCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHCCCCEECCCCCCEEEE
RCDRPQICLQQALLSHGLLIRRCADYPGLDPRYYRVCVRLRSDNLRLIAALRTCLCAG
ECCCHHHHHHHHHHHCCHHHHHHCCCCCCCHHHHHHEEECCCCCCHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11677608; 12644504 [H]